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Showing Protein G-protein coupled receptor 4 (HMDBP14653)
| Identification | |
|---|---|
| HMDB Protein ID | HMDBP14653 |
| Secondary Accession Numbers | None |
| Name | G-protein coupled receptor 4 |
| Synonyms | Not Available |
| Gene Name | GPR4 |
| Protein Type | Unknown |
| Biological Properties | |
| General Function | Not Available |
| Specific Function | Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO2H+. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 19 |
| Locus | 19q13.32 |
| SNPs | Not Available |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 362 |
| Molecular Weight | 40.0 |
| Theoretical pI | Not Available |
| Pfam Domain Function | Not Available |
| Signals | Not Available |
| Transmembrane Regions | Not Available |
| Protein Sequence | Not Available |
| External Links | |
| GenBank ID Protein | AAA63180.1 |
| UniProtKB/Swiss-Prot ID | P46093 |
| UniProtKB/Swiss-Prot Entry Name | GPR4_HUMAN |
| PDB IDs | Not Available |
| GenBank Gene ID | Not Available |
| GeneCard ID | Not Available |
| GenAtlas ID | Not Available |
| HGNC ID | HGNC:4497 |
| References | |
| General References | Not Available |