Accession NumberHMDB02351
Common_Name8,9-Dihydroxyeicosatrienoic acid
Description8,9-Dihydroxyeicosatrienoic acid is a putative endothelium-derived hyperpolarizing factor, the metabolite of soluble epoxide hydrolase (EC 3.3.2.10, sEH) derived from epoxyeicosatrienoic acids (EETs). Epoxyeicosatrienoic acids are derived from arachidonic acid; the CYP2C epoxygenase branch of the P450 arachidonic acid (EC 1.14.14.1) monooxygenases catalyzes the epoxidation of arachidonic acid to EET8,9-Dihydroxyeicosatrienoic modulates microvascular tone by hyperpolarizing vascular smooth muscle cells through modulation of the K(+) (BK) channel gating behaviour, and by enhancing the channel sensitivities to Ca(2+) and voltage. 8,9-Dihydroxyeicosatrienoic acid dilates human coronary arterioles via activation blockade of large-conductance Ca2+-activated K+ channels. (PMID: 16258029, 11483698)
Chemical_IUPAC_Name(5E,11E,14E)-8,9-dihydroxyicosa-5,11,14-trienoic acid
Chemical FormulaC20H34O4
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Predicted 1H NMR SpectrumDownload
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Predicted 13C NMR PeaklistDownload
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