Showing metabocard for Guanosine (HMDB0000133)

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.

Gene Name:

NT5E

Uniprot ID:

P21589

Molecular weight:

57948.125

Reactions

General function:

Involved in nucleotide binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

Gene Name:

NT5C1B

Uniprot ID:

Q96P26

Molecular weight:

68803.055

Reactions

General function:

Involved in nucleotide binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.

Gene Name:

NT5C1A

Uniprot ID:

Q9BXI3

Molecular weight:

41020.145

Reactions

General function:

Involved in metal ion binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

Gene Name:

NT5C

Uniprot ID:

Q8TCD5

Molecular weight:

Not Available

Reactions

General function:

Involved in phosphatase activity

Specific function:

Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.

Gene Name:

NT5M

Uniprot ID:

Q9NPB1

Molecular weight:

Not Available

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Can act both as nucleotidase and as phosphotransferase.

Gene Name:

NT5C3

Uniprot ID:

Q9H0P0

Molecular weight:

33914.91

Reactions

General function:

Involved in 5'-nucleotidase activity

Specific function:

May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.

Gene Name:

NT5C2

Uniprot ID:

P49902

Molecular weight:

64969.2

Reactions

General function:

Involved in purine-nucleoside phosphorylase activity

Specific function:

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

Gene Name:

PNP

Uniprot ID:

P00491

Molecular weight:

32117.69

Reactions

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]