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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:25 UTC
HMDB IDHMDB0001065
Secondary Accession Numbers
  • HMDB01065
Metabolite Identification
Common Name2-Hydroxyphenethylamine
Description2-Hydroxyphenethylamine, also known as beta-phenethanolamine or 2-amino-1-phenylethanol, belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group. It is the simplest member of the class of phenylethanolamines that is 2-aminoethanol bearing a phenyl substituent at the 1-position. 2-Hydroxyphenethylamine exists in all living organisms, ranging from bacteria to humans. 2-Hydroxyphenethylamine ia an amine found in the brain. It may be modulator of sympathetic functions. Its derivatives are adrenergic agonists and antagonists.
Structure
Data?1676999725
Synonyms
ValueSource
2-Amino-1-phenylethanolChEBI
2-Hydroxy-2-phenylethylamineChEBI
2-Phenyl-2-hydroxyethylamineChEBI
alpha-(Aminomethyl)benzyl alcoholChEBI
beta-Hydroxy-beta-phenylethylamineChEBI
beta-HydroxyphenethylamineChEBI
beta-PhenethanolamineChEBI
beta-PhenylethanolamineChEBI
BisnorephedrineChEBI
PhenethanolamineChEBI
a-(Aminomethyl)benzyl alcoholGenerator
Α-(aminomethyl)benzyl alcoholGenerator
b-Hydroxy-b-phenylethylamineGenerator
Β-hydroxy-β-phenylethylamineGenerator
b-HydroxyphenethylamineGenerator
Β-hydroxyphenethylamineGenerator
b-PhenethanolamineGenerator
Β-phenethanolamineGenerator
b-PhenylethanolamineGenerator
Β-phenylethanolamineGenerator
2-amino-1-Phenyl-1-ethanolHMDB
2-amino-1-Phenylethanol-1HMDB
beta-Hydroxy-beta-phenyl-ethylamineHMDB
beta-Hydroxy-phenethylamineHMDB
beta-HydroxyphenylethylamineHMDB
DL-beta-Phenyl-beta-hydroxyethylamineHMDB
HydroxyethylamineHMDB
PhenylethanolamineHMDB
beta PhenylethanolamineMeSH, HMDB
2 HydroxyphenethylamineMeSH, HMDB
2 PhenylethanolamineMeSH, HMDB
2-PhenylethanolamineMeSH, HMDB
beta HydroxyphenethylamineMeSH, HMDB
2-HydroxyphenethylamineChEBI
Chemical FormulaC8H11NO
Average Molecular Weight137.179
Monoisotopic Molecular Weight137.084063979
IUPAC Name2-amino-1-phenylethan-1-ol
Traditional Nameβ phenylethanolamine
CAS Registry Number7568-93-6
SMILES
NCC(O)C1=CC=CC=C1
InChI Identifier
InChI=1S/C8H11NO/c9-6-8(10)7-4-2-1-3-5-7/h1-5,8,10H,6,9H2
InChI KeyULSIYEODSMZIPX-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassAmines
Direct ParentAralkylamines
Alternative Parents
Substituents
  • Aralkylamine
  • Benzenoid
  • Monocyclic benzene moiety
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Organic oxygen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Primary amine
  • Organooxygen compound
  • Primary aliphatic amine
  • Alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point56.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility45.8 mg/mLNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility21.4 g/LALOGPS
logP0.31ALOGPS
logP0.47ChemAxon
logS-0.81ALOGPS
pKa (Strongest Acidic)14.13ChemAxon
pKa (Strongest Basic)9.13ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area46.25 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity40.49 m³·mol⁻¹ChemAxon
Polarizability15.18 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+128.35931661259
DarkChem[M+H]+128.35931661259
DarkChem[M-H]-124.82731661259
DarkChem[M-H]-124.82731661259
AllCCS[M+H]+130.70732859911
AllCCS[M-H]-129.22532859911
DeepCCS[M+H]+128.43930932474
DeepCCS[M-H]-124.79730932474
DeepCCS[M-2H]-162.21730932474
DeepCCS[M+Na]+137.38930932474
AllCCS[M+H]+130.732859911
AllCCS[M+H-H2O]+126.132859911
AllCCS[M+NH4]+135.032859911
AllCCS[M+Na]+136.332859911
AllCCS[M-H]-129.232859911
AllCCS[M+Na-2H]-131.032859911
AllCCS[M+HCOO]-132.932859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
2-HydroxyphenethylamineNCC(O)C1=CC=CC=C11929.1Standard polar33892256
2-HydroxyphenethylamineNCC(O)C1=CC=CC=C11263.8Standard non polar33892256
2-HydroxyphenethylamineNCC(O)C1=CC=CC=C11326.1Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
2-Hydroxyphenethylamine,1TMS,isomer #1C[Si](C)(C)OC(CN)C1=CC=CC=C11359.7Semi standard non polar33892256
2-Hydroxyphenethylamine,1TMS,isomer #2C[Si](C)(C)NCC(O)C1=CC=CC=C11462.7Semi standard non polar33892256
2-Hydroxyphenethylamine,2TMS,isomer #1C[Si](C)(C)NCC(O[Si](C)(C)C)C1=CC=CC=C11422.2Semi standard non polar33892256
2-Hydroxyphenethylamine,2TMS,isomer #1C[Si](C)(C)NCC(O[Si](C)(C)C)C1=CC=CC=C11517.6Standard non polar33892256
2-Hydroxyphenethylamine,2TMS,isomer #1C[Si](C)(C)NCC(O[Si](C)(C)C)C1=CC=CC=C11711.9Standard polar33892256
2-Hydroxyphenethylamine,2TMS,isomer #2C[Si](C)(C)N(CC(O)C1=CC=CC=C1)[Si](C)(C)C1602.5Semi standard non polar33892256
2-Hydroxyphenethylamine,2TMS,isomer #2C[Si](C)(C)N(CC(O)C1=CC=CC=C1)[Si](C)(C)C1697.2Standard non polar33892256
2-Hydroxyphenethylamine,2TMS,isomer #2C[Si](C)(C)N(CC(O)C1=CC=CC=C1)[Si](C)(C)C1875.8Standard polar33892256
2-Hydroxyphenethylamine,3TMS,isomer #1C[Si](C)(C)OC(CN([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C11667.9Semi standard non polar33892256
2-Hydroxyphenethylamine,3TMS,isomer #1C[Si](C)(C)OC(CN([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C11679.7Standard non polar33892256
2-Hydroxyphenethylamine,3TMS,isomer #1C[Si](C)(C)OC(CN([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C11725.2Standard polar33892256
2-Hydroxyphenethylamine,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(CN)C1=CC=CC=C11596.8Semi standard non polar33892256
2-Hydroxyphenethylamine,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)NCC(O)C1=CC=CC=C11690.3Semi standard non polar33892256
2-Hydroxyphenethylamine,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)NCC(O[Si](C)(C)C(C)(C)C)C1=CC=CC=C11872.9Semi standard non polar33892256
2-Hydroxyphenethylamine,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)NCC(O[Si](C)(C)C(C)(C)C)C1=CC=CC=C11924.6Standard non polar33892256
2-Hydroxyphenethylamine,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)NCC(O[Si](C)(C)C(C)(C)C)C1=CC=CC=C12007.0Standard polar33892256
2-Hydroxyphenethylamine,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N(CC(O)C1=CC=CC=C1)[Si](C)(C)C(C)(C)C2021.2Semi standard non polar33892256
2-Hydroxyphenethylamine,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N(CC(O)C1=CC=CC=C1)[Si](C)(C)C(C)(C)C2082.9Standard non polar33892256
2-Hydroxyphenethylamine,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N(CC(O)C1=CC=CC=C1)[Si](C)(C)C(C)(C)C2092.5Standard polar33892256
2-Hydroxyphenethylamine,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C1=CC=CC=C12288.2Semi standard non polar33892256
2-Hydroxyphenethylamine,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C1=CC=CC=C12249.0Standard non polar33892256
2-Hydroxyphenethylamine,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C1=CC=CC=C12093.8Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxyphenethylamine GC-MS (Non-derivatized) - 70eV, Positivesplash10-001i-9300000000-3c170028e90978bc78a42017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxyphenethylamine GC-MS (1 TMS) - 70eV, Positivesplash10-00gi-7900000000-4e2e2029648810b696112017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxyphenethylamine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 10V, Negative-QTOFsplash10-004i-9000000000-f2517cf936d9f21d158a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 20V, Negative-QTOFsplash10-004i-9200000000-51bc9ce0c5b6d016f9402021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 40V, Negative-QTOFsplash10-000i-9000000000-ed3ceb3389fd7dae6eab2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-014i-0000900000-548706c8c2ce9f09a5482012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-00di-0900000000-c3f1f0f273348db1d32d2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-0udi-6900000000-bdb37afcb3284184bb382012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 35V, Positive-QTOFsplash10-0fk9-2900000000-3bcb695c5b0cc370aa242021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 35V, Positive-QTOFsplash10-00di-0900000000-86abd5e86e5c59cb0a092021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 10V, Positive-QTOFsplash10-00di-0900000000-9c580bd32266d4f029162021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 20V, Positive-QTOFsplash10-0udi-3900000000-3768160518b34fa454212021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 40V, Positive-QTOFsplash10-004i-9000000000-e243bccdf642ef6d157c2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 20V, Positive-QTOFsplash10-0udi-3900000000-e0a333a28c523433bf7f2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 10V, Positive-QTOFsplash10-00di-0900000000-ae56725698697f1c19022021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxyphenethylamine 40V, Positive-QTOFsplash10-004i-9000000000-bd82f79b668f12d414562021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 10V, Negative-QTOFsplash10-000i-0900000000-f801fd7106bd297ab8be2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 20V, Negative-QTOFsplash10-05n0-2900000000-f0de7984aa0ca45bf4582017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 40V, Negative-QTOFsplash10-004i-9300000000-2d60aec56b29f9023bce2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 10V, Negative-QTOFsplash10-014r-3900000000-461ccf661690efd8885e2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 20V, Negative-QTOFsplash10-016u-8900000000-c402bd52eafa7e43b7422021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 40V, Negative-QTOFsplash10-0059-9300000000-967a3865b7420c1832352021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 10V, Positive-QTOFsplash10-00dr-0900000000-7cef59c17238b64bcf362017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 20V, Positive-QTOFsplash10-0uk9-0900000000-2c5c6655275c451875962017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 40V, Positive-QTOFsplash10-0udi-9700000000-1cbd1ee009138bc1c30a2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 10V, Positive-QTOFsplash10-00di-2900000000-a937d4b5d96c3f30b42d2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxyphenethylamine 20V, Positive-QTOFsplash10-0006-9400000000-8d40a0ed200312a3740e2021-09-22Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Experimental 1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)2021-10-10Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)2012-12-05Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
Tissue Locations
  • Testis
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.00033 +/- 0.00023 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.0052 +/- 0.0016 uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.00052 +/- 0.00052 uMAdult (>18 years old)BothCirrhosis details
Associated Disorders and Diseases
Disease References
Cirrhosis
  1. Yonekura T, Kamata S, Wasa M, Okada A, Yamatodani A, Watanabe T, Wada H: Simultaneous determination of plasma phenethylamine, phenylethanolamine, tyramine and octopamine by high-performance liquid chromatography using derivatization with fluorescamine. J Chromatogr. 1988 Jun 3;427(2):320-5. [PubMed:3137238 ]
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022404
KNApSAcK IDNot Available
Chemspider ID975
KEGG Compound IDC02735
BioCyc IDPHENYLETHANOLAMINE
BiGG IDNot Available
Wikipedia LinkPhenylethanolamine
METLIN ID59
PubChem Compound1000
PDB IDNot Available
ChEBI ID16343
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceYe, Qizhuang. Syntheses of conformationally defined analogs of tyramine and phenylethanolamine and their biological evaluations at central dopamine receptors and the active site of phenylethanolamine N-methyltransferase. (1988), 152 pp.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Buller KM, Hamlin AS, Osborne PB: Dissection of peripheral and central endogenous opioid modulation of systemic interleukin-1beta responses using c-fos expression in the rat brain. Neuropharmacology. 2005 Aug;49(2):230-42. [PubMed:15993445 ]
  2. Davidoff MS, Ungefroren H, Middendorff R, Koeva Y, Bakalska M, Atanassova N, Holstein AF, Jezek D, Pusch W, Muller D: Catecholamine-synthesizing enzymes in the adult and prenatal human testis. Histochem Cell Biol. 2005 Sep;124(3-4):313-23. Epub 2005 Oct 28. [PubMed:16052322 ]
  3. Evinger MJ, Mathew E, Cikos S, Powers JF, Lee YS, Sheikh S, Ross RA, Tischler AS: Nicotine stimulates expression of the PNMT gene through a novel promoter sequence. J Mol Neurosci. 2005;26(1):39-55. [PubMed:15968085 ]
  4. Gee CL, Nourse A, Hsin AY, Wu Q, Tyndall JD, Grunewald GL, McLeish MJ, Martin JL: Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active. Biochim Biophys Acta. 2005 Jun 15;1750(1):82-92. Epub 2005 Apr 2. [PubMed:15893506 ]

Enzymes

General function:
Involved in methyltransferase activity
Specific function:
Converts noradrenaline to adrenaline.
Gene Name:
PNMT
Uniprot ID:
P11086
Molecular weight:
30854.745
Reactions
S-Adenosylmethionine + 2-Hydroxyphenethylamine → S-Adenosylhomocysteine + N-Methylphenylethanolaminedetails