Accession NumberHMDB02344
Common_NameHydroxyeicosatetraenoic acid
DescriptionHydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonic acid (AA) metabolized by Cytochrome P450 (P450) enzymes in the liver, brain, lung, kidney and peripheral blood vessels. P450 enzymes have emerged as a pivotal pathway of AA metabolism and the metabolites formed are known to play crucial roles in the regulation of vascular tone in renal, cerebral, and coronary and pulmonary circulation. HETEs have different biological properties based on sites of production and can be stored in tissue lipids and released in response to hormonal stimuli. Eicosanoids generated during the actions of growth factors and vasoconstrictors can modulate disease processes by affecting vascular homeostasis, inflammation, cellular growth, apoptosis and oxidant stress. In lung, the presence of these eicosanoids in the pulmonary vasculature and airways, including effects on pulmonary vascular and bronchial smooth muscle tone and airway epithelial ion transport. (PMID: 16258232, 14626496, 12681244, 11123211)
Chemical_IUPAC_Name(2E,4E,6E,8E)-20-hydroxyicosa-2,4,6,8-tetraenoic acid
Chemical FormulaC20H32O3
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