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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:37 UTC
HMDB IDHMDB0001330
Secondary Accession Numbers
  • HMDB0062578
  • HMDB01330
  • HMDB62578
Metabolite Identification
Common Name2-Amino-3-carboxymuconic acid semialdehyde
Description2-Amino-3-carboxymuconic acid semialdehyde (CAS: 16597-58-3) is an intermediate metabolite of the tryptophan-niacin catabolic pathway. Current interest in the degradation of tryptophan is mostly due to the role of quinolinate and other metabolites in several neuropathological conditions. Quinolinate is a neurotoxin formed nonenzymatically from 2-amino-3-carboxymuconic semialdehyde in mammalian tissues. 2-Amino-3-carboxymuconic acid semialdehyde is enzymatically converted into 2-aminomuconate via 2-aminomuconic semialdehyde (PMID: 10510494 , 16267312 , 14275129 ).
Structure
Data?1676999737
Synonyms
ValueSource
2-Amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioateChEBI
2-Amino-3-(3-oxoprop-1-enyl)-but-2-enedioateChEBI
2-Amino-3-carboxymuconate semialdehydeChEBI
2-Amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioic acidGenerator
2-Amino-3-(3-oxoprop-1-enyl)-but-2-enedioic acidGenerator
2-Amino-3-carboxymuconate-6-semialdehydeHMDB
ACSHMDB
Amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioateHMDB
Amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioic acidHMDB
Chemical FormulaC7H7NO5
Average Molecular Weight185.1342
Monoisotopic Molecular Weight185.032422339
IUPAC Name(2Z)-2-amino-3-[(1Z)-3-oxoprop-1-en-1-yl]but-2-enedioic acid
Traditional Name(2Z)-2-amino-3-[(1Z)-3-oxoprop-1-en-1-yl]but-2-enedioic acid
CAS Registry Number16597-19-6
SMILES
N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O
InChI Identifier
InChI=1S/C7H7NO5/c8-5(7(12)13)4(6(10)11)2-1-3-9/h1-3H,8H2,(H,10,11)(H,12,13)/b2-1-,5-4-
InChI KeyKACPVQQHDVBVFC-OIFXTYEKSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acids
Alternative Parents
Substituents
  • Alpha-amino acid
  • Medium-chain fatty acid
  • Amino fatty acid
  • Branched fatty acid
  • Dicarboxylic acid or derivatives
  • Unsaturated fatty acid
  • Fatty acid
  • Fatty acyl
  • Vinylogous amide
  • Alpha,beta-unsaturated aldehyde
  • Enal
  • Amino acid
  • Carboxylic acid
  • Enamine
  • Organic oxide
  • Primary aliphatic amine
  • Organonitrogen compound
  • Organooxygen compound
  • Aldehyde
  • Primary amine
  • Carbonyl group
  • Organopnictogen compound
  • Organic oxygen compound
  • Amine
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
  • 2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid (CHEBI:995 )
Ontology
Physiological effectNot Available
Disposition
Process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility1.64 g/LALOGPS
logP-0.05ALOGPS
logP-3.7ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)2.38ChemAxon
pKa (Strongest Basic)6.72ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area117.69 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity43.62 m³·mol⁻¹ChemAxon
Polarizability15.75 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
AllCCS[M+H]+140.38332859911
AllCCS[M-H]-132.84732859911
DeepCCS[M+H]+135.5430932474
DeepCCS[M-H]-133.10430932474
DeepCCS[M-2H]-168.42630932474
DeepCCS[M+Na]+143.43430932474
AllCCS[M+H]+140.432859911
AllCCS[M+H-H2O]+136.532859911
AllCCS[M+NH4]+144.032859911
AllCCS[M+Na]+145.032859911
AllCCS[M-H]-132.832859911
AllCCS[M+Na-2H]-133.932859911
AllCCS[M+HCOO]-135.232859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
2-Amino-3-carboxymuconic acid semialdehydeN\C(C(O)=O)=C(\C=C/C=O)/C(O)=O2778.5Standard polar33892256
2-Amino-3-carboxymuconic acid semialdehydeN\C(C(O)=O)=C(\C=C/C=O)/C(O)=O1439.9Standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehydeN\C(C(O)=O)=C(\C=C/C=O)/C(O)=O2016.4Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
2-Amino-3-carboxymuconic acid semialdehyde,1TMS,isomer #1C[Si](C)(C)OC(=O)/C(N)=C(\C=C/C=O)C(=O)O1920.2Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,1TMS,isomer #2C[Si](C)(C)OC(=O)C(/C=C\C=O)=C(\N)C(=O)O1930.5Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,1TMS,isomer #3C[Si](C)(C)N/C(C(=O)O)=C(/C=C\C=O)C(=O)O1926.1Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,2TMS,isomer #1C[Si](C)(C)OC(=O)/C(N)=C(\C=C/C=O)C(=O)O[Si](C)(C)C1947.8Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,2TMS,isomer #2C[Si](C)(C)N/C(C(=O)O[Si](C)(C)C)=C(/C=C\C=O)C(=O)O2005.1Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,2TMS,isomer #3C[Si](C)(C)N/C(C(=O)O)=C(/C=C\C=O)C(=O)O[Si](C)(C)C1981.3Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,2TMS,isomer #4C[Si](C)(C)N(/C(C(=O)O)=C(/C=C\C=O)C(=O)O)[Si](C)(C)C2088.2Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TMS,isomer #1C[Si](C)(C)N/C(C(=O)O[Si](C)(C)C)=C(/C=C\C=O)C(=O)O[Si](C)(C)C2006.3Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TMS,isomer #1C[Si](C)(C)N/C(C(=O)O[Si](C)(C)C)=C(/C=C\C=O)C(=O)O[Si](C)(C)C1908.9Standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TMS,isomer #1C[Si](C)(C)N/C(C(=O)O[Si](C)(C)C)=C(/C=C\C=O)C(=O)O[Si](C)(C)C2467.1Standard polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TMS,isomer #2C[Si](C)(C)OC(=O)/C(=C(\C=C/C=O)C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2107.3Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TMS,isomer #2C[Si](C)(C)OC(=O)/C(=C(\C=C/C=O)C(=O)O)N([Si](C)(C)C)[Si](C)(C)C1928.5Standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TMS,isomer #2C[Si](C)(C)OC(=O)/C(=C(\C=C/C=O)C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2344.1Standard polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TMS,isomer #3C[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2079.7Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TMS,isomer #3C[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O)N([Si](C)(C)C)[Si](C)(C)C1871.0Standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TMS,isomer #3C[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2265.8Standard polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,4TMS,isomer #1C[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2097.8Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,4TMS,isomer #1C[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1953.5Standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,4TMS,isomer #1C[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2063.1Standard polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)/C(N)=C(\C=C/C=O)C(=O)O2158.8Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)C(/C=C\C=O)=C(\N)C(=O)O2166.8Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)N/C(C(=O)O)=C(/C=C\C=O)C(=O)O2182.7Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)/C(N)=C(\C=C/C=O)C(=O)O[Si](C)(C)C(C)(C)C2377.1Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N/C(C(=O)O[Si](C)(C)C(C)(C)C)=C(/C=C\C=O)C(=O)O2453.0Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)N/C(C(=O)O)=C(/C=C\C=O)C(=O)O[Si](C)(C)C(C)(C)C2472.1Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)N(/C(C(=O)O)=C(/C=C\C=O)C(=O)O)[Si](C)(C)C(C)(C)C2534.3Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N/C(C(=O)O[Si](C)(C)C(C)(C)C)=C(/C=C\C=O)C(=O)O[Si](C)(C)C(C)(C)C2651.2Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N/C(C(=O)O[Si](C)(C)C(C)(C)C)=C(/C=C\C=O)C(=O)O[Si](C)(C)C(C)(C)C2559.3Standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N/C(C(=O)O[Si](C)(C)C(C)(C)C)=C(/C=C\C=O)C(=O)O[Si](C)(C)C(C)(C)C2666.8Standard polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)/C(=C(\C=C/C=O)C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2767.7Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)/C(=C(\C=C/C=O)C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2558.5Standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)/C(=C(\C=C/C=O)C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2576.8Standard polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2755.0Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2497.0Standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2514.7Standard polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2941.0Semi standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2717.0Standard non polar33892256
2-Amino-3-carboxymuconic acid semialdehyde,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)C(/C=C\C=O)=C(/C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2450.3Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde GC-MS (Non-derivatized) - 70eV, Positivesplash10-01ox-4900000000-62ebd57b1dadb165bc362017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde GC-MS (2 TMS) - 70eV, Positivesplash10-0300-8793000000-3b592a4ef216b8fdf12e2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 10V, Positive-QTOFsplash10-00r6-0900000000-0a2ef2dbb21b597d6fc42017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 20V, Positive-QTOFsplash10-00dl-4900000000-53b3810106e9c56f7d0a2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 40V, Positive-QTOFsplash10-014l-9100000000-fa0ffd8141b90a0202462017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 10V, Negative-QTOFsplash10-00ec-1900000000-590832d218cda44b13f82017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 20V, Negative-QTOFsplash10-0229-5900000000-74f5fb374736aa5270712017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 40V, Negative-QTOFsplash10-00dl-9300000000-84211b6b70277d6fb1462017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 10V, Negative-QTOFsplash10-0006-5900000000-210673f89c9ac44375752021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 20V, Negative-QTOFsplash10-01oy-8900000000-1eabc10d32130d827b372021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 40V, Negative-QTOFsplash10-014i-9200000000-3900709db9f9f0db1c3b2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 10V, Positive-QTOFsplash10-00kf-0900000000-1ac99f0053d2cc748f292021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 20V, Positive-QTOFsplash10-03kc-2900000000-f5ecf269380d030c89a92021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Amino-3-carboxymuconic acid semialdehyde 40V, Positive-QTOFsplash10-066u-9100000000-df3d348bf5ff10948d702021-09-24Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
Biospecimen LocationsNot Available
Tissue Locations
  • Brain
  • Kidney
  • Liver
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022559
KNApSAcK IDNot Available
Chemspider ID4444266
KEGG Compound IDC04409
BioCyc IDNot Available
BiGG ID1445617
Wikipedia LinkNot Available
METLIN ID6165
PubChem Compound5280673
PDB IDNot Available
ChEBI ID995
Food Biomarker OntologyNot Available
VMH IDCMUSA
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Ftukijwatari T, Murakami M, Ohta M, Kimura N, Jin-No Y, Sasaki R, Shibata K: Changes in the urinary excretion of the metabolites of the tryptophan-niacin pathway during pregnancy in Japanese women and rats. J Nutr Sci Vitaminol (Tokyo). 2004 Dec;50(6):392-8. [PubMed:15895513 ]
  2. He Z, Spain J: Preparation of 2-aminomuconate from 2-aminophenol by coupled enzymatic dioxygenation and dehydrogenation reactions. J Ind Microbiol Biotechnol. 1999 Aug;23(2):138-142. [PubMed:10510494 ]
  3. NISHIZUKA Y, ICHIYAMA A, GHOLSON RK, HAYAISHI O: STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. I. ENZYMIC FORMATION OF GLUTARIC ACID FROM 3-HYDROXYANTHRANILIC ACID. J Biol Chem. 1965 Feb;240:733-9. [PubMed:14275129 ]
  4. Colabroy KL, Begley TP: Tryptophan catabolism: identification and characterization of a new degradative pathway. J Bacteriol. 2005 Nov;187(22):7866-9. [PubMed:16267312 ]

Enzymes

General function:
Involved in catalytic activity
Specific function:
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Gene Name:
ACMSD
Uniprot ID:
Q8TDX5
Molecular weight:
38035.045
Reactions
2-Amino-3-carboxymuconic acid semialdehyde → 2-Aminomuconic acid semialdehyde + CO(2)details
2-Amino-3-carboxymuconic acid semialdehyde → 2-Aminomuconic acid semialdehyde + Carbon dioxidedetails
General function:
Involved in 3-hydroxyanthranilate 3,4-dioxygenase activity
Specific function:
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Gene Name:
HAAO
Uniprot ID:
P46952
Molecular weight:
32555.935
Reactions
3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehydedetails