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Showing metabocard for 3-Mercaptopyruvic acid (HMDB0001368)

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IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesenzymes (10) Show 10 proteinsXML
enzymes (10) Show 10 proteins
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2021-09-07 16:45:29 UTC
HMDB IDHMDB0001368
Secondary Accession Numbers
  • HMDB01368
Metabolite Identification
Common Name3-Mercaptopyruvic acid
Description3-Mercaptopyruvic acid, also known as 3-mercapto-2-oxopropanoate or beta-thiopyruvate, belongs to the class of organic compounds known as alpha-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon. 3-Mercaptopyruvic acid is an intermediate in cysteine metabolism. 3-Mercaptopyruvic acid exists in all living organisms, ranging from bacteria to humans. Within humans, 3-mercaptopyruvic acid participates in a number of enzymatic reactions. In particular, 3-mercaptopyruvic acid and cyanide can be converted into pyruvic acid and thiocyanate; which is mediated by the enzyme 3-mercaptopyruvate sulfurtransferase. In addition, 3-mercaptopyruvic acid can be biosynthesized from 3-mercaptolactic acid; which is mediated by the enzyme L-lactate dehydrogenase. It has been studied as a potential treatment for cyanide poisoning, but its half-life is too short for it to be clinically effective. In humans, 3-mercaptopyruvic acid is involved in cystinosis, ocular nonnephropathic. Outside of the human body, 3-mercaptopyruvic acid has been detected, but not quantified in several different foods, such as lima beans, spinachs, shallots, mexican groundcherries, and white lupines. This could make 3-mercaptopyruvic acid a potential biomarker for the consumption of these foods.
Structure
Data?1582752196
MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0001368 (3-Mercaptopyruvic acid)


  Mrv1652305261923572D          

  7  6  0  0  0  0            999 V2000
   -0.1025    0.1785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6112   -0.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8162   -0.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1025    1.0021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6112   -1.0629    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3287    0.1785    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5336    0.1785    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  2  0  0  0  0
  2  5  1  0  0  0  0
  2  6  2  0  0  0  0
  3  7  1  0  0  0  0
M  END
Download

3D MOL for HMDB0001368 (3-Mercaptopyruvic acid)

Download
3D SDF for HMDB0001368 (3-Mercaptopyruvic acid)

  Mrv1652305261923572D          

  7  6  0  0  0  0            999 V2000
   -0.1025    0.1785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6112   -0.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8162   -0.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1025    1.0021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6112   -1.0629    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3287    0.1785    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5336    0.1785    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  2  0  0  0  0
  2  5  1  0  0  0  0
  2  6  2  0  0  0  0
  3  7  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0001368

> <DATABASE_NAME>
hmdb

> <SMILES>
OC(=O)C(=O)CS

> <INCHI_IDENTIFIER>
InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)

> <INCHI_KEY>
OJOLFAIGOXZBCI-UHFFFAOYSA-N

> <FORMULA>
C3H4O3S

> <MOLECULAR_WEIGHT>
120.127

> <EXACT_MASS>
119.988114684

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
11

> <JCHEM_AVERAGE_POLARIZABILITY>
10.147025919940411

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-oxo-3-sulfanylpropanoic acid

> <ALOGPS_LOGP>
0.15

> <JCHEM_LOGP>
0.29243937466666664

> <ALOGPS_LOGS>
-1.12

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
9.607725794599306

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.9127072837959105

> <JCHEM_PKA_STRONGEST_BASIC>
-9.88372855258473

> <JCHEM_POLAR_SURFACE_AREA>
54.37

> <JCHEM_REFRACTIVITY>
25.818900000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
9.09e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
β-mercaptopyruvic acid

> <JCHEM_VEBER_RULE>
0

$$$$

Download
3D-SDF for HMDB0001368 (3-Mercaptopyruvic acid)
https://cactus.nci.nih.gov/chemical/structure/OC(=O)C(=O)CS/file?format=sdf&g...
 OpenBabel09142113213D
Jmol version 14.31.45  2021-07-21 05:08 EXTRACT: ({0:10})
 11 10  0  0  0  0  0  0  0  0999 V2000
    2.5988   -0.7476    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6278    0.1844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9176    1.3620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1962   -0.2308   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925   -1.4036   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8911    0.8127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5116   -0.0024    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5121   -0.4301    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7974    1.4350    0.8900 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7974    1.4350   -0.8900 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3708    1.0324   -0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  8  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
M  END
$$$$

Download
PDB for HMDB0001368 (3-Mercaptopyruvic acid)
HEADER    PROTEIN                                 26-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   26-MAY-19         0                                  
HETATM    1  C   UNK     0      -0.191   0.333   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.141  -0.439   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.524  -0.439   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      -0.191   1.871   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0       1.141  -1.984   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0       2.480   0.333   0.000  0.00  0.00           O+0
HETATM    7  S   UNK     0      -2.863   0.333   0.000  0.00  0.00           S+0
CONECT    1    2    3    4                                                  
CONECT    2    1    5    6                                                  
CONECT    3    1    7                                                       
CONECT    4    1                                                            
CONECT    5    2                                                            
CONECT    6    2                                                            
CONECT    7    3                                                            
MASTER        0    0    0    0    0    0    0    0    7    0   12    0
END

Download
3D PDB for HMDB0001368 (3-Mercaptopyruvic acid)
COMPND    https://cactus.nci.nih.gov/chemical/structure/OC(=O)C(=O)CS/file?format=sdf&g... 
AUTHOR    GENERATED BY OPEN BABEL 3.1.0
HETATM    1  O   UNL     1       2.599  -0.748   0.000  1.00  0.00           O  
HETATM    2  C   UNL     1       1.628   0.184   0.000  1.00  0.00           C  
HETATM    3  O   UNL     1       1.918   1.362   0.000  1.00  0.00           O  
HETATM    4  C   UNL     1       0.196  -0.231   0.000  1.00  0.00           C  
HETATM    5  O   UNL     1      -0.092  -1.404   0.000  1.00  0.00           O  
HETATM    6  C   UNL     1      -0.891   0.813   0.000  1.00  0.00           C  
HETATM    7  S   UNL     1      -2.512  -0.002   0.000  1.00  0.00           S  
HETATM    8  H   UNL     1       3.512  -0.430   0.000  1.00  0.00           H  
HETATM    9  H   UNL     1      -0.797   1.435   0.890  1.00  0.00           H  
HETATM   10  H   UNL     1      -0.797   1.435  -0.890  1.00  0.00           H  
HETATM   11  H   UNL     1      -3.371   1.032   0.000  1.00  0.00           H  
CONECT    1    2    8                                                 
CONECT    2    1    3    3    4                                       
CONECT    3    2    2                                                 
CONECT    4    2    5    5    6                                       
CONECT    5    4    4                                                 
CONECT    6    4    7    9   10                                       
CONECT    7    6   11                                                 
CONECT    8    1                                                      
CONECT    9    6                                                      
CONECT   10    6                                                      
CONECT   11    7                                                      
MASTER        0    0    0    0    0    0    0    0   11    0   11    0
END

Download
SMILES for HMDB0001368 (3-Mercaptopyruvic acid)
OC(=O)C(=O)CS
Download
INCHI for HMDB0001368 (3-Mercaptopyruvic acid)
InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)
Download
View in JSmolView Stereo Labels
Synonyms
ValueSource
3-Mercapto-2-oxopropanoic acidChEBI
3-MercaptopyruvateChEBI
MercaptopyruvateChEBI
3-Mercapto-2-oxopropanoateGenerator
Mercaptopyruvic acidGenerator
3-Mercapto-pyruvateHMDB
3-Mercapto-pyruvic acidHMDB
beta-3-Mercapto-2-oxo-propanoateHMDB
beta-3-Mercapto-2-oxo-propanoic acidHMDB
beta-MercaptopyruvateHMDB
beta-Mercaptopyruvic acidHMDB
beta-ThiopyruvateHMDB
beta-Thiopyruvic acidHMDB
ThiopyruvateHMDB
3-Mercaptopyruvate monosodium saltHMDB
Chemical FormulaC3H4O3S
Average Molecular Weight120.127
Monoisotopic Molecular Weight119.988114684
IUPAC Name2-oxo-3-sulfanylpropanoic acid
Traditional Nameβ-mercaptopyruvic acid
CAS Registry Number2464-23-5
SMILES
OC(=O)C(=O)CS
InChI Identifier
InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)
InChI KeyOJOLFAIGOXZBCI-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as alpha-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon.
KingdomOrganic compounds  
Super ClassOrganic acids and derivatives  
ClassKeto acids and derivatives  
Sub ClassAlpha-keto acids and derivatives  
Direct ParentAlpha-keto acids and derivatives  
Alternative Parents
Substituents
  • Alpha-keto acid
    • 

  • Alpha-hydroxy ketone
    • 

  • Ketone
    • 

  • Monocarboxylic acid or derivatives
    • 

  • Carboxylic acid
    • 

  • Carboxylic acid derivative
    • 

  • Alkylthiol
    • 

  • Organic oxygen compound
    • 

  • Organic oxide
    • 

  • Hydrocarbon derivative
    • 

  • Organosulfur compound
    • 

  • Organooxygen compound
    • 

  • Carbonyl group
    • 

  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Disposition
Route of exposure:
Source:
Biological location:
Process
Naturally occurring process:
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility9.09 g/LALOGPS
logP0.15ALOGPS
logP0.29ChemAxon
logS-1.1ALOGPS
pKa (Strongest Acidic)2.91ChemAxon
pKa (Strongest Basic)-9.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area54.37 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity25.82 m³·mol⁻¹ChemAxon
Polarizability10.15 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Spectral Properties
Collision Cross Sections
NameAdductTypeData SourceValueReference
DarkChem[M+H]+PredictedNot Available123.67831661259  
DarkChem[M-H]-PredictedNot Available116.78231661259  
AllCCS[M+H]+PredictedNot Available128.5932859911  
AllCCS[M-H]-PredictedNot Available126.92132859911  
Retention Indices
Underivatized
Not Available
Derivatized
DerivativeValueReference
3-Mercaptopyruvic acid,1TMS,#11154.8595https://arxiv.org/abs/1905.12712
3-Mercaptopyruvic acid,1TMS,#21329.556https://arxiv.org/abs/1905.12712
3-Mercaptopyruvic acid,1TMS,#31304.0723https://arxiv.org/abs/1905.12712
3-Mercaptopyruvic acid,1TBDMS,#11417.5919https://arxiv.org/abs/1905.12712
3-Mercaptopyruvic acid,1TBDMS,#21585.6139https://arxiv.org/abs/1905.12712
3-Mercaptopyruvic acid,1TBDMS,#31542.2278https://arxiv.org/abs/1905.12712
Spectra
GC-MS
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-00di-9000000000-b81f8808977132c3a8ac2017-09-01View Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positivesplash10-00di-9300000000-5100fd5cbb3bf9df1e752017-10-06View Spectrum
LC-MS/MS
Spectrum TypeDescriptionSplash KeyDeposition DateView
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Negative (Annotated)splash10-003r-9200000000-f1e0c53958ad51dc00682012-07-24View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Negative (Annotated)splash10-001j-9000000000-60f6deb41f42078dd60c2012-07-24View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Negative (Annotated)splash10-001i-9000000000-5dc69d3b59bd15290aef2012-07-24View Spectrum
LC-MS/MSLC-MS/MS Spectrum -  40V, Negativesplash10-02t9-9000000000-e1511333b005fa9113122021-09-20View Spectrum
LC-MS/MSLC-MS/MS Spectrum -  20V, Negativesplash10-00kf-9000000000-65854057c742d34c8dbb2021-09-20View Spectrum
LC-MS/MSLC-MS/MS Spectrum -  10V, Negativesplash10-006w-9000000000-66939f30bca1061b4b832021-09-20View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum -  10V, Positivesplash10-0fk9-2900000000-0da521157f8235fe77582017-09-01View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum -  20V, Positivesplash10-0fk9-7900000000-8c127be0565b54938cd22017-09-01View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum -  40V, Positivesplash10-0ab9-9000000000-d4a8d07d451ba309b2e22017-09-01View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum -  10V, Negativesplash10-014i-1900000000-849e74ceb9308736ba6d2017-09-01View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum -  20V, Negativesplash10-0gb9-2900000000-5a713232367a68a966a02017-09-01View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum -  40V, Negativesplash10-0fk9-9300000000-564344466a63b943c6da2017-09-01View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum -  10V, Negativesplash10-006x-9200000000-95772f7f626a811df4892021-09-08View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum -  20V, Negativesplash10-001i-9000000000-32551e3b5faf0b1e70002021-09-08View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum -  40V, Negativesplash10-001i-9000000000-572c315b879edca344fa2021-09-08View Spectrum
NMR
Spectrum TypeDescriptionDeposition DateView
1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, experimental)2012-12-04View Spectrum
2D NMR[1H, 13C] NMR Spectrum (2D, 600 MHz, H2O, predicted)2012-12-05View Spectrum
Biological Properties
Cellular Locations
  • Mitochondria
Biospecimen Locations
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected and Quantified0.0400-0.310 umol/mmol creatinineNot SpecifiedBothNormal  details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected and Quantified0.72 umol/mmol creatinineAdult (>18 years old)FemaleBeta-mercaptolactate-cysteine Disulfiduria  details
Associated Disorders and Diseases
Disease References
Beta-mercaptolactate-cysteine Disulfiduria
  1. Hannestad U, Martensson J, Sjodahl R, Sorbo B: 3-mercaptolactate cysteine disulfiduria: biochemical studies on affected and unaffected members of a family. Biochem Med. 1981 Aug;26(1):106-14. [PubMed:6945862  ] 
Associated OMIM IDs
  • 249650   (Beta-mercaptolactate-cysteine Disulfiduria)
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB030434  
KNApSAcK IDC00007464  
Chemspider ID96  
KEGG Compound IDC00957  
BioCyc ID3-MERCAPTO-PYRUVATE  
BiGG ID36476  
Wikipedia Link3-Mercaptopyruvic_acid  
METLIN ID6195  
PubChem Compound98  
PDB IDNot Available
ChEBI ID16208  
Food Biomarker OntologyNot Available
VMH IDMERCPPYR  
MarkerDB IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General ReferencesNot Available
Enzymes
  Enzyme Details
1. Aspartate aminotransferase, cytoplasmic
General function:
Involved in transferase activity, transferring nitrogenous groups
Specific function:
Plays a key role in amino acid metabolism (By similarity).

Gene Name:
GOT1
Uniprot ID:
P17174  
Molecular weight:
46247.14
Reactions
L-Cysteine + Oxoglutaric acid → 3-Mercaptopyruvic acid + DL-Glutamatedetails
  Enzyme Details
2. Aspartate aminotransferase, mitochondrial
General function:
Involved in transferase activity, transferring nitrogenous groups
Specific function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Gene Name:
GOT2
Uniprot ID:
P00505  
Molecular weight:
47517.285
Reactions
L-Cysteine + Oxoglutaric acid → 3-Mercaptopyruvic acid + DL-Glutamatedetails
  Enzyme Details
3. Cystathionine gamma-lyase
General function:
Involved in pyridoxal phosphate binding
Specific function:
Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.

Gene Name:
CTH
Uniprot ID:
P32929  
Molecular weight:
41259.91
  Enzyme Details
4. 3-mercaptopyruvate sulfurtransferase
General function:
Involved in thiosulfate sulfurtransferase activity
Specific function:
Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis.

Gene Name:
MPST
Uniprot ID:
P25325  
Molecular weight:
33178.15
Reactions
3-Mercaptopyruvic acid + Hydrogen cyanide → Pyruvic acid + Thiocyanatedetails
3-Mercaptopyruvic acid + Sulfite → Thiosulfate + Pyruvic aciddetails
  Enzyme Details
5. L-lactate dehydrogenase A-like 6A
General function:
Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Specific function:
Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.

Gene Name:
LDHAL6A
Uniprot ID:
Q6ZMR3  
Molecular weight:
36507.015
Reactions
3-Mercaptolactic acid + NAD → 3-Mercaptopyruvic acid + NADH + Hydrogen Iondetails
  Enzyme Details
6. Thiosulfate sulfurtransferase
General function:
Involved in thiosulfate sulfurtransferase activity
Specific function:
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.

Gene Name:
TST
Uniprot ID:
Q16762  
Molecular weight:
33428.69
Reactions
3-Mercaptopyruvic acid + Sulfite → Thiosulfate + Pyruvic aciddetails
Hydrogen cyanide + 3-Mercaptopyruvic acid → Thiocyanate + Pyruvic aciddetails
  Enzyme Details
7. L-lactate dehydrogenase B chain
General function:
Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Specific function:
Not Available
Gene Name:
LDHB
Uniprot ID:
P07195  
Molecular weight:
36638.225
Reactions
3-Mercaptolactic acid + NAD → 3-Mercaptopyruvic acid + NADH + Hydrogen Iondetails
  Enzyme Details
8. L-lactate dehydrogenase C chain
General function:
Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Specific function:
Possible role in sperm motility.

Gene Name:
LDHC
Uniprot ID:
P07864  
Molecular weight:
36310.965
Reactions
3-Mercaptolactic acid + NAD → 3-Mercaptopyruvic acid + NADH + Hydrogen Iondetails
  Enzyme Details
9. L-lactate dehydrogenase A chain
General function:
Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Specific function:
Not Available
Gene Name:
LDHA
Uniprot ID:
P00338  
Molecular weight:
30204.975
Reactions
3-Mercaptolactic acid + NAD → 3-Mercaptopyruvic acid + NADH + Hydrogen Iondetails
  Enzyme Details
10. L-lactate dehydrogenase A-like 6B
General function:
Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Specific function:
Not Available
Gene Name:
LDHAL6B
Uniprot ID:
Q9BYZ2  
Molecular weight:
41942.53
Reactions
3-Mercaptolactic acid + NAD → 3-Mercaptopyruvic acid + NADH + Hydrogen Iondetails