Accession Number | HMDB01189 |
Common_Name | 2(N)-Methyl-norsalsolinol |
Description | 2(N)-methyl-norsalsolinol (NMNorsal) is a dihydroxylated tetrahydroisoquinoline derivative 2(N)-analogue of salsolinol, identified as a putative endogenous neurotoxin in patients with Parkinson's disease. A prominent blood-brain barrier (BBB) is described to exist for salsolinol, but penetration of NMNorsal occurs through the BBB into the caudate nucleus of the rat brain. There was no alteration in extracellular dopamine or 3,4-dihydroxyphenylacetic acid levels. (PMID 11924888)
2(N)-methyl-norsalsolinol was identified in L-DOPA-treated patients with Parkinson's disease and proposed to be responsible for behavioral changes. Atypical heterocyclic L-DOPA/dopamine metabolite NMNorsal is able to modify long-term regulation of serotonin and opioid receptor expression in striatum. Since the occurrence of hallucinosis or psychosis following L-DOPA treatment is related to the serotonergic system, these results probably reflect a link between NMNorsal and L-DOPA side effects in Parkinson's disease. (PMID 14607311) |
Chemical_IUPAC_Name | 2-methyl-3,4-dihydro-1H-isoquinoline-6,7-diol |
Chemical Formula | C10H13NO2 |
Sample Concentration | Not Available |
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Predicted 1H NMR Spectrum | Download |
Predicted 1H NMR Peaklist | Download |
Predicted 13C NMR Spectrum | Download |
Predicted 13C NMR Peaklist | Download |
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1H NMR Spectrum | Not Available |
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Low Energy Voltage | Not Available |
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Hight Energy Spectrum | Not Available |