Accession NumberHMDB04694
Common_Name11,14,15-THETA
Description11,14,15-trihydroxyeicosatrienoic acid (11,14,15-THETA) is a metabolite of the 15-lipoxygenase (15-LO) pathway of arachidonic acid (AA). Increased amounts of 11,14,15-THETA are synthesized in subacute hypoxia. Prolonged exposure to reduced PO2 activates 15-LO in small pulmonary arteries (PA); activation of 15-LO is associated with translocation of the enzyme from the cytosol to membrane. 11,14,15-THETA is an endothelium-derived relaxing factor. (PMID: 12690037, 9812980, 15388505, 14622984)
Chemical_IUPAC_Name(5Z,8Z,12E)-11,14,15-trihydroxyicosa-5,8,12-trienoic acid
Chemical FormulaC20H34O5
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