Showing metabocard for 2-Ketobutyric acid (HMDB0000005)

General function:

Involved in catalytic activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

Gene Name:

PDHB

Uniprot ID:

P11177

Molecular weight:

39233.1

References

1. Paxton R, Scislowski PW, Davis EJ, Harris RA: Role of branched-chain 2-oxo acid dehydrogenase and pyruvate dehydrogenase in 2-oxobutyrate metabolism. Biochem J. 1986 Mar 1;234(2):295-303. [PubMed:3718468 ]

General function:

Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

Gene Name:

PDHA1

Uniprot ID:

P08559

Molecular weight:

43295.255

References

1. Paxton R, Scislowski PW, Davis EJ, Harris RA: Role of branched-chain 2-oxo acid dehydrogenase and pyruvate dehydrogenase in 2-oxobutyrate metabolism. Biochem J. 1986 Mar 1;234(2):295-303. [PubMed:3718468 ]

General function:

Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

Gene Name:

PDHA2

Uniprot ID:

P29803

Molecular weight:

42932.855

References

1. Paxton R, Scislowski PW, Davis EJ, Harris RA: Role of branched-chain 2-oxo acid dehydrogenase and pyruvate dehydrogenase in 2-oxobutyrate metabolism. Biochem J. 1986 Mar 1;234(2):295-303. [PubMed:3718468 ]

General function:

Involved in catalytic activity

Specific function:

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

Gene Name:

BCKDHB

Uniprot ID:

P21953

Molecular weight:

43122.065

General function:

Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Specific function:

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

Gene Name:

BCKDHA

Uniprot ID:

P12694

Molecular weight:

50470.58

General function:

Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Gene Name:

OGDH

Uniprot ID:

Q02218

Molecular weight:

48179.59

General function:

Involved in pyridoxal phosphate binding

Specific function:

Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.

Gene Name:

CTH

Uniprot ID:

P32929

Molecular weight:

41259.91

Reactions

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

SDS

Uniprot ID:

P20132

Molecular weight:

34625.105

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.

Gene Name:

LDHAL6A

Uniprot ID:

Q6ZMR3

Molecular weight:

36507.015

Reactions

General function:

Involved in urocanate hydratase activity

Specific function:

Not Available

Gene Name:

UROC1

Uniprot ID:

Q96N76

Molecular weight:

80911.275