Showing metabocard for 3-Mercaptopyruvic acid (HMDB0001368)

General function:

Involved in transferase activity, transferring nitrogenous groups

Specific function:

Plays a key role in amino acid metabolism (By similarity).

Gene Name:

GOT1

Uniprot ID:

P17174

Molecular weight:

46247.14

Reactions

General function:

Involved in transferase activity, transferring nitrogenous groups

Specific function:

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Gene Name:

GOT2

Uniprot ID:

P00505

Molecular weight:

47517.285

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.

Gene Name:

CTH

Uniprot ID:

P32929

Molecular weight:

41259.91

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis.

Gene Name:

MPST

Uniprot ID:

P25325

Molecular weight:

33178.15

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.

Gene Name:

LDHAL6A

Uniprot ID:

Q6ZMR3

Molecular weight:

36507.015

Reactions

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.

Gene Name:

TST

Uniprot ID:

Q16762

Molecular weight:

33428.69

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Not Available

Gene Name:

LDHB

Uniprot ID:

P07195

Molecular weight:

36638.225

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Possible role in sperm motility.

Gene Name:

LDHC

Uniprot ID:

P07864

Molecular weight:

36310.965

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Not Available

Gene Name:

LDHA

Uniprot ID:

P00338

Molecular weight:

30204.975

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Not Available

Gene Name:

LDHAL6B

Uniprot ID:

Q9BYZ2

Molecular weight:

41942.53

Reactions