Accession NumberHMDB00725
Common_NameHydroxyproline
DescriptionHydroxyproline is an uncommon amino acid. Hydroxyproline differs from proline by the presence of a hydroxyl (OH) group attached to the C (gamma) atom. Hydroxyproline is produced by hydroxylation of the amino acid proline. It is not directly coded for by DNA, however, and is hydroxylated after protein synthesis. Hydroxyproline is a major component of the protein collagen. Hydroxyproline and proline play key roles for collagen stability. They permit the sharp twisting of the collagen helix. It helps provide stability to the triple-helical structure of collagen by forming hydrogen bonds. Hydroxyproline is found in few proteins other than collagen. The only other mammalian protein which includes hydroxyproline is elastin. For this reason, hydroxyproline content has been used as an indicator to determine collagen and/or gelatin amount. Proline hydroxylation requires ascorbic acid. The most obvious, first effects (gum and hair problems) of absence of ascorbic acid in humans come from the resulting defect in hydroxylation of proline residues of collagen, with reduced stability of the collagen molecule causing scurvy. (http://en.wikipedia.org/wiki/Hydroxyproline) Hydroxyproline levels increase in cases of psychotic depression. These patients also may require extra vitamin C. (http://www.dcnutrition.com/AminoAcids)
Chemical_IUPAC_Name(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid
Chemical FormulaC5H9NO3
Sample ConcentrationNot Available
Mass Value1
Mass Unitmg
ManufacturerQuattro_QQQ
AnalyzerTriple_Quad
DeliveryFlow_Injection
IonizationPositive
Predicted 1H NMR SpectrumDownload
Predicted 1H NMR PeaklistDownload
Predicted 13C NMR SpectrumDownload
Predicted 13C NMR PeaklistDownload
Sample ConcentrationNot Available
Mass ValueNot Available
Mass UnitNot Available
ManufacturerNot Available
FrequencyNot Available
1H NMR Spectrum
Sample ConcentrationNot Available
Mass ValueNot Available
Mass UnitNot Available
ManufacturerNot Available
FrequencyNot Available
13C NMR Spectrum
Low Energy Voltage10
Low Energy SpectrumDownload
Low Energy PeaklistDownload
Medium Energy SpectrumDownload
High Energy SpectrumDownload