Accession NumberHMDB06725
Common_NameCholestryl myristic acid
DescriptionCholestryl myristic acid is a cholesteryl ester. A cholesteryl ester is an ester of cholesterol. Fatty acid esters of cholesterol constitute about two-thirds of the cholesterol in the plasma. Cholesterol is a sterol (a combination steroid and alcohol) and a lipid found in the cell membranes of all body tissues, and transported in the blood plasma of all animals. The accumulation of cholesterol esters in the arterial intima (the innermost layer of an artery, in direct contact with the flowing blood) is a characteristic feature of atherosclerosis. Atherosclerosis is a disease affecting arterial blood vessels. It is a chronic inflammatory response in the walls of arteries, in large part to the deposition of lipoproteins (plasma proteins that carry cholesterol and triglycerides). Analysis of the Dietary and Nutritional Survey of British Adults reveals that if the intake of polyunsaturated fatty acids falls below a threshold of about 5% energy, the cholesterol-raising properties of certain saturated fatty acids, e.g. myristic acid, are greatly augmented. On the basis of a limited number of well-controlled studies, it appears that myristic acid is the most potent hypercholesterolemic saturated fatty acids. Cholestryl myristic acid is an atherogenic factor (Atherogenesis is the developmental process of plaques). (PMID: 10343356, 9129503, 8660400)
Chemical_IUPAC_Name[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] tetradecanoate
Chemical FormulaC41H72O2
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Predicted 1H NMR SpectrumDownload
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Predicted 13C NMR PeaklistDownload
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