Accession NumberHMDB00227
Common_NameMevalonic acid
DescriptionMevalonic acid is a key organic compound in biochemistry. It is a precursor in the biosynthetic pathway, known as the HMG-CoA reductase pathway, that produces terpenes and steroids. Mevalonate is produced by NADPH from 3-hydroxy-3-methylglutaryl CoA via reduction. This reaction occurs in the cytosol. It is the committed step in cholesterol synthesis, -- Wikipedia The production of mevalonic acid (MVA) by the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, is the rate-limiting step in the biosynthesis of cholesterol. (Jemal et. al, Rapid Communications in Mass Spectrometry, 2003, 17:1715) Plasma concentrations and urinary excretion of MVA are decreased by HMG-CoA reductase inhibitor drugs such as pravastatin, simvastatin and atorvastatin. Naoumova RP, Marais AD, Mountney J, Firth JC, Rendell NB, Taylor GW, Thompson GR. Atherosclerosis 1996; 119: 203.
Chemical_IUPAC_Name3,5-dihydroxy-3-methyl-Pentanoic acid
Chemical FormulaC6H12O4
Sample Concentration1
Mass Value1
Mass Unitmg
ManufacturerQuattro_QQQ
AnalyzerTriple_Quad
DeliveryFlow_Injection
IonizationPositive
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Sample ConcentrationNot Available
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FrequencyNot Available
1H NMR SpectrumNot Available
Sample ConcentrationNot Available
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FrequencyNot Available
13C NMR SpectrumNot Available
Low Energy Voltage10
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