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Showing Protein Glucagon-like peptide 1 receptor (HMDBP14647)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14647
Secondary Accession Numbers None
Name Glucagon-like peptide 1 receptor
Synonyms
  1. GLP-1 receptor
  2. GLP-1-R
  3. GLP-1R
Gene Name GLP1R
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Pathways
  • cAMP signaling pathway
  • Insulin secretion
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
cAMP-mediated signaling
negative regulation of inflammatory response to antigenic stimulus
elevation of cytosolic calcium ion concentration
positive regulation of blood pressure
G-protein coupled receptor signaling pathway
cell surface receptor signaling pathway
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of insulin secretion
activation of adenylate cyclase activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
plasma membrane
integral to membrane
integral to plasma membrane
Molecular Function
G-protein coupled peptide receptor activity
peptide hormone binding
transmembrane signaling receptor activity
glucagon receptor activity
glucagon-like peptide 1 receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 463
Molecular Weight 53025.22
Theoretical pI 8.137
Pfam Domain Function
Signals
  • 1-23;
Transmembrane Regions
  • 140-164;176-201;228-251;266-290;306-328;349-370;384-404;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P43220
UniProtKB/Swiss-Prot Entry Name GLP1R_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [PubMed:14574404 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Thorens B, Porret A, Buhler L, Deng SP, Morel P, Widmann C: Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes. 1993 Nov;42(11):1678-82. doi: 10.2337/diab.42.11.1678. [PubMed:8405712 ]
  4. Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo-Warren H, Permutt MA, Boyd AE 3rd: Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor. Endocrinology. 1993 Oct;133(4):1907-10. doi: 10.1210/endo.133.4.8404634. [PubMed:8404634 ]
  5. Graziano MP, Hey PJ, Borkowski D, Chicchi GG, Strader CD: Cloning and functional expression of a human glucagon-like peptide-1 receptor. Biochem Biophys Res Commun. 1993 Oct 15;196(1):141-6. doi: 10.1006/bbrc.1993.2226. [PubMed:8216285 ]
  6. van Eyll B, Lankat-Buttgereit B, Bode HP, Goke R, Goke B: Signal transduction of the GLP-1-receptor cloned from a human insulinoma. FEBS Lett. 1994 Jul 4;348(1):7-13. doi: 10.1016/0014-5793(94)00553-2. [PubMed:7517895 ]
  7. Wei Y, Mojsov S: Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett. 1995 Jan 30;358(3):219-24. doi: 10.1016/0014-5793(94)01430-9. [PubMed:7843404 ]
  8. Lankat-Buttgereit B, Goke B: Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene. Peptides. 1997;18(5):617-24. doi: 10.1016/s0196-9781(97)00001-6. [PubMed:9213353 ]
  9. Mann RJ, Al-Sabah S, de Maturana RL, Sinfield JK, Donnelly D: Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket. Peptides. 2010 Dec;31(12):2289-93. doi: 10.1016/j.peptides.2010.09.015. Epub 2010 Oct 1. [PubMed:20869417 ]
  10. Dezelak M, Bavec A: Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase. Mol Biol Rep. 2012 Apr;39(4):4375-81. doi: 10.1007/s11033-011-1225-0. Epub 2011 Sep 8. [PubMed:21901419 ]
  11. Whitaker GM, Lynn FC, McIntosh CH, Accili EA: Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization. PLoS One. 2012;7(3):e32675. doi: 10.1371/journal.pone.0032675. Epub 2012 Mar 7. [PubMed:22412906 ]
  12. Runge S, Thogersen H, Madsen K, Lau J, Rudolph R: Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem. 2008 Apr 25;283(17):11340-7. doi: 10.1074/jbc.M708740200. Epub 2008 Feb 20. [PubMed:18287102 ]
  13. Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S: Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. J Biol Chem. 2010 Jan 1;285(1):723-30. doi: 10.1074/jbc.M109.033829. Epub 2009 Oct 27. [PubMed:19861722 ]
  14. Hennen S, Kodra JT, Soroka V, Krogh BO, Wu X, Kaastrup P, Orskov C, Ronn SG, Schluckebier G, Barbateskovic S, Gandhi PS, Reedtz-Runge S: Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor. Sci Rep. 2016 May 19;6:26236. doi: 10.1038/srep26236. [PubMed:27196125 ]
  15. Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC: Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 Jun 8;546(7657):312-315. doi: 10.1038/nature22378. Epub 2017 May 17. [PubMed:28514449 ]