Showing metabocard for Serotonin (HMDB0000259)

General function:

Involved in N-acetyltransferase activity

Specific function:

Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.

Gene Name:

AANAT

Uniprot ID:

Q16613

Molecular weight:

23343.8

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Gene Name:

MAOB

Uniprot ID:

P27338

Molecular weight:

58762.475

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Gene Name:

MAOA

Uniprot ID:

P21397

Molecular weight:

59681.27

Reactions

General function:

Involved in carboxy-lyase activity

Specific function:

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Gene Name:

DDC

Uniprot ID:

P20711

Molecular weight:

53893.755

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

Gene Name:

AKR1C3

Uniprot ID:

P42330

Molecular weight:

36866.91

General function:

Involved in methyltransferase activity

Specific function:

Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.

Gene Name:

INMT

Uniprot ID:

O95050

Molecular weight:

28833.695

Reactions

General function:

Involved in heme binding

Specific function:

Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.

Gene Name:

IDO1

Uniprot ID:

P14902

Molecular weight:

45325.89

Reactions

General function:

Involved in protein methyltransferase activity

Specific function:

Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins

Gene Name:

PRMT3

Uniprot ID:

O60678

Molecular weight:

59902.7

General function:

Involved in G-protein coupled receptor protein signaling pathway

Specific function:

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

Gene Name:

HTR4

Uniprot ID:

Q13639

Molecular weight:

43761.0

General function:

Involved in G-protein coupled receptor protein signaling pathway

Specific function:

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

Gene Name:

HTR7

Uniprot ID:

P34969

Molecular weight:

53554.4