Accession NumberHMDB05080
Common_Name8-HETE
Description8-HETE is a lipoxygenase-catalyzed metabolite of arachidonic acid. Lipoxygenase (LO) and cytochrome P450 monooxygenase products of arachidonic acid (AA) have been implicated in a large number of vasoregulatory processes. ex-vivo-perfused human lungs release 8-HETE into the vascular compartment in response to inflammatory challenge. 8-HETE is fatty acid metabolite known to activate the PPAR receptors. In the rat, 8-HETE is the key metabolite of arachidonic acid that regulates corneal epithelial cell migration during wound healing. (PMID: 10956057, 10852767, 10832716, 16137885)
Chemical_IUPAC_Name(5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid
Chemical FormulaC20H32O3
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Predicted 13C NMR PeaklistDownload
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