Record Information |
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Version | 4.0 |
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Status | Expected but not Quantified |
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Creation Date | 2005-11-16 15:48:42 UTC |
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Update Date | 2020-06-17 16:54:24 UTC |
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HMDB ID | HMDB0001128 |
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Secondary Accession Numbers | - HMDB0002347
- HMDB01128
- HMDB02347
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Metabolite Identification |
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Common Name | 5-Phosphoribosylamine |
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Description | 5-Phosphoribosylamine, also known as 5-p-beta-D-ribosyl-amine or PRA, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. The beta-anomer of 5-phospho-D-ribosylamine. 5-Phosphoribosylamine is a very strong basic compound (based on its pKa). 5-Phosphoribosylamine exists in all eukaryotes, ranging from yeast to humans. Within humans, 5-phosphoribosylamine participates in a number of enzymatic reactions. In particular, 5-phosphoribosylamine and L-glutamic acid can be converted into L-glutamine and phosphoribosyl pyrophosphate; which is mediated by the enzyme amidophosphoribosyltransferase. In addition, 5-phosphoribosylamine and glycine can be converted into glycineamideribotide through the action of the enzyme trifunctional purine biosynthetic protein adenosine-3. In humans, 5-phosphoribosylamine is involved in the metabolic disorder called the purine nucleoside phosphorylase deficiency pathway. |
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Structure | |
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Synonyms | Value | Source |
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5-Phospho-beta-D-ribosylamine | KEGG | 5-Phospho-D-ribosylamine | KEGG, ChEBI | 5-Phosphoribosyl-1-amine | KEGG, ChEBI | 5-Phospho-b-D-ribosylamine | Generator | 5-Phospho-β-D-ribosylamine | Generator | 5-P-beta-D-Ribosyl-amine | HMDB | 5-Phospho-beta-D-ribosyl-amine | HMDB | PRA | HMDB | Phosphoribosyl-1-amine | HMDB | Phosphoribosylamine | HMDB | beta-Phosphoribosyl-1-amine | HMDB | β-Phosphoribosyl-1-amine | HMDB |
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Chemical Formula | C5H12NO7P |
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Average Molecular Weight | 229.125 |
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Monoisotopic Molecular Weight | 229.035138255 |
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IUPAC Name | {[(2R,3S,4R,5R)-5-amino-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid |
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Traditional Name | 5-phospho-β-D-ribosylamine |
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CAS Registry Number | 6062-06-2 |
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SMILES | N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |
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InChI Identifier | InChI=1S/C5H12NO7P/c6-5-4(8)3(7)2(13-5)1-12-14(9,10)11/h2-5,7-8H,1,6H2,(H2,9,10,11)/t2-,3-,4-,5-/m1/s1 |
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InChI Key | SKCBPEVYGOQGJN-TXICZTDVSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. |
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Kingdom | Organic compounds |
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Super Class | Organic oxygen compounds |
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Class | Organooxygen compounds |
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Sub Class | Carbohydrates and carbohydrate conjugates |
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Direct Parent | Pentose phosphates |
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Alternative Parents | |
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Substituents | - Pentose phosphate
- Pentose-5-phosphate
- Monosaccharide phosphate
- Monoalkyl phosphate
- Organic phosphoric acid derivative
- Phosphoric acid ester
- Alkyl phosphate
- Tetrahydrofuran
- Secondary alcohol
- 1,2-diol
- Hemiaminal
- Organoheterocyclic compound
- Oxacycle
- Alcohol
- Organic oxide
- Organopnictogen compound
- Organonitrogen compound
- Organic nitrogen compound
- Primary aliphatic amine
- Hydrocarbon derivative
- Aliphatic heteromonocyclic compound
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Molecular Framework | Aliphatic heteromonocyclic compounds |
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External Descriptors | |
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Ontology |
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Disposition | Source: |
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Process | Naturally occurring process: |
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Physical Properties |
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State | Solid |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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| Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-002b-9200000000-1c4fff9bc3c106e53faa | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive | splash10-03dj-9741000000-81d2b48c346eaf5bd609 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-001i-2490000000-890344ea8a2dc31a68cd | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-01q9-8950000000-3968c4c6838390005385 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0007-9100000000-696f573fba92b8542f35 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-9040000000-95218a5e49093dd3dec6 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004i-9000000000-909c9da9ed8687627fbe | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-004i-9000000000-d063b8fd7634dcdf6580 | Spectrum |
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