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HMDB Protein ID HMDBP14653
Secondary Accession Numbers None
Name G-protein coupled receptor 4
Synonyms Not Available
Gene Name GPR4
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO2H+.
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 19
Locus 19q13.32
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 362
Molecular Weight 40.0
Theoretical pI Not Available
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein AAA63180.1
UniProtKB/Swiss-Prot ID P46093
UniProtKB/Swiss-Prot Entry Name GPR4_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
General References Not Available