Hmdb loader

Showing metabocard for L-Arginine (HMDB0000517)

Jump To Section:
IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesenzymes (25) Show 25 proteinsXML
enzymes (25) Show 25 proteins
Read more...Show more...Show more...Show more...Show more...Show more...Show more...Show more...
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-05-30 20:55:55 UTC
HMDB IDHMDB0000517
Secondary Accession Numbers
  • HMDB00517
Metabolite Identification
Common NameL-Arginine
Description
Structure
Thumb
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000517 (L-Arginine)

  Mrv1652309272007312D          

 12 11  0  0  1  0            999 V2000
    2.0245    0.9626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0245    0.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7390   -0.2750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3100   -0.2750    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3100   -1.1001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5953    0.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1191   -0.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8336    0.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5481   -0.2750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2628    0.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2628    0.9626    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9774   -0.2750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  3  2  1  0  0  0  0
  4  2  1  0  0  0  0
  4  5  1  1  0  0  0
  6  4  1  0  0  0  0
  7  6  1  0  0  0  0
  9  8  1  0  0  0  0
  7  8  1  0  0  0  0
 10  9  1  0  0  0  0
 11 10  2  0  0  0  0
 12 10  1  0  0  0  0
M  END
Download

3D MOL for HMDB0000517 (L-Arginine)

HMDB0000517
     RDKit          3D
L-Arginine
 26 25  0  0  0  0  0  0  0  0999 V2000
    4.1224   -0.9254    0.5144 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5106    0.0965    0.0198 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2260    1.3380    0.0466 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2069    0.0328   -0.5313 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1035   -0.2421    0.3250 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2309   -0.2099   -0.4313 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2831   -0.5235    0.6106 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6763   -0.5179    0.0326 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.8626   -1.4726   -1.0178 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9994    0.8878   -0.3794 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3937    1.1461   -1.5448 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8294    1.8520    0.6130 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7319   -1.8747    0.5608 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8295    2.2424    0.3432 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2250    1.3111   -0.2621 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1031    0.1874   -1.5551 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0220    0.6018    1.0575 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1635   -1.1936    0.8604 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4196    0.7647   -0.9065 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1650   -0.9810   -1.2253 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0348   -1.4781    1.1099 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2343    0.2869    1.3688 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3638   -0.7950    0.8693 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8844   -1.3874   -1.3084 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3084   -1.1778   -1.8725 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5589    2.0316    1.2890 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  3
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 10 12  1  0
  1 13  1  0
  3 14  1  0
  3 15  1  0
  4 16  1  0
  5 17  1  0
  5 18  1  0
  6 19  1  0
  6 20  1  0
  7 21  1  0
  7 22  1  0
  8 23  1  1
  9 24  1  0
  9 25  1  0
 12 26  1  0
M  END
Download

3D SDF for HMDB0000517 (L-Arginine)

  Mrv1652309272007312D          

 12 11  0  0  1  0            999 V2000
    2.0245    0.9626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0245    0.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7390   -0.2750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3100   -0.2750    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3100   -1.1001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5953    0.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1191   -0.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8336    0.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5481   -0.2750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2628    0.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2628    0.9626    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9774   -0.2750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  3  2  1  0  0  0  0
  4  2  1  0  0  0  0
  4  5  1  1  0  0  0
  6  4  1  0  0  0  0
  7  6  1  0  0  0  0
  9  8  1  0  0  0  0
  7  8  1  0  0  0  0
 10  9  1  0  0  0  0
 11 10  2  0  0  0  0
 12 10  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000517

> <DATABASE_NAME>
hmdb

> <SMILES>
N[C@@H](CCCNC(N)=N)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

> <INCHI_KEY>
ODKSFYDXXFIFQN-BYPYZUCNSA-N

> <FORMULA>
C6H14N4O2

> <MOLECULAR_WEIGHT>
174.201

> <EXACT_MASS>
174.111675712

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
26

> <JCHEM_AVERAGE_POLARIZABILITY>
17.798401776145056

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S)-2-amino-5-carbamimidamidopentanoic acid

> <ALOGPS_LOGP>
-3.49

> <JCHEM_LOGP>
-3.1559373774200568

> <ALOGPS_LOGS>
-1.88

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.4118378885304885

> <JCHEM_PKA_STRONGEST_BASIC>
12.41100429474531

> <JCHEM_POLAR_SURFACE_AREA>
125.21999999999998

> <JCHEM_REFRACTIVITY>
53.9231

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.28e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
L-arginine

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0000517 (L-Arginine)

HMDB0000517
     RDKit          3D
L-Arginine
 26 25  0  0  0  0  0  0  0  0999 V2000
    4.1224   -0.9254    0.5144 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5106    0.0965    0.0198 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2260    1.3380    0.0466 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2069    0.0328   -0.5313 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1035   -0.2421    0.3250 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2309   -0.2099   -0.4313 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2831   -0.5235    0.6106 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6763   -0.5179    0.0326 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.8626   -1.4726   -1.0178 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9994    0.8878   -0.3794 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3937    1.1461   -1.5448 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8294    1.8520    0.6130 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7319   -1.8747    0.5608 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8295    2.2424    0.3432 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2250    1.3111   -0.2621 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1031    0.1874   -1.5551 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0220    0.6018    1.0575 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1635   -1.1936    0.8604 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4196    0.7647   -0.9065 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1650   -0.9810   -1.2253 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0348   -1.4781    1.1099 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2343    0.2869    1.3688 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3638   -0.7950    0.8693 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8844   -1.3874   -1.3084 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3084   -1.1778   -1.8725 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5589    2.0316    1.2890 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  3
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 10 12  1  0
  1 13  1  0
  3 14  1  0
  3 15  1  0
  4 16  1  0
  5 17  1  0
  5 18  1  0
  6 19  1  0
  6 20  1  0
  7 21  1  0
  7 22  1  0
  8 23  1  1
  9 24  1  0
  9 25  1  0
 12 26  1  0
M  END
Download

PDB for HMDB0000517 (L-Arginine)

HEADER    PROTEIN                                 27-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-SEP-20         0                                  
HETATM    1  O   UNK     0       3.779   1.797   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       3.779   0.257   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       5.113  -0.513   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0       2.445  -0.513   0.000  0.00  0.00           C+0
HETATM    5  N   UNK     0       2.445  -2.054   0.000  0.00  0.00           N+0
HETATM    6  C   UNK     0       1.111   0.257   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -0.222  -0.513   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.556   0.257   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0      -2.890  -0.513   0.000  0.00  0.00           N+0
HETATM   10  C   UNK     0      -4.224   0.257   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0      -4.224   1.797   0.000  0.00  0.00           N+0
HETATM   12  N   UNK     0      -5.558  -0.513   0.000  0.00  0.00           N+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7                                                       
CONECT    7    6    8                                                       
CONECT    8    9    7                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10                                                            
MASTER        0    0    0    0    0    0    0    0   12    0   22    0
END
Download

3D PDB for HMDB0000517 (L-Arginine)

COMPND    HMDB0000517
HETATM    1  N1  UNL     1       4.122  -0.925   0.514  1.00  0.00           N  
HETATM    2  C1  UNL     1       3.511   0.097   0.020  1.00  0.00           C  
HETATM    3  N2  UNL     1       4.226   1.338   0.047  1.00  0.00           N  
HETATM    4  N3  UNL     1       2.207   0.033  -0.531  1.00  0.00           N  
HETATM    5  C2  UNL     1       1.104  -0.242   0.325  1.00  0.00           C  
HETATM    6  C3  UNL     1      -0.231  -0.210  -0.431  1.00  0.00           C  
HETATM    7  C4  UNL     1      -1.283  -0.524   0.611  1.00  0.00           C  
HETATM    8  C5  UNL     1      -2.676  -0.518   0.033  1.00  0.00           C  
HETATM    9  N4  UNL     1      -2.863  -1.473  -1.018  1.00  0.00           N  
HETATM   10  C6  UNL     1      -2.999   0.888  -0.379  1.00  0.00           C  
HETATM   11  O1  UNL     1      -3.394   1.146  -1.545  1.00  0.00           O  
HETATM   12  O2  UNL     1      -2.829   1.852   0.613  1.00  0.00           O  
HETATM   13  H1  UNL     1       3.732  -1.875   0.561  1.00  0.00           H  
HETATM   14  H2  UNL     1       3.830   2.242   0.343  1.00  0.00           H  
HETATM   15  H3  UNL     1       5.225   1.311  -0.262  1.00  0.00           H  
HETATM   16  H4  UNL     1       2.103   0.187  -1.555  1.00  0.00           H  
HETATM   17  H5  UNL     1       1.022   0.602   1.058  1.00  0.00           H  
HETATM   18  H6  UNL     1       1.164  -1.194   0.860  1.00  0.00           H  
HETATM   19  H7  UNL     1      -0.420   0.765  -0.906  1.00  0.00           H  
HETATM   20  H8  UNL     1      -0.165  -0.981  -1.225  1.00  0.00           H  
HETATM   21  H9  UNL     1      -1.035  -1.478   1.110  1.00  0.00           H  
HETATM   22  H10 UNL     1      -1.234   0.287   1.369  1.00  0.00           H  
HETATM   23  H11 UNL     1      -3.364  -0.795   0.869  1.00  0.00           H  
HETATM   24  H12 UNL     1      -3.884  -1.387  -1.308  1.00  0.00           H  
HETATM   25  H13 UNL     1      -2.308  -1.178  -1.872  1.00  0.00           H  
HETATM   26  H14 UNL     1      -3.559   2.032   1.289  1.00  0.00           H  
CONECT    1    2    2   13
CONECT    2    3    4
CONECT    3   14   15
CONECT    4    5   16
CONECT    5    6   17   18
CONECT    6    7   19   20
CONECT    7    8   21   22
CONECT    8    9   10   23
CONECT    9   24   25
CONECT   10   11   11   12
CONECT   12   26
END
Download

SMILES for HMDB0000517 (L-Arginine)

N[C@@H](CCCNC(N)=N)C(O)=O
Download

INCHI for HMDB0000517 (L-Arginine)

InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
Download
View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
Chemical FormulaC6H14N4O2
Average Molecular Weight174.201
Monoisotopic Molecular Weight174.111675712
IUPAC Name(2S)-2-amino-5-carbamimidamidopentanoic acid
Traditional NameL-arginine
CAS Registry Number74-79-3
SMILES
N[C@@H](CCCNC(N)=N)C(O)=O
InChI Identifier
InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChI KeyODKSFYDXXFIFQN-BYPYZUCNSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentL-alpha-amino acids
Alternative Parents
Substituents
  • L-alpha-amino acid
  • Fatty acid
  • Guanidine
  • Amino acid
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Carboximidamide
  • Propargyl-type 1,3-dipolar organic compound
  • Organic 1,3-dipolar compound
  • Amine
  • Hydrocarbon derivative
  • Organic oxide
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organopnictogen compound
  • Primary aliphatic amine
  • Organic oxygen compound
  • Organic nitrogen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect
Health effectOrganoleptic effect
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Industrial applicationBiological role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point222 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility182 mg/mL at 25 °CHuman Metabolome Project
LogP-4.20HANSCH,C ET AL. (1995)
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Astarita_neg133.730932474
[M-H]-Baker138.2430932474
[M-H]-McLean138.37330932474
[M-H]-MetCCS_test_neg134.330932474
[M+H]+Astarita_pos133.030932474
[M+H]+Baker136.6330932474
[M+H]+McLean136.64230932474
[M+H]+MetCCS_test_pos136.39930932474
[M-H]-Not Available136.6http://allccs.zhulab.cn/database/detail?ID=AllCCS00000086
[M+H]+Not Available136.7http://allccs.zhulab.cn/database/detail?ID=AllCCS00000086
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Saliva
  • Sweat
  • Urine
Tissue Locations
  • Adipose Tissue
  • Adrenal Cortex
  • Bladder
  • Epidermis
  • Fibroblasts
  • Intestine
  • Kidney
  • Liver
  • Neuron
  • Ovary
  • Pancreas
  • Placenta
  • Platelet
  • Prostate
  • Skeletal Muscle
  • Spleen
  • Testis
Pathways
Normal Concentrations
Abnormal Concentrations
Associated Disorders and Diseases
Disease References
Intestinal failure
  1. Crenn P, Coudray-Lucas C, Thuillier F, Cynober L, Messing B: Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology. 2000 Dec;119(6):1496-505. [PubMed:11113071 ]
Alzheimer's disease
  1. Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10. [PubMed:17031479 ]
  2. Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Heart failure
  1. Norrelund H, Wiggers H, Halbirk M, Frystyk J, Flyvbjerg A, Botker HE, Schmitz O, Jorgensen JO, Christiansen JS, Moller N: Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure. J Intern Med. 2006 Jul;260(1):11-21. [PubMed:16789974 ]
Argininemia
  1. Michels VV, Beaudet AL: Arginase deficiency in multiple tissues in argininemia. Clin Genet. 1978 Jan;13(1):61-7. [PubMed:624188 ]
  2. Brockstedt M, Smit LM, de Grauw AJ, van der Klei-van Moorsel JM, Jakobs C: A new case of hyperargininaemia: neurological and biochemical findings prior to and during dietary treatment. Eur J Pediatr. 1990 Feb;149(5):341-3. [PubMed:2311630 ]
  3. Schlune A, Vom Dahl S, Haussinger D, Ensenauer R, Mayatepek E: Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. Amino Acids. 2015 Sep;47(9):1751-62. doi: 10.1007/s00726-015-2032-z. Epub 2015 Jun 27. [PubMed:26123990 ]
  4. Therrell BL, Currier R, Lapidus D, Grimm M, Cederbaum SD: Newborn screening for hyperargininemia due to arginase 1 deficiency. Mol Genet Metab. 2017 Aug;121(4):308-313. doi: 10.1016/j.ymgme.2017.06.003. Epub 2017 Jun 20. [PubMed:28659245 ]
  5. G.Frauendienst-Egger, Friedrich K. Trefz (2017). MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de). METAGENE consortium.
Chronic renal failure
  1. Kikuchi T, Orita Y, Ando A, Mikami H, Fujii M, Okada A, Abe H: Liquid-chromatographic determination of guanidino compounds in plasma and erythrocyte of normal persons and uremic patients. Clin Chem. 1981 Nov;27(11):1899-902. [PubMed:7296840 ]
Colorectal cancer
  1. Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14. [PubMed:25105552 ]
  2. Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. [PubMed:27275383 ]
  3. Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ]
  4. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
Early preeclampsia
  1. Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28. [PubMed:22494326 ]
Pregnancy
  1. Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28. [PubMed:22494326 ]
  2. Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13. [PubMed:23159745 ]
  3. Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomic analysis for first-trimester Down syndrome prediction. Am J Obstet Gynecol. 2013 May;208(5):371.e1-8. doi: 10.1016/j.ajog.2012.12.035. Epub 2013 Jan 8. [PubMed:23313728 ]
  4. Bahado-Singh RO, Akolekar R, Chelliah A, Mandal R, Dong E, Kruger M, Wishart DS, Nicolaides K: Metabolomic analysis for first-trimester trisomy 18 detection. Am J Obstet Gynecol. 2013 Jul;209(1):65.e1-9. doi: 10.1016/j.ajog.2013.03.028. Epub 2013 Mar 25. [PubMed:23535240 ]
Late-onset preeclampsia
  1. Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13. [PubMed:23159745 ]
Lysinuric protein intolerance
  1. Habib A, Azize NA, Yakob Y, Md Yunus Z, Wee TK: Biochemical and molecular characteristics of Malaysian patients with lysinuric protein intolerance. Malays J Pathol. 2016 Dec;38(3):305-310. [PubMed:28028301 ]
  2. Kurko J, Tringham M, Tanner L, Nanto-Salonen K, Vaha-Makila M, Nygren H, Poho P, Lietzen N, Mattila I, Olkku A, Hyotylainen T, Oresic M, Simell O, Niinikoski H, Mykkanen J: Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI). Metabolism. 2016 Sep;65(9):1361-75. doi: 10.1016/j.metabol.2016.05.012. Epub 2016 May 27. [PubMed:27506743 ]
  3. Olli Simell (1995). Lysinuric Protein Intolerance and Other Cationic Aminoacidurias. The metabolic and molecular bases of inherited disease, 7/e; Editors: C.R.Scriver, A.L.Beaudet, W.S.Sly, D.Valle; McGraw-Hill Inc. (1995) DOI: 10.1036/ommbid.225. McGraw-Hill Inc..
N-acetylglutamate synthetase deficiency
  1. Guffon N, Vianey-Saban C, Bourgeois J, Rabier D, Colombo JP, Guibaud P: A new neonatal case of N-acetylglutamate synthase deficiency treated by carbamylglutamate. J Inherit Metab Dis. 1995;18(1):61-5. [PubMed:7623444 ]
  2. Schubiger G, Bachmann C, Barben P, Colombo JP, Tonz O, Schupbach D: N-acetylglutamate synthetase deficiency: diagnosis, management and follow-up of a rare disorder of ammonia detoxication. Eur J Pediatr. 1991 Mar;150(5):353-6. [PubMed:2044610 ]
Citrullinemia type I
  1. Kose E, Unal O, Bulbul S, Gunduz M, Haberle J, Arslan N: Identification of three novel mutations in fourteen patients with citrullinemia type 1. Clin Biochem. 2017 Aug;50(12):686-689. doi: 10.1016/j.clinbiochem.2017.01.011. Epub 2017 Jan 27. [PubMed:28132756 ]
Obesity
  1. Simone Wahl, Christina Holzapfel, Zhonghao Yu, Michaela Breier, Ivan Kondofersky, Christiane Fuchs, Paula Singmann, Cornelia Prehn, Jerzy Adamski, Harald Grallert, Thomas Illig, Rui Wang-Sattler, Thomas Reinehr (2013). Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children. Metabolomics.
Pearson Syndrome
  1. Crippa BL, Leon E, Calhoun A, Lowichik A, Pasquali M, Longo N: Biochemical abnormalities in Pearson syndrome. Am J Med Genet A. 2015 Mar;167A(3):621-8. doi: 10.1002/ajmg.a.36939. [PubMed:25691415 ]
Citrullinemia type II, neonatal-onset
  1. Ohura T, Kobayashi K, Tazawa Y, Nishi I, Abukawa D, Sakamoto O, Iinuma K, Saheki T: Neonatal presentation of adult-onset type II citrullinemia. Hum Genet. 2001 Feb;108(2):87-90. [PubMed:11281457 ]
Cutis laxa, autosomal recessive, type IIIA
  1. Baumgartner MR, Hu CA, Almashanu S, Steel G, Obie C, Aral B, Rabier D, Kamoun P, Saudubray JM, Valle D: Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase. Hum Mol Genet. 2000 Nov 22;9(19):2853-8. [PubMed:11092761 ]
Duchenne Muscular Dystrophy
  1. Horster I, Weigt-Usinger K, Carmann C, Chobanyan-Jurgens K, Kohler C, Schara U, Kayacelebi AA, Beckmann B, Tsikas D, Lucke T: The L-arginine/NO pathway and homoarginine are altered in Duchenne muscular dystrophy and improved by glucocorticoids. Amino Acids. 2015 Sep;47(9):1853-63. doi: 10.1007/s00726-015-2018-x. Epub 2015 Jun 12. [PubMed:26066683 ]
Myopathy, lactic acidosis, and sideroblastic anemia 1
  1. Parfait B, de Lonlay P, von Kleist-Retzow JC, Cormier-Daire V, Chretien D, Rotig A, Rabier D, Saudubray JM, Rustin P, Munnich A: The neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome mtDNA mutation (T8993G) triggers muscle ATPase deficiency and hypocitrullinaemia. Eur J Pediatr. 1999 Jan;158(1):55-8. [PubMed:9950309 ]
Phosphoenolpyruvate Carboxykinase Deficiency 1, Cytosolic
  1. Vieira P, Cameron J, Rahikkala E, Keski-Filppula R, Zhang LH, Santra S, Matthews A, Myllynen P, Nuutinen M, Moilanen JS, Rodenburg RJ, Rolfs A, Uusimaa J, van Karnebeek CDM: Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction. Mol Genet Metab. 2017 Apr;120(4):337-341. doi: 10.1016/j.ymgme.2017.02.003. Epub 2017 Feb 6. [PubMed:28216384 ]
  2. Santra S, Cameron JM, Shyr C, Zhang L, Drogemoller B, Ross CJ, Wasserman WW, Wevers RA, Rodenburg RJ, Gupte G, Preece MA, van Karnebeek CD: Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis. Mol Genet Metab. 2016 May;118(1):21-7. doi: 10.1016/j.ymgme.2016.03.001. Epub 2016 Mar 4. [PubMed:26971250 ]
Hyperargininemia
  1. Mizutani N, Hayakawa C, Ohya Y, Watanabe K, Watanabe Y, Mori A: Guanidino compounds in hyperargininemia. Tohoku J Exp Med. 1987 Nov;153(3):197-205. [PubMed:3433275 ]
Leukemia
  1. Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14. [PubMed:15911239 ]
Schizophrenia
  1. Do KQ, Lauer CJ, Schreiber W, Zollinger M, Gutteck-Amsler U, Cuenod M, Holsboer F: gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. J Neurochem. 1995 Dec;65(6):2652-62. [PubMed:7595563 ]
  2. He Y, Yu Z, Giegling I, Xie L, Hartmann AM, Prehn C, Adamski J, Kahn R, Li Y, Illig T, Wang-Sattler R, Rujescu D: Schizophrenia shows a unique metabolomics signature in plasma. Transl Psychiatry. 2012 Aug 14;2:e149. doi: 10.1038/tp.2012.76. [PubMed:22892715 ]
Irritable bowel syndrome
  1. Le Gall G, Noor SO, Ridgway K, Scovell L, Jamieson C, Johnson IT, Colquhoun IJ, Kemsley EK, Narbad A: Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome. J Proteome Res. 2011 Sep 2;10(9):4208-18. doi: 10.1021/pr2003598. Epub 2011 Aug 8. [PubMed:21761941 ]
Ulcerative colitis
  1. Le Gall G, Noor SO, Ridgway K, Scovell L, Jamieson C, Johnson IT, Colquhoun IJ, Kemsley EK, Narbad A: Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome. J Proteome Res. 2011 Sep 2;10(9):4208-18. doi: 10.1021/pr2003598. Epub 2011 Aug 8. [PubMed:21761941 ]
  2. Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Autism
  1. De Angelis M, Piccolo M, Vannini L, Siragusa S, De Giacomo A, Serrazzanetti DI, Cristofori F, Guerzoni ME, Gobbetti M, Francavilla R: Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. PLoS One. 2013 Oct 9;8(10):e76993. doi: 10.1371/journal.pone.0076993. eCollection 2013. [PubMed:24130822 ]
Crohn's disease
  1. Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Frontotemporal dementia
  1. Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Lewy body disease
  1. Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Attachment loss
  1. Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26. [PubMed:31026179 ]
Missing teeth
  1. Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26. [PubMed:31026179 ]
Periodontal Probing Depth
  1. Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26. [PubMed:31026179 ]
Cystinuria
  1. Fjellstedt E, Harnevik L, Jeppsson JO, Tiselius HG, Soderkvist P, Denneberg T: Urinary excretion of total cystine and the dibasic amino acids arginine, lysine and ornithine in relation to genetic findings in patients with cystinuria treated with sulfhydryl compounds. Urol Res. 2003 Dec;31(6):417-25. Epub 2003 Oct 25. [PubMed:14586528 ]
  2. G.Frauendienst-Egger, Friedrich K. Trefz (2017). MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de). METAGENE consortium.
Argininosuccinic aciduria
  1. Gronwald W, Klein MS, Kaspar H, Fagerer SR, Nurnberger N, Dettmer K, Bertsch T, Oefner PJ: Urinary metabolite quantification employing 2D NMR spectroscopy. Anal Chem. 2008 Dec 1;80(23):9288-97. doi: 10.1021/ac801627c. [PubMed:19551947 ]
Propionic acidemia
  1. Gronwald W, Klein MS, Kaspar H, Fagerer SR, Nurnberger N, Dettmer K, Bertsch T, Oefner PJ: Urinary metabolite quantification employing 2D NMR spectroscopy. Anal Chem. 2008 Dec 1;80(23):9288-97. doi: 10.1021/ac801627c. [PubMed:19551947 ]
Tyrosinemia I
  1. Gronwald W, Klein MS, Kaspar H, Fagerer SR, Nurnberger N, Dettmer K, Bertsch T, Oefner PJ: Urinary metabolite quantification employing 2D NMR spectroscopy. Anal Chem. 2008 Dec 1;80(23):9288-97. doi: 10.1021/ac801627c. [PubMed:19551947 ]
Maple syrup urine disease
  1. Gronwald W, Klein MS, Kaspar H, Fagerer SR, Nurnberger N, Dettmer K, Bertsch T, Oefner PJ: Urinary metabolite quantification employing 2D NMR spectroscopy. Anal Chem. 2008 Dec 1;80(23):9288-97. doi: 10.1021/ac801627c. [PubMed:19551947 ]
Eosinophilic esophagitis
  1. Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work). NA.
Hyperdibasic aminoaciduria I
  1. Whelan DT, Scriver CR: Hyperdibasicaminoaciduria: an inherited disorder of amino acid transport. Pediatr Res. 1968 Nov;2(6):525-34. [PubMed:5727921 ]
Hyperlysinemia I, familial
  1. Tondo M, Calpena E, Arriola G, Sanz P, Martorell L, Ormazabal A, Castejon E, Palacin M, Ugarte M, Espinos C, Perez B, Perez-Duenas B, Perez-Cerda C, Artuch R: Clinical, biochemical, molecular and therapeutic aspects of 2 new cases of 2-aminoadipic semialdehyde synthase deficiency. Mol Genet Metab. 2013 Nov;110(3):231-6. doi: 10.1016/j.ymgme.2013.06.021. Epub 2013 Jul 6. [PubMed:23890588 ]
Hyperlysinuria
  1. Fjellstedt E, Harnevik L, Jeppsson JO, Tiselius HG, Soderkvist P, Denneberg T: Urinary excretion of total cystine and the dibasic amino acids arginine, lysine and ornithine in relation to genetic findings in patients with cystinuria treated with sulfhydryl compounds. Urol Res. 2003 Dec;31(6):417-25. Epub 2003 Oct 25. [PubMed:14586528 ]
Associated OMIM IDs
DrugBank IDDB00125
Phenol Explorer Compound IDNot Available
FooDB IDFDB002257
KNApSAcK IDC00001340
Chemspider ID6082
KEGG Compound IDC00062
BioCyc IDARG
BiGG ID33707
Wikipedia LinkL-arginine
METLIN ID5502
PubChem Compound6322
PDB IDNot Available
ChEBI ID16467
Food Biomarker OntologyNot Available
VMH IDARG_L
MarkerDB IDMDB00000179
Good Scents IDNot Available
References
Synthesis ReferenceMeyer, Helmut E.; Swiderek, Kristine; Hoffmann-Posorske, Edeltraut; Korte, Horst; Heilmeyer, Ludwig M. G., Jr. Quantitative determination of phosphoserine by high-performance liquid chromatography as the phenylthiocarbamyl-S-ethylcysteine. Application to
Material Safety Data Sheet (MSDS)Not Available
General References

Only showing the first 10 proteins. There are 25 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Arginase-1
General function:
Involved in arginase activity
Specific function:
Not Available
Gene Name:
ARG1
Uniprot ID:
P05089
Molecular weight:
34734.655
Reactions
L-Arginine + Water → Ornithine + Ureadetails
Enzyme Details
2. Glycine amidinotransferase, mitochondrial
General function:
Amino acid transport and metabolism
Specific function:
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Gene Name:
GATM
Uniprot ID:
P50440
Molecular weight:
48455.01
Reactions
L-Arginine + Glycine → Ornithine + Guanidoacetic aciddetails
L-Arginine + gamma-Aminobutyric acid → Ornithine + 4-Guanidinobutanoic aciddetails
Enzyme Details
3. Arginine--tRNA ligase, cytoplasmic
General function:
Involved in nucleotide binding
Specific function:
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
Gene Name:
RARS
Uniprot ID:
P54136
Molecular weight:
75378.295
Reactions
Adenosine triphosphate + L-Arginine + tRNA(Arg) → Adenosine monophosphate + Pyrophosphate + L-arginyl-tRNA(Arg)details
Adenosine triphosphate + L-Arginine + tRNA(Arg) → Adenosine monophosphate + Pyrophosphate + L-Arginyl-tRNA(Arg)details
Enzyme Details
4. Argininosuccinate synthase
General function:
Involved in argininosuccinate synthase activity
Specific function:
Not Available
Gene Name:
ASS1
Uniprot ID:
P00966
Molecular weight:
46530.055
Enzyme Details
5. Protein-arginine deiminase type-4
General function:
Involved in protein-arginine deiminase activity
Specific function:
Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
Gene Name:
PADI4
Uniprot ID:
Q9UM07
Molecular weight:
74078.65
Enzyme Details
6. Protein-arginine deiminase type-3
General function:
Involved in protein-arginine deiminase activity
Specific function:
Catalyzes the deimination of arginine residues of proteins.
Gene Name:
PADI3
Uniprot ID:
Q9ULW8
Molecular weight:
74742.705
Enzyme Details
7. Argininosuccinate lyase
General function:
Involved in argininosuccinate lyase activity
Specific function:
Not Available
Gene Name:
ASL
Uniprot ID:
P04424
Molecular weight:
51657.505
Reactions
Argininosuccinic acid → Fumaric acid + L-Argininedetails
Enzyme Details
8. NAD-dependent protein deacetylase sirtuin-6
General function:
Involved in zinc ion binding
Specific function:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Gene Name:
SIRT6
Uniprot ID:
Q8N6T7
Molecular weight:
36064.295
Enzyme Details
9. Ecto-ADP-ribosyltransferase 3
General function:
Involved in NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Specific function:
Not Available
Gene Name:
ART3
Uniprot ID:
Q13508
Molecular weight:
43922.97
Enzyme Details
10. Ecto-ADP-ribosyltransferase 5
General function:
Involved in NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Specific function:
Not Available
Gene Name:
ART5
Uniprot ID:
Q96L15
Molecular weight:
32053.48

Only showing the first 10 proteins. There are 25 proteins in total.

Show all enzymes and transporters