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Record Information |
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Version | 4.0 |
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Status | Detected and Quantified |
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Creation Date | 2006-08-16 14:01:37 UTC |
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Update Date | 2020-10-09 21:09:59 UTC |
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HMDB ID | HMDB0001371 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Nitrogen |
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Description | Elemental nitrogen is a colorless, odorless, tasteless and mostly inert diatomic gas at standard conditions, constituting 78% by volume of Earth's atmosphere. Nitrogen occurs in all living organisms. It is a constituent element of amino acids and therefore of proteins and nucleic acids (DNA and RNA). Nitrogen is found in the chemical structure of almost all neurotransmitters and is a key component of alkaloids. Specific bacteria (e.g. Rhizobium trifolium) possess nitrogenase enzymes which can fix atmospheric nitrogen into a form (ammonium ion) which is chemically useful to higher organisms. Animals use nitrogen-containing amino acids from plant sources, as starting materials for all nitrogen-compound animal biochemistry, including the manufacture of proteins and nucleic acids. Animal metabolism of NO (nitric oxide) results in production of nitrite. Animal metabolism of nitrogen in proteins generally results in excretion of urea, while animal metabolism of nucleic acids results in excretion of urea and uric acid. The characteristic odor of animal flesh decay is caused by nitrogen-containing long-chain amines, such as putrescine and cadaverine. Decay of organisms and their waste products may produce small amounts of nitrate, but most decay eventually returns nitrogen content to the atmosphere, as molecular nitrogen. The circulation of nitrogen from the atmosphere through organics and then back to the atmosphere is commonly referred to as the nitrogen cycle. Nitrogen can be measured in urine with the Kjeldahl method or by spectrophotometric methods (enzymic tests). Total urinary nitrogen is calculated based on urea urinary nitrogen quantified with these methods. |
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Structure | |
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Synonyms | Value | Source |
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Molecular nitrogen | ChEBI | N2 | ChEBI | N#N | ChEBI | Nitrogen | ChEBI | Dinitrogen | HMDB | Nitrogen gas | HMDB |
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Chemical Formula | N2 |
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Average Molecular Weight | 28.0134 |
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Monoisotopic Molecular Weight | 28.00614801 |
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IUPAC Name | diazyne |
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Traditional Name | nitrogen |
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CAS Registry Number | 7727-37-9 |
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SMILES | N#N |
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InChI Identifier | InChI=1S/N2/c1-2 |
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InChI Key | IJGRMHOSHXDMSA-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of inorganic compounds known as other non-metal nitrides. These are inorganic compounds of nitrogen where nitrogen has a formal oxidation state of -3, and the heaviest atom bonded to it belongs to the class of 'other non-metals'. |
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Kingdom | Inorganic compounds |
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Super Class | Homogeneous non-metal compounds |
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Class | Other non-metal organides |
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Sub Class | Other non-metal nitrides |
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Direct Parent | Other non-metal nitrides |
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Alternative Parents | |
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Substituents | - Other non-metal nitride
- Inorganic nitride
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Molecular Framework | Not Available |
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External Descriptors | |
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Ontology |
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Disposition | Route of exposure: Source: Biological location: |
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Role | Biological role: Industrial application: |
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Physical Properties |
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State | Liquid |
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Experimental Properties | Property | Value | Reference |
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Melting Point | -210.01 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | 18.1 mg/mL at 21 °C | Not Available | LogP | 0.67 | HANSCH,C ET AL. (1995) |
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Predicted Properties | |
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Spectra |
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| Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-004i-9000000000-900558b878d696839ddd | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-004i-9000000000-096cae140ae566643e88 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-004i-9000000000-096cae140ae566643e88 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-004i-9000000000-096cae140ae566643e88 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-9000000000-6d8e7ecefdead45cc87d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004i-9000000000-6d8e7ecefdead45cc87d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-004i-9000000000-6d8e7ecefdead45cc87d | Spectrum | MS | Mass Spectrum (Electron Ionization) | splash10-004i-9000000000-6369f2c7b3a3b0e3772c | Spectrum |
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Biological Properties |
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Cellular Locations | - Cytoplasm (predicted from logP)
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Biospecimen Locations | |
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Tissue Locations | |
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Pathways | |
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Normal Concentrations |
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Urine | Detected and Quantified | 161827.316 +/- 35697.202 umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 231793.832 +/- 43788.568 umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 30842.383 +/- 7615.403 umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 32106.667 +/- 15380 umol/mmol creatinine | Adolescent (13-18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 35866.667 +/- 9333.333 umol/mmol creatinine | Children (1 - 13 years old) | Both | Normal | | details | Urine | Detected and Quantified | 41866.667 +/- 11333.333 umol/mmol creatinine | Children (1 - 13 years old) | Both | Normal | | details | Urine | Detected and Quantified | 23560.153 +/- 4521.646 umol/mmol creatinine | Adult (>18 years old) | Female | Normal | | details | Urine | Detected and Quantified | 27106.0754 +/- 5473.571 umol/mmol creatinine | Adult (>18 years old) | Female | Normal | | details | Urine | Detected and Quantified | 30461.612 +/- 4759.627 umol/mmol creatinine | Adult (>18 years old) | Male | Normal | | details | Urine | Detected and Quantified | 35030.854 +/- 7853.384 umol/mmol creatinine | Adult (>18 years old) | Male | Normal | | details |
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Abnormal Concentrations |
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Urine | Detected and Quantified | 171346.570 +/- 38077.0155 umol/mmol creatinine | Adult (>18 years old) | Female | Pregnancy | | details |
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Associated Disorders and Diseases |
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Disease References | Pregnancy |
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- Mikkelsen TB, Osler M, Olsen SF: Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort. Public Health Nutr. 2006 Sep;9(6):771-8. [PubMed:16925883 ]
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Associated OMIM IDs | None |
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External Links |
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DrugBank ID | Not Available |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | Not Available |
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KNApSAcK ID | Not Available |
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Chemspider ID | Not Available |
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KEGG Compound ID | C00697 |
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BioCyc ID | NITROGEN-MOLECULE |
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BiGG ID | Not Available |
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Wikipedia Link | Nitrogen |
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METLIN ID | Not Available |
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PubChem Compound | 947 |
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PDB ID | Not Available |
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ChEBI ID | 17997 |
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Food Biomarker Ontology | Not Available |
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VMH ID | Not Available |
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MarkerDB ID | MDB00029899 |
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References |
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Synthesis Reference | Not Available |
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Material Safety Data Sheet (MSDS) | Download (PDF) |
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General References | - Balafa C, Smith-Thomas L, Phillips J, Moustafa M, George E, Blount M, Nicol S, Westgate G, MacNeil S: Dopa oxidase activity in the hair, skin and ocular melanocytes is increased in the presence of stressed fibroblasts. Exp Dermatol. 2005 May;14(5):363-72. [PubMed:15854130 ]
- Konya C, Sanada H, Sugama J, Kitayama Y, Ishikawa S, Togashi H, Tamura S: Skin debris and micro-organisms on the periwound skin of pressure ulcers and the influence of periwound cleansing on microbial flora. Ostomy Wound Manage. 2005 Jan;51(1):50-9. [PubMed:15695835 ]
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