Hmdb loader

Showing metabocard for 4-Methoxycinnamic acid (HMDB0002040)

Jump To Section:
IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesenzymes (1) Show 1 proteinXML
enzymes (1) Show 1 protein
Show more...Show more...Show more...Show more...Show more...
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-05-22 14:17:33 UTC
Update Date2023-02-21 17:16:05 UTC
HMDB IDHMDB0002040
Secondary Accession Numbers
  • HMDB02040
Metabolite Identification
Common Name4-Methoxycinnamic acid
Description4-Methoxycinnamic acid, also known as para-methoxycinnamate or O-methyl-p-coumarate, belongs to the class of organic compounds known as cinnamic acids. These are organic aromatic compounds containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid. Outside of the human body, 4-Methoxycinnamic acid is found, on average, in the highest concentration within turmerics. 4-Methoxycinnamic acid has also been detected, but not quantified in cow milk and wild celeries. This could make 4-methoxycinnamic acid a potential biomarker for the consumption of these foods.
Structure
Thumb
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0002040 (4-Methoxycinnamic acid)

  Mrv1652306141922352D          

 13 13  0  0  0  0            999 V2000
    1.7862    0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0718    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5008    1.0314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2152    0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9298    1.0314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9298    1.8564    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6443    0.6188    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.6186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0718   -0.2061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  1  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 11  1  0  0  0  0
  9 10  2  0  0  0  0
  4 12  1  0  0  0  0
 12 13  1  0  0  0  0
M  END
Download

3D MOL for HMDB0002040 (4-Methoxycinnamic acid)

HMDB0002040
     RDKit          3D
4-Methoxycinnamic acid
 23 23  0  0  0  0  0  0  0  0999 V2000
   -4.2689    0.5623    0.8586 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5344   -0.5471    0.4335 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1630   -0.5223    0.2294 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5147   -1.6741   -0.1946 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1532   -1.6886   -0.4083 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6270   -0.5427   -0.2059 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0689   -0.5964   -0.4429 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8900    0.4221   -0.2827 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3124    0.2955   -0.5373 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8206   -0.7802   -0.9183 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1367    1.3864   -0.3571 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0574    0.5683    0.2122 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4112    0.6039    0.4306 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2161    0.6204    1.9512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3516    0.4846    0.5855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9253    1.5132    0.3551 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0983   -2.5827   -0.3605 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3785   -2.5720   -0.7388 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5435   -1.5231   -0.7769 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4729    1.3604    0.0456 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8768    2.2349    0.1127 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4959    1.4764    0.3826 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9292    1.5009    0.7630 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
  6 12  1  0
 12 13  2  0
 13  3  1  0
  1 14  1  0
  1 15  1  0
  1 16  1  0
  4 17  1  0
  5 18  1  0
  7 19  1  0
  8 20  1  0
 11 21  1  0
 12 22  1  0
 13 23  1  0
M  END
Download

3D SDF for HMDB0002040 (4-Methoxycinnamic acid)

  Mrv1652306141922352D          

 13 13  0  0  0  0            999 V2000
    1.7862    0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0718    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572    0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5008    1.0314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2152    0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9298    1.0314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9298    1.8564    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6443    0.6188    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.6186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0718   -0.2061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  1  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 11  1  0  0  0  0
  9 10  2  0  0  0  0
  4 12  1  0  0  0  0
 12 13  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0002040

> <DATABASE_NAME>
hmdb

> <SMILES>
COC1=CC=C(\C=C\C(O)=O)C=C1

> <INCHI_IDENTIFIER>
InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+

> <INCHI_KEY>
AFDXODALSZRGIH-QPJJXVBHSA-N

> <FORMULA>
C10H10O3

> <MOLECULAR_WEIGHT>
178.1846

> <EXACT_MASS>
178.062994186

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
23

> <JCHEM_AVERAGE_POLARIZABILITY>
18.34403874731484

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2E)-3-(4-methoxyphenyl)prop-2-enoic acid

> <ALOGPS_LOGP>
2.37

> <JCHEM_LOGP>
1.978414994333333

> <ALOGPS_LOGS>
-2.51

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.109550179068184

> <JCHEM_PKA_STRONGEST_BASIC>
-4.823943867272176

> <JCHEM_POLAR_SURFACE_AREA>
46.53

> <JCHEM_REFRACTIVITY>
49.523100000000014

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.49e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
p-methoxy-cinnamic acid

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0002040 (4-Methoxycinnamic acid)

HMDB0002040
     RDKit          3D
4-Methoxycinnamic acid
 23 23  0  0  0  0  0  0  0  0999 V2000
   -4.2689    0.5623    0.8586 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5344   -0.5471    0.4335 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1630   -0.5223    0.2294 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5147   -1.6741   -0.1946 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1532   -1.6886   -0.4083 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6270   -0.5427   -0.2059 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0689   -0.5964   -0.4429 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8900    0.4221   -0.2827 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3124    0.2955   -0.5373 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8206   -0.7802   -0.9183 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1367    1.3864   -0.3571 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0574    0.5683    0.2122 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4112    0.6039    0.4306 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2161    0.6204    1.9512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3516    0.4846    0.5855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9253    1.5132    0.3551 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0983   -2.5827   -0.3605 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3785   -2.5720   -0.7388 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5435   -1.5231   -0.7769 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4729    1.3604    0.0456 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8768    2.2349    0.1127 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4959    1.4764    0.3826 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9292    1.5009    0.7630 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
  6 12  1  0
 12 13  2  0
 13  3  1  0
  1 14  1  0
  1 15  1  0
  1 16  1  0
  4 17  1  0
  5 18  1  0
  7 19  1  0
  8 20  1  0
 11 21  1  0
 12 22  1  0
 13 23  1  0
M  END
Download

PDB for HMDB0002040 (4-Methoxycinnamic acid)

HEADER    PROTEIN                                 14-JUN-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   14-JUN-19         0                                  
HETATM    1  C   UNK     0       3.334   1.155   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.001   1.925   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.667   1.155   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.667  -0.385   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.000  -1.155   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.334  -0.385   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.668   1.925   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.002   1.155   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.336   1.925   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       7.336   3.465   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0       8.669   1.155   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0      -0.667  -1.155   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0      -2.001  -0.385   0.000  0.00  0.00           C+0
CONECT    1    2    6    7                                                  
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5   12                                                  
CONECT    5    4    6                                                       
CONECT    6    5    1                                                       
CONECT    7    1    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   11   10                                                  
CONECT   10    9                                                            
CONECT   11    9                                                            
CONECT   12    4   13                                                       
CONECT   13   12                                                            
MASTER        0    0    0    0    0    0    0    0   13    0   26    0
END
Download

3D PDB for HMDB0002040 (4-Methoxycinnamic acid)

COMPND    HMDB0002040
HETATM    1  C1  UNL     1      -4.269   0.562   0.859  1.00  0.00           C  
HETATM    2  O1  UNL     1      -3.534  -0.547   0.434  1.00  0.00           O  
HETATM    3  C2  UNL     1      -2.163  -0.522   0.229  1.00  0.00           C  
HETATM    4  C3  UNL     1      -1.515  -1.674  -0.195  1.00  0.00           C  
HETATM    5  C4  UNL     1      -0.153  -1.689  -0.408  1.00  0.00           C  
HETATM    6  C5  UNL     1       0.627  -0.543  -0.206  1.00  0.00           C  
HETATM    7  C6  UNL     1       2.069  -0.596  -0.443  1.00  0.00           C  
HETATM    8  C7  UNL     1       2.890   0.422  -0.283  1.00  0.00           C  
HETATM    9  C8  UNL     1       4.312   0.295  -0.537  1.00  0.00           C  
HETATM   10  O2  UNL     1       4.821  -0.780  -0.918  1.00  0.00           O  
HETATM   11  O3  UNL     1       5.137   1.386  -0.357  1.00  0.00           O  
HETATM   12  C9  UNL     1      -0.057   0.568   0.212  1.00  0.00           C  
HETATM   13  C10 UNL     1      -1.411   0.604   0.431  1.00  0.00           C  
HETATM   14  H1  UNL     1      -4.216   0.620   1.951  1.00  0.00           H  
HETATM   15  H2  UNL     1      -5.352   0.485   0.586  1.00  0.00           H  
HETATM   16  H3  UNL     1      -3.925   1.513   0.355  1.00  0.00           H  
HETATM   17  H4  UNL     1      -2.098  -2.583  -0.361  1.00  0.00           H  
HETATM   18  H5  UNL     1       0.379  -2.572  -0.739  1.00  0.00           H  
HETATM   19  H6  UNL     1       2.544  -1.523  -0.777  1.00  0.00           H  
HETATM   20  H7  UNL     1       2.473   1.360   0.046  1.00  0.00           H  
HETATM   21  H8  UNL     1       4.877   2.235   0.113  1.00  0.00           H  
HETATM   22  H9  UNL     1       0.496   1.476   0.383  1.00  0.00           H  
HETATM   23  H10 UNL     1      -1.929   1.501   0.763  1.00  0.00           H  
CONECT    1    2   14   15   16
CONECT    2    3
CONECT    3    4    4   13
CONECT    4    5   17
CONECT    5    6    6   18
CONECT    6    7   12
CONECT    7    8    8   19
CONECT    8    9   20
CONECT    9   10   10   11
CONECT   11   21
CONECT   12   13   13   22
CONECT   13   23
END
Download

SMILES for HMDB0002040 (4-Methoxycinnamic acid)

COC1=CC=C(\C=C\C(O)=O)C=C1
Download

INCHI for HMDB0002040 (4-Methoxycinnamic acid)

InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+
Download
View in JSmolView Stereo Labels
Synonyms
Chemical FormulaC10H10O3
Average Molecular Weight178.1846
Monoisotopic Molecular Weight178.062994186
IUPAC Name(2E)-3-(4-methoxyphenyl)prop-2-enoic acid
Traditional Namep-methoxy-cinnamic acid
CAS Registry Number943-89-5
SMILES
COC1=CC=C(\C=C\C(O)=O)C=C1
InChI Identifier
InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+
InChI KeyAFDXODALSZRGIH-QPJJXVBHSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as cinnamic acids. These are organic aromatic compounds containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassCinnamic acids and derivatives
Sub ClassCinnamic acids
Direct ParentCinnamic acids
Alternative Parents
Substituents
  • Cinnamic acid
  • Phenoxy compound
  • Anisole
  • Methoxybenzene
  • Styrene
  • Phenol ether
  • Alkyl aryl ether
  • Monocyclic benzene moiety
  • Benzenoid
  • Carboxylic acid derivative
  • Carboxylic acid
  • Ether
  • Monocarboxylic acid or derivatives
  • Organic oxygen compound
  • Carbonyl group
  • Organic oxide
  • Organooxygen compound
  • Hydrocarbon derivative
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
Disposition
Biological locationRoute of exposureSource
ProcessNot Available
Role
Industrial applicationBiological role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point173 - 175 °CNot Available
Boiling Point342.59 °C. @ 760.00 mm Hg (est)The Good Scents Company Information System
Water Solubility0.71 mg/mL at 25 °CNot Available
LogP2.68HANSCH,C ET AL. (1995)
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-MetCCS_train_neg146.27930932474
[M+H]+MetCCS_train_pos140.84930932474
[M-H]-Not Available146.279http://allccs.zhulab.cn/database/detail?ID=AllCCS00000433
[M+H]+Not Available141.375http://allccs.zhulab.cn/database/detail?ID=AllCCS00000433
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Membrane (predicted from logP)
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB002667
KNApSAcK IDNot Available
Chemspider ID609479
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID6453
PubChem Compound699414
PDB IDNot Available
ChEBI ID260249
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1417131
References
Synthesis ReferencePuscaru, E.; Zotta, V.; Serper, Ana; Popescu, Margareta; Hociung, Jana; Gasmet, Ana; Spataru, Rodica. The N-methyl series of piperazine. II. Cinnamic acid derivatives. Farmacia (Bucharest, Romania) (1961), 9 345-50.
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. UDP-glucuronosyltransferase 1-1
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular weight:
59590.91
Reactions
4-Methoxycinnamic acid → 3,4,5-trihydroxy-6-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]oxy}oxane-2-carboxylic aciddetails