Accession NumberHMDB02342
Common_Name14,15-Dihydroxyeicosatrienoic acid
Description14,15-Dihydroxyeicosatrienoic acid (14,15-DHET) is a metabolite of arachidonic acid metabolism. 14,15-DHET is the main product of 14,15-epoxyeicosatrienoic acid (14,15-EET) metabolism in intact human blood vessels. Epoxyeicosatrienoic acids (EETs) are potent regulators of vascular homeostasis and are bound by cytosolic fatty acid-binding proteins (FABPs); FABPs are potent inhibitors of 14,15-EET conversion to 14,15-DHET. Endothelial cells, but not smooth muscle cells, convert 14,15-EET to 14,15-DHET, and this conversion results in a loss of vasodilator activity. 14,15-DHET is a potent activator of peroxisome proliferator-activated receptor alpha (PPARalpha). (PMID: 6798994, 6792198, 17431031, 15284062, 14529287, 11959628)
Chemical_IUPAC_Name(5E,8E,11E)-14,15-dihydroxyicosa-5,8,11-trienoic acid
Chemical FormulaC20H34O4
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Predicted 13C NMR PeaklistDownload
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