You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.

Jump To Section:

Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References enzymes (149) Show 149 proteins XML

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2005-11-16 15:48:42 UTC

Update Date

2021-09-14 15:39:00 UTC

HMDB ID

HMDB0000295

Secondary Accession Numbers

HMDB00295

Metabolite Identification

Common Name

Uridine 5'-diphosphate

Description

Uridine 5'-diphosphate, also known as 5'-UDP, UDP or uridine diphosphoric acid, belongs to the class of organic compounds known as pyrimidine ribonucleoside diphosphates. These are pyrimidine ribonucleotides with diphosphate group linked to the ribose moiety. UDP is also classified as a nucleotide diphosphate. It is an ester of pyrophosphoric acid with the nucleoside uridine. UDP consists of a pyrophosphate group, a pentose sugar ribose, and the nucleobase uracil. UDP exists in all living species, ranging from bacteria to plants to humans. In mammals UDP is an important factor in glycogenesis or the formation of glycogen in the liver. Before glucose can be stored as glycogen in the liver and muscles, the enzyme UDP-glucose pyrophosphorylase forms a UDP-glucose unit by combining glucose 1-phosphate with uridine triphosphate, cleaving a pyrophosphate ion in the process. Then, the enzyme glycogen synthase combines UDP-glucose units to form a glycogen chain. UDP is also an important extracellular pyrimidine signaling molecule that mediates diverse biological effects via P1 and P2 purinergic receptors, such as the uptake of thymidine and proliferation of gliomas. UDP plays a key role in the function of Uridine 5'-diphospho-glucuronosyltransferases (UDP-glucuronosyltransferases, UGTs) which catalyze the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. UDP-Glucuronosyltransferases are responsible for the process of glucuronidation, a major part of phase II metabolism. The reaction catalyzed by UGT enzymes involves the addition of a glucuronic acid moiety to xenobiotics and is the most important pathway for the human body's elimination of the most frequently prescribed drugs. It is also the major pathway for foreign chemical (dietary, environmental, pharmaceutical) removal for most drugs, dietary substances, toxins and endogenous substances. UGT is present in humans, other animals, plants, and bacteria. Famously, UGT enzymes are not present in the genus Felis (PMID: 10862526 ) and this accounts for a number of unusual toxicities in the cat family.

Structure

MOL SDF 3D SDF PDB 3D PDB SMILES InChI


  Mrv1652306262018212D          

 25 26  0  0  0  0            999 V2000
 9998.433210001.5481    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.222310001.5399    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.6882 9999.6899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.211410000.9255    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.403510000.1010    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.1168 9999.6899    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
 9995.7809 9998.4518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.832110000.1010    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.7066 9998.9756    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.5312 9998.9756    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10003.5536 9999.7023    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
10003.1414 9998.9880    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10004.269010000.1133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10003.9659 9998.9880    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9997.210010000.1022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.4955 9999.6897    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9996.4955 9998.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.2100 9998.4522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.9245 9998.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.9245 9999.6897    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9999.3096 9999.6069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.642210000.0919    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9998.897110000.8765    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9999.722110000.8765    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9999.977010000.0919    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  2  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 20  1  0  0  0  0
 19 20  1  0  0  0  0
 15  4  2  0  0  0  0
 17  7  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 22  1  0  0  0  0
 21 25  1  0  0  0  0
 23  1  1  6  0  0  0
 22 20  1  1  0  0  0
 24  2  1  6  0  0  0
 25  3  1  1  0  0  0
M  END
> <DATABASE_ID>
HMDB0000295

> <DATABASE_NAME>
hmdb

> <SMILES>
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

> <INCHI_KEY>
XCCTYIAWTASOJW-XVFCMESISA-N

> <FORMULA>
C9H14N2O12P2

> <MOLECULAR_WEIGHT>
404.1612

> <EXACT_MASS>
404.002196946

> <JCHEM_ACCEPTOR_COUNT>
10

> <JCHEM_ATOM_COUNT>
39

> <JCHEM_AVERAGE_POLARIZABILITY>
30.434393627025816

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
6

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid

> <ALOGPS_LOGP>
-0.94

> <JCHEM_LOGP>
-2.960606651999999

> <ALOGPS_LOGS>
-1.66

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
3.210398156718922

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.7717429601440289

> <JCHEM_PKA_STRONGEST_BASIC>
-3.664543362840705

> <JCHEM_POLAR_SURFACE_AREA>
212.38999999999996

> <JCHEM_REFRACTIVITY>
74.31139999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
8.89e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
UDP

> <JCHEM_VEBER_RULE>
0

$$$$

https://cactus.nci.nih.gov/chemical/structure/O%5BC@H%5D1%5BC@@H%5D(O)%5BC@@H...
 OpenBabel09142113213D
Jmol version 14.31.45  2021-07-21 05:08 EXTRACT: ({0:38})
 39 40  0  0  0  0  0  0  0  0999 V2000
    1.8941    3.9637    0.2114 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8779    2.6436   -0.3356 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7048    2.6790   -1.4112 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2029    1.9123   -0.0243 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.6836    1.5840   -0.9458 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0791    2.7595    0.7219 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7700    0.6956    0.8235 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8521    0.9249    1.8859 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3899    0.4675    0.4637 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7986    1.7834    0.3583 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5782    2.1807    1.3491 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4748    1.7289   -0.4881 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4693    0.9644    0.1963 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9393    0.6997   -0.4048 P   0  0  1  0  0  0  0  0  0  0  0  0
   -3.7342    2.0957   -0.5133 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8206    0.0937   -1.7497 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7437   -0.3017    0.5661 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0250   -1.2573    0.3735 P   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5731   -2.6204   -0.3543 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6586   -1.6020    1.8129 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0357   -0.5660   -0.4576 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5862   -0.4745    0.4906 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4191   -1.0105    1.4346 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1711   -2.0892    1.1279 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0808   -2.6450   -0.1711 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7489   -3.6179   -0.4711 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2480   -2.0871   -1.0730 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5058   -1.0151   -0.7388 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7592   -0.5227   -1.5625 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5731    4.5383   -0.1679 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3343    3.5682    0.2570 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8445    2.7408   -0.6537 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2536    1.2613   -1.4476 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8492    2.5496    0.3328 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9105   -3.1268    0.1352 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4361   -2.1755    1.7732 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4749   -0.5728    2.4204 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8328   -2.5220    1.8635 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1807   -2.4621   -1.9650 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1 30  1  0  0  0  0
  2  3  1  6  0  0  0
  2  4  1  0  0  0  0
  2 10  1  0  0  0  0
  4  5  1  6  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6 31  1  0  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  7 22  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 32  1  0  0  0  0
 12 33  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  6  0  0  0
 14 17  1  0  0  0  0
 15 34  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 35  1  0  0  0  0
 20 36  1  0  0  0  0
 22 23  1  0  0  0  0
 22 28  1  0  0  0  0
 23 24  2  0  0  0  0
 23 37  1  0  0  0  0
 24 25  1  0  0  0  0
 24 38  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 39  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
$$$$

HEADER    PROTEIN                                 26-JUN-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   26-JUN-20         0                                  
HETATM    1  O   UNK     0    8663.7428669.556   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0    8667.0828669.541   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0    8667.9518666.088   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0    8661.4618668.394   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0    8669.2878666.855   0.000  0.00  0.00           O+0
HETATM    6  P   UNK     0    8670.6188666.088   0.000  0.00  0.00           P+0
HETATM    7  O   UNK     0    8658.7918663.777   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0    8671.9538666.855   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0    8669.8528664.754   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0    8671.3928664.754   0.000  0.00  0.00           O+0
HETATM   11  P   UNK     0    8673.3008666.111   0.000  0.00  0.00           P+0
HETATM   12  O   UNK     0    8672.5318664.778   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0    8674.6358666.878   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0    8674.0708664.778   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0    8661.4598666.857   0.000  0.00  0.00           C+0
HETATM   16  N   UNK     0    8660.1258666.087   0.000  0.00  0.00           N+0
HETATM   17  C   UNK     0    8660.1258664.547   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0    8661.4598663.777   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0    8662.7928664.547   0.000  0.00  0.00           C+0
HETATM   20  N   UNK     0    8662.7928666.087   0.000  0.00  0.00           N+0
HETATM   21  O   UNK     0    8665.3788665.933   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0    8664.1328666.838   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0    8664.6088668.303   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0    8666.1488668.303   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0    8666.6248666.838   0.000  0.00  0.00           C+0
CONECT    1   23                                                            
CONECT    2   24                                                            
CONECT    3    5   25                                                       
CONECT    4   15                                                            
CONECT    5    3    6                                                       
CONECT    6    5    8    9   10                                             
CONECT    7   17                                                            
CONECT    8    6   11                                                       
CONECT    9    6                                                            
CONECT   10    6                                                            
CONECT   11    8   12   13   14                                             
CONECT   12   11                                                            
CONECT   13   11                                                            
CONECT   14   11                                                            
CONECT   15   16   20    4                                                  
CONECT   16   15   17                                                       
CONECT   17   18   16    7                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   15   19   22                                                  
CONECT   21   22   25                                                       
CONECT   22   23   21   20                                                  
CONECT   23   22   24    1                                                  
CONECT   24   23   25    2                                                  
CONECT   25   24   21    3                                                  
MASTER        0    0    0    0    0    0    0    0   25    0   52    0
END

COMPND    https://cactus.nci.nih.gov/chemical/structure/O%5BC@H%5D1%5BC@@H%5D(O)%5BC@@H... 
AUTHOR    GENERATED BY OPEN BABEL 3.1.0
HETATM    1  O   UNL     1       1.894   3.964   0.211  1.00  0.00           O  
HETATM    2  C   UNL     1       1.878   2.644  -0.336  1.00  0.00           C  
HETATM    3  H   UNL     1       1.705   2.679  -1.411  1.00  0.00           H  
HETATM    4  C   UNL     1       3.203   1.912  -0.024  1.00  0.00           C  
HETATM    5  H   UNL     1       3.684   1.584  -0.946  1.00  0.00           H  
HETATM    6  O   UNL     1       4.079   2.760   0.722  1.00  0.00           O  
HETATM    7  C   UNL     1       2.770   0.696   0.824  1.00  0.00           C  
HETATM    8  H   UNL     1       2.852   0.925   1.886  1.00  0.00           H  
HETATM    9  O   UNL     1       1.390   0.468   0.464  1.00  0.00           O  
HETATM   10  C   UNL     1       0.799   1.783   0.358  1.00  0.00           C  
HETATM   11  H   UNL     1       0.578   2.181   1.349  1.00  0.00           H  
HETATM   12  C   UNL     1      -0.475   1.729  -0.488  1.00  0.00           C  
HETATM   13  O   UNL     1      -1.469   0.964   0.196  1.00  0.00           O  
HETATM   14  P   UNL     1      -2.939   0.700  -0.405  1.00  0.00           P  
HETATM   15  O   UNL     1      -3.734   2.096  -0.513  1.00  0.00           O  
HETATM   16  O   UNL     1      -2.821   0.094  -1.750  1.00  0.00           O  
HETATM   17  O   UNL     1      -3.744  -0.302   0.566  1.00  0.00           O  
HETATM   18  P   UNL     1      -5.025  -1.257   0.373  1.00  0.00           P  
HETATM   19  O   UNL     1      -4.573  -2.620  -0.354  1.00  0.00           O  
HETATM   20  O   UNL     1      -5.659  -1.602   1.813  1.00  0.00           O  
HETATM   21  O   UNL     1      -6.036  -0.566  -0.458  1.00  0.00           O  
HETATM   22  N   UNL     1       3.586  -0.474   0.491  1.00  0.00           N  
HETATM   23  C   UNL     1       4.419  -1.010   1.435  1.00  0.00           C  
HETATM   24  C   UNL     1       5.171  -2.089   1.128  1.00  0.00           C  
HETATM   25  C   UNL     1       5.081  -2.645  -0.171  1.00  0.00           C  
HETATM   26  O   UNL     1       5.749  -3.618  -0.471  1.00  0.00           O  
HETATM   27  N   UNL     1       4.248  -2.087  -1.073  1.00  0.00           N  
HETATM   28  C   UNL     1       3.506  -1.015  -0.739  1.00  0.00           C  
HETATM   29  O   UNL     1       2.759  -0.523  -1.562  1.00  0.00           O  
HETATM   30  H   UNL     1       2.573   4.538  -0.168  1.00  0.00           H  
HETATM   31  H   UNL     1       4.334   3.568   0.257  1.00  0.00           H  
HETATM   32  H   UNL     1      -0.845   2.741  -0.654  1.00  0.00           H  
HETATM   33  H   UNL     1      -0.254   1.261  -1.448  1.00  0.00           H  
HETATM   34  H   UNL     1      -3.849   2.550   0.333  1.00  0.00           H  
HETATM   35  H   UNL     1      -3.910  -3.127   0.135  1.00  0.00           H  
HETATM   36  H   UNL     1      -6.436  -2.175   1.773  1.00  0.00           H  
HETATM   37  H   UNL     1       4.475  -0.573   2.420  1.00  0.00           H  
HETATM   38  H   UNL     1       5.833  -2.522   1.863  1.00  0.00           H  
HETATM   39  H   UNL     1       4.181  -2.462  -1.965  1.00  0.00           H  
CONECT    1    2   30                                                 
CONECT    2    1    3    4   10                                       
CONECT    3    2                                                      
CONECT    4    2    5    6    7                                       
CONECT    5    4                                                      
CONECT    6    4   31                                                 
CONECT    7    4    8    9   22                                       
CONECT    8    7                                                      
CONECT    9    7   10                                                 
CONECT   10    9   11    2   12                                       
CONECT   11   10                                                      
CONECT   12   10   13   32   33                                       
CONECT   13   12   14                                                 
CONECT   14   13   15   16   16                                       
CONECT   14   17                                                      
CONECT   15   14   34                                                 
CONECT   16   14   14                                                 
CONECT   17   14   18                                                 
CONECT   18   17   19   20   21                                       
CONECT   18   21                                                      
CONECT   19   18   35                                                 
CONECT   20   18   36                                                 
CONECT   21   18   18                                                 
CONECT   22    7   23   28                                            
CONECT   23   22   24   24   37                                       
CONECT   24   23   23   25   38                                       
CONECT   25   24   26   26   27                                       
CONECT   26   25   25                                                 
CONECT   27   25   28   39                                            
CONECT   28   27   22   29   29                                       
CONECT   29   28   28                                                 
CONECT   30    1                                                      
CONECT   31    6                                                      
CONECT   32   12                                                      
CONECT   33   12                                                      
CONECT   34   15                                                      
CONECT   35   19                                                      
CONECT   36   20                                                      
CONECT   37   23                                                      
CONECT   38   24                                                      
CONECT   39   27                                                      
MASTER        0    0    0    0    0    0    0    0   39    0   39    0
END

https://cactus.nci.nih.gov/chemical/structure/O%5BC@H%5D1%5BC@@H%5D(O)%5BC@@H...
 OpenBabel09142113213D
Jmol version 14.31.45  2021-07-21 05:08 EXTRACT: ({0:38})
 39 40  0  0  0  0  0  0  0  0999 V2000
    1.8941    3.9637    0.2114 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8779    2.6436   -0.3356 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7048    2.6790   -1.4112 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2029    1.9123   -0.0243 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.6836    1.5840   -0.9458 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0791    2.7595    0.7219 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7700    0.6956    0.8235 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8521    0.9249    1.8859 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3899    0.4675    0.4637 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7986    1.7834    0.3583 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5782    2.1807    1.3491 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4748    1.7289   -0.4881 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4693    0.9644    0.1963 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9393    0.6997   -0.4048 P   0  0  1  0  0  0  0  0  0  0  0  0
   -3.7342    2.0957   -0.5133 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8206    0.0937   -1.7497 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7437   -0.3017    0.5661 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0250   -1.2573    0.3735 P   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5731   -2.6204   -0.3543 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6586   -1.6020    1.8129 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0357   -0.5660   -0.4576 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5862   -0.4745    0.4906 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4191   -1.0105    1.4346 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1711   -2.0892    1.1279 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0808   -2.6450   -0.1711 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7489   -3.6179   -0.4711 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2480   -2.0871   -1.0730 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5058   -1.0151   -0.7388 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7592   -0.5227   -1.5625 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5731    4.5383   -0.1679 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3343    3.5682    0.2570 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8445    2.7408   -0.6537 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2536    1.2613   -1.4476 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8492    2.5496    0.3328 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9105   -3.1268    0.1352 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4361   -2.1755    1.7732 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4749   -0.5728    2.4204 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8328   -2.5220    1.8635 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1807   -2.4621   -1.9650 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1 30  1  0  0  0  0
  2  3  1  6  0  0  0
  2  4  1  0  0  0  0
  2 10  1  0  0  0  0
  4  5  1  6  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6 31  1  0  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  7 22  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 32  1  0  0  0  0
 12 33  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  6  0  0  0
 14 17  1  0  0  0  0
 15 34  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 35  1  0  0  0  0
 20 36  1  0  0  0  0
 22 23  1  0  0  0  0
 22 28  1  0  0  0  0
 23 24  2  0  0  0  0
 23 37  1  0  0  0  0
 24 25  1  0  0  0  0
 24 38  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 39  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
$$$$

View in JSmol View Stereo Labels

Synonyms

Value	Source
Uridine diphosphate	ChEBI
Uridine diphosphoric acid	Generator
Uridine 5'-diphosphoric acid	Generator
5'-UDP	HMDB
UDP	HMDB
Uridine 5'-pyrophosphate	HMDB
Uridine 5'-pyrophosphorate	HMDB
Uridine 5'-pyrophosphoric acid	HMDB
Uridine pyrophosphate	HMDB
Pyrophosphate, uridine	HMDB
Diphosphate, uridine	HMDB
5’-UDP	HMDB
Uridine 5'-(trihydrogen pyrophosphate)	HMDB
Uridine 5'-diphosphate	HMDB
Uridine 5’-(trihydrogen pyrophosphate)	HMDB
Uridine 5’-diphosphate	HMDB
Uridine 5’-diphosphoric acid	HMDB
Uridine 5’-pyrophosphate	HMDB
Uridine 5’-pyrophosphoric acid	HMDB

Chemical Formula

C₉H₁₄N₂O₁₂P₂

Average Molecular Weight

404.1612

Monoisotopic Molecular Weight

404.002196946

IUPAC Name

[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid

Traditional Name

UDP

CAS Registry Number

58-98-0

SMILES

O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O

InChI Identifier

InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

InChI Key

XCCTYIAWTASOJW-XVFCMESISA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyrimidine ribonucleoside diphosphates. These are pyrimidine ribonucleotides with diphosphate group linked to the ribose moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Pyrimidine nucleotides

Sub Class

Pyrimidine ribonucleotides

Direct Parent

Pyrimidine ribonucleoside diphosphates

Alternative Parents

Substituents

Pyrimidine ribonucleoside diphosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
Monosaccharide phosphate
Organic pyrophosphate
Hydroxypyrimidine
Pyrimidone
Monoalkyl phosphate
Hydropyrimidine
Monosaccharide
Organic phosphoric acid derivative
Phosphoric acid ester
Pyrimidine
Alkyl phosphate
Heteroaromatic compound
Tetrahydrofuran
Secondary alcohol
1,2-diol
Oxacycle
Azacycle
Organoheterocyclic compound
Organic nitrogen compound
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Organic oxide
Alcohol
Organopnictogen compound
Organic oxygen compound
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

pyrimidine ribonucleoside 5'-diphosphate (CHEBI:17659 )
uridine 5'-phosphate (CHEBI:17659 )
Ribonucleotides (C00015 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Organ and components:

Prostate

Endocrine gland:

Thyroid gland

Tissue and substructures:

Placenta

Biofluid and excreta:

Blood

Subcellular:

Cell and elements:

Extracellular

Process

Naturally occurring process:

Biological process:

Biochemical pathway:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	8.89 g/L	ALOGPS
logP	-0.94	ALOGPS
logP	-3	ChemAxon
logS	-1.7	ALOGPS
pKa (Strongest Acidic)	1.77	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	212.39 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	74.31 m³·mol⁻¹	ChemAxon
Polarizability	30.43 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

GC-MS

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-004i-4911000000-e0e7874495a5b5baf6b1	2017-09-01	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive	splash10-00pi-3795210000-ef08b4deabe40209df75	2017-10-06	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-004i-4911000000-e0e7874495a5b5baf6b1	2021-09-05	View Spectrum

LC-MS/MS

Spectrum Type	Description	Splash Key	Deposition Date	View
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0002-9000000000-7c065a8df0e08b8c365f	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0002-9000000000-73234233232c376d095c	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0002-9000000000-7c065a8df0e08b8c365f	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-0pdi-6910600000-bf4136774851b6559f17	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0pdi-6910600000-bf4136774851b6559f17	2017-09-14	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-03di-1901000000-4c9ba16543da8ee18c74	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03di-4901000000-1ff9973ec00da457d453	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03di-7900000000-f88f01d934d46a57fefb	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0ik9-3904300000-454bc02fb8862a1d0fac	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-057l-9801000000-5aabcad933dc7e5003a8	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9100000000-7a6d480c699f409f2f36	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0zfr-0301900000-5982e30a90f44090f97e	2021-09-06	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9310100000-5890642f8c3624f36d55	2021-09-06	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9100000000-7bb49a1f0cfcf1695e1e	2021-09-06	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0bt9-0630900000-ff34650c58a8429ecb3c	2021-09-07	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03fr-2960000000-62a0e10267c1a3466957	2021-09-07	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03di-6900000000-7237951ebe305f184b3e	2021-09-07	View Spectrum

NMR

Spectrum Type	Description	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	2012-12-04	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	2016-10-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	2016-10-22	View Spectrum
2D NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, H₂O, predicted)	2012-12-05	View Spectrum

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Mitochondria
Nucleus
Lysosome
Endoplasmic reticulum
Golgi apparatus

Biospecimen Locations

Blood

Tissue Locations

Placenta
Prostate
Thyroid Gland

Pathways

Name	SMPDB/Pathwhiz	KEGG
Lactose Synthesis		Not Available
Pyrimidine Metabolism
Amino Sugar Metabolism
Sialuria or French Type Sialuria		Not Available
Salla Disease/Infantile Sialic Acid Storage Disease		Not Available

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	41.0 +/- 12.0 uM	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

DB03435

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

Not Available

PubChem Compound

6031

PDB ID

Not Available

ChEBI ID

17659

Food Biomarker Ontology

Not Available

VMH ID

UDP

MarkerDB ID

Not Available

References

Synthesis Reference

Zeng, Bin; Rao, Linfan; Li, Gaowo. Method for manufacturing uridine diphosphate. Faming Zhuanli Shenqing Gongkai Shuomingshu (2007), 14pp.

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Brouwer A, Morse DC, Lans MC, Schuur AG, Murk AJ, Klasson-Wehler E, Bergman A, Visser TJ: Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health. Toxicol Ind Health. 1998 Jan-Apr;14(1-2):59-84. [PubMed:9460170 ]
Kamisako T, Kobayashi Y, Takeuchi K, Ishihara T, Higuchi K, Tanaka Y, Gabazza EC, Adachi Y: Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J Gastroenterol. 2000;35(9):659-64. [PubMed:11023036 ]
Syme MR, Paxton JW, Keelan JA: Drug transfer and metabolism by the human placenta. Clin Pharmacokinet. 2004;43(8):487-514. [PubMed:15170365 ]
Collier AC, Tingle MD, Paxton JW, Mitchell MD, Keelan JA: Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption. Hum Reprod. 2002 Oct;17(10):2564-72. [PubMed:12351530 ]
Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
Morrone FB, Jacques-Silva MC, Horn AP, Bernardi A, Schwartsmann G, Rodnight R, Lenz G: Extracellular nucleotides and nucleosides induce proliferation and increase nucleoside transport in human glioma cell lines. J Neurooncol. 2003 Sep;64(3):211-8. [PubMed:14558596 ]
Rise A: [Drugs and the fetus]. Tidsskr Nor Laegeforen. 1976 Jan 10;96(1):41-2. [PubMed:1257952 ]
Court MH, Greenblatt DJ: Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms. Pharmacogenetics. 2000 Jun;10(4):355-69. doi: 10.1097/00008571-200006000-00009. [PubMed:10862526 ]

Only showing the first 10 proteins. There are 149 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. UMP-CMP kinase

General function:: Involved in ATP binding
Specific function:: Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
Gene Name:: CMPK1
Uniprot ID:: P30085
Molecular weight:: 20180.12

Reactions

Adenosine triphosphate + Uridine 5'-monophosphate → ADP + Uridine 5'-diphosphate	details

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Enzyme Details

2. Ectonucleoside triphosphate diphosphohydrolase 1

General function:: Involved in hydrolase activity
Specific function:: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:: ENTPD1
Uniprot ID:: P49961
Molecular weight:: 58706.0

Reactions

Uridine 5'-diphosphate + Water → Uridine 5'-monophosphate + Phosphate	details
Uridine triphosphate + Water → Uridine 5'-diphosphate + Phosphate	details

Enzyme Details

3. Soluble calcium-activated nucleotidase 1

General function:: Involved in calcium ion binding
Specific function:: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:: CANT1
Uniprot ID:: Q8WVQ1
Molecular weight:: 44839.24

Reactions

Uridine 5'-diphosphate + Water → Uridine 5'-monophosphate + Phosphate	details

Enzyme Details

4. Ectonucleoside triphosphate diphosphohydrolase 3

General function:: Involved in hydrolase activity
Specific function:: Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:: ENTPD3
Uniprot ID:: O75355
Molecular weight:: 59104.76

Reactions

Uridine 5'-diphosphate + Water → Uridine 5'-monophosphate + Phosphate	details
Uridine triphosphate + Water → Uridine 5'-diphosphate + Phosphate	details

Enzyme Details

5. Uridine-cytidine kinase 1

General function:: Involved in ATP binding
Specific function:: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:: UCK1
Uniprot ID:: Q9HA47
Molecular weight:: 22760.43

Reactions

Uridine triphosphate + Cytidine → Uridine 5'-diphosphate + Cytidine monophosphate	details
Uridine triphosphate + Uridine → Uridine 5'-diphosphate + Uridine 5'-monophosphate	details

Enzyme Details

6. Nucleoside diphosphate kinase, mitochondrial

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:: NME4
Uniprot ID:: O00746
Molecular weight:: 20658.45

Reactions

Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphate	details

Enzyme Details

7. Ribonucleoside-diphosphate reductase large subunit

General function:: Involved in oxidation reduction
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene Name:: RRM1
Uniprot ID:: P23921
Molecular weight:: 90069.375

Enzyme Details

8. Nucleoside diphosphate kinase A

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:: NME1
Uniprot ID:: P15531
Molecular weight:: 17148.635

Reactions

Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphate	details

Enzyme Details

9. Nucleoside diphosphate kinase 7

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:: NME7
Uniprot ID:: Q9Y5B8
Molecular weight:: 42491.365

Reactions

Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphate	details

Enzyme Details

10. Ribonucleoside-diphosphate reductase subunit M2

General function:: Involved in oxidoreductase activity
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Gene Name:: RRM2
Uniprot ID:: P31350
Molecular weight:: 44877.25

Only showing the first 10 proteins. There are 149 proteins in total.

Show all enzymes and transporters

Showing metabocard for Uridine 5'-diphosphate (HMDB0000295)

MOL for HMDB0000295 (Uridine 5'-diphosphate)

3D MOL for HMDB0000295 (Uridine 5'-diphosphate)

3D SDF for HMDB0000295 (Uridine 5'-diphosphate)

3D-SDF for HMDB0000295 (Uridine 5'-diphosphate)

PDB for HMDB0000295 (Uridine 5'-diphosphate)

3D PDB for HMDB0000295 (Uridine 5'-diphosphate)

SMILES for HMDB0000295 (Uridine 5'-diphosphate)

INCHI for HMDB0000295 (Uridine 5'-diphosphate)

Structure for HMDB0000295 (Uridine 5'-diphosphate)

3D Structure for HMDB0000295 (Uridine 5'-diphosphate)

GC-MS

LC-MS/MS

NMR

Enzymes

Reactions

References

Reactions

Reactions

Reactions

Reactions

Reactions

Reactions

Reactions