Accession NumberHMDB05943
Common_Name5beta-Pregnanediol
Description5beta-Pregnanediol is an endogenous human metabolite of testosterone. The 5beta-Pregnanediol excretion is low in women with suspected placental insufficiency and in women with uterine fibroma. 5beta-Pregnanediol levels can change in endocrine disturbances such as hirsutism or Cushing's syndrome, depending on the stage of the disease. 5beta-Pregnanediol has been tried as a more reliable compound to measure in screening of urinary steroids when suspecting doping, due to its not significant isotopic fractionation that could lead to false positive results in anti-doping testing. 13C-enrichment caused by a diet change might be a reason of concern in athletes that move around between places and might have a considerable change of diet between competitions. In contrast to the results obtained with the carbon isotopic ratio, profiling of urinary testosterone/epitestosterone (T/E) ratios is found to be unaffected by a diet change. (PMID: 16338181, 5172227, 13636945, 14440289)
Chemical_IUPAC_Name17-(1-hydroxyethyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
Chemical FormulaC21H36O2
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