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Showing metabocard for Isopentenyl pyrophosphate (HMDB0001347)

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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2020-04-30 16:48:31 UTC
HMDB IDHMDB0001347
Secondary Accession Numbers
  • HMDB0004196
  • HMDB01347
  • HMDB04196
Metabolite Identification
Common NameIsopentenyl pyrophosphate
DescriptionIsopentenyl pyrophosphate, also known as IPP or delta(3)-isopentenyl-PP, belongs to the class of organic compounds known as isoprenoid phosphates. These are prenol lipids containing a phosphate group linked to an isoprene (2-methylbuta-1,3-diene) unit. Isopentenyl pyrophosphate is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0001347 (Isopentenyl pyrophosphate)

  Mrv1652309042000212D          

 14 13  0  0  0  0            999 V2000
   16.3566   -5.2503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.9279   -5.2503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.6422   -4.0128    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.2134   -4.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0711   -4.0127    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.7856   -5.2503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4990   -5.2503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7845   -4.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0699   -5.2503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7844   -4.0131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0711   -4.8377    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   17.0712   -5.6627    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.6422   -4.8377    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   15.6422   -5.6629    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 13  3  2  0  0  0  0
 11  5  2  0  0  0  0
  8 10  2  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 11  6  1  0  0  0  0
  1 11  1  0  0  0  0
  2  4  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 13  2  1  0  0  0  0
 13  1  1  0  0  0  0
M  END
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3D MOL for HMDB0001347 (Isopentenyl pyrophosphate)

HMDB0001347
     RDKit          3D
Isopentenyl pyrophosphate
 26 25  0  0  0  0  0  0  0  0999 V2000
   -4.2406   -0.7625    0.7080 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2726   -0.2072    0.0036 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4075    1.2101   -0.4592 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0354   -0.9591   -0.3480 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7978   -0.2912    0.2095 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3017   -1.0481   -0.1597 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7519   -0.4188    0.3955 P   0  0  0  0  0  5  0  0  0  0  0  0
    1.5181    0.3202    1.6927 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7918   -1.7044    0.7321 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4854    0.6112   -0.7126 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0593    0.9067   -0.1756 P   0  0  0  0  0  5  0  0  0  0  0  0
    4.0283    2.1801    0.6383 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1437    1.0411   -1.4634 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5576   -0.4203    0.7669 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1876   -1.7824    1.0635 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1282   -0.1949    0.9496 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2007    1.8891    0.4168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4107    1.4488   -0.8215 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6356    1.4382   -1.2229 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9294   -1.0206   -1.4655 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1534   -1.9977    0.0220 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7639    0.7419   -0.1291 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8472   -0.3045    1.3228 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2914   -2.5401    0.8114 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3627    2.0125   -1.5679 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7189   -0.1483    1.7017 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  3
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  7 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 11 14  1  0
  1 15  1  0
  1 16  1  0
  3 17  1  0
  3 18  1  0
  3 19  1  0
  4 20  1  0
  4 21  1  0
  5 22  1  0
  5 23  1  0
  9 24  1  0
 13 25  1  0
 14 26  1  0
M  END
Download

3D SDF for HMDB0001347 (Isopentenyl pyrophosphate)

  Mrv1652309042000212D          

 14 13  0  0  0  0            999 V2000
   16.3566   -5.2503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.9279   -5.2503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.6422   -4.0128    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.2134   -4.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0711   -4.0127    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.7856   -5.2503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4990   -5.2503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7845   -4.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0699   -5.2503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7844   -4.0131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0711   -4.8377    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   17.0712   -5.6627    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.6422   -4.8377    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   15.6422   -5.6629    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 13  3  2  0  0  0  0
 11  5  2  0  0  0  0
  8 10  2  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 11  6  1  0  0  0  0
  1 11  1  0  0  0  0
  2  4  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 13  2  1  0  0  0  0
 13  1  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0001347

> <DATABASE_NAME>
hmdb

> <SMILES>
CC(=C)CCOP(O)(=O)OP(O)(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)

> <INCHI_KEY>
NUHSROFQTUXZQQ-UHFFFAOYSA-N

> <FORMULA>
C5H12O7P2

> <MOLECULAR_WEIGHT>
246.0921

> <EXACT_MASS>
246.005825762

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
26

> <JCHEM_AVERAGE_POLARIZABILITY>
19.011958475186823

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
({hydroxy[(3-methylbut-3-en-1-yl)oxy]phosphoryl}oxy)phosphonic acid

> <ALOGPS_LOGP>
0.04

> <JCHEM_LOGP>
0.19933072100000007

> <ALOGPS_LOGS>
-1.57

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
3.219951501702814

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.7784542453586973

> <JCHEM_POLAR_SURFACE_AREA>
113.29

> <JCHEM_REFRACTIVITY>
48.2068

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.69e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
isopentenyl-diphosphate

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for HMDB0001347 (Isopentenyl pyrophosphate)

HMDB0001347
     RDKit          3D
Isopentenyl pyrophosphate
 26 25  0  0  0  0  0  0  0  0999 V2000
   -4.2406   -0.7625    0.7080 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2726   -0.2072    0.0036 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4075    1.2101   -0.4592 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0354   -0.9591   -0.3480 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7978   -0.2912    0.2095 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3017   -1.0481   -0.1597 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7519   -0.4188    0.3955 P   0  0  0  0  0  5  0  0  0  0  0  0
    1.5181    0.3202    1.6927 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7918   -1.7044    0.7321 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4854    0.6112   -0.7126 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0593    0.9067   -0.1756 P   0  0  0  0  0  5  0  0  0  0  0  0
    4.0283    2.1801    0.6383 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1437    1.0411   -1.4634 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5576   -0.4203    0.7669 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1876   -1.7824    1.0635 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1282   -0.1949    0.9496 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2007    1.8891    0.4168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4107    1.4488   -0.8215 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6356    1.4382   -1.2229 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9294   -1.0206   -1.4655 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1534   -1.9977    0.0220 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7639    0.7419   -0.1291 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8472   -0.3045    1.3228 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2914   -2.5401    0.8114 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3627    2.0125   -1.5679 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7189   -0.1483    1.7017 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  3
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  7 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 11 14  1  0
  1 15  1  0
  1 16  1  0
  3 17  1  0
  3 18  1  0
  3 19  1  0
  4 20  1  0
  4 21  1  0
  5 22  1  0
  5 23  1  0
  9 24  1  0
 13 25  1  0
 14 26  1  0
M  END
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PDB for HMDB0001347 (Isopentenyl pyrophosphate)

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  O   UNK     0      30.532  -9.801   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      27.865  -9.801   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      29.199  -7.491   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0      26.532  -9.030   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      31.866  -7.490   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0      33.200  -9.801   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0      25.198  -9.801   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      23.864  -9.030   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      22.530  -9.801   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      23.864  -7.491   0.000  0.00  0.00           C+0
HETATM   11  P   UNK     0      31.866  -9.030   0.000  0.00  0.00           P+0
HETATM   12  O   UNK     0      31.866 -10.570   0.000  0.00  0.00           O+0
HETATM   13  P   UNK     0      29.199  -9.030   0.000  0.00  0.00           P+0
HETATM   14  O   UNK     0      29.199 -10.571   0.000  0.00  0.00           O+0
CONECT    1   11   13                                                       
CONECT    2    4   13                                                       
CONECT    3   13                                                            
CONECT    4    2    7                                                       
CONECT    5   11                                                            
CONECT    6   11                                                            
CONECT    7    4    8                                                       
CONECT    8   10    7    9                                                  
CONECT    9    8                                                            
CONECT   10    8                                                            
CONECT   11    5   12    6    1                                             
CONECT   12   11                                                            
CONECT   13    3   14    2    1                                             
CONECT   14   13                                                            
MASTER        0    0    0    0    0    0    0    0   14    0   26    0
END
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3D PDB for HMDB0001347 (Isopentenyl pyrophosphate)

COMPND    HMDB0001347
HETATM    1  C1  UNL     1      -4.241  -0.763   0.708  1.00  0.00           C  
HETATM    2  C2  UNL     1      -3.273  -0.207   0.004  1.00  0.00           C  
HETATM    3  C3  UNL     1      -3.408   1.210  -0.459  1.00  0.00           C  
HETATM    4  C4  UNL     1      -2.035  -0.959  -0.348  1.00  0.00           C  
HETATM    5  C5  UNL     1      -0.798  -0.291   0.210  1.00  0.00           C  
HETATM    6  O1  UNL     1       0.302  -1.048  -0.160  1.00  0.00           O  
HETATM    7  P1  UNL     1       1.752  -0.419   0.395  1.00  0.00           P  
HETATM    8  O2  UNL     1       1.518   0.320   1.693  1.00  0.00           O  
HETATM    9  O3  UNL     1       2.792  -1.704   0.732  1.00  0.00           O  
HETATM   10  O4  UNL     1       2.485   0.611  -0.713  1.00  0.00           O  
HETATM   11  P2  UNL     1       4.059   0.907  -0.176  1.00  0.00           P  
HETATM   12  O5  UNL     1       4.028   2.180   0.638  1.00  0.00           O  
HETATM   13  O6  UNL     1       5.144   1.041  -1.463  1.00  0.00           O  
HETATM   14  O7  UNL     1       4.558  -0.420   0.767  1.00  0.00           O  
HETATM   15  H1  UNL     1      -4.188  -1.782   1.063  1.00  0.00           H  
HETATM   16  H2  UNL     1      -5.128  -0.195   0.950  1.00  0.00           H  
HETATM   17  H3  UNL     1      -3.201   1.889   0.417  1.00  0.00           H  
HETATM   18  H4  UNL     1      -4.411   1.449  -0.821  1.00  0.00           H  
HETATM   19  H5  UNL     1      -2.636   1.438  -1.223  1.00  0.00           H  
HETATM   20  H6  UNL     1      -1.929  -1.021  -1.465  1.00  0.00           H  
HETATM   21  H7  UNL     1      -2.153  -1.998   0.022  1.00  0.00           H  
HETATM   22  H8  UNL     1      -0.764   0.742  -0.129  1.00  0.00           H  
HETATM   23  H9  UNL     1      -0.847  -0.305   1.323  1.00  0.00           H  
HETATM   24  H10 UNL     1       2.291  -2.540   0.811  1.00  0.00           H  
HETATM   25  H11 UNL     1       5.363   2.013  -1.568  1.00  0.00           H  
HETATM   26  H12 UNL     1       4.719  -0.148   1.702  1.00  0.00           H  
CONECT    1    2    2   15   16
CONECT    2    3    4
CONECT    3   17   18   19
CONECT    4    5   20   21
CONECT    5    6   22   23
CONECT    6    7
CONECT    7    8    8    9   10
CONECT    9   24
CONECT   10   11
CONECT   11   12   12   13   14
CONECT   13   25
CONECT   14   26
END
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SMILES for HMDB0001347 (Isopentenyl pyrophosphate)

CC(=C)CCOP(O)(=O)OP(O)(O)=O
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INCHI for HMDB0001347 (Isopentenyl pyrophosphate)

InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)
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Synonyms
Chemical FormulaC5H12O7P2
Average Molecular Weight246.0921
Monoisotopic Molecular Weight246.005825762
IUPAC Name({hydroxy[(3-methylbut-3-en-1-yl)oxy]phosphoryl}oxy)phosphonic acid
Traditional Nameisopentenyl-diphosphate
CAS Registry Number358-71-4
SMILES
CC(=C)CCOP(O)(=O)OP(O)(O)=O
InChI Identifier
InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)
InChI KeyNUHSROFQTUXZQQ-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as isoprenoid phosphates. These are prenol lipids containing a phosphate group linked to an isoprene (2-methylbuta-1,3-diene) unit.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassPrenol lipids
Sub ClassIsoprenoid phosphates
Direct ParentIsoprenoid phosphates
Alternative Parents
Substituents
  • Organic pyrophosphate
  • Isoprenoid phosphate
  • Monoalkyl phosphate
  • Alkyl phosphate
  • Phosphoric acid ester
  • Organic phosphoric acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
Naturally occurring process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-MetCCS_train_neg141.70830932474
[M-H]-Not Available141.708http://allccs.zhulab.cn/database/detail?ID=AllCCS00000246
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Peroxisome
Biospecimen LocationsNot Available
Tissue Locations
  • Spleen
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB04714
Phenol Explorer Compound IDNot Available
FooDB IDFDB030946
KNApSAcK IDC00000848
Chemspider ID1158
KEGG Compound IDC00129
BioCyc IDDELTA3-ISOPENTENYL-PP
BiGG ID33956
Wikipedia LinkIsopentenyl pyrophosphate
METLIN ID6181
PubChem Compound1195
PDB IDNot Available
ChEBI ID16584
Food Biomarker OntologyNot Available
VMH IDIPDP
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceKao, Chai-Lin; Kittleman, William; Zhang, Hua; Seto, Haruo; Liu, Hung-Wen. Stereochemical Analysis of Isopentenyl Diphosphate Isomerase Type II from Staphylococcus aureus Using Chemically Synthesized (S)- and (R)-[2-2H]Isopentenyl Diphosphates. Org Lett. 2005 Dec 8;7(25):5677-80.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Daubenberger CA, Salomon M, Vecino W, Hubner B, Troll H, Rodriques R, Patarroyo ME, Pluschke G: Functional and structural similarity of V gamma 9V delta 2 T cells in humans and Aotus monkeys, a primate infection model for Plasmodium falciparum malaria. J Immunol. 2001 Dec 1;167(11):6421-30. [PubMed:11714808 ]

Enzymes

Enzyme Details
1. Geranylgeranyl pyrophosphate synthase
General function:
Involved in isoprenoid biosynthetic process
Specific function:
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Gene Name:
GGPS1
Uniprot ID:
O95749
Molecular weight:
34870.625
Reactions
Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Pyrophosphate + Geranyl-PPdetails
Geranyl-PP + Isopentenyl pyrophosphate → Pyrophosphate + Farnesyl pyrophosphatedetails
Farnesyl pyrophosphate + Isopentenyl pyrophosphate → Pyrophosphate + Geranylgeranyl-PPdetails
Enzyme Details
2. Farnesyl pyrophosphate synthase
General function:
Involved in isoprenoid biosynthetic process
Specific function:
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Gene Name:
FDPS
Uniprot ID:
P14324
Molecular weight:
48275.03
Reactions
Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Pyrophosphate + Geranyl-PPdetails
Geranyl-PP + Isopentenyl pyrophosphate → Pyrophosphate + Farnesyl pyrophosphatedetails
Enzyme Details
3. Diphosphomevalonate decarboxylase
General function:
Involved in ATP binding
Specific function:
Performs the first committed step in the biosynthesis of isoprenes.
Gene Name:
MVD
Uniprot ID:
P53602
Molecular weight:
43404.125
Reactions
Adenosine triphosphate + (R)-5-Diphosphomevalonic acid → ADP + Phosphate + Isopentenyl pyrophosphate + CO(2)details
Adenosine triphosphate + (R)-5-Diphosphomevalonic acid → ADP + Phosphate + Isopentenyl pyrophosphate + Carbon dioxidedetails
Enzyme Details
4. Isopentenyl-diphosphate Delta-isomerase 2
General function:
Lipid transport and metabolism
Specific function:
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Gene Name:
IDI2
Uniprot ID:
Q9BXS1
Molecular weight:
26752.33
Reactions
Isopentenyl pyrophosphate → Dimethylallylpyrophosphatedetails
Enzyme Details
5. Isopentenyl-diphosphate Delta-isomerase 1
General function:
Involved in isopentenyl-diphosphate delta-isomerase activity
Specific function:
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Gene Name:
IDI1
Uniprot ID:
Q13907
Molecular weight:
32485.165
Reactions
Isopentenyl pyrophosphate → Dimethylallylpyrophosphatedetails
Enzyme Details
6. tRNA isopentenyltransferase 1 variant
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
TRIT1
Uniprot ID:
Q53F11
Molecular weight:
52727.9
Enzyme Details
7. Decaprenyl-diphosphate synthase subunit 2
General function:
Not Available
Specific function:
Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.
Gene Name:
PDSS2
Uniprot ID:
Q86YH6
Molecular weight:
44128.17
Reactions
Farnesyl pyrophosphate + Isopentenyl pyrophosphate → Pyrophosphate + all-trans-Decaprenyl diphosphatedetails
Enzyme Details
8. Decaprenyl-diphosphate synthase subunit 1
General function:
Not Available
Specific function:
Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.
Gene Name:
PDSS1
Uniprot ID:
Q5T2R2
Molecular weight:
46260.6
Reactions
Farnesyl pyrophosphate + Isopentenyl pyrophosphate → Pyrophosphate + all-trans-Decaprenyl diphosphatedetails