Hmdb loader
Identification
HMDB Protein ID HMDBP14635
Secondary Accession Numbers None
Name Alpha-amylase 1A
Synonyms
  1. 1,4-alpha-D-glucan glucanohydrolase 1
  2. Salivary alpha-amylase
Gene Name AMY1A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). Catalyzes the hydrolysis of internal (1->4)-alpha-D-glucosidic bonds, yielding a mixture of maltose, isomaltose, small amounts of glucose as well as small linear and branched oligosaccharides called dextrins (PubMed:12527308).
Pathways
  • Carbohydrate digestion and absorption
  • Pancreatic secretion
  • Salivary secretion
  • Starch and sucrose metabolism
Reactions Not Available
GO Classification
Biological Process
oligosaccharide metabolic process
Cellular Component
extracellular vesicular exosome
extracellular space
Molecular Function
alpha-amylase activity
chloride ion binding
calcium ion binding
alpha-amylase activity (releasing maltohexaose)
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 511
Molecular Weight 57767.49
Theoretical pI 6.927
Pfam Domain Function
Signals
  • 1-15;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P0DUB6
UniProtKB/Swiss-Prot Entry Name AMY1A_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  6. Nishide T, Emi M, Nakamura Y, Matsubara K: Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected]. Gene. 1984 May;28(2):263-70. [PubMed:6610603 ]
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  8. Handy DE, Larsen SH, Karn RC, Hodes ME: Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1. Mol Biol Med. 1987 Jun;4(3):145-55. [PubMed:2442579 ]
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