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Record Information
StatusExpected but not Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2021-09-16 15:27:11 UTC
Secondary Accession Numbers
  • HMDB00865
Metabolite Identification
Common NameMuricholic acid
DescriptionA bile acid. Bile acids are steroid acids found predominantly in the bile of mammals. The distinction between different bile acids is minute, depending only on the presence or absence of hydroxyl groups on positions 3, 7, and 12. Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g. membrane disruption) and there are a plethora of mechanisms to limit their accumulation in blood and tissues (PMID: 11316487 , 16037564 , 12576301 , 11907135 ).
(3alpha,5beta)-3,6,7-Trihydroxy-cholan-24-Oic acidHMDB
3,6,7-Trihydroxy-5-cholanoic acidHMDB
3alpha,6alpha,7beta-Trihydroxy-5beta-cholanoic acidHMDB
Hyocholic acidHMDB
Trihydroxy-5alpha-cholanoic acidHMDB
3 alpha,6 alpha,7 beta-Trihydroxy-5 beta-cholanoic acidHMDB
alpha-Muricholic acidHMDB
beta-Muricholic acidHMDB
Muricholic acid, (3alpha,5alpha,6alpha,7alpha)-isomerHMDB
Muricholic acid, (3alpha,5beta,6alpha,7alpha)-isomerHMDB
Muricholic acid, (3alpha,5beta,6alpha,7beta)-isomerHMDB
Muricholic acid, (3alpha,5beta,6beta,7alpha)-isomerHMDB
Muricholic acid, (3alpha,5beta,6beta,7beta)-isomerHMDB
Muricholic acid, sodium saltHMDB
Omega-muricholic acidHMDB
Trihydroxy-5 alpha-cholanoic acidHMDB
Muricholic acidMeSH
Chemical FormulaC24H40O5
Average Molecular Weight408.5714
Monoisotopic Molecular Weight408.28757439
IUPAC Name(4R)-4-[(1S,2R,5R,7R,10S,11S,14R,15R)-5,8,9-trihydroxy-2,15-dimethyltetracyclo[^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
Traditional Name(4R)-4-[(1S,2R,5R,7R,10S,11S,14R,15R)-5,8,9-trihydroxy-2,15-dimethyltetracyclo[^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
CAS Registry Number39016-49-4
InChI Identifier
Chemical Taxonomy
Description Belongs to the class of organic compounds known as trihydroxy bile acids, alcohols and derivatives. These are prenol lipids structurally characterized by a bile acid or alcohol which bears three hydroxyl groups.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassBile acids, alcohols and derivatives
Direct ParentTrihydroxy bile acids, alcohols and derivatives
Alternative Parents
  • Trihydroxy bile acid, alcohol, or derivatives
  • 3-hydroxysteroid
  • 6-hydroxysteroid
  • 7-hydroxysteroid
  • 3-alpha-hydroxysteroid
  • Hydroxysteroid
  • Cyclic alcohol
  • Secondary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Polyol
  • Monocarboxylic acid or derivatives
  • Organic oxide
  • Alcohol
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Carbonyl group
  • Organooxygen compound
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External DescriptorsNot Available

Biological location


Route of exposure

Physical Properties
Experimental Molecular Properties
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
Experimental Spectral PropertiesNot Available
Predicted Molecular Properties
Water Solubility0.069 g/LALOGPS
logP10(2.16) g/LALOGPS
logP10(2.72) g/LChemAxon
logS10(-3.8) g/LALOGPS
pKa (Strongest Acidic)4.6ChemAxon
pKa (Strongest Basic)-2.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area97.99 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity110.56 m³·mol⁻¹ChemAxon
Polarizability47.23 ųChemAxon
Number of Rings4ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Spectral Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference

Predicted Kovats Retention Indices


Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Muricholic acid,1TMS,#1C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C)C(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3465.8Semi standard non polar
Muricholic acid,1TMS,#2C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O)C(O[Si](C)(C)C)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3478.3Semi standard non polar
Muricholic acid,1TMS,#3C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O)C(O)[C@@H]4C[C@H](O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3515.4Semi standard non polar
Muricholic acid,1TMS,#4C[C@H](CCC(=O)O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O)C(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3442.9Semi standard non polar
Muricholic acid,2TMS,#1C[C@H](CCC(=O)O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C)C(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3401.5Semi standard non polar
Muricholic acid,2TMS,#2C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C)C(O[Si](C)(C)C)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3384.2Semi standard non polar
Muricholic acid,2TMS,#3C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C)C(O)[C@@H]4C[C@H](O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3429.5Semi standard non polar
Muricholic acid,2TMS,#4C[C@H](CCC(=O)O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O)C(O[Si](C)(C)C)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3405.4Semi standard non polar
Muricholic acid,2TMS,#5C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O)C(O[Si](C)(C)C)[C@@H]4C[C@H](O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3445.7Semi standard non polar
Muricholic acid,2TMS,#6C[C@H](CCC(=O)O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O)C(O)[C@@H]4C[C@H](O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3466.5Semi standard non polar
Muricholic acid,3TMS,#1C[C@H](CCC(=O)O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C)C(O[Si](C)(C)C)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3351.9Semi standard non polar
Muricholic acid,3TMS,#2C[C@H](CCC(=O)O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C)C(O)[C@@H]4C[C@H](O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3383.4Semi standard non polar
Muricholic acid,3TMS,#3C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C)C(O[Si](C)(C)C)[C@@H]4C[C@H](O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3392.0Semi standard non polar
Muricholic acid,3TMS,#4C[C@H](CCC(=O)O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O)C(O[Si](C)(C)C)[C@@H]4C[C@H](O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3396.3Semi standard non polar
Muricholic acid,4TMS,#1C[C@H](CCC(=O)O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C)C(O[Si](C)(C)C)[C@@H]4C[C@H](O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3364.6Semi standard non polar
Muricholic acid,1TBDMS,#1C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C(C)(C)C)C(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3679.8Semi standard non polar
Muricholic acid,1TBDMS,#2C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O)C(O[Si](C)(C)C(C)(C)C)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3698.9Semi standard non polar
Muricholic acid,1TBDMS,#3C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O)C(O)[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3752.9Semi standard non polar
Muricholic acid,1TBDMS,#4C[C@H](CCC(=O)O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O)C(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3710.8Semi standard non polar
Muricholic acid,2TBDMS,#1C[C@H](CCC(=O)O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C(C)(C)C)C(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3837.1Semi standard non polar
Muricholic acid,2TBDMS,#2C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3814.9Semi standard non polar
Muricholic acid,2TBDMS,#3C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C(C)(C)C)C(O)[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3855.3Semi standard non polar
Muricholic acid,2TBDMS,#4C[C@H](CCC(=O)O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O)C(O[Si](C)(C)C(C)(C)C)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3850.6Semi standard non polar
Muricholic acid,2TBDMS,#5C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O)C(O[Si](C)(C)C(C)(C)C)[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3888.0Semi standard non polar
Muricholic acid,2TBDMS,#6C[C@H](CCC(=O)O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O)C(O)[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3943.0Semi standard non polar
Muricholic acid,3TBDMS,#1C[C@H](CCC(=O)O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3990.4Semi standard non polar
Muricholic acid,3TBDMS,#2C[C@H](CCC(=O)O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C(C)(C)C)C(O)[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C4024.1Semi standard non polar
Muricholic acid,3TBDMS,#3C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C4024.4Semi standard non polar
Muricholic acid,3TBDMS,#4C[C@H](CCC(=O)O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O)C(O[Si](C)(C)C(C)(C)C)[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C4047.6Semi standard non polar
Muricholic acid,4TBDMS,#1C[C@H](CCC(=O)O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C4194.6Semi standard non polar

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Muricholic acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-004l-0229000000-ffb958adac1bd99cb8c82017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Muricholic acid GC-MS (4 TMS) - 70eV, Positivesplash10-001i-1110029000-d964e134586fffeb91332017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Muricholic acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 10V, Positive-QTOFsplash10-006x-0009100000-aeaf5bcdde74fe1ddf762017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 20V, Positive-QTOFsplash10-00dm-0009000000-4af1ebd01d1d670d4f422017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 40V, Positive-QTOFsplash10-003u-2209000000-454d741b691e592d251a2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 10V, Negative-QTOFsplash10-0a4i-0007900000-e501198616f74730538f2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 20V, Negative-QTOFsplash10-052r-1009300000-9efc23876fa89e243bc62017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 40V, Negative-QTOFsplash10-0a4l-9007000000-e10e02b21078730f3ff92017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 10V, Negative-QTOFsplash10-0a4i-0001900000-3a052136aaad1f7a69382021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 20V, Negative-QTOFsplash10-0a4r-0007900000-22aa0ad4e0928aedf2ca2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 40V, Negative-QTOFsplash10-0a4i-1007900000-6419c8b1ffa27ffadfc82021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 10V, Positive-QTOFsplash10-0a4i-0009500000-dcb14c8cf8d9d980be592021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 20V, Positive-QTOFsplash10-000j-2389100000-31f9fcf2f00a46e40c202021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Muricholic acid 40V, Positive-QTOFsplash10-0002-9650000000-1b93af04c335777ff2952021-09-22Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
Biospecimen LocationsNot Available
Tissue Locations
  • Gall Bladder
  • Intestine
  • Kidney
  • Liver
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID106701
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkMuricholic_acid
PubChem Compound119473
PDB IDNot Available
ChEBI ID134216
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
Synthesis ReferenceAranda G; Bertranne M; Fetizon M; Infante R Synthesis of 6 alpha-tritiated beta-muricholic acid for use as a molecular probe. Steroids (1992), 57(4), 205-7.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Nakashima T, Yoh T, Sumida Y, Kakisaka Y, Mitsuyoshi H: Differences in the efficacy of ursodeoxycholic acid and bile acid metabolism between viral liver diseases and primary biliary cirrhosis. J Gastroenterol Hepatol. 2001 May;16(5):541-7. [PubMed:11350551 ]
  2. Lundell K, Wikvall K: Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21). Biochim Biophys Acta. 2003 Nov 15;1634(3):86-96. [PubMed:14643796 ]
  3. Strandvik B, Wikstrom SA: Tetrahydroxylated bile acids in healthy human newborns. Eur J Clin Invest. 1982 Aug;12(4):301-5. [PubMed:6814920 ]
  4. Bremmelgaard A, Sjovall J: Hydroxylation of cholic, chenodeoxycholic, and deoxycholic acids in patients with intrahepatic cholestasis. J Lipid Res. 1980 Nov;21(8):1072-81. [PubMed:7462803 ]
  5. Kimura A, Yamakawa R, Ushijima K, Fujisawa T, Kuriya N, Kato H, Inokuchi T, Mahara R, Kurosawa T, Tohma M: Fetal bile acid metabolism during infancy: analysis of 1 beta-hydroxylated bile acids in urine, meconium and feces. Hepatology. 1994 Oct;20(4 Pt 1):819-24. [PubMed:7927221 ]
  6. Kayahara T, Tamura T, Amuro Y, Higashino K, Igimi H, Uchida K: Delta 22-beta-muricholic acid in monoassociated rats and conventional rats. Lipids. 1994 Apr;29(4):289-96. [PubMed:8177022 ]
  7. Nakashima T, Sakamoto Y, Inaba K, Mitsuyoshi H, Ishikawa H, Nakajima Y, Sakai M, Shima T, Kashima K: A paucity of unusual trihydroxy bile acids in the urine of patients with severe liver diseases. Hepatology. 1999 May;29(5):1518-22. [PubMed:10216137 ]
  8. Narushima S, Itoh K, Takamine F, Uchida K: Absence of cecal secondary bile acids in gnotobiotic mice associated with two human intestinal bacteria with the ability to dehydroxylate bile acids in vitro. Microbiol Immunol. 1999;43(9):893-7. [PubMed:10553682 ]
  9. Kano M, Matsumoto M, Kamano T, Tsurumaru M: ELISA determination of serum hyocholic acid concentrations in humans and their possible clinical significance. Hepatogastroenterology. 1999 Mar-Apr;46(26):983-4. [PubMed:10370651 ]
  10. Ushijima K, Kimura A, Inokuchi T, Yamato Y, Maeda K, Yamashita Y, Nakashima E, Kato H: Placental transport of bile acids: analysis of bile acids in maternal serum and urine, umbilical cord blood, and amniotic fluid. Kurume Med J. 2001;48(2):87-91. [PubMed:11501503 ]
  11. van Berge Henegouwen GP, Brandt KH, Eyssen H, Parmentier G: Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut. 1976 Nov;17(11):861-9. [PubMed:1001976 ]
  12. St-Pierre MV, Kullak-Ublick GA, Hagenbuch B, Meier PJ: Transport of bile acids in hepatic and non-hepatic tissues. J Exp Biol. 2001 May;204(Pt 10):1673-86. [PubMed:11316487 ]
  13. Claudel T, Staels B, Kuipers F: The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2020-30. Epub 2005 Jul 21. [PubMed:16037564 ]
  14. Chiang JY: Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors. Am J Physiol Gastrointest Liver Physiol. 2003 Mar;284(3):G349-56. [PubMed:12576301 ]
  15. Davis RA, Miyake JH, Hui TY, Spann NJ: Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP. J Lipid Res. 2002 Apr;43(4):533-43. [PubMed:11907135 ]


General function:
Involved in binding
Specific function:
Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis
Gene Name:
Uniprot ID:
Molecular weight:
  1. Kurz M, Brachvogel V, Matter H, Stengelin S, Thuring H, Kramer W: Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. Proteins. 2003 Feb 1;50(2):312-28. [PubMed:12486725 ]


General function:
Involved in transporter activity
Specific function:
Mediates the Na(+)-independent transport of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP)
Gene Name:
Uniprot ID:
Molecular weight:
General function:
Involved in transporter activity
Specific function:
Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver
Gene Name:
Uniprot ID:
Molecular weight:
  1. Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J: A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J Biol Chem. 2002 Nov 8;277(45):43058-63. Epub 2002 Aug 23. [PubMed:12196548 ]
General function:
Involved in ATP binding
Specific function:
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes
Gene Name:
Uniprot ID:
Molecular weight:
General function:
Involved in ATP binding
Specific function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes
Gene Name:
Uniprot ID:
Molecular weight:
General function:
Involved in bile acid:sodium symporter activity
Specific function:
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism
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  1. Kramer W, Girbig F, Glombik H, Corsiero D, Stengelin S, Weyland C: Identification of a ligand-binding site in the Na+/bile acid cotransporting protein from rabbit ileum. J Biol Chem. 2001 Sep 21;276(38):36020-7. Epub 2001 Jul 10. [PubMed:11447228 ]
General function:
Involved in bile acid:sodium symporter activity
Specific function:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
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General function:
Involved in transporter activity
Specific function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids
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General function:
Involved in transporter activity
Specific function:
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate
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