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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2022-03-07 02:49:06 UTC
HMDB IDHMDB0000840
Secondary Accession Numbers
  • HMDB00840
Metabolite Identification
Common NameSalicyluric acid
DescriptionSalicyluric acid is an aryl glycine conjugate formed by the body to eliminate excess salicylates, including aspirin. Aspirin is rapidly hydrolysed to salicylic acid which is further metabolized to various compounds, including salicyluric acid (SU) as well as various acyl and phenolic glucuronides, and hydroxylated metabolites. SU is the major metabolite of SA excreted in urine and it is present in the urine of people who have not taken salicylate drugs, although it has no anti-inflammatory effects in humans or in animals. More salicyluric acid (SU) is excreted in the urine of vegetarians than in non-vegetarians, primarily because fruits and vegetables are important sources of dietary salicylates. However, significantly less (10-15X) SU is excreted by vegetarians than individuals taking low-dose aspirin (PMID: 12944546 ). The induction of the salicyluric acid formation is one of the saturable pathways of salicylate elimination. The formation of the methyl ester of salicyluric acid is observed during the quantitation of salicyluric acid and other salicylate metabolites in urine by high-pressure liquid chromatography. This methyl ester formation causes artificially low values for salicyluric acid and high values for salicylic acid. (PMID: 6101164 , 6857178 ). Salicyluric acid has been found to be a microbial metabolite.
Structure
Data?1582752159
Synonyms
ValueSource
N-(2-Hydroxybenzoyl)-glycineChEBI
N-SalicyloylglycineChEBI
O-Hydroxyhippuric acidChEBI
SalicyloylglycineChEBI
SalicylurateChEBI
O-HydroxyhippateGenerator
O-Hydroxyhippic acidGenerator
SalicylateGenerator
Salicylic acidGenerator
((2-Hydroxybenzoyl)amino)acetic acidHMDB
(2-Hydroxybenzoyl)glycineHMDB
2-HydroxybenzoylaminoacetateHMDB
2-Hydroxybenzoylaminoacetic acidHMDB
2-HydroxybenzoylglycineHMDB
2-HydroxyhippurateHMDB
2-Hydroxyhippuric acidHMDB
N-O-HydroxybenzoylglycineHMDB
O-Hydroxy-hippurateHMDB
O-Hydroxy-hippuric acidHMDB
O-HydroxyhippurateHMDB
Ortho-hydroxyhippurateHMDB
Ortho-hydroxyhippuric acidHMDB
SalicylglycineHMDB
[(2-Hydroxybenzoyl)amino]acetateHMDB
[(2-Hydroxybenzoyl)amino]acetic acidHMDB
Salicylurate, monosodium saltHMDB
N-(O-Hydroxybenzoyl)glycineHMDB
2-[(2-Hydroxybenzoyl)amino]acetic acidHMDB
2'-Hydroxyhippuric acidHMDB
Chemical FormulaC9H9NO4
Average Molecular Weight195.1721
Monoisotopic Molecular Weight195.053157781
IUPAC Name2-[(2-hydroxyphenyl)formamido]acetic acid
Traditional Namesalicyluric acid
CAS Registry Number487-54-7
SMILES
OC(=O)CNC(=O)C1=C(O)C=CC=C1
InChI Identifier
InChI=1S/C9H9NO4/c11-7-4-2-1-3-6(7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
InChI KeyONJSZLXSECQROL-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hippuric acids. Hippuric acids are compounds containing hippuric acid, which consists of a of a benzoyl group linked to the N-terminal of a glycine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzoic acids and derivatives
Direct ParentHippuric acids
Alternative Parents
Substituents
  • Hippuric acid
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Alpha-amino acid or derivatives
  • Salicylic acid or derivatives
  • Salicylamide
  • Benzoyl
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Vinylogous acid
  • Carboxamide group
  • Secondary carboxylic acid amide
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic nitrogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Carbonyl group
  • Organic oxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point168 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP0.95HANSCH,C ET AL. (1995)
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-MetCCS_train_neg133.0130932474
[M-H]-Not Available135.5http://allccs.zhulab.cn/database/detail?ID=AllCCS00000294
Predicted Molecular Properties
PropertyValueSource
Water Solubility4.04 g/LALOGPS
logP0.51ALOGPS
logP0.87ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)3.27ChemAxon
pKa (Strongest Basic)-1.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area86.63 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity48.1 m³·mol⁻¹ChemAxon
Polarizability18.4 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+142.77831661259
DarkChem[M-H]-136.85731661259
AllCCS[M+H]+141.99432859911
AllCCS[M-H]-140.06832859911
DeepCCS[M+H]+139.53830932474
DeepCCS[M-H]-137.14330932474
DeepCCS[M-2H]-172.01830932474
DeepCCS[M+Na]+146.50530932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Salicyluric acidOC(=O)CNC(=O)C1=C(O)C=CC=C12997.0Standard polar33892256
Salicyluric acidOC(=O)CNC(=O)C1=C(O)C=CC=C11848.4Standard non polar33892256
Salicyluric acidOC(=O)CNC(=O)C1=C(O)C=CC=C11931.5Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Salicyluric acid,1TMS,isomer #1C[Si](C)(C)OC(=O)CNC(=O)C1=CC=CC=C1O1958.6Semi standard non polar33892256
Salicyluric acid,1TMS,isomer #2C[Si](C)(C)OC1=CC=CC=C1C(=O)NCC(=O)O1993.1Semi standard non polar33892256
Salicyluric acid,1TMS,isomer #3C[Si](C)(C)N(CC(=O)O)C(=O)C1=CC=CC=C1O1933.4Semi standard non polar33892256
Salicyluric acid,2TMS,isomer #1C[Si](C)(C)OC(=O)CNC(=O)C1=CC=CC=C1O[Si](C)(C)C2085.3Semi standard non polar33892256
Salicyluric acid,2TMS,isomer #2C[Si](C)(C)OC(=O)CN(C(=O)C1=CC=CC=C1O)[Si](C)(C)C1926.0Semi standard non polar33892256
Salicyluric acid,2TMS,isomer #3C[Si](C)(C)OC1=CC=CC=C1C(=O)N(CC(=O)O)[Si](C)(C)C2002.8Semi standard non polar33892256
Salicyluric acid,3TMS,isomer #1C[Si](C)(C)OC(=O)CN(C(=O)C1=CC=CC=C1O[Si](C)(C)C)[Si](C)(C)C2016.3Semi standard non polar33892256
Salicyluric acid,3TMS,isomer #1C[Si](C)(C)OC(=O)CN(C(=O)C1=CC=CC=C1O[Si](C)(C)C)[Si](C)(C)C2007.6Standard non polar33892256
Salicyluric acid,3TMS,isomer #1C[Si](C)(C)OC(=O)CN(C(=O)C1=CC=CC=C1O[Si](C)(C)C)[Si](C)(C)C2151.2Standard polar33892256
Salicyluric acid,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)C1=CC=CC=C1O2204.0Semi standard non polar33892256
Salicyluric acid,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=CC=CC=C1C(=O)NCC(=O)O2245.1Semi standard non polar33892256
Salicyluric acid,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)N(CC(=O)O)C(=O)C1=CC=CC=C1O2175.6Semi standard non polar33892256
Salicyluric acid,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)C1=CC=CC=C1O[Si](C)(C)C(C)(C)C2547.3Semi standard non polar33892256
Salicyluric acid,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)CN(C(=O)C1=CC=CC=C1O)[Si](C)(C)C(C)(C)C2417.7Semi standard non polar33892256
Salicyluric acid,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC1=CC=CC=C1C(=O)N(CC(=O)O)[Si](C)(C)C(C)(C)C2489.8Semi standard non polar33892256
Salicyluric acid,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)CN(C(=O)C1=CC=CC=C1O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2685.1Semi standard non polar33892256
Salicyluric acid,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)CN(C(=O)C1=CC=CC=C1O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2615.7Standard non polar33892256
Salicyluric acid,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)CN(C(=O)C1=CC=CC=C1O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2530.1Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Salicyluric acid GC-MS (3 TMS)splash10-0006-1921000000-494271209c45ba6e054e2014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Salicyluric acid GC-MS (2 TMS)splash10-0a4l-3942000000-04aa13977839f7430e872014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Salicyluric acid GC-MS (Non-derivatized)splash10-0006-1921000000-494271209c45ba6e054e2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Salicyluric acid GC-MS (Non-derivatized)splash10-0a4l-3942000000-04aa13977839f7430e872017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Salicyluric acid GC-EI-TOF (Non-derivatized)splash10-0006-0921000000-3ee04ebbc6ba044f6e252017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Salicyluric acid GC-EI-TOF (Non-derivatized)splash10-0a4l-1942000000-14e4da43f05418868f3d2017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-00di-2900000000-558ece7e40b6a2505e9b2016-09-22Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (2 TMS) - 70eV, Positivesplash10-00dl-7972000000-6d3342d12b15e7739ff02017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TMS_1_3) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TMS_2_2) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TMS_2_3) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TBDMS_1_1) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TBDMS_1_2) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TBDMS_1_3) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TBDMS_2_1) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TBDMS_2_2) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Salicyluric acid GC-MS (TBDMS_2_3) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-00di-0900000000-5fc858fcdd858768270f2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-00di-3900000000-05f9fa1a8cebedcf52c92012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-01bc-9200000000-169ad1809ba2a4accf082012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative-QTOFsplash10-0006-0900000000-d6d7f1809f1779d278b32012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative-QTOFsplash10-0udi-2900000000-d099d157b6253af681d32012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative-QTOFsplash10-0006-9100000000-96900edd4f6aa1f2c3b92012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative-QTOFsplash10-0006-9000000000-511684503214f5c466682012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative-QTOFsplash10-0006-9000000000-8daa85624d5a460188582012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ , negative-QTOFsplash10-0006-0900000000-d6d7f1809f1779d278b32017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ , negative-QTOFsplash10-0udi-2900000000-d099d157b6253af681d32017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ , negative-QTOFsplash10-0006-9100000000-96900edd4f6aa1f2c3b92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ , negative-QTOFsplash10-0006-9000000000-511684503214f5c466682017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-QQ , negative-QTOFsplash10-0006-9000000000-8daa85624d5a460188582017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid LC-ESI-IT , negative-QTOFsplash10-0udi-0900000000-7f8ca4379a27c9d6fad92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid 10V, Negative-QTOFsplash10-0udi-1900000000-9b88237d9c8a1f5864a82021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid 40V, Negative-QTOFsplash10-0006-9000000000-5f0973db56ba7f4637a52021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid 20V, Negative-QTOFsplash10-0006-9100000000-8d96e93a2efb83a5b59b2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid 30V, Negative-QTOFsplash10-0006-9000000000-b7f5fb721797c78801422021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Salicyluric acid 40V, Negative-QTOFsplash10-0006-9000000000-e41d3042048b1bf5a6372021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Salicyluric acid 10V, Positive-QTOFsplash10-0002-2900000000-329e9ccbe80298c87ec22016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Salicyluric acid 20V, Positive-QTOFsplash10-0fk9-5900000000-be142fe17e5fc055f83c2016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Salicyluric acid 40V, Positive-QTOFsplash10-00fu-9200000000-1490fe4359681e391fd32016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Salicyluric acid 10V, Negative-QTOFsplash10-0006-0900000000-47cf95d67574e923d0002016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Salicyluric acid 20V, Negative-QTOFsplash10-0f6x-3900000000-65d91bbe9e076cff41772016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Salicyluric acid 40V, Negative-QTOFsplash10-006x-9100000000-e75a3b91d96f8d45614e2016-09-12Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Experimental 1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, experimental)2012-12-04Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)2012-12-05Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Feces
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
BloodDetected and Quantified1.000 +/- 0.015 uMAdult (>18 years old)BothNormal details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified0.59-0.87 umol/mmol creatinineAdult (>18 years old)FemaleNormal details
UrineDetected and Quantified0.7 (0.3-1.8) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified0.5 umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.23 (0.01-0.8) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified11.0 (0.3-28) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableConsuming polyphenols described by Phenol-Explorer entry 928 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableConsuming polyphenols described by Phenol-Explorer entry 928 details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.61-0.87 umol/mmol creatinineAdult (>18 years old)MaleNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer
details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothBladder cancer details
Associated Disorders and Diseases
Disease References
Colorectal cancer
  1. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB010505
KNApSAcK IDNot Available
Chemspider ID9835
KEGG Compound IDC07588
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkSalicyluric_acid
METLIN ID617
PubChem Compound10253
PDB IDNot Available
ChEBI ID9008
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Buskin JN, Upton RA, Williams RL: Improved liquid-chromatography of aspirin, salicylate, and salicyluric acid in plasma, with a modification for determining aspirin metabolites in urine. Clin Chem. 1982 May;28(5):1200-3. [PubMed:7074905 ]
  2. Cham BE, Bochner F, Imhoff DM, Johns D, Rowland M: Simultaneous liquid-chromatographic quantitation of salicylic acid, salicyluric acid, and gentisic acid in urine. Clin Chem. 1980 Jan;26(1):111-4. [PubMed:7356541 ]
  3. Sakurai M, Ohsako M, Nagano M, Nakamura C, Tsuzuki O, Ichikawa M, Matsumoto Y: [Effect of human serum albumin on transport of drugs through human erythrocyte membranes]. Yakugaku Zasshi. 1996 Aug;116(8):630-8. [PubMed:8831264 ]
  4. Pirker R, Huck CW, Popp M, Bonn GK: Simultaneous determination of gentisic, salicyluric and salicylic acid in human plasma using solid-phase extraction, liquid chromatography and electrospray ionization mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Oct 5;809(2):257-64. [PubMed:15315774 ]
  5. Lares-Asseff I, Juarez-Olguin H, Flores-Perez J, Guille-Perez A, Vargas A: Pharmacokinetics and metabolic rates of acetyl salicylic acid and its metabolites in an Otomi ethnic group of Mexico. Biol Pharm Bull. 2004 May;27(5):706-9. [PubMed:15133250 ]
  6. Farid NA, Born GS, Kessler WV, Shaw SM, Lange WE: Improved colorimetric determination of salicylic acid and its metabolites in urine. Clin Chem. 1975 Jul;21(8):1167-8. [PubMed:1137922 ]
  7. Kershaw RA, Mays DC, Bianchine JR, Gerber N: Disposition of aspirin and its metabolites in the semen of man. J Clin Pharmacol. 1987 Apr;27(4):304-9. [PubMed:3680588 ]
  8. Lawrence JR, Peter R, Baxter GJ, Robson J, Graham AB, Paterson JR: Urinary excretion of salicyluric and salicylic acids by non-vegetarians, vegetarians, and patients taking low dose aspirin. J Clin Pathol. 2003 Sep;56(9):651-3. [PubMed:12944546 ]
  9. Arancibia JA, Olivieri AC, Escandar GM: First- and second-order multivariate calibration applied to biological samples: determination of anti-inflammatories in serum and urine. Anal Bioanal Chem. 2002 Oct;374(3):451-9. Epub 2002 Sep 11. [PubMed:12373394 ]
  10. Baxter GJ, Lawrence JR, Graham AB, Wiles D, Paterson JR: Identification and determination of salicylic acid and salicyluric acid in urine of people not taking salicylate drugs. Ann Clin Biochem. 2002 Jan;39(Pt 1):50-5. [PubMed:11853189 ]
  11. Day RO, Dromgoole SH, Furst DE, Hignite C, Paulus HE: Formation of methyl ester of salicyluric acid during quantitation of salicyluric acid in urine by high-pressure liquid chromatography. J Pharm Sci. 1981 Sep;70(9):1090-2. [PubMed:6101164 ]
  12. Olsson B: Decreasing serum salicylate concentrations during long-term administration of acetylsalicylic acid in healthy volunteers. Discussion of possible clinical implications. Scand J Rheumatol. 1983;12(2):81-4. [PubMed:6857178 ]

Enzymes

General function:
Involved in glycine N-acyltransferase activity
Specific function:
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
Gene Name:
GLYAT
Uniprot ID:
Q6IB77
Molecular weight:
18506.33
Reactions
Salicylic acid → Salicyluric aciddetails
General function:
Involved in glycine N-acyltransferase activity
Specific function:
Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.
Gene Name:
GLYATL1
Uniprot ID:
Q969I3
Molecular weight:
35100.895
General function:
Involved in glycine N-acyltransferase activity
Specific function:
Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.
Gene Name:
GLYATL2
Uniprot ID:
Q8WU03
Molecular weight:
34277.055
General function:
Involved in glycine N-acyltransferase activity
Specific function:
Acyltransferase which transfers the acyl group to the N- terminus of glycine
Gene Name:
GLYATL3
Uniprot ID:
Q5SZD4
Molecular weight:
32703.3