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Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2005-11-16 15:48:42 UTC

Update Date

2021-09-14 15:40:03 UTC

HMDB ID

HMDB0001548

Secondary Accession Numbers

HMDB01548

Metabolite Identification

Common Name

D-Ribose 5-phosphate

Description

D-Ribose 5-phosphate (CAS: 4300-28-1), also known as R-5-P, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. D-Ribose 5-phosphate exists in all living species, ranging from bacteria to humans. Within humans, D-ribose 5-phosphate participates in a number of enzymatic reactions. In particular, D-ribose 5-phosphate can be biosynthesized from D-ribulose 5-phosphate; which is mediated by the enzyme ribose-5-phosphate isomerase. In addition, D-ribose 5-phosphate can be biosynthesized from D-ribose; which is catalyzed by the enzyme ribokinase. Outside of the human body, D-ribose 5-phosphate has been detected, but not quantified in cow milk and rices. D-Ribose 5-phosphate is both a product and an intermediate of the pentose phosphate pathway. The last step of the oxidative reactions in the pentose phosphate pathway is the production of ribulose 5-phosphate. D-Ribose 5-phosphate is an important intermediate metabolite in the pentose phosphate pathway and in the purine metabolism pathway. The intracellular ribose 5-phosphate concentration is an important determinant of the rate of de novo purine synthesis (PMID:6699001 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

  Mrv1652309042000242D          

 14 14  0  0  0  0            999 V2000
10000.348810000.5677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.063610000.1557    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.776310000.5677    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
10001.366410001.2804    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.493210000.1557    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.190410001.2804    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9999.8423 9998.7095    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.0546 9998.7177    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9997.516710000.4111    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.965610000.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.298210000.1650    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9998.5531 9999.3804    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9999.3781 9999.3804    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9999.633010000.1650    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 11  1  0  0  0  0
 10 14  1  0  0  0  0
 14  1  1  6  0  0  0
 13  7  1  1  0  0  0
 12  8  1  1  0  0  0
 11  9  1  1  0  0  0
M  END
> <DATABASE_ID>
HMDB0001548

> <DATABASE_NAME>
hmdb

> <SMILES>
O[C@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O

> <INCHI_IDENTIFIER>
InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1

> <INCHI_KEY>
KTVPXOYAKDPRHY-AIHAYLRMSA-N

> <FORMULA>
C5H11O8P

> <MOLECULAR_WEIGHT>
230.1098

> <EXACT_MASS>
230.01915384

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
25

> <JCHEM_AVERAGE_POLARIZABILITY>
18.250781635212405

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
{[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy}phosphonic acid

> <ALOGPS_LOGP>
-2.07

> <JCHEM_LOGP>
-2.425770307333333

> <ALOGPS_LOGS>
-0.84

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
6.248502666590344

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.2226866612133929

> <JCHEM_PKA_STRONGEST_BASIC>
-3.680084519580305

> <JCHEM_POLAR_SURFACE_AREA>
136.68

> <JCHEM_REFRACTIVITY>
40.8338

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.36e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
α-D-ribose 5-phosphate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  C   UNK     0    8667.3188667.726   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0    8668.6528666.957   0.000  0.00  0.00           O+0
HETATM    3  P   UNK     0    8669.9828667.726   0.000  0.00  0.00           P+0
HETATM    4  O   UNK     0    8669.2178669.057   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0    8671.3218666.957   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0    8670.7558669.057   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0    8666.3728664.258   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0    8663.0358664.273   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0    8662.0318667.434   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0    8664.7368667.880   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0    8663.4908666.975   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0    8663.9668665.510   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0    8665.5068665.510   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0    8665.9828666.975   0.000  0.00  0.00           C+0
CONECT    1    2   14                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4    5    6                                             
CONECT    4    3                                                            
CONECT    5    3                                                            
CONECT    6    3                                                            
CONECT    7   13                                                            
CONECT    8   12                                                            
CONECT    9   11                                                            
CONECT   10   11   14                                                       
CONECT   11   12   10    9                                                  
CONECT   12   11   13    8                                                  
CONECT   13   12   14    7                                                  
CONECT   14   13   10    1                                                  
MASTER        0    0    0    0    0    0    0    0   14    0   28    0
END

View in JSmol View NMR Assignments View Stereo Labels

Synonyms

Value	Source
5-O-Phosphono-alpha-D-ribofuranose	ChEBI
alpha-D-Ribose 5-phosphate	ChEBI
5-O-Phosphono-a-D-ribofuranose	Generator
5-O-Phosphono-α-D-ribofuranose	Generator
a-D-Ribose 5-phosphate	Generator
a-D-Ribose 5-phosphoric acid	Generator
alpha-D-Ribose 5-phosphoric acid	Generator
Α-D-ribose 5-phosphate	Generator
Α-D-ribose 5-phosphoric acid	Generator
D-Ribose 5-phosphoric acid	Generator
D-Ribofuranose 5-phosphate	HMDB
R-5-p	HMDB
Ribose 5-(dihydrogen phosphate)	HMDB
Ribose 5-monophosphate	HMDB
Ribose 5-phosphate	HMDB
alpha-D-Ribose-5-phosphate	HMDB
Α-D-ribose-5-phosphate	HMDB
D-Ribose 5-phosphate	HMDB

Chemical Formula

C₅H₁₁O₈P

Average Molecular Weight

230.1098

Monoisotopic Molecular Weight

230.01915384

IUPAC Name

{[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy}phosphonic acid

Traditional Name

α-D-ribose 5-phosphate

CAS Registry Number

34980-65-9

SMILES

O[C@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O

InChI Identifier

InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1

InChI Key

KTVPXOYAKDPRHY-AIHAYLRMSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Pentose phosphates

Alternative Parents

Substituents

Pentose phosphate
Pentose-5-phosphate
Monosaccharide phosphate
Monoalkyl phosphate
Alkyl phosphate
Phosphoric acid ester
Organic phosphoric acid derivative
Tetrahydrofuran
1,2-diol
Secondary alcohol
Hemiacetal
Polyol
Oxacycle
Organoheterocyclic compound
Hydrocarbon derivative
Organic oxide
Alcohol
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

D-ribofuranose 5-phosphate (CHEBI:18189 )

Ontology

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct Type	Data Source	CCS Value (Å²)	Reference
[M-H]-	Baker	141.657	30932474
[M-H]-	Astarita_neg	137.3	30932474
[M-H]-	Not Available	139.4	http://allccs.zhulab.cn/database/detail?ID=AllCCS00002110

Predicted Molecular Properties

Property	Value	Source
Water Solubility	33.6 g/L	ALOGPS
logP	-2.1	ALOGPS
logP	-2.4	ChemAxon
logS	-0.84	ALOGPS
pKa (Strongest Acidic)	1.22	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	136.68 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	40.83 m³·mol⁻¹	ChemAxon
Polarizability	18.25 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DeepCCS	[M+H]+	140.721	30932474
DeepCCS	[M-H]-	138.479	30932474
DeepCCS	[M-2H]-	173.203	30932474
DeepCCS	[M+Na]+	147.365	30932474
AllCCS	[M+H]+	150.1	32859911
AllCCS	[M+H-H2O]+	146.3	32859911
AllCCS	[M+NH4]+	153.6	32859911
AllCCS	[M+Na]+	154.6	32859911
AllCCS	[M-H]-	140.1	32859911
AllCCS	[M+Na-2H]-	140.7	32859911
AllCCS	[M+HCOO]-	141.5	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
D-Ribose 5-phosphate	O[C@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O	3141.1	Standard polar	33892256
D-Ribose 5-phosphate	O[C@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O	1844.8	Standard non polar	33892256
D-Ribose 5-phosphate	O[C@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O	1963.4	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
D-Ribose 5-phosphate,1TMS,isomer #1	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O	2022.1	Semi standard non polar	33892256
D-Ribose 5-phosphate,1TMS,isomer #2	C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O)O[C@H](O)[C@@H]1O	2007.7	Semi standard non polar	33892256
D-Ribose 5-phosphate,1TMS,isomer #3	C[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O)O)[C@H]1O	2032.9	Semi standard non polar	33892256
D-Ribose 5-phosphate,1TMS,isomer #4	C[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@H](O)[C@H](O)[C@@H]1O	2052.1	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TMS,isomer #1	C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O)O[C@H](O[Si](C)(C)C)[C@@H]1O	2007.5	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TMS,isomer #2	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O[Si](C)(C)C	2021.8	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TMS,isomer #3	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O)[C@H]1O	2074.2	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TMS,isomer #4	C[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O)O)[C@H]1O[Si](C)(C)C	2019.2	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TMS,isomer #5	C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O[Si](C)(C)C)O[C@H](O)[C@@H]1O	2066.5	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TMS,isomer #6	C[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@H]1O	2085.9	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TMS,isomer #7	C[Si](C)(C)OP(=O)(OC[C@H]1O[C@H](O)[C@H](O)[C@@H]1O)O[Si](C)(C)C	2057.6	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TMS,isomer #1	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2015.2	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TMS,isomer #2	C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O[Si](C)(C)C)O[C@H](O[Si](C)(C)C)[C@@H]1O	2059.2	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TMS,isomer #3	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O)[C@H]1O[Si](C)(C)C	2074.3	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TMS,isomer #4	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H]1O	2052.9	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TMS,isomer #5	C[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2091.3	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TMS,isomer #6	C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H](O)[C@@H]1O	2061.4	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TMS,isomer #7	C[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@H]1O	2110.9	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #1	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2062.9	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #1	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2043.7	Standard non polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #1	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2391.5	Standard polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #2	C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H](O[Si](C)(C)C)[C@@H]1O	2102.0	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #2	C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H](O[Si](C)(C)C)[C@@H]1O	2069.9	Standard non polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #2	C[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H](O[Si](C)(C)C)[C@@H]1O	2250.7	Standard polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #3	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H]1O[Si](C)(C)C	2110.2	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #3	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H]1O[Si](C)(C)C	2077.3	Standard non polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #3	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)[C@H]1O[Si](C)(C)C	2278.2	Standard polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #4	C[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2130.2	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #4	C[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2072.1	Standard non polar	33892256
D-Ribose 5-phosphate,4TMS,isomer #4	C[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2251.0	Standard polar	33892256
D-Ribose 5-phosphate,5TMS,isomer #1	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2107.4	Semi standard non polar	33892256
D-Ribose 5-phosphate,5TMS,isomer #1	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2074.5	Standard non polar	33892256
D-Ribose 5-phosphate,5TMS,isomer #1	C[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C	2188.1	Standard polar	33892256
D-Ribose 5-phosphate,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O	2259.5	Semi standard non polar	33892256
D-Ribose 5-phosphate,1TBDMS,isomer #2	CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O)O[C@H](O)[C@@H]1O	2263.7	Semi standard non polar	33892256
D-Ribose 5-phosphate,1TBDMS,isomer #3	CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O)O)[C@H]1O	2289.1	Semi standard non polar	33892256
D-Ribose 5-phosphate,1TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@H](O)[C@H](O)[C@@H]1O	2281.6	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O)O[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O	2413.7	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TBDMS,isomer #2	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O[Si](C)(C)C(C)(C)C	2424.2	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TBDMS,isomer #3	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H]1O	2503.3	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TBDMS,isomer #4	CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O)O)[C@H]1O[Si](C)(C)C(C)(C)C	2452.9	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TBDMS,isomer #5	CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[C@H](O)[C@@H]1O	2503.7	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TBDMS,isomer #6	CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@H]1O	2522.9	Semi standard non polar	33892256
D-Ribose 5-phosphate,2TBDMS,isomer #7	CC(C)(C)[Si](C)(C)OP(=O)(OC[C@H]1O[C@H](O)[C@H](O)[C@@H]1O)O[Si](C)(C)C(C)(C)C	2497.0	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2636.3	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TBDMS,isomer #2	CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O	2692.6	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TBDMS,isomer #3	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H]1O[Si](C)(C)C(C)(C)C	2709.1	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TBDMS,isomer #4	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H]1O	2716.9	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TBDMS,isomer #5	CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2726.7	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TBDMS,isomer #6	CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H](O)[C@@H]1O	2711.8	Semi standard non polar	33892256
D-Ribose 5-phosphate,3TBDMS,isomer #7	CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]1O	2736.6	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2910.5	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2776.2	Standard non polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2768.6	Standard polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #2	CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O	2918.0	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #2	CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O	2756.9	Standard non polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #2	CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O	2661.7	Standard polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #3	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H]1O[Si](C)(C)C(C)(C)C	2931.5	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #3	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H]1O[Si](C)(C)C(C)(C)C	2760.8	Standard non polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #3	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H]1O[Si](C)(C)C(C)(C)C	2685.8	Standard polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #4	CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2939.6	Semi standard non polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #4	CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2775.9	Standard non polar	33892256
D-Ribose 5-phosphate,4TBDMS,isomer #4	CC(C)(C)[Si](C)(C)O[C@H]1[C@@H](O)O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2660.6	Standard polar	33892256
D-Ribose 5-phosphate,5TBDMS,isomer #1	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	3145.7	Semi standard non polar	33892256
D-Ribose 5-phosphate,5TBDMS,isomer #1	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2902.7	Standard non polar	33892256
D-Ribose 5-phosphate,5TBDMS,isomer #1	CC(C)(C)[Si](C)(C)O[C@H]1O[C@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]1O[Si](C)(C)C(C)(C)C	2695.0	Standard polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Experimental GC-MS	GC-MS Spectrum - D-Ribose 5-phosphate GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (5 TMS)	splash10-014j-1942000000-8c3468eabd202324a3ae	2020-03-06	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - D-Ribose 5-phosphate GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (5 TMS)	splash10-0fr2-1943000000-b5d1468f33c224a23bd3	2020-03-06	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - D-Ribose 5-phosphate GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (5 TMS; 1 MEOX)	splash10-00di-9532000000-693524b08b2ccd6179c5	2020-03-06	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - D-Ribose 5-phosphate GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (5 TMS; 1 MEOX)	splash10-00di-9421000000-dbcd94d0a73f35716059	2020-03-06	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - D-Ribose 5-phosphate GC-EI-TOF (Non-derivatized)	splash10-014j-1942000000-8c3468eabd202324a3ae	2020-03-06	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - D-Ribose 5-phosphate GC-EI-TOF (Non-derivatized)	splash10-0fr2-1943000000-b5d1468f33c224a23bd3	2020-03-06	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - D-Ribose 5-phosphate GC-EI-TOF (Non-derivatized)	splash10-00di-9532000000-693524b08b2ccd6179c5	2020-03-06	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - D-Ribose 5-phosphate GC-EI-TOF (Non-derivatized)	splash10-00di-9421000000-dbcd94d0a73f35716059	2020-03-06	HMDB team, MONA, MassBank	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - D-Ribose 5-phosphate GC-MS (Non-derivatized) - 70eV, Positive	splash10-0002-9320000000-9b5fdcbd0e9ea3ece549	2016-09-22	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - D-Ribose 5-phosphate GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - D-Ribose 5-phosphate GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate Quattro_QQQ 10V, Positive-QTOF (Annotated)	splash10-0002-9320000000-7f3d980d223a6b9f5f3f	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate Quattro_QQQ 25V, Positive-QTOF (Annotated)	splash10-0002-9000000000-a5df0614f5cbd8b55405	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative-QTOF	splash10-056r-0090700000-ea86961dacc666b5fc7d	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative-QTOF	splash10-0002-9100000000-6cbb3e84820a37a47fbb	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative-QTOF	splash10-004i-0090000000-10949588537786dbae1e	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative-QTOF	splash10-0a4i-0000900000-10d8b4fd09ed514cc12e	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative-QTOF	splash10-002b-9000000000-49264a7584727750bd70	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate LC-ESI-ITFT , negative-QTOF	splash10-0002-9100000000-6cbb3e84820a37a47fbb	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate LC-ESI-ITFT , negative-QTOF	splash10-004i-0090000000-10949588537786dbae1e	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate LC-ESI-ITFT , negative-QTOF	splash10-0a4i-0000900000-10d8b4fd09ed514cc12e	2020-03-06	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - D-Ribose 5-phosphate LC-ESI-QTOF , negative-QTOF	splash10-002b-9000000000-340deaecb0169ce2acd3	2020-03-06	HMDB team, MONA	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 10V, Positive-QTOF	splash10-001i-1790000000-a3ced14cd6c2537c6d8f	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 20V, Positive-QTOF	splash10-001i-5940000000-8bcb763477232ce1dd2c	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 40V, Positive-QTOF	splash10-00y1-9300000000-ff5bd2489969fca00eb7	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 10V, Negative-QTOF	splash10-004i-7190000000-184075252146923d2684	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 20V, Negative-QTOF	splash10-004i-9000000000-917b1eb059131caa49ac	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 40V, Negative-QTOF	splash10-004i-9000000000-579393c266ea056c9e74	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 10V, Positive-QTOF	splash10-0159-1900000000-c7b876b70c54c880bdf3	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 20V, Positive-QTOF	splash10-01c1-9600000000-649e860a529bc7f5b4f8	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 40V, Positive-QTOF	splash10-053s-9000000000-f9d938955d2446665511	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 10V, Negative-QTOF	splash10-004j-9040000000-9ee7ba6767ffa3f356db	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 20V, Negative-QTOF	splash10-004i-9000000000-a5e502a2627af2048a1f	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - D-Ribose 5-phosphate 40V, Negative-QTOF	splash10-004i-9000000000-a5e502a2627af2048a1f	2021-09-22	Wishart Lab	View Spectrum

NMR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Experimental 1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	2020-03-06	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Experimental 2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	2020-03-06	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Cytoplasm
Mitochondria

Biospecimen Locations

Blood
Cellular Cytoplasm
Feces
Saliva
Urine

Tissue Locations

Not Available

Pathways

Name	SMPDB/PathBank	KEGG
Purine metabolism	Not Available
pentose phosphate pathway	Not Available	Not Available
Glucose-6-phosphate dehydrogenase deficiency		Not Available
Ribose-5-phosphate isomerase deficiency		Not Available
Transaldolase deficiency		Not Available

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	32966057	details
Blood	Detected and Quantified	13.2 +/- 4.8 uM	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details
Cellular Cytoplasm	Detected and Quantified	0.281 uM	Adult (>18 years old)	Both	Normal	15882454	details
Feces	Detected but not Quantified	Not Quantified	Children (6 - 18 years old)	Not Specified	Normal	27609529	details
Saliva	Detected and Quantified	0.720 +/- 0.402 uM	Adult (>18 years old)	Not Specified	Normal	Sugimoto et al. (...	details
Saliva	Detected and Quantified	1.31 +/- 0.77 uM	Adult (>18 years old)	Female	Normal	23857558	details
Saliva	Detected and Quantified	0.264 +/- 0.406 uM	Adult (>18 years old)	Not Specified	Normal	Sugimoto et al. (...	details
Urine	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	32966057	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Feces	Detected but not Quantified	Not Quantified	Children (6 - 18 years old)	Both	Ulcerative colitis	27609529	details
Feces	Detected but not Quantified	Not Quantified	Children (6 - 18 years old)	Not Specified	Crohns disease	27609529	details
Feces	Detected but not Quantified	Not Quantified	Children (6 - 18 years old)	Not Specified	Ulcerative colitis	27609529	details
Feces	Detected but not Quantified	Not Quantified	Children (6 - 18 years old)	Not Specified	Unclassified IBD	27609529	details
Saliva	Detected and Quantified	1.00 +/- 0.44 uM	Adult (>18 years old)	Male	Alzheimer's disease	23857558	details
Saliva	Detected and Quantified	1.32 +/- 0.68 uM	Adult (>18 years old)	Male	Frontotemporal lobe dementia	23857558	details
Saliva	Detected and Quantified	1.79 +/- 1.79 uM	Adult (>18 years old)	Both	Lewy body disease	23857558	details

Associated Disorders and Diseases

Disease References

Ulcerative colitis
Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Crohn's disease
Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Alzheimer's disease
Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Frontotemporal dementia
Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Lewy body disease
Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]

Associated OMIM IDs

266600 (Crohn's disease)
104300 (Alzheimer's disease)
600274 (Frontotemporal dementia)

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB001615

KNApSAcK ID

Not Available

Chemspider ID

389102

KEGG Compound ID

C03736

BioCyc ID

RIBOSE-5P

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

440101

PDB ID

Not Available

ChEBI ID

18189

Food Biomarker Ontology

Not Available

VMH ID

R5P

MarkerDB ID

MDB00000336

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18. [PubMed:15882454 ]
Pilz RB, Willis RC, Boss GR: The influence of ribose 5-phosphate availability on purine synthesis of cultured human lymphoblasts and mitogen-stimulated lymphocytes. J Biol Chem. 1984 Mar 10;259(5):2927-35. [PubMed:6699001 ]

Only showing the first 10 proteins. There are 17 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. Ribose-phosphate pyrophosphokinase 3

General function:: Involved in magnesium ion binding
Specific function:: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Gene Name:: PRPS1L1
Uniprot ID:: P21108
Molecular weight:: 34838.915

Reactions

Adenosine triphosphate + D-Ribose 5-phosphate → Adenosine monophosphate + Phosphoribosyl pyrophosphate	details

Enzyme Details

2. ADP-sugar pyrophosphatase

General function:: Involved in hydrolase activity
Specific function:: Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.
Gene Name:: NUDT5
Uniprot ID:: Q9UKK9
Molecular weight:: 24327.41

Reactions

Adenosine diphosphate ribose + Water → Adenosine monophosphate + D-Ribose 5-phosphate	details
Adenosine diphosphate ribose + Water → Adenosine monophosphate + D-Ribose 5-phosphate	details

Enzyme Details

3. Ribose-phosphate pyrophosphokinase 1

General function:: Involved in magnesium ion binding
Specific function:: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Gene Name:: PRPS1
Uniprot ID:: P60891
Molecular weight:: 12324.195

Reactions

Adenosine triphosphate + D-Ribose 5-phosphate → Adenosine monophosphate + Phosphoribosyl pyrophosphate	details

Enzyme Details

4. Ribose-phosphate pyrophosphokinase 2

General function:: Involved in magnesium ion binding
Specific function:: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Gene Name:: PRPS2
Uniprot ID:: P11908
Molecular weight:: 35054.06

Reactions

Adenosine triphosphate + D-Ribose 5-phosphate → Adenosine monophosphate + Phosphoribosyl pyrophosphate	details

Enzyme Details

5. ADP-ribose pyrophosphatase, mitochondrial

General function:: Involved in hydrolase activity
Specific function:: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Gene Name:: NUDT9
Uniprot ID:: Q9BW91
Molecular weight:: 35448.725

Reactions

Adenosine diphosphate ribose + Water → Adenosine monophosphate + D-Ribose 5-phosphate	details
Adenosine diphosphate ribose + Water → Adenosine monophosphate + D-Ribose 5-phosphate	details

Enzyme Details

6. Transketolase-like protein 1

General function:: Involved in catalytic activity
Specific function:: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity).
Gene Name:: TKTL1
Uniprot ID:: P51854
Molecular weight:: 59302.195

Reactions

D-Sedoheptulose 7-phosphate + Glyceraldehyde 3-phosphate → D-Ribose 5-phosphate + Xylulose 5-phosphate	details
D-Sedoheptulose 7-phosphate + Glyceraldehyde 3-phosphate → D-Ribose 5-phosphate + Xylulose 5-phosphate	details
Aminofructose 6-phosphate + D-Ribose 5-phosphate → Iminoerythrose 4-phosphate + D-Sedoheptulose 7-phosphate	details

Enzyme Details

7. Transketolase

General function:: Involved in catalytic activity
Specific function:: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Gene Name:: TKT
Uniprot ID:: P29401
Molecular weight:: 67876.95

Reactions

D-Sedoheptulose 7-phosphate + Glyceraldehyde 3-phosphate → D-Ribose 5-phosphate + Xylulose 5-phosphate	details
D-Sedoheptulose 7-phosphate + Glyceraldehyde 3-phosphate → D-Ribose 5-phosphate + Xylulose 5-phosphate	details
Aminofructose 6-phosphate + D-Ribose 5-phosphate → Iminoerythrose 4-phosphate + D-Sedoheptulose 7-phosphate	details

Enzyme Details

8. Ribokinase

General function:: Involved in ribokinase activity
Specific function:: Not Available
Gene Name:: RBKS
Uniprot ID:: Q9H477
Molecular weight:: 34142.685

Reactions

Adenosine triphosphate + D-Ribose → ADP + D-Ribose 5-phosphate	details

Enzyme Details

9. Phosphoglucomutase-1

General function:: Involved in intramolecular transferase activity, phosphotransferases
Specific function:: This enzyme participates in both the breakdown and synthesis of glucose.
Gene Name:: PGM1
Uniprot ID:: P36871
Molecular weight:: 63789.985

Reactions

Ribose 1-phosphate → D-Ribose 5-phosphate	details

Enzyme Details

10. Phosphoacetylglucosamine mutase

General function:: Involved in intramolecular transferase activity, phosphotransferases
Specific function:: Interconverts GlcNAc-6-P and GlcNAc-1-P.
Gene Name:: PGM3
Uniprot ID:: O95394
Molecular weight:: 62940.905

Only showing the first 10 proteins. There are 17 proteins in total.

Show all enzymes and transporters

Showing metabocard for D-Ribose 5-phosphate (HMDB0001548)

MOL for HMDB0001548 (D-Ribose 5-phosphate)

3D MOL for HMDB0001548 (D-Ribose 5-phosphate)

3D SDF for HMDB0001548 (D-Ribose 5-phosphate)

3D-SDF for HMDB0001548 (D-Ribose 5-phosphate)

PDB for HMDB0001548 (D-Ribose 5-phosphate)

3D PDB for HMDB0001548 (D-Ribose 5-phosphate)

SMILES for HMDB0001548 (D-Ribose 5-phosphate)

INCHI for HMDB0001548 (D-Ribose 5-phosphate)

Structure for HMDB0001548 (D-Ribose 5-phosphate)

3D Structure for HMDB0001548 (D-Ribose 5-phosphate)

Experimental Collision Cross Sections

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

NMR Spectra

Enzymes

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