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Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References enzymes (194) Show 194 proteins XML

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2006-08-16 13:22:34 UTC

Update Date

2022-03-07 02:49:09 UTC

HMDB ID

HMDB0001333

Secondary Accession Numbers

HMDB01333

Metabolite Identification

Common Name

Manganese

Description

Manganese is an essential trace nutrient in all forms of life. Physiologically, it. exists as an ion in the body. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

View in JSmol View Stereo Labels

Synonyms

Value	Source
MANGANESE (II) ion	ChEBI
Manganese(II)	ChEBI
Manganese, ion (MN2+)	ChEBI
Manganous ion	ChEBI
MN(II)	ChEBI
MN(2+)	ChEBI
MN2+	ChEBI

Chemical Formula

Average Molecular Weight

54.938

Monoisotopic Molecular Weight

54.938049636

IUPAC Name

manganese(2+) ion

Traditional Name

manganese(2+) ion

CAS Registry Number

7439-96-5

SMILES

[Mn++]

InChI Identifier

InChI=1S/Mn/q+2

InChI Key

WAEMQWOKJMHJLA-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.

Kingdom

Inorganic compounds

Super Class

Homogeneous metal compounds

Class

Homogeneous transition metal compounds

Sub Class

Not Available

Direct Parent

Homogeneous transition metal compounds

Alternative Parents

Not Available

Substituents

Homogeneous transition metal

Molecular Framework

Not Available

External Descriptors

monoatomic dication (CHEBI:29035 )
divalent metal cation (CHEBI:29035 )
manganese cation (CHEBI:29035 )
a cation (MN+2 )

Ontology

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	1244 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
logP	-0.16	ChemAxon
pKa (Strongest Acidic)	3.09	ChemAxon
Physiological Charge	2	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m³·mol⁻¹	ChemAxon
Polarizability	1.78 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Manganese	[Mn++]	708.4	Standard polar	33892256
Manganese	[Mn++]	272.1	Standard non polar	33892256
Manganese	[Mn++]	53.7	Semi standard non polar	33892256

Spectra

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Manganese 10V, Positive-QTOF	splash10-0a4i-9000000000-6f3891a406ae3fe4f883	2015-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Manganese 20V, Positive-QTOF	splash10-0a4i-9000000000-6f3891a406ae3fe4f883	2015-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Manganese 40V, Positive-QTOF	splash10-0a4i-9000000000-6f3891a406ae3fe4f883	2015-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Manganese 10V, Negative-QTOF	splash10-0udi-9000000000-c3110d268939143a5f80	2015-09-15	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Manganese 20V, Negative-QTOF	splash10-0udi-9000000000-c3110d268939143a5f80	2015-09-15	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Manganese 40V, Negative-QTOF	splash10-0udi-9000000000-c3110d268939143a5f80	2015-09-15	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Blood
Cerebrospinal Fluid (CSF)
Saliva
Urine

Tissue Locations

Basal Ganglia
Brain
Hair
Liver

Pathways

Name	SMPDB/PathBank	KEGG
Alanine, aspartate and glutamate metabolism	Not Available
Primary Hyperoxaluria Type I		Not Available
Pyruvate Carboxylase Deficiency		Not Available
Lactic Acidemia		Not Available
Citric Acid Cycle

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	0.0070 - 0.0190 uM	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details
Blood	Detected and Quantified	0.18858(0.18020-0.19659) uM	Not Available	Both	Normal	Report on Human B...	details
Blood	Detected and Quantified	0.17292(0.16382-0.18202) uM	Adult (>18 years old)	Both	Normal	Report on Human B...	details
Blood	Detected and Quantified	0.012 +/- 0.0044 uM	Elderly (>65 years old)	Both	Normal	16244393	details
Blood	Detected and Quantified	<0.320 uM	Children (1-13 years old)	Not Specified	Normal	18392750	details
Blood	Detected and Quantified	0.0730-0.325 uM	Children (1-13 years old)	Not Specified	Normal	27231142	details
Blood	Detected and Quantified	0.01 (0.007 - 0.019) uM	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0218 +/- 0.0309 uM	Elderly (>65 years old)	Both	Normal	9720975	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.149 +/- 0.177 uM	Adult (>18 years old)	Not Specified	Normal	22546835	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.021 (0.015 - 0.027) uM	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details
Saliva	Detected and Quantified	0.292 +/- 0.18 uM	Adult (>18 years old)	Both	Normal	Zerihun T. Dame, ...	details
Saliva	Detected and Quantified	0.0535 +/- 0.0513 uM	Adult (>18 years old)	Male	Normal	20604873	details
Saliva	Detected and Quantified	0.0411 +/- 0.0346 uM	Adult (>18 years old)	Male	Normal	20604873	details
Saliva	Detected and Quantified	0.0579 +/- 0.0368 uM	Adult (>18 years old)	Male	Normal	20604873	details
Saliva	Detected and Quantified	0.0619 +/- 0.0431 uM	Adult (>18 years old)	Male	Normal	20604873	details
Saliva	Detected and Quantified	36.223 +/- 37.133 uM	Adult (>18 years old)	Male	Normal	10378074	details
Saliva	Detected and Quantified	25.483 +/- 30.762 uM	Adult (>18 years old)	Male	Normal	10378074	details
Saliva	Detected and Quantified	0.109 +/- 0.0546 uM	Adult (>18 years old)	Not Specified	Normal	Natheer H. Al-Raw...	details
Urine	Detected and Quantified	0.00058 (0.00023-0.00101) umol/mmol creatinine	Not Available	Both	Normal	Report on Human B...	details
Urine	Detected and Quantified	0.00043 (0.00029-0.00056) umol/mmol creatinine	Adult (>18 years old)	Both	Normal	Report on Human B...	details
Urine	Detected and Quantified	0.013 (0.002-0.051) umol/mmol creatinine	Adult (>18 years old)	Both	Normal	24023812	details
Urine	Detected and Quantified	0.011 (0.0-0.023) umol/mmol creatinine	Adult (>18 years old)	Male	Normal	Geigy Scientific ... West Cadwell, N.J... Basel, Switzerlan...	details
Urine	Detected and Quantified	0.095 (0-0.053) umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	28478178	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	3.48 uM	Children (1-13 years old)	Male	Hypermanganesemia with dystonia 1	11040156	details
Blood	Detected and Quantified	0.15 +/- .072 uM	Adult (>18 years old)	Both	Multiple sclerosis	16244395	details
Blood	Detected and Quantified	0.012 +/- 0.0044 uM	Adult (>18 years old)	Both	Parkinson's disease	16244392	details
Blood	Detected and Quantified	3.285 uM	Children (1-13 years old)	Female	Hypermanganesemia with dystonia 1	18392750	details
Blood	Detected and Quantified	1.511-14.973 uM	Children (1-13 years old)	Male	Hypermanganesemia with dystonia 1	27117033	details
Blood	Detected and Quantified	0.963-3.830 uM	Children (1-13 years old)	Both	Hypermanganesemia with dystonia 2	27231142	details
Blood	Detected and Quantified	0.011 +/- 0 .004 uM	Elderly (>65 years old)	Both	Alzheimer's disease	16244393	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0346 +/- 0.0182 uM	Adult (>18 years old)	Not Specified	control	21292280	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0400 +/- 0.0273 uM	Adult (>18 years old)	Not Specified	amyotrophic lateral sclerosis	21292280	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0400 +/- 0.0255 uM	Adult (>18 years old)	Not Specified	amyotrophic lateral sclerosis (classic)	21292280	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0419 +/- 0.0291 uM	Adult (>18 years old)	Not Specified	Amyotrophic lateral sclerosis (bulbar onset)	21292280	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0328 +/- 0.0164 uM	Adult (>18 years old)	Not Specified	Alzheimer's disease	21292280	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0218 +/- 0.00546 uM	Adult (>18 years old)	Not Specified	Alzheimer's disease (early-onset)	21292280	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0382 +/- 0.0182 uM	Adult (>18 years old)	Not Specified	Alzheimer's disease (late-onset)	21292280	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0546 +/- 0.0382 uM	Adult (>18 years old)	Not Specified	Parkinson's disease	21292280	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0146 +/- 0.0146 uM	Elderly (>65 years old)	Both	Alzheimer's disease	9720975	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	14.6 +/- 13.7 uM	Elderly (>65 years old)	Not Specified	Alzheimer's disease	9720975	details
Saliva	Detected and Quantified	0.910 +/- 0.546 uM	Adult (>18 years old)	Not Specified	Oral squamous cell carcinoma	Natheer H. Al-Raw...	details
Saliva	Detected and Quantified	1.0921 +/- 0.546 uM	Adult (>18 years old)	Not Specified	Oral squamous cell carcinoma	Natheer H. Al-Raw...	details
Saliva	Detected and Quantified	1.456 +/- 0.546 uM	Adult (>18 years old)	Not Specified	Oral squamous cell carcinoma	Natheer H. Al-Raw...	details

Associated Disorders and Diseases

Disease References

Multiple sclerosis
Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6. [PubMed:16244395 ]
Parkinson's disease
Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B: Metals and oxidative stress in patients with Parkinson's disease. Ann Ist Super Sanita. 2005;41(2):189-95. [PubMed:16244392 ] Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T: Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011 Apr 15;303(1-2):95-9. doi: 10.1016/j.jns.2011.01.003. Epub 2011 Feb 2. [PubMed:21292280 ]
Hypermanganesemia with dystonia 1
Tuschl K, Mills PB, Parsons H, Malone M, Fowler D, Bitner-Glindzicz M, Clayton PT: Hepatic cirrhosis, dystonia, polycythaemia and hypermanganesaemia--a new metabolic disorder. J Inherit Metab Dis. 2008 Apr;31(2):151-63. doi: 10.1007/s10545-008-0813-1. Epub 2008 Apr 4. [PubMed:18392750 ] Mukhtiar K, Ibrahim S, Tuschl K, Mills P: Hypermanganesemia with Dystonia, Polycythemia and Cirrhosis (HMDPC) due to mutation in the SLC30A10 gene. Brain Dev. 2016 Oct;38(9):862-5. doi: 10.1016/j.braindev.2016.04.005. Epub 2016 Apr 23. [PubMed:27117033 ] Gospe SM Jr, Caruso RD, Clegg MS, Keen CL, Pimstone NR, Ducore JM, Gettner SS, Kreutzer RA: Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis. Arch Dis Child. 2000 Nov;83(5):439-42. [PubMed:11040156 ]
Hypermanganesemia with dystonia 2
Tuschl K, Meyer E, Valdivia LE, Zhao N, Dadswell C, Abdul-Sada A, Hung CY, Simpson MA, Chong WK, Jacques TS, Woltjer RL, Eaton S, Gregory A, Sanford L, Kara E, Houlden H, Cuno SM, Prokisch H, Valletta L, Tiranti V, Younis R, Maher ER, Spencer J, Straatman-Iwanowska A, Gissen P, Selim LA, Pintos-Morell G, Coroleu-Lletget W, Mohammad SS, Yoganathan S, Dale RC, Thomas M, Rihel J, Bodamer OA, Enns CA, Hayflick SJ, Clayton PT, Mills PB, Kurian MA, Wilson SW: Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Nat Commun. 2016 May 27;7:11601. doi: 10.1038/ncomms11601. [PubMed:27231142 ]
Alzheimer's disease
Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm (Vienna). 1998;105(4-5):479-88. [PubMed:9720975 ] Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203. [PubMed:16244393 ] Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T: Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011 Apr 15;303(1-2):95-9. doi: 10.1016/j.jns.2011.01.003. Epub 2011 Feb 2. [PubMed:21292280 ]
Amyotrophic lateral sclerosis
Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T: Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011 Apr 15;303(1-2):95-9. doi: 10.1016/j.jns.2011.01.003. Epub 2011 Feb 2. [PubMed:21292280 ]

Associated OMIM IDs

126200 (Multiple sclerosis)
168600 (Parkinson's disease)
613280 (Hypermanganesemia with dystonia 1)
617013 (Hypermanganesemia with dystonia 2)
104300 (Alzheimer's disease)
105400 (Amyotrophic lateral sclerosis)

External Links

DrugBank ID

DB06757

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB031005

KNApSAcK ID

Not Available

Chemspider ID

25916

KEGG Compound ID

C19610

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Manganese

METLIN ID

Not Available

PubChem Compound

27854

PDB ID

Not Available

ChEBI ID

29035

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

MDB00000315

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Ikeda S, Sera Y, Yoshida M, Ohshiro H, Uchino S, Oka Y, Lee KJ, Kotera A: Manganese deposits in patients with biliary atresia after hepatic porto-enterostomy. J Pediatr Surg. 2000 Mar;35(3):450-3. [PubMed:10726687 ]
Greger JL: Nutrition versus toxicology of manganese in humans: evaluation of potential biomarkers. Neurotoxicology. 1999 Apr-Jun;20(2-3):205-12. [PubMed:10385884 ]
Lander F, Kristiansen J, Lauritsen JM: Manganese exposure in foundry furnacemen and scrap recycling workers. Int Arch Occup Environ Health. 1999 Nov;72(8):546-50. [PubMed:10592008 ]
Mizoguchi N, Nishimura Y, Ono H, Sakura N: Manganese elevations in blood of children with congenital portosystemic shunts. Eur J Pediatr. 2001 Apr;160(4):247-50. [PubMed:11317649 ]
Woolf A, Wright R, Amarasiriwardena C, Bellinger D: A child with chronic manganese exposure from drinking water. Environ Health Perspect. 2002 Jun;110(6):613-6. [PubMed:12055054 ]
Ikeda S, Yamaguchi Y, Sera Y, Ohshiro H, Uchino S, Yamashita Y, Ogawa M: Manganese deposition in the globus pallidus in patients with biliary atresia. Transplantation. 2000 Jun 15;69(11):2339-43. [PubMed:10868637 ]
Wardle CA, Forbes A, Roberts NB, Jawhari AV, Shenkin A: Hypermanganesemia in long-term intravenous nutrition and chronic liver disease. JPEN J Parenter Enteral Nutr. 1999 Nov-Dec;23(6):350-5. [PubMed:10574484 ]
Mergler D, Baldwin M, Belanger S, Larribe F, Beuter A, Bowler R, Panisset M, Edwards R, de Geoffroy A, Sassine MP, Hudnell K: Manganese neurotoxicity, a continuum of dysfunction: results from a community based study. Neurotoxicology. 1999 Apr-Jun;20(2-3):327-42. [PubMed:10385894 ]
Butterworth RF: Hepatic encephalopathy. Alcohol Res Health. 2003;27(3):240-6. [PubMed:15535452 ]
Herynek V, Babis M, Trunecka P, Filip K, Vymazal J, Dezortova M, Hajek M: Chronic liver disease: relaxometry in the brain after liver transplantation. MAGMA. 2001 Mar;12(1):10-5. [PubMed:11255087 ]
Miranda M, Caballero L: [Chronic hepatic encephalopathy: the role of high serum manganese levels and its relation with basal ganglia lesions in nuclear magnetic resonance of the brain. Clinical case]. Rev Med Chil. 2001 Sep;129(9):1051-5. [PubMed:11725469 ]
Barceloux DG: Manganese. J Toxicol Clin Toxicol. 1999;37(2):293-307. [PubMed:10382563 ]
Bader M, Dietz MC, Ihrig A, Triebig G: Biomonitoring of manganese in blood, urine and axillary hair following low-dose exposure during the manufacture of dry cell batteries. Int Arch Occup Environ Health. 1999 Nov;72(8):521-7. [PubMed:10592004 ]
Kao HJ, Chen WH, Liu JS: Rapid progression of parkinsonism associated with an increase of blood manganese. Kaohsiung J Med Sci. 1999 May;15(5):297-301. [PubMed:10375873 ]
Melo TM, Larsen C, White LR, Aasly J, Sjobakk TE, Flaten TP, Sonnewald U, Syversen T: Manganese, copper, and zinc in cerebrospinal fluid from patients with multiple sclerosis. Biol Trace Elem Res. 2003 Summer;93(1-3):1-8. [PubMed:12835484 ]
Lees-Haley PR, Rohling ML, Langhinrichsen-Rohling J: A meta-analysis of the neuropsychological effects of occupational exposure to manganese. Clin Neuropsychol. 2006 Feb;20(1):90-107. [PubMed:16393922 ]
Sadek AH, Rauch R, Schulz PE: Parkinsonism due to manganism in a welder. Int J Toxicol. 2003 Sep-Oct;22(5):393-401. [PubMed:14555414 ]
Wang X, Li GJ, Zheng W: Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro. Brain Res. 2006 Jun 30;1097(1):1-10. Epub 2006 May 26. [PubMed:16729984 ]
Takeda A: Manganese action in brain function. Brain Res Brain Res Rev. 2003 Jan;41(1):79-87. [PubMed:12505649 ]
Baldwin M, Mergler D, Larribe F, Belanger S, Tardif R, Bilodeau L, Hudnell K: Bioindicator and exposure data for a population based study of manganese. Neurotoxicology. 1999 Apr-Jun;20(2-3):343-53. [PubMed:10385895 ]

Only showing the first 10 proteins. There are 194 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. Acetyl-CoA carboxylase 2

General function:: Involved in acetyl-CoA carboxylase activity
Specific function:: ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:: ACACB
Uniprot ID:: O00763
Molecular weight:: 276538.575

Enzyme Details

2. Pyruvate carboxylase, mitochondrial

General function:: Involved in catalytic activity
Specific function:: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Gene Name:: PC
Uniprot ID:: P11498
Molecular weight:: 129632.565

Enzyme Details

3. Acetyl-CoA carboxylase 1

General function:: Involved in acetyl-CoA carboxylase activity
Specific function:: Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:: ACACA
Uniprot ID:: Q13085
Molecular weight:: 269997.01

Enzyme Details

4. Arginase-1

General function:: Involved in arginase activity
Specific function:: Not Available
Gene Name:: ARG1
Uniprot ID:: P05089
Molecular weight:: 34734.655

Enzyme Details

5. Beta-1,4-galactosyltransferase 2

General function:: Involved in transferase activity, transferring glycosyl groups
Specific function:: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.
Gene Name:: B4GALT2
Uniprot ID:: O60909
Molecular weight:: 41971.815

Enzyme Details

6. Beta-1,4-galactosyltransferase 1

General function:: Involved in transferase activity, transferring glycosyl groups
Specific function:: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
Gene Name:: B4GALT1
Uniprot ID:: P15291
Molecular weight:: 43919.895

Enzyme Details

7. Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

General function:: Involved in transferase activity, transferring hexosyl groups
Specific function:: Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens
Gene Name:: GBGT1
Uniprot ID:: Q8N5D6
Molecular weight:: 40126.9

Enzyme Details

8. Aminopeptidase N

General function:: Involved in proteolysis
Specific function:: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Gene Name:: ANPEP
Uniprot ID:: P15144
Molecular weight:: Not Available

Enzyme Details

9. High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

General function:: Involved in catalytic activity
Specific function:: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Gene Name:: PDE8A
Uniprot ID:: O60658
Molecular weight:: 86047.88

Enzyme Details

10. Bis(5'-adenosyl)-triphosphatase

General function:: Involved in catalytic activity
Specific function:: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.
Gene Name:: FHIT
Uniprot ID:: P49789
Molecular weight:: 16858.11

Only showing the first 10 proteins. There are 194 proteins in total.

Show all enzymes and transporters

Showing metabocard for Manganese (HMDB0001333)

MOL for HMDB0001333 (Manganese)

3D MOL for HMDB0001333 (Manganese)

3D SDF for HMDB0001333 (Manganese)

3D-SDF for HMDB0001333 (Manganese)

PDB for HMDB0001333 (Manganese)

3D PDB for HMDB0001333 (Manganese)

SMILES for HMDB0001333 (Manganese)

INCHI for HMDB0001333 (Manganese)

Structure for HMDB0001333 (Manganese)

3D Structure for HMDB0001333 (Manganese)

Predicted Kovats Retention Indices

Underivatized

MS/MS Spectra

Enzymes