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Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References enzymes (787)transporters (2) Show 789 proteins XML

enzymes (787)transporters (2) Show 789 proteins

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2005-11-16 15:48:42 UTC

Update Date

2023-02-21 17:15:41 UTC

HMDB ID

HMDB0001429

Secondary Accession Numbers

HMDB0000973
HMDB0002105
HMDB0002142
HMDB0005947
HMDB00973
HMDB01429
HMDB02105
HMDB02142
HMDB05947

Metabolite Identification

Common Name

Phosphate

Description

Phosphate is a salt of phosphoric acid and is an essential component of life. Organic phosphates are important in biochemistry, biogeochemistry, and ecology. In biological systems, phosphorus is found as a free phosphate ion in solution and is called inorganic phosphate, to distinguish it from phosphates bound in various phosphate esters. Inorganic phosphate is generally denoted Pi and at physiological (neutral) pH primarily consists of a mixture of HPO2-4 and H2PO-4 ions. Phosphates are most commonly found in the form of adenosine phosphates (AMP, ADP, and ATP) and in DNA and RNA, and can be released by the hydrolysis of ATP or ADP. Similar reactions exist for the other nucleoside diphosphates and triphosphates. Phosphoanhydride bonds in ADP and ATP, or other nucleoside diphosphates and triphosphates, contain high amounts of energy which give them their vital role in all living organisms. Phosphate must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent Pi transporters carry out this task. Remarkably, the two families transport different Pi species: whereas type II Na+/Pi cotransporters (SCL34) prefer divalent HPO4(2), type III Na+/Pi cotransporters (SLC20) transport monovalent H2PO4. The SCL34 family comprises both electrogenic and electroneutral members that are expressed in various epithelia and other polarized cells. Through regulated activity in apical membranes of the gut and kidney, they maintain body Pi homeostasis, and in salivary and mammary glands, liver, and testes they play a role in modulating the Pi content of luminal fluids. Phosphate levels in the blood play an important role in hormone signalling and in bone homeostasis. In classical endocrine regulation, low serum phosphate induces the renal production of the secosteroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). This active metabolite of vitamin D acts to restore circulating mineral (i.e. phosphate and calcium) levels by increasing absorption in the intestine, reabsorption in the kidney, and mobilization of calcium and phosphate from bone. Thus, chronic renal failure is associated with hyperparathyroidism, which in turn contributes to osteomalacia (softening of the bones). Another complication of chronic renal failure is hyperphosphatemia (low levels of phosphate in the blood). Hyperphosphatemia (excess levels of phosphate in the blood) is a prevalent condition in kidney dialysis patients and is associated with increased risk of mortality. Hypophosphatemia (hungry bone syndrome) has been associated with postoperative electrolyte aberrations and after parathyroidectomy (PMID: 17581921 , 11169009 , 11039261 , 9159312 , 17625581 ). Fibroblast growth factor 23 (FGF-23) has recently been recognized as a key mediator of phosphate homeostasis and its most notable effect is the promotion of phosphate excretion. FGF-23 was discovered to be involved in diseases such as autosomal dominant hypophosphatemic rickets, X-linked hypophosphatemia, and tumour-induced osteomalacia in which phosphate wasting was coupled to inappropriately low levels of 1,25(OH)2D3. FGF-23 is regulated by dietary phosphate in humans. In particular, it was found that phosphate restriction decreased FGF-23, and phosphate loading increased FGF-23. In agriculture, phosphate refers to one of the three primary plant nutrients, and it is a component of fertilizers. In ecological terms, because of its important role in biological systems, phosphate is a highly sought after resource. Consequently, it is often a limiting reagent in environments, and its availability may govern the rate of growth of organisms. Addition of high levels of phosphate to environments and to micro-environments in which it is typically rare can have significant ecological consequences. In the context of pollution, phosphates are a principal component of total dissolved solids, a major indicator of water quality. Dihydrogen phosphate is an inorganic salt used in numerous analytical methods, and in buffer solutions (PMID: 15369738 ). It is one of several forms of the phosphate ion that can exist physiologically. It readily forms salts with sodium or potassium cations.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

View in JSmol View Stereo Labels

Synonyms

Value	Source
[PO(OH)3]	ChEBI
Acide phosphorique	ChEBI
Acidum phosphoricum	ChEBI
H3PO4	ChEBI
Orthophosphoric acid	ChEBI
Phosphorsaeureloesungen	ChEBI
Phosphorsaeure	ChEBI
Phosphoric acid	Kegg
Orthophosphate	Generator
Concise etchant	MeSH
Condact	MeSH
K-Etchant	MeSH
Uni-etch	MeSH
Phosphate	ChEBI
Diphosphate tetrasodium	HMDB
Marphos	HMDB
NFB	HMDB
ortho- Phosphoric acid	HMDB
Phosphoric acid (acd/name 4.0)	HMDB
Sodium pyrophosphate	HMDB
Sodium pyrophosphate decahydrate	HMDB
Sodium pyrophosphate decahydrate biochemica	HMDB
Sonac	HMDB
Tetra-sodium pyrophosphate	HMDB
Tetrasodium pyrophosphate 10-hydrate	HMDB
Tetrasodium pyrophosphate decahydrate	HMDB
White phosphoric acid	HMDB
Hydrogen phosphoric acid	Generator
Dihydrogen phosphate	HMDB
Hydrogen phosphate	HMDB

Chemical Formula

H₃O₄P

Average Molecular Weight

97.9952

Monoisotopic Molecular Weight

97.976895096

IUPAC Name

phosphoric acid

Traditional Name

phosphoric acid

CAS Registry Number

14265-44-2

SMILES

OP(O)(O)=O

InChI Identifier

InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)

InChI Key

NBIIXXVUZAFLBC-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion.

Kingdom

Inorganic compounds

Super Class

Homogeneous non-metal compounds

Class

Non-metal oxoanionic compounds

Sub Class

Non-metal phosphates

Direct Parent

Non-metal phosphates

Alternative Parents

Inorganic oxides

Substituents

Non-metal phosphate
Inorganic oxide

Molecular Framework

Not Available

External Descriptors

phosphoric acids (CHEBI:26078 )

Ontology

Not Available

Not Available

Not Available

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	41.00 to 44.00 °C. @ 760.00 mm Hg	The Good Scents Company Information System
Boiling Point	158.00 °C. @ 760.00 mm Hg	The Good Scents Company Information System
Water Solubility	1000 mg/mL	MERCK INDEX (1996)
LogP	-2.150	The Good Scents Company Information System

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
logP	-1	ChemAxon
pKa (Strongest Acidic)	1.8	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	77.76 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	14.65 m³·mol⁻¹	ChemAxon
Polarizability	5.81 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DeepCCS	[M+H]+	120.046	30932474
DeepCCS	[M-H]-	117.38	30932474
DeepCCS	[M-2H]-	153.717	30932474
DeepCCS	[M+Na]+	128.26	30932474
AllCCS	[M+H]+	117.5	32859911
AllCCS	[M+H-H2O]+	113.2	32859911
AllCCS	[M+NH4]+	121.6	32859911
AllCCS	[M+Na]+	122.7	32859911
AllCCS	[M-H]-	131.7	32859911
AllCCS	[M+Na-2H]-	137.4	32859911
AllCCS	[M+HCOO]-	143.7	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Phosphate	OP(O)(O)=O	2102.0	Standard polar	33892256
Phosphate	OP(O)(O)=O	1058.3	Standard non polar	33892256
Phosphate	OP(O)(O)=O	1059.9	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
Phosphate,1TMS,isomer #1	C[Si](C)(C)OP(=O)(O)O	1173.7	Semi standard non polar	33892256
Phosphate,1TMS,isomer #1	C[Si](C)(C)OP(=O)(O)O	1068.7	Standard non polar	33892256
Phosphate,1TMS,isomer #1	C[Si](C)(C)OP(=O)(O)O	1578.2	Standard polar	33892256
Phosphate,2TMS,isomer #1	C[Si](C)(C)OP(=O)(O)O[Si](C)(C)C	1209.0	Semi standard non polar	33892256
Phosphate,2TMS,isomer #1	C[Si](C)(C)OP(=O)(O)O[Si](C)(C)C	1179.7	Standard non polar	33892256
Phosphate,2TMS,isomer #1	C[Si](C)(C)OP(=O)(O)O[Si](C)(C)C	1343.5	Standard polar	33892256
Phosphate,3TMS,isomer #1	C[Si](C)(C)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C	1254.1	Semi standard non polar	33892256
Phosphate,3TMS,isomer #1	C[Si](C)(C)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C	1301.5	Standard non polar	33892256
Phosphate,3TMS,isomer #1	C[Si](C)(C)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C	1239.3	Standard polar	33892256
Phosphate,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OP(=O)(O)O	1440.0	Semi standard non polar	33892256
Phosphate,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OP(=O)(O)O	1312.0	Standard non polar	33892256
Phosphate,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OP(=O)(O)O	1755.2	Standard polar	33892256
Phosphate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OP(=O)(O)O[Si](C)(C)C(C)(C)C	1664.0	Semi standard non polar	33892256
Phosphate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OP(=O)(O)O[Si](C)(C)C(C)(C)C	1605.0	Standard non polar	33892256
Phosphate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OP(=O)(O)O[Si](C)(C)C(C)(C)C	1630.9	Standard polar	33892256
Phosphate,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	1885.5	Semi standard non polar	33892256
Phosphate,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	1908.7	Standard non polar	33892256
Phosphate,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	1634.3	Standard polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Experimental GC-MS	GC-MS Spectrum - Hydrogen phosphate GC-MS (3 TMS)	splash10-0002-0794000000-6c866e626b9356994d46	2014-06-16	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - Hydrogen phosphate EI-B (Non-derivatized)	splash10-0002-0394000000-3a469377821d88bd699f	2017-09-12	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - Hydrogen phosphate GC-MS (Non-derivatized)	splash10-0002-0794000000-6c866e626b9356994d46	2017-09-12	HMDB team, MONA, MassBank	View Spectrum
Experimental GC-MS	GC-MS Spectrum - Hydrogen phosphate GC-EI-TOF (Non-derivatized)	splash10-000t-0972000000-2ddd7182426dbace5342	2017-09-12	HMDB team, MONA, MassBank	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Hydrogen phosphate GC-MS (Non-derivatized) - 70eV, Positive	splash10-0002-9000000000-1805c2208b5ff15a75b1	2016-09-22	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Hydrogen phosphate GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate Quattro_QQQ 10V, N/A-QTOF (Annotated)	splash10-000t-9000000000-0e85f764ac98e8949759	2012-07-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate Quattro_QQQ 25V, N/A-QTOF (Annotated)	splash10-001i-9000000000-869a362083996a0cec77	2012-07-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate Quattro_QQQ 40V, N/A-QTOF (Annotated)	splash10-03di-9000000000-801101cccfd6c25271d4	2012-07-25	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 10V, positive-QTOF	splash10-0002-9000000000-6f386712e664a4b37a0f	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 20V, positive-QTOF	splash10-0002-9000000000-94c04c712e24776fb333	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 40V, positive-QTOF	splash10-0002-9000000000-9cc1283f5af78eb26124	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate LC-ESI-QFT , negative-QTOF	splash10-0002-9000000000-c1da993c0996e8d60830	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 35V, negative-QTOF	splash10-002b-9000000000-ccb36e7b3439fcc25313	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 10V, negative-QTOF	splash10-004i-9000000000-e618cbd5a94aa5860a29	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 20V, negative-QTOF	splash10-004i-9000000000-b7f0efd9272b1a27eac4	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 40V, negative-QTOF	splash10-004i-9000000000-8cadeed88c84e8c2b6c2	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate n/a 6V, negative-QTOF	splash10-014i-9000000000-093cd2a2a662118d8432	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate n/a 6V, negative-QTOF	splash10-004i-9000000000-46d4cee1b5ac630ba9b8	2020-07-21	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate QqQ 1V, negative-QTOF	splash10-0006-0090000000-40333890e636692e7970	2020-07-22	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate QqQ 2V, negative-QTOF	splash10-0006-0190000000-52fa21c93ab4c97f8df2	2020-07-22	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate QqQ 3V, negative-QTOF	splash10-0006-0490000000-32e316211facaa3d3bb2	2020-07-22	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate QqQ 4V, negative-QTOF	splash10-0005-0960000000-bd7aaa47a8ffd82012d3	2020-07-22	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate QqQ 5V, negative-QTOF	splash10-0002-0920000000-463d7b1bf72bcc10126f	2020-07-22	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Phosphate QqQ 6V, negative-QTOF	splash10-0002-0910000000-3c9c666ac95b68e43224	2020-07-22	HMDB team, MONA	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phosphate 10V, Positive-QTOF	splash10-0002-9000000000-12a5e23d24cd494e99c1	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phosphate 20V, Positive-QTOF	splash10-0002-9000000000-91e06ca38117aabdb14c	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phosphate 40V, Positive-QTOF	splash10-000t-9000000000-19b1c041aa5e2adcc3e6	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phosphate 10V, Negative-QTOF	splash10-0002-9000000000-e56eecd6724dfbf74160	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phosphate 20V, Negative-QTOF	splash10-004i-9000000000-0a46ba32971030356ac5	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phosphate 40V, Negative-QTOF	splash10-004i-9000000000-3a53d27e23b39429d092	2016-09-14	Wishart Lab	View Spectrum

IR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)	2023-02-03	FELIX lab	View Spectrum
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)	2023-02-03	FELIX lab	View Spectrum
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)	2023-02-03	FELIX lab	View Spectrum

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Mitochondria
Nucleus
Lysosome
Endoplasmic reticulum
Golgi apparatus
Peroxisome

Biospecimen Locations

Blood
Feces
Saliva
Sweat
Urine

Tissue Locations

Kidney
Liver
Placenta
Prostate

Pathways

Name	SMPDB/PathBank	KEGG
Alanine, aspartate and glutamate metabolism	Not Available
Primary Hyperoxaluria Type I		Not Available
Pyruvate Carboxylase Deficiency		Not Available
Lactic Acidemia		Not Available
Aspartate Metabolism

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	379.1 +/- 31.6 uM	Adult (>18 years old)	Male	Normal	3654974	details
Blood	Detected and Quantified	820.4 uM	Adult (>18 years old)	Both	Normal	21359215	details
Blood	Detected and Quantified	1400-2200 uM	Not Specified	Not Specified	Normal	23430506	details
Blood	Detected and Quantified	589.65-1105.60 uM	Newborn (0 - <14 days old)	Both	Normal	CALIPER Paediatri...	details
Blood	Detected and Quantified	505.42-884.45 uM	Infant (15 days - <1 year old)	Both	Normal	CALIPER Paediatri...	details
Blood	Detected and Quantified	452.77-716.01 uM	Children (1 - <5 years old)	Both	Normal	CALIPER Paediatri...	details
Blood	Detected and Quantified	431.71-621.24 uM	Children (5 - <13 years old)	Both	Normal	CALIPER Paediatri...	details
Blood	Detected and Quantified	336.94-579.12 uM	Adolescent (13 - <16 years old)	Female	Normal	CALIPER Paediatri...	details
Blood	Detected and Quantified	305.36-526.47 uM	Adolescent (16 - <19 years old)	Both	Normal	CALIPER Paediatri...	details
Blood	Detected and Quantified	368.53-652.83 uM	Adolescent (13 - <16 years old)	Male	Normal	CALIPER Paediatri...	details
Blood	Detected and Quantified	1100 +/- 190 uM	Adult (>18 years old)	Both	Normal	2301398	details
Blood	Detected and Quantified	1200-1960 uM	Infant (0-1 year old)	Not Specified	Normal	2001103	details
Blood	Detected and Quantified	400.120-684.417 uM	Children (1-13 years old)	Not Specified	Normal	23322328	details
Blood	Detected and Quantified	1100.0 (810.0-1450.0) uM	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details
Blood	Detected and Quantified	1200-2000 uM	Infant (0-1 year old)	Not Specified	Normal	2017228	details
Blood	Detected and Quantified	1000-2200 uM	Children (1-13 years old)	Not Specified	Normal	2017228	details
Feces	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	20669995	details
Feces	Detected but not Quantified	Not Quantified	Infant (0-1 year old)	Both	Normal	22411374	details
Feces	Detected but not Quantified	Not Quantified	Infant (0-1 year old)	Not Specified	Normal	24628373	details
Feces	Detected but not Quantified	Not Quantified	Infant (0-1 year old)	Not Specified	Normal	24628373	details
Feces	Detected but not Quantified	Not Quantified	Infant (0-1 year old)	Not Available	Normal	24628373	details
Feces	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	22944170	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	27543620	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	25037050	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	29808030	details
Saliva	Detected and Quantified	27850 +/- 36040 uM	Adult (>18 years old)	Both	Normal	24246267	details
Saliva	Detected and Quantified	28550 +/- 33790 uM	Adult (>18 years old)	Both	Normal	24246267	details
Saliva	Detected and Quantified	21450 +/- 21020 uM	Adult (>18 years old)	Both	Normal	24246267	details
Saliva	Detected and Quantified	17620 +/- 13800 uM	Adult (>18 years old)	Both	Normal	24246267	details
Saliva	Detected and Quantified	21630 +/- 15830 uM	Adult (>18 years old)	Both	Normal	24246267	details
Saliva	Detected and Quantified	24100 +/- 16390 uM	Adult (>18 years old)	Both	Normal	24246267	details
Saliva	Detected and Quantified	22690 +/- 19270 uM	Adult (>18 years old)	Both	Normal	24246267	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Normal	22308371	details
Saliva	Detected and Quantified	2787.81 +/- 1528.51 uM	Adult (>18 years old)	Both	Normal	Zerihun T. Dame, ...	details
Sweat	Detected but not Quantified	Not Quantified	Adult	Both	Normal	26755145	details
Urine	Detected and Quantified	784 (425-1170) umol/mmol creatinine	Adult (>18 years old)	Both	Normal	24023812	details
Urine	Detected and Quantified	1000-4900 umol/mmol creatinine	Adult (>18 years old)	Both	Normal	Great Plains Labo...	details
Urine	Detected and Quantified	1364.27 +/- 915.27 umol/mmol creatinine	Infant (0-1 year old)	Both	Normal	2026685	details
Urine	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	28157703	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	450 +/- 30 uM	Adult (>18 years old)	Not Specified	Hypophosphatemia	16932412	details
Blood	Detected and Quantified	290 +/- 50 uM	Adult (>18 years old)	Not Specified	Hypophosphatemia	16932412	details
Blood	Detected and Quantified	2800 uM	Infant (0-1 year old)	Female	Pyroglutamic aciduria	23430506	details
Blood	Detected and Quantified	653.0 +/- 126.0 uM	Adult (>18 years old)	Both	Hemodialysis	18085392	details
Blood	Detected and Quantified	2700-4700 uM	Infant (0-1 year old)	Both	Hypoparathyroidism-retardation-dysmorphism syndrome	2001103	details
Blood	Detected and Quantified	1300 +/- 170 uM	Adult (>18 years old)	Both	Hypophosphatasia, infantile	2301398	details
Blood	Detected and Quantified	126.354 uM	Adult (>18 years old)	Female	Fanconi syndrome	1982686	details
Blood	Detected and Quantified	315.885 uM	Children (1-13 years old)	Female	Hyperphosphatasia	23322328	details
Blood	Detected and Quantified	270 (0-540) uM	Adult (>18 years old)	Not Specified	Hypophosphatemia	16932412	details
Blood	Detected and Quantified	610 +/- 130 uM	Adult (>18 years old)	Not Specified	Hypophosphatemia	16932412	details
Blood	Detected and Quantified	1700-2000 uM	Infant (0-1 year old)	Not Specified	Oculocerebrorenal Syndrome of Lowe	2017228	details
Blood	Detected and Quantified	900-2000 uM	Children (1-13 years old)	Not Specified	Oculocerebrorenal Syndrome of Lowe	2017228	details
Blood	Detected and Quantified	800-1400 uM	Adolescent (13-18 years old)	Not Specified	Oculocerebrorenal Syndrome of Lowe	2017228	details
Blood	Detected and Quantified	1000-1300 uM	Adult (>18 years old)	Not Specified	Oculocerebrorenal Syndrome of Lowe	2017228	details
Blood	Detected and Quantified	231.649 uM	Adult (>18 years old)	Male	Bartter Syndrome, Type 4A, Neonatal, with Sensorineural Deafness	26537508	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Colorectal cancer	27015276	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Colorectal cancer	25037050	details
Feces	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Cryptosporidium infection	22944170	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Colorectal Cancer	27275383	details
Saliva	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Male	Supragingival Plaque	31026179	details
Urine	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Bladder cancer	28157703	details

Associated Disorders and Diseases

Disease References

Hemodialysis
Oikawa O, Higuchi T, Yamazaki T, Yamamoto C, Fukuda N, Matsumoto K: Evaluation of serum fetuin-A relationships with biochemical parameters in patients on hemodialysis. Clin Exp Nephrol. 2007 Dec;11(4):304-8. Epub 2007 Dec 21. [PubMed:18085392 ]
Hypophosphatemia
Amanzadeh J, Reilly RF Jr: Hypophosphatemia: an evidence-based approach to its clinical consequences and management. Nat Clin Pract Nephrol. 2006 Mar;2(3):136-48. [PubMed:16932412 ]
Bartter Syndrome, Type 4A, Neonatal, with Sensorineural Deafness
Heilberg IP, Totoli C, Calado JT: Adult presentation of Bartter syndrome type IV with erythrocytosis. Einstein (Sao Paulo). 2015 Oct-Dec;13(4):604-6. doi: 10.1590/S1679-45082015RC3013. Epub 2015 Oct 30. [PubMed:26537508 ]
Fanconi syndrome
Cheng HM, Jap TS, Ho LT: Fanconi syndrome: report of a case. J Formos Med Assoc. 1990 Dec;89(12):1115-7. [PubMed:1982686 ]
Hyperphosphatasia
Saki F, Karamizadeh Z, Nasirabadi S, Mumm S, McAlister WH, Whyte MP: Juvenile paget's disease in an Iranian kindred with vitamin D deficiency and novel homozygous TNFRSF11B mutation. J Bone Miner Res. 2013 Jun;28(6):1501-8. doi: 10.1002/jbmr.1868. [PubMed:23322328 ]
Hypoparathyroidism-retardation-dysmorphism syndrome
Sanjad SA, Sakati NA, Abu-Osba YK, Kaddoura R, Milner RD: A new syndrome of congenital hypoparathyroidism, severe growth failure, and dysmorphic features. Arch Dis Child. 1991 Feb;66(2):193-6. [PubMed:2001103 ]
Hypophosphatasia
Chodirker BN, Evans JA, Seargeant LE, Cheang MS, Greenberg CR: Hyperphosphatemia in infantile hypophosphatasia: implications for carrier diagnosis and screening. Am J Hum Genet. 1990 Feb;46(2):280-5. [PubMed:2301398 ]
Oculocerebrorenal syndrome
Charnas LR, Bernardini I, Rader D, Hoeg JM, Gahl WA: Clinical and laboratory findings in the oculocerebrorenal syndrome of Lowe, with special reference to growth and renal function. N Engl J Med. 1991 May 9;324(19):1318-25. doi: 10.1056/NEJM199105093241904. [PubMed:2017228 ]
Colorectal cancer
Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. [PubMed:27275383 ] Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ] Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
Supragingival Plaque
Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26. [PubMed:31026179 ]

Associated OMIM IDs

602522 (Bartter Syndrome, Type 4A, Neonatal, with Sensorineural Deafness)
239000 (Hyperphosphatasia)
241410 (Hypoparathyroidism-retardation-dysmorphism syndrome)
241500 (Hypophosphatasia)
309000 (Oculocerebrorenal syndrome)
114500 (Colorectal cancer)

External Links

DrugBank ID

DB09394

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Phosphoric_Acid

METLIN ID

Not Available

PubChem Compound

1004

PDB ID

Not Available

ChEBI ID

26078

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

MDB00013437

Good Scents ID

rw1033561

References

Synthesis Reference

Cremer, Josef; Hartmann, Fridolin; Rodis, Franz; Hinz, Arnulf. Preparation of alkali or alkaline earth phosphates with simultaneous recovery of volatile mineral acids. Ger. (1966), 2 pp. CODEN: GWXXAW DE 1227435 19661027 CAN 66:12584 AN 1967:12584

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
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Hem SL, Hogenesch H: Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. Expert Rev Vaccines. 2007 Oct;6(5):685-98. [PubMed:17931150 ]
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Keul P, Sattler K, Levkau B: HDL and its sphingosine-1-phosphate content in cardioprotection. Heart Fail Rev. 2007 Dec;12(3-4):301-6. [PubMed:17554629 ]
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Tiwari S, Riazi S, Ecelbarger CA: Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes. Am J Physiol Renal Physiol. 2007 Oct;293(4):F974-84. Epub 2007 Aug 8. [PubMed:17686957 ]
Argraves KM, Argraves WS: HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects. J Lipid Res. 2007 Nov;48(11):2325-33. Epub 2007 Aug 13. [PubMed:17698855 ]
Brown BA, Kantesaria PP, McDevitt LM: Fingolimod: a novel immunosuppressant for multiple sclerosis. Ann Pharmacother. 2007 Oct;41(10):1660-8. Epub 2007 Sep 4. [PubMed:17785617 ]
Toussaint ND, Kerr PG: Vascular calcification and arterial stiffness in chronic kidney disease: implications and management. Nephrology (Carlton). 2007 Oct;12(5):500-9. [PubMed:17803475 ]
Munteanu A, Zingg JM: Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention. Mol Aspects Med. 2007 Oct-Dec;28(5-6):538-90. Epub 2007 Aug 3. [PubMed:17825403 ]
Nauseef WM: How human neutrophils kill and degrade microbes: an integrated view. Immunol Rev. 2007 Oct;219:88-102. [PubMed:17850484 ]
Allen LA, McCaffrey RL: To activate or not to activate: distinct strategies used by Helicobacter pylori and Francisella tularensis to modulate the NADPH oxidase and survive in human neutrophils. Immunol Rev. 2007 Oct;219:103-17. [PubMed:17850485 ]
Giavazzi R, Bani MR, Taraboletti G: Tumor-host interaction in the optimization of paclitaxel-based combination therapies with vascular targeting compounds. Cancer Metastasis Rev. 2007 Dec;26(3-4):481-8. [PubMed:17896168 ]
Tonelli M, Wiebe N, Culleton B, Lee H, Klarenbach S, Shrive F, Manns B: Systematic review of the clinical efficacy and safety of sevelamer in dialysis patients. Nephrol Dial Transplant. 2007 Oct;22(10):2856-66. [PubMed:17906326 ]
Miyamoto K, Tatsumi S, Ito M, Segawa H: [New aspect of renal phosphate reabsorption and phosphate metabolism]. Clin Calcium. 2007 Oct;17(10):1485-92. [PubMed:17906398 ]
Michigami T: [Vitamin D metabolism and action]. Clin Calcium. 2007 Oct;17(10):1493-8. [PubMed:17906399 ]
Hoshi K: [Mechanisms of bone calcification]. Clin Calcium. 2007 Oct;17(10):1499-507. [PubMed:17906400 ]
Takeuchi Y: [Pathophysiology in rickets/osteomalacia]. Clin Calcium. 2007 Oct;17(10):1508-13. [PubMed:17906401 ]
Ito N, Fukumoto S: [FGF23-related hypophosphatemic rickets/osteomalacia]. Clin Calcium. 2007 Oct;17(10):1514-20. [PubMed:17906402 ]
Sekine T: [Rickets/osteomalacia due to tubular dysfunction]. Clin Calcium. 2007 Oct;17(10):1529-33. [PubMed:17906404 ]
Sato K: [Drug-induced osteomalacia]. Clin Calcium. 2007 Oct;17(10):1536-42. [PubMed:17906405 ]
Hasegawa Y, Miyamoto J: [Hypophosphatemic rickets/osteomalacia. - Mainly on patients with PHEX mutations -]. Clin Calcium. 2007 Oct;17(10):1592-9. [PubMed:17906414 ]
Bragadeesh TK, Mathur G, Clark AL, Cleland JG: Novel cardiac myosin activators for acute heart failure. Expert Opin Investig Drugs. 2007 Oct;16(10):1541-8. [PubMed:17922619 ]
Worthington HV, Clarkson JE, Eden OB: Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD000978. [PubMed:17943748 ]
Nixon GF, Mathieson FA, Hunter I: The potential roles of sphingolipids in vascular smooth-muscle function. Biochem Soc Trans. 2007 Nov;35(Pt 5):908-9. [PubMed:17956243 ]
Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ: Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells. Biochem Soc Trans. 2007 Nov;35(Pt 5):1208-10. [PubMed:17956314 ]
Ku NO, Strnad P, Zhong BH, Tao GZ, Omary MB: Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies. Hepatology. 2007 Nov;46(5):1639-49. [PubMed:17969036 ]
Beutler E, Duparc S: Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development. Am J Trop Med Hyg. 2007 Oct;77(4):779-89. [PubMed:17978087 ]
Van Brocklyn JR: Sphingolipid signaling pathways as potential therapeutic targets in gliomas. Mini Rev Med Chem. 2007 Oct;7(10):984-90. [PubMed:17979800 ]
Raben DM, Tu-Sekine B: Nuclear diacylglycerol kinases: regulation and roles. Front Biosci. 2008 Jan 1;13:590-7. [PubMed:17981572 ]
Dubin A, Estenssoro E: Mechanisms of tissue hypercarbia in sepsis. Front Biosci. 2008 Jan 1;13:1340-51. [PubMed:17981634 ]
Deng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J, Bennett E, Reid R, Manning D, Xue A, Montag AG, Luu HH, Haydon RC, He TC: Regulation of osteogenic differentiation during skeletal development. Front Biosci. 2008 Jan 1;13:2001-21. [PubMed:17981687 ]
Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW, Hannun YA, Holman DH, Rubinchik S, Szulc Z, Keane TE, Tavassoli M, Norris JS: Acid ceramidase inhibition: a novel target for cancer therapy. Front Biosci. 2008 Jan 1;13:2293-8. [PubMed:17981711 ]
Su N, Du X, Chen L: FGF signaling: its role in bone development and human skeleton diseases. Front Biosci. 2008 Jan 1;13:2842-65. [PubMed:17981758 ]
Trimble JL, Kockler DR: Statin treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Ann Pharmacother. 2007 Dec;41(12):2019-23. Epub 2007 Nov 6. [PubMed:17986515 ]
Zeitels SM, Burns JA: Office-based laryngeal laser surgery with the 532-nm pulsed-potassium-titanyl-phosphate laser. Curr Opin Otolaryngol Head Neck Surg. 2007 Dec;15(6):394-400. [PubMed:17986877 ]
Pebay A, Bonder CS, Pitson SM: Stem cell regulation by lysophospholipids. Prostaglandins Other Lipid Mediat. 2007 Nov;84(3-4):83-97. Epub 2007 Sep 5. [PubMed:17991611 ]
Komarova YA, Mehta D, Malik AB: Dual regulation of endothelial junctional permeability. Sci STKE. 2007 Nov 13;2007(412):re8. [PubMed:18000237 ]
Burger EL, Patel V: Calcium phosphates as bone graft extenders. Orthopedics. 2007 Nov;30(11):939-42. [PubMed:18019987 ]
Qin C, D'Souza R, Feng JQ: Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis. J Dent Res. 2007 Dec;86(12):1134-41. [PubMed:18037646 ]
Andress DL: Bone and mineral guidelines for patients with chronic kidney disease: a call for revision. Clin J Am Soc Nephrol. 2008 Jan;3(1):179-83. Epub 2007 Dec 5. [PubMed:18057310 ]
Fukumoto S: [Parathyroid and bone. Calcimimetics and bone metabolism]. Clin Calcium. 2007 Dec;17(12):1865-9. [PubMed:18057662 ]
Fei X, Qin Z, Liang Z: Contribution of CDP/Cux, a transcription factor, to cell cycle progression. Acta Biochim Biophys Sin (Shanghai). 2007 Dec;39(12):923-30. [PubMed:18064384 ]
Bonomini F, Tengattini S, Fabiano A, Bianchi R, Rezzani R: Atherosclerosis and oxidative stress. Histol Histopathol. 2008 Mar;23(3):381-90. doi: 10.14670/HH-23.381. [PubMed:18072094 ]
Orcel P, Chapurlat R: [Fibrous dysplasia of bone]. Rev Prat. 2007 Oct 31;57(16):1749-55. [PubMed:18092715 ]
Damron TA: Use of 3D beta-tricalcium phosphate (Vitoss) scaffolds in repairing bone defects. Nanomedicine (Lond). 2007 Dec;2(6):763-75. [PubMed:18095844 ]
Hertz A, Bruce IJ: Inorganic materials for bone repair or replacement applications. Nanomedicine (Lond). 2007 Dec;2(6):899-918. [PubMed:18095853 ]
Cappellini MD, Fiorelli G: Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008 Jan 5;371(9606):64-74. doi: 10.1016/S0140-6736(08)60073-2. [PubMed:18177777 ]
Faiman C, Moorhouse JA: Diurnal variation in the levels of glucose and related substances in healthy and diabetic subjects during starvation. Clin Sci. 1967 Feb;32(1):111-26. [PubMed:5336272 ]
Virkki LV, Biber J, Murer H, Forster IC: Phosphate transporters: a tale of two solute carrier families. Am J Physiol Renal Physiol. 2007 Sep;293(3):F643-54. Epub 2007 Jun 20. [PubMed:17581921 ]
Pohlmeier R, Vienken J: Phosphate removal and hemodialysis conditions. Kidney Int Suppl. 2001 Feb;78:S190-4. [PubMed:11169009 ]
Gallar P, Ortega O, Gutierrez M, Munoz M, Hilara L, Oliet A, Rodriguez I, Gimenez E, Vigil A: [Influencing factors in the control of phosphorus in peritoneal dialysis. Therapeutic options]. Nefrologia. 2000 Jul-Aug;20(4):355-61. [PubMed:11039261 ]
Cruz DN, Perazella MA: Biochemical aberrations in a dialysis patient following parathyroidectomy. Am J Kidney Dis. 1997 May;29(5):759-62. [PubMed:9159312 ]
Nemere I: The ins and outs of phosphate homeostasis. Kidney Int. 2007 Jul;72(2):140-2. [PubMed:17625581 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Only showing the first 10 proteins. There are 789 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. 5'-nucleotidase

General function:: Involved in hydrolase activity
Specific function:: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Gene Name:: NT5E
Uniprot ID:: P21589
Molecular weight:: 57948.125

Reactions

A 5'-ribonucleotide + Water → a ribonucleoside + Phosphate	details
Adenosine monophosphate + Water → Adenosine + Phosphate	details
Cytidine monophosphate + Water → Cytidine + Phosphate	details
Uridine 5'-monophosphate + Water → Uridine + Phosphate	details
Inosinic acid + Water → Inosine + Phosphate	details
Guanosine monophosphate + Water → Guanosine + Phosphate	details
5-Thymidylic acid + Water → Thymidine + Phosphate	details
dCMP + Water → Deoxycytidine + Phosphate	details
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphate	details
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphate	details
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphate	details
Xanthylic acid + Water → Xanthosine + Phosphate	details
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphate	details

Enzyme Details

2. Cytosolic 5'-nucleotidase 1B

General function:: Involved in nucleotide binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:: NT5C1B
Uniprot ID:: Q96P26
Molecular weight:: 68803.055

Reactions

A 5'-ribonucleotide + Water → a ribonucleoside + Phosphate	details
Adenosine monophosphate + Water → Adenosine + Phosphate	details
Cytidine monophosphate + Water → Cytidine + Phosphate	details
Uridine 5'-monophosphate + Water → Uridine + Phosphate	details
Inosinic acid + Water → Inosine + Phosphate	details
Guanosine monophosphate + Water → Guanosine + Phosphate	details
5-Thymidylic acid + Water → Thymidine + Phosphate	details
dCMP + Water → Deoxycytidine + Phosphate	details
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphate	details
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphate	details
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphate	details
Xanthylic acid + Water → Xanthosine + Phosphate	details
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphate	details

Enzyme Details

3. Cytosolic 5'-nucleotidase 1A

General function:: Involved in nucleotide binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:: NT5C1A
Uniprot ID:: Q9BXI3
Molecular weight:: 41020.145

Reactions

A 5'-ribonucleotide + Water → a ribonucleoside + Phosphate	details
Adenosine monophosphate + Water → Adenosine + Phosphate	details
Cytidine monophosphate + Water → Cytidine + Phosphate	details
Uridine 5'-monophosphate + Water → Uridine + Phosphate	details
Inosinic acid + Water → Inosine + Phosphate	details
Guanosine monophosphate + Water → Guanosine + Phosphate	details
5-Thymidylic acid + Water → Thymidine + Phosphate	details
dCMP + Water → Deoxycytidine + Phosphate	details
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphate	details
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphate	details
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphate	details
Xanthylic acid + Water → Xanthosine + Phosphate	details
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphate	details

Enzyme Details

4. 5'(3')-deoxyribonucleotidase, cytosolic type

General function:: Involved in metal ion binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:: NT5C
Uniprot ID:: Q8TCD5
Molecular weight:: Not Available

Reactions

Adenosine monophosphate + Water → Adenosine + Phosphate	details
Cytidine monophosphate + Water → Cytidine + Phosphate	details
Uridine 5'-monophosphate + Water → Uridine + Phosphate	details
Inosinic acid + Water → Inosine + Phosphate	details
Guanosine monophosphate + Water → Guanosine + Phosphate	details
5-Thymidylic acid + Water → Thymidine + Phosphate	details
dCMP + Water → Deoxycytidine + Phosphate	details
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphate	details
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphate	details
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphate	details
Xanthylic acid + Water → Xanthosine + Phosphate	details
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphate	details

Enzyme Details

5. 5'(3')-deoxyribonucleotidase, mitochondrial

General function:: Involved in phosphatase activity
Specific function:: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:: NT5M
Uniprot ID:: Q9NPB1
Molecular weight:: Not Available

Reactions

Adenosine monophosphate + Water → Adenosine + Phosphate	details
Cytidine monophosphate + Water → Cytidine + Phosphate	details
Uridine 5'-monophosphate + Water → Uridine + Phosphate	details
Inosinic acid + Water → Inosine + Phosphate	details
Guanosine monophosphate + Water → Guanosine + Phosphate	details
5-Thymidylic acid + Water → Thymidine + Phosphate	details
dCMP + Water → Deoxycytidine + Phosphate	details
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphate	details
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphate	details
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphate	details
Xanthylic acid + Water → Xanthosine + Phosphate	details
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphate	details

Enzyme Details

6. ATP-citrate synthase

General function:: Involved in ATP citrate synthase activity
Specific function:: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Gene Name:: ACLY
Uniprot ID:: P53396
Molecular weight:: 120838.27

Reactions

ADP + Phosphate + Acetyl-CoA + Oxalacetic acid → Adenosine triphosphate + Citric acid + Coenzyme A	details
Adenosine triphosphate + Citric acid + Coenzyme A → ADP + Phosphate + Acetyl-CoA + Oxalacetic acid	details

Enzyme Details

7. Acetyl-CoA carboxylase 2

General function:: Involved in acetyl-CoA carboxylase activity
Specific function:: ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:: ACACB
Uniprot ID:: O00763
Molecular weight:: 276538.575

Reactions

Adenosine triphosphate + Acetyl-CoA + Hydrogen carbonate → ADP + Phosphate + Malonyl-CoA	details
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphate + carboxy-biotin-[carboxyl-carrier-protein]	details
Adenosine triphosphate + Holo-[carboxylase] + Hydrogen carbonate → ADP + Phosphate + Carboxybiotin-carboxyl-carrier protein	details

Enzyme Details

8. Pyruvate carboxylase, mitochondrial

General function:: Involved in catalytic activity
Specific function:: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Gene Name:: PC
Uniprot ID:: P11498
Molecular weight:: 129632.565

Reactions

Adenosine triphosphate + Pyruvic acid + Hydrogen carbonate → ADP + Phosphate + Oxalacetic acid	details

Enzyme Details

9. Acetyl-coenzyme A synthetase 2-like, mitochondrial

General function:: Involved in acetate-CoA ligase activity
Specific function:: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Gene Name:: ACSS1
Uniprot ID:: Q9NUB1
Molecular weight:: 74625.88

Enzyme Details

10. Acetyl-CoA carboxylase 1

General function:: Involved in acetyl-CoA carboxylase activity
Specific function:: Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:: ACACA
Uniprot ID:: Q13085
Molecular weight:: 269997.01

Reactions

Adenosine triphosphate + Acetyl-CoA + Hydrogen carbonate → ADP + Phosphate + Malonyl-CoA	details
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphate + carboxy-biotin-[carboxyl-carrier-protein]	details
Adenosine triphosphate + Holo-[carboxylase] + Hydrogen carbonate → ADP + Phosphate + Carboxybiotin-carboxyl-carrier protein	details

Transporters

Enzyme Details

1. Copper-transporting ATPase 2

General function:: Involved in ATP binding
Specific function:: Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Gene Name:: ATP7B
Uniprot ID:: P35670
Molecular weight:: 157261.34

Enzyme Details

2. Copper-transporting ATPase 1

General function:: Involved in ATP binding
Specific function:: May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Gene Name:: ATP7A
Uniprot ID:: Q04656
Molecular weight:: 163372.275

Only showing the first 10 proteins. There are 789 proteins in total.

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Showing metabocard for Phosphate (HMDB0001429)

MOL for HMDB0001429 (Phosphate)

3D MOL for HMDB0001429 (Phosphate)

3D SDF for HMDB0001429 (Phosphate)

3D-SDF for HMDB0001429 (Phosphate)

PDB for HMDB0001429 (Phosphate)

3D PDB for HMDB0001429 (Phosphate)

SMILES for HMDB0001429 (Phosphate)

INCHI for HMDB0001429 (Phosphate)

Structure for HMDB0001429 (Phosphate)

3D Structure for HMDB0001429 (Phosphate)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

IR Spectra

Enzymes

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Transporters