HMDBP00087 | Tyrosinase | P14679 | TYR | 11q14-q21 | Unknown | - Wood JM, Schallreuter-Wood KU, Lindsey NJ, Callaghan S, Gardner ML: A specific tetrahydrobiopterin binding domain on tyrosinase controls melanogenesis. Biochem Biophys Res Commun. 1995 Jan 17;206(2):480-5. [PubMed:7826365 ]
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HMDBP00273 | Tyrosine 3-monooxygenase | P07101 | TH | 11p15.5 | Enzyme | - Madsen JT, Jansen P, Hesslinger C, Meyer M, Zimmer J, Gramsbergen JB: Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures. J Neurochem. 2003 Apr;85(1):214-23. [PubMed:12641743 ]
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HMDBP00280 | Phenylalanine-4-hydroxylase | P00439 | PAH | 12q22-q24.2 | Enzyme | - Andersen OA, Flatmark T, Hough E: High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin. J Mol Biol. 2001 Nov 23;314(2):279-91. [PubMed:11718561 ]
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HMDBP00435 | 6-pyruvoyl tetrahydrobiopterin synthase | Q03393 | PTS | 11q22.3 | Unknown | Not Available |
HMDBP00436 | Sepiapterin reductase | P35270 | SPR | 2p14-p12 | Enzyme | - Auerbach G, Nar H: The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase. Biol Chem. 1997 Mar-Apr;378(3-4):185-92. [PubMed:9165069 ]
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HMDBP00469 | Tryptophan 5-hydroxylase 1 | P17752 | TPH1 | 11p15.3-p14 | Enzyme | - Sumi-Ichinose C, Urano F, Kuroda R, Ohye T, Kojima M, Tazawa M, Shiraishi H, Hagino Y, Nagatsu T, Nomura T, Ichinose H: Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice. J Biol Chem. 2001 Nov 2;276(44):41150-60. Epub 2001 Aug 21. [PubMed:11517215 ]
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HMDBP00471 | Tryptophan 5-hydroxylase 2 | Q8IWU9 | TPH2 | 12q21.1 | Enzyme | Not Available |
HMDBP00545 | Dihydropteridine reductase | P09417 | QDPR | 4p15.31 | Unknown | - Shen RS: Inhibition of dopamine autoxidation by tetrahydrobiopterin and NADH in the presence of dihydropteridine reductase. Neurotoxicology. 1991 Summer;12(2):201-8. [PubMed:1956581 ]
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HMDBP00926 | Nitric oxide synthase, inducible | P35228 | NOS2 | 17q11.2-q12 | Unknown | Not Available |
HMDBP00928 | Nitric oxide synthase, brain | P29475 | NOS1 | 12q24.2-q24.31 | Unknown | - Kamada Y, Jenkins GJ, Lau M, Dunbar AY, Lowe ER, Osawa Y: Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase. Brain Res Mol Brain Res. 2005 Dec 7;142(1):19-27. Epub 2005 Oct 10. [PubMed:16216381 ]
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HMDBP00929 | Nitric oxide synthase, endothelial | P29474 | NOS3 | 7q36 | Unknown | - Shirodaria C, Antoniades C, Lee J, Jackson CE, Robson MD, Francis JM, Moat SJ, Ratnatunga C, Pillai R, Refsum H, Neubauer S, Channon KM: Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation. 2007 May 1;115(17):2262-70. Epub 2007 Apr 9. [PubMed:17420345 ]
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HMDBP00938 | GTP cyclohydrolase 1 | P30793 | GCH1 | 14q22.1-q22.2 | Unknown | - Auerbach G, Nar H: The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase. Biol Chem. 1997 Mar-Apr;378(3-4):185-92. [PubMed:9165069 ]
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HMDBP01961 | GTP cyclohydrolase 1 feedback regulatory protein | P30047 | GCHFR | 15q15 | Unknown | - Kapatos G, Hirayama K, Shimoji M, Milstien S: GTP cyclohydrolase I feedback regulatory protein is expressed in serotonin neurons and regulates tetrahydrobiopterin biosynthesis. J Neurochem. 1999 Feb;72(2):669-75. [PubMed:9930739 ]
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HMDBP02872 | Pterin-4-alpha-carbinolamine dehydratase | P61457 | PCBD1 | 10q22 | Enzyme | - Hirayama K, Kapatos G: Expression and regulation of rat 6-pyruvoyl tetrahydropterin synthase mRNA. Neurochem Int. 1995 Jun;26(6):601-6. [PubMed:7545485 ]
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HMDBP10682 | Calcium-calmodulin independent nitric oxide synthase iNOS protein | Q9UM94 | | | Enzyme | Not Available |