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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-03-10 10:07:06 UTC
Update Date2021-09-14 15:07:06 UTC
HMDB IDHMDB0001903
Secondary Accession Numbers
  • HMDB01903
Metabolite Identification
Common NameCalcitriol
DescriptionCalcitriol, also known as rocaltrol or 1a,25(OH)2D3, belongs to the class of organic compounds known as vitamin d and derivatives. Vitamin D and derivatives are compounds containing a secosteroid backbone, usually secoergostane or secocholestane. Thus, calcitriol is considered to be a secosteroid lipid molecule. Calcitriol is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Calcitriol is a potentially toxic compound.
Structure
Data?1582752216
Synonyms
ValueSource
(1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triolChEBI
(1S,3R,5Z,7E)-9,10-Secocholesta-5,7,10-triene-1,3,25-triolChEBI
(5Z,7E)-(1S,3R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triolChEBI
1,25-DHCCChEBI
1-alpha-25-Dihydroxyvitamin D3ChEBI
1alpha,25(OH)2D3ChEBI
1alpha,25-DihydroxycholecalciferolChEBI
1alpha,25-Dihydroxyvitamin D3ChEBI
5-{2-[1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diolChEBI
CalcijexChEBI
CalcitriolumChEBI
DecostriolChEBI
RocaltrolChEBI
(1S,3R,5Z,7E)-9,10-Seco-5,7,10(19)-cholestatriene-1,3,25-triolKegg
(1a,3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triolGenerator
(1Α,3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triolGenerator
1-a-25-Dihydroxyvitamin D3Generator
1-Α-25-dihydroxyvitamin D3Generator
1a,25(OH)2D3Generator
1Α,25(OH)2D3Generator
1a,25-DihydroxycholecalciferolGenerator
1Α,25-dihydroxycholecalciferolGenerator
1a,25-Dihydroxyvitamin D3Generator
1Α,25-dihydroxyvitamin D3Generator
(3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trienetriolHMDB
1,25 DihydroxycholecalciferolHMDB
1,25-DihydroxycholecalciferolHMDB
1,25-Dihydroxyvitamin DHMDB
1,25-Dihydroxyvitamin D3HMDB
1-alpha,25-Dihydroxyvitamin D3HMDB
1a,25-(OH)2D3HMDB
25-DihydroxycholecalciferolHMDB
Dihydroxyvitamin D3HMDB
Ro 21-5535HMDB
SilkisHMDB
SoltriolHMDB
TopitriolHMDB
ToptriolHMDB
1 alpha, 25-Dihydroxy-20-epi-vitamin D3HMDB
1 alpha,25-DihydroxycholecalciferolHMDB
1,25(OH)2-20EPi-D3HMDB
BocatriolHMDB
Calcitriol alphapharm brandHMDB
Calcitriol kyramedHMDB
Calcitriol-nefroHMDB
Hoffmann-la roche brand OF calcitriolHMDB
KyraMed, calcitriolHMDB
TirocalHMDB
alpha,25-Dihydroxyvitamin D3, 1HMDB
1,25-Dihydroxy-20-epi-vitamin D3HMDB
20 Epi 1alpha,25 dihydroxycholecaliferolHMDB
Abbott brand OF calcitriolHMDB
Calcitriol galderma brandHMDB
Calcitriol jenapharm brandHMDB
Calcitriol leo brandHMDB
Cryopharma brand OF calcitriolHMDB
Medice brand OF calcitriolHMDB
RenatriolHMDB
Roche brand OF calcitriolHMDB
1 alpha,25 DihydroxycholecalciferolHMDB
1 alpha,25-Dihydroxyvitamin D3HMDB
20-Epi-1alpha,25-dihydroxycholecaliferolHMDB
Calcitriol gry brandHMDB
Calcitriol kyramed brandHMDB
Calcitriol medice brandHMDB
Calcitriol nefroHMDB
Calcitriol renacare brandHMDB
Calcitriol roche brandHMDB
D3, 1,25-DihydroxyvitaminHMDB
D3, 1,25-Dihydroxy-20-epi-vitaminHMDB
Galderma brand OF calcitriolHMDB
Hoffmann la roche brand OF calcitriolHMDB
KyraMed brand OF calcitriolHMDB
Leo brand OF calcitriolHMDB
RenaCare brand OF calcitriolHMDB
SitriolHMDB
1 alpha, 25 Dihydroxy 20 epi vitamin D3HMDB
1 alpha,25 Dihydroxyvitamin D3HMDB
1,25 Dihydroxyvitamin D3HMDB
1,25 Dihydroxy 20 epi vitamin D3HMDB
Alphapharm brand OF calcitriolHMDB
Calcitriol abbott brandHMDB
Calcitriol cryopharma brandHMDB
CalcitriolNefroHMDB
D3, 1 alpha,25-DihydroxyvitaminHMDB
Gry brand OF calcitriolHMDB
Jenapharm brand OF calcitriolHMDB
OsteotriolHMDB
1a,25-Dihydroxyvitamin D3 / 1a,25-dihydroxycholecalciferol / calcitriolHMDB
1Α,25-dihydroxyvitamin D3 / 1α,25-dihydroxycholecalciferol / calcitriolHMDB
CalcitriolMeSH
Chemical FormulaC27H44O3
Average Molecular Weight416.6365
Monoisotopic Molecular Weight416.329045274
IUPAC Name(1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
Traditional Namecalcitriol
CAS Registry Number32222-06-3
SMILES
C[C@H](CCCC(C)(C)O)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
InChI Identifier
InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChI KeyGMRQFYUYWCNGIN-NKMMMXOESA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as vitamin d and derivatives. Vitamin D and derivatives are compounds containing a secosteroid backbone, usually secoergostane or secocholestane.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassVitamin D and derivatives
Direct ParentVitamin D and derivatives
Alternative Parents
Substituents
  • Triterpenoid
  • Tertiary alcohol
  • Cyclic alcohol
  • Secondary alcohol
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point113 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.0067 g/LALOGPS
logP10(5.51) g/LALOGPS
logP10(4.35) g/LChemAxon
logS10(-4.8) g/LALOGPS
pKa (Strongest Acidic)14.39ChemAxon
pKa (Strongest Basic)-1.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area60.69 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity126.53 m³·mol⁻¹ChemAxon
Polarizability51.02 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+202.62231661259
DarkChem[M-H]-196.77831661259
AllCCS[M+H]+208.61532859911
AllCCS[M-H]-206.87532859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
CalcitriolC[C@H](CCCC(C)(C)O)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C3862.7Standard polar33892256
CalcitriolC[C@H](CCCC(C)(C)O)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C3335.7Standard non polar33892256
CalcitriolC[C@H](CCCC(C)(C)O)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C3536.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Calcitriol,1TMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O[Si](C)(C)C)C[C@@H](O)C[C@@H]1O3529.7Semi standard non polar33892256
Calcitriol,1TMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O)C[C@@H](O[Si](C)(C)C)C[C@@H]1O3374.1Semi standard non polar33892256
Calcitriol,1TMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O)C[C@@H](O)C[C@@H]1O[Si](C)(C)C3376.5Semi standard non polar33892256
Calcitriol,2TMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O[Si](C)(C)C)C[C@@H](O[Si](C)(C)C)C[C@@H]1O3485.3Semi standard non polar33892256
Calcitriol,2TMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O[Si](C)(C)C)C[C@@H](O)C[C@@H]1O[Si](C)(C)C3470.9Semi standard non polar33892256
Calcitriol,2TMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O)C[C@@H](O[Si](C)(C)C)C[C@@H]1O[Si](C)(C)C3296.4Semi standard non polar33892256
Calcitriol,3TMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O[Si](C)(C)C)C[C@@H](O[Si](C)(C)C)C[C@@H]1O[Si](C)(C)C3400.3Semi standard non polar33892256
Calcitriol,1TBDMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O)C[C@@H]1O3756.9Semi standard non polar33892256
Calcitriol,1TBDMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O3584.0Semi standard non polar33892256
Calcitriol,1TBDMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O)C[C@@H](O)C[C@@H]1O[Si](C)(C)C(C)(C)C3573.8Semi standard non polar33892256
Calcitriol,2TBDMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O3934.9Semi standard non polar33892256
Calcitriol,2TBDMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O)C[C@@H]1O[Si](C)(C)C(C)(C)C3892.9Semi standard non polar33892256
Calcitriol,2TBDMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O[Si](C)(C)C(C)(C)C3694.6Semi standard non polar33892256
Calcitriol,3TBDMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O[Si](C)(C)C(C)(C)C4050.3Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Calcitriol GC-MS (Non-derivatized) - 70eV, Positivesplash10-0aba-2019200000-f91cfe8e2e00e1a8f6da2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Calcitriol GC-MS (3 TMS) - 70eV, Positivesplash10-014i-2200139000-8f9b07740968867d2e472017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Calcitriol GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 10V, Positive-QTOFsplash10-001j-0009100000-5d85e3fe2656c4f2c7982016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 20V, Positive-QTOFsplash10-001j-0239000000-16579742f7806ac7c5802016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 40V, Positive-QTOFsplash10-0080-3297000000-1ded6f55cc278e5facb82016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 10V, Negative-QTOFsplash10-014i-0006900000-58dff5fdfef8e2a6c7c92016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 20V, Negative-QTOFsplash10-00kb-0009300000-93004eb4d3b2dee27fe82016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 40V, Negative-QTOFsplash10-000t-1119000000-a3201818a6bc9ce6cac42016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 10V, Positive-QTOFsplash10-001j-0119000000-f58eb6212ebcce40560e2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 20V, Positive-QTOFsplash10-014r-4396100000-7177c9113a57f65c8c662021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 40V, Positive-QTOFsplash10-01w1-1961000000-2ac1cc3761902eada6c42021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 10V, Negative-QTOFsplash10-014i-0000900000-67ea14fb7a26b9b2d9292021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 20V, Negative-QTOFsplash10-014i-0505900000-160a8d14ac12dfdfe86e2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Calcitriol 40V, Negative-QTOFsplash10-02k9-0839500000-5c13b18b5994b1b652882021-09-23Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane (predicted from logP)
  • Mitochondria
Biospecimen Locations
  • Blood
  • Feces
Tissue Locations
  • Adrenal Medulla
  • Bladder
  • Epidermis
  • Fibroblasts
  • Intestine
  • Kidney
  • Ovary
  • Pancreas
  • Placenta
  • Prostate
  • Skeletal Muscle
  • Spleen
  • Testis
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.000086 (0.000029-0.00016) uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.000074 (0.000052-0.000096) uMAdult (>18 years old)BothNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedNewborn (0-30 days old)Not Specified
Premature neonates
details
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00136
Phenol Explorer Compound IDNot Available
FooDB IDFDB021822
KNApSAcK IDNot Available
Chemspider ID4444108
KEGG Compound IDC01673
BioCyc IDCALCITRIOL
BiGG ID2289241
Wikipedia LinkCalcitriol
METLIN ID6382
PubChem Compound5280453
PDB IDNot Available
ChEBI ID17823
Food Biomarker OntologyNot Available
VMH ID1A25DHVITD3
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceChen, Yang-sheng; Zhai, Cui-yun; Ren, Li. Synthesis of calcitriol. Zhongguo Xinyao Zazhi (2005), 14(1), 69-72.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Mason RS, Lissner D, Grunstein HS, Posen S: A simplified assay for dihydroxylated vitamin D metabolites in human serum: application to hyper- and hypovitaminosis D. Clin Chem. 1980 Mar;26(3):444-50. [PubMed:6892691 ]
  2. Shepard RM, Horst RL, Hamstra AJ, DeLuca HF: Determination of vitamin D and its metabolites in plasma from normal and anephric man. Biochem J. 1979 Jul 15;182(1):55-69. [PubMed:227368 ]
  3. Mason RS, Frankel T, Chan YL, Lissner D, Posen S: Vitamin D conversion by sarcoid lymph node homogenate. Ann Intern Med. 1984 Jan;100(1):59-61. [PubMed:6546329 ]
  4. Mallette LE: Case report: hypoparathyroidism with menses-associated hypocalcemia. Am J Med Sci. 1992 Jul;304(1):32-7. [PubMed:1642251 ]
  5. Ott SM, Chesnut CH 3rd: Calcitriol treatment is not effective in postmenopausal osteoporosis. Ann Intern Med. 1989 Feb 15;110(4):267-74. [PubMed:2913914 ]
  6. Bhan I, Shah A, Holmes J, Isakova T, Gutierrez O, Burnett SM, Juppner H, Wolf M: Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'? Kidney Int. 2006 Oct;70(8):1486-94. Epub 2006 Aug 30. [PubMed:16941023 ]
  7. Josephson MA, Schumm LP, Chiu MY, Marshall C, Thistlethwaite JR, Sprague SM: Calcium and calcitriol prophylaxis attenuates posttransplant bone loss. Transplantation. 2004 Oct 27;78(8):1233-6. [PubMed:15502727 ]
  8. Gallagher JC, Goldgar D: Treatment of postmenopausal osteoporosis with high doses of synthetic calcitriol. A randomized controlled study. Ann Intern Med. 1990 Nov 1;113(9):649-55. [PubMed:2221645 ]
  9. Lehmann B, Sauter W, Knuschke P, Dressler S, Meurer M: Demonstration of UVB-induced synthesis of 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis. Arch Dermatol Res. 2003 Apr;295(1):24-8. Epub 2003 Mar 11. [PubMed:12709817 ]
  10. Moreno J, Krishnan AV, Swami S, Nonn L, Peehl DM, Feldman D: Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells. Cancer Res. 2005 Sep 1;65(17):7917-25. [PubMed:16140963 ]
  11. Kalkwarf HJ, Specker BL, Heubi JE, Vieira NE, Yergey AL: Intestinal calcium absorption of women during lactation and after weaning. Am J Clin Nutr. 1996 Apr;63(4):526-31. [PubMed:8599316 ]

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
Gene Name:
CYP27B1
Uniprot ID:
O15528
Molecular weight:
56503.475
Reactions
Calcidiol + NADPH + Oxygen → Calcitriol + NADP + Waterdetails
Calcidiol + Oxygen + NADPH + Hydrogen Ion → Calcitriol + NADP + Waterdetails
General function:
Involved in sequence-specific DNA binding transcription factor activity
Specific function:
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis
Gene Name:
VDR
Uniprot ID:
P11473
Molecular weight:
48288.6
General function:
Involved in monooxygenase activity
Specific function:
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
Gene Name:
CYP24A1
Uniprot ID:
Q07973
Molecular weight:
58874.695
Reactions
Calcitriol + NADPH + Oxygen → 24-Hydroxycalcitriol + NADP + Waterdetails
Calcitriol + NADPH + Hydrogen Ion + Oxygen → 24-Hydroxycalcitriol + NADP + Waterdetails