Accession NumberHMDB06583
Common_NamePoly-N-acetyllactosamine
DescriptionPoly-N-acetyllactosamine is a sequence similarity in the carbohydrate recognition domain of glycoconjugates. Galectins constitute a family of structurally related beta-galactoside-binding proteins, which are defined by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and sequence similarities in the carbohydrate recognition domain. By crosslinking specific glycoconjugates, different members of the galectin family behave as pro-inflammatory or anti-inflammatory agents, acting at different levels of acute and chronic inflammatory responses. Galectin-1 contributes to different events associated with cancer biology, including tumour transformation, cell cycle regulation, apoptosis, cell adhesion, migration and inflammation. Repeated N-acetyllactosamine units can represent a pathogen antigen. A monoclonal antibody (MAb H6-3C4) produced by a human-mouse heterohybridoma was established from the peripheral blood lymphocytes of an infertile patient. N-linked carbohydrate present in the molecular structure of male reproductive tract CD52 (mrtCD52) were identified as an antigenic epitope for sperm-immobilizing antibody. (PMID: 16107278, 15785741, 15191517)
Chemical_IUPAC_NameN-[(2R,3R,4R,5R)-3,5,6-trihydroxy-1-oxo-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hexan-2-yl]acetamide
Chemical FormulaC14H25NO11
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Predicted 1H NMR SpectrumDownload
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