Description | 1-Oleoyl-lysophosphatidic acid is a phospholipid mediator with multiple biological functions and is implicated in various human diseases. 1-Oleoyl-lysophosphatidic acid is produced in various conditions both in cells and in biological fluids, where multiple synthetic reactions occur. In serum and plasma, 1-Oleoyl-lysophosphatidic acid is mainly converted from lysophospholipids, whereas in platelets and some cancer cells is converted from phosphatidic acid. In each pathway, at least two phospholipase activities are required: phospholipase A1 (PLA1)/PLA2 plus lysophospholipase D (lysoPLD) activities are involved in the first pathway and phospholipase D (PLD) plus PLA1/PLA2 activities are involved in the second pathway. (PMID 15271293) The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). (PMID 15271294) 1-Oleoyl-lysophosphatidic acid is a phospholipid mediator with multiple biological functions and is implicated in various human diseases. 1-Oleoyl-lysophosphatidic acid is produced in various conditions both in cells and in biological fluids, where multiple synthetic reactions occur. In serum and plasma, 1-Oleoyl-lysophosphatidic acid is mainly converted from lysophospholipids, whereas in platelets and some cancer cells is converted from phosphatidic acid. In each pathway, at least two phospholipase activities are required: phospholipase A1 (PLA1)/PLA2 plus lysophospholipase D (lysoPLD) activities are involved in the first pathway and phospholipase D (PLD) plus PLA1/PLA2 activities are involved in the second pathway. (PMID 15271293) The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). (PMID 15271294) Lysophospholipids are small lipid molecules defined by a 3-carbon backbone to which an acyl chain having variable length and saturation is attached and represent one class of lipids that has many important actions mediated by G protein-coupled receptors. (PMID 16099390) |