Hmdb loader
HMDB Protein ID HMDBP14631
Secondary Accession Numbers None
Name Pulmonary surfactant-associated protein D
  1. PSP-D
  2. SP-D
  3. Collectin-7
  4. Lung surfactant protein D
Gene Name SFTPD
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
  • Phagosome
Reactions Not Available
GO Classification
Biological Process
regulation of cytokine production
induction of bacterial agglutination
defense response to bacterium
reactive oxygen species metabolic process
respiratory gaseous exchange
cellular protein metabolic process
positive regulation of phagocytosis
surfactant homeostasis
innate immune response
toll-like receptor signaling pathway
macrophage chemotaxis
negative regulation by host of symbiont molecular function
regulation of adhesion of symbiont to host epithelial cell
lung alveolus development
negative regulation of T cell proliferation
negative regulation of interleukin-2 production
regulation of immune response
receptor-mediated endocytosis
Cellular Component
endoplasmic reticulum membrane
endocytic vesicle
multivesicular body
extracellular region
extracellular space
clathrin-coated endocytic vesicle
rough endoplasmic reticulum
Molecular Function
carbohydrate binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 375
Molecular Weight 37728.19
Theoretical pI 6.6
Pfam Domain Function
  • 1-20;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P35247
UniProtKB/Swiss-Prot Entry Name SFTPD_HUMAN
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
General References
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  2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054 ]
  3. Lu J, Willis AC, Reid KB: Purification, characterization and cDNA cloning of human lung surfactant protein D. Biochem J. 1992 Jun 15;284 ( Pt 3):795-802. [PubMed:1339284 ]
  4. Crouch E, Rust K, Veile R, Donis-Keller H, Grosso L: Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1. J Biol Chem. 1993 Feb 5;268(4):2976-83. [PubMed:8428971 ]
  5. Crouch E, Persson A, Chang D: Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. Am J Pathol. 1993 Jan;142(1):241-8. [PubMed:8424457 ]
  6. Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E: Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain. Arch Biochem Biophys. 1991 Oct;290(1):116-26. [PubMed:1898081 ]
  7. Hakansson K, Lim NK, Hoppe HJ, Reid KB: Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D. Structure. 1999 Mar 15;7(3):255-64. [PubMed:10368295 ]
  8. Wang Y, Kuan PJ, Xing C, Cronkhite JT, Torres F, Rosenblatt RL, DiMaio JM, Kinch LN, Grishin NV, Garcia CK: Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. Am J Hum Genet. 2009 Jan;84(1):52-9. doi: 10.1016/j.ajhg.2008.11.010. Epub 2008 Dec 18. [PubMed:19100526 ]
  9. Ortega FJ, Pueyo N, Moreno-Navarrete JM, Sabater M, Rodriguez-Hermosa JI, Ricart W, Tinahones FJ, Fernandez-Real JM: The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status. Int J Obes (Lond). 2013 Dec;37(12):1532-8. doi: 10.1038/ijo.2013.23. Epub 2013 Mar 12. [PubMed:23478426 ]