Description | Disialyllacto-N-tetraose is a sialyl hexasaccharide from human milk, which has been also isolated from human pregnancy urine, and also been found in feces of preterm human newborn. Its structure is that of lacto-N-tetraose with one of the residues of sialic acid linked alpha-(2->3) to the terminal nonreducing residue of D-galactose and the other sialic acid residue linked alpha-(2->6) to the N-acetyl-D-glucosamine residue. Sialylated oligosaccharides are important components of glycoproteins and glycolipids and also occur as free oligosaccharides in several body fluids. In human milk, both free and bound sialylated oligosaccharides have potential biological activity and are known to inhibit viral infection. (PMID: 10683228, 809156, 5363606, 1000529, 3421714) |
Chemical_IUPAC_Name | (2S,4S,5R,6R)-5-acetamido-2-[(2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-5-acetamido-2-[[(2R,4S,5R,6R)-5-acetamido-2-carboxylato-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxymethyl]-6-[(2R,3R,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-oxan-4-yl]oxy-3-hydroxy-oxan-4-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate |