Accession NumberHMDB00632
Common_NameDermatan
DescriptionA naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from chondroitin sulfate A (see chondroitin sulfateS) by containing Iduronic acid in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed) Dermatan sulfate consists of sulfated N-acetylgalactosamine alternating with uronic acid residues. The latter are predominantly L-Iduronic acid, some of which are sulfated; there are also occasional glucuronic acid residues. Degradation proceeds stepwise from the nonreducing end by the sequential action of three exo-glycosidases (alpha-L-iduronidase, beta-glucuronidase, and beta-hexosaminidase) and two sulfatases (iduronate 2-sulfatase and N-acetylgalactosamine 4-sulfatase). An endoglycosidase, hyaluronidase, may also participate to a limited extent in the degradation process by cleaving next to the occasional glucuronic acid residues. -- OMMBID 136-2
Chemical_IUPAC_Name(2R,3S,4S,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2-hydroxy-6-(hydroxymethyl)-5-sulfonatooxy-oxan-4-yl]oxy-3,4,5-trihydroxy-oxane-2-carboxylate
Chemical FormulaC18H30NO14S
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Predicted 1H NMR SpectrumDownload
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Predicted 13C NMR SpectrumDownload
Predicted 13C NMR PeaklistDownload
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