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Showing metabocard for Water (HMDB0002111)

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IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesenzymes (1157)transporters (2) Show 1159 proteinsXML
enzymes (1157)transporters (2) Show 1159 proteins
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-05-22 14:17:36 UTC
Update Date2023-02-21 17:16:10 UTC
HMDB IDHMDB0002111
Secondary Accession Numbers
  • HMDB02111
Metabolite Identification
Common NameWater
DescriptionWater is a chemical substance that is essential to all known forms of life. It appears colorless to the naked eye in small quantities, though it is actually slightly blue in color. It covers 71% of Earth's surface. Current estimates suggest that there are 1.4 billion cubic kilometers (330 million m3) of it available on Earth, and it exists in many forms. It appears mostly in the oceans (saltwater) and polar ice caps, but it is also present as clouds, rain water, rivers, freshwater aquifers, lakes, and sea ice. Water in these bodies perpetually moves through a cycle of evaporation, precipitation, and runoff to the sea. Clean water is essential to human life. In many parts of the world, it is in short supply. From a biological standpoint, water has many distinct properties that are critical for the proliferation of life that set it apart from other substances. It carries out this role by allowing organic compounds to react in ways that ultimately allow replication. All known forms of life depend on water. Water is vital both as a solvent in which many of the body's solutes dissolve and as an essential part of many metabolic processes within the body. Metabolism is the sum total of anabolism and catabolism. In anabolism, water is removed from molecules (through energy requiring enzymatic chemical reactions) in order to grow larger molecules (e.g. starches, triglycerides and proteins for storage of fuels and information). In catabolism, water is used to break bonds in order to generate smaller molecules (e.g. glucose, fatty acids and amino acids to be used for fuels for energy use or other purposes). Water is thus essential and central to these metabolic processes. Water is also central to photosynthesis and respiration. Photosynthetic cells use the sun's energy to split off water's hydrogen from oxygen. Hydrogen is combined with CO2 (absorbed from air or water) to form glucose and release oxygen. All living cells use such fuels and oxidize the hydrogen and carbon to capture the sun's energy and reform water and CO2 in the process (cellular respiration). Water is also central to acid-base neutrality and enzyme function. An acid, a hydrogen ion (H+, that is, a proton) donor, can be neutralized by a base, a proton acceptor such as hydroxide ion (OH-) to form water. Water is considered to be neutral, with a pH (the negative log of the hydrogen ion concentration) of 7. Acids have pH values less than 7 while bases have values greater than 7. Stomach acid (HCl) is useful to digestion. However, its corrosive effect on the esophagus during reflux can temporarily be neutralized by ingestion of a base such as aluminum hydroxide to produce the neutral molecules water and the salt aluminum chloride. Human biochemistry that involves enzymes usually performs optimally around a biologically neutral pH of 7.4. (Wikipedia ).
Structure
Data?1676999770
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0002111 (Water)


  Mrv1652309042000262D          

  1  0  0  0  0  0            999 V2000
   25.6983  -15.0132    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
M  END
Download

3D MOL for HMDB0002111 (Water)

HMDB0002111
     RDKit          3D
Water
  3  2  0  0  0  0  0  0  0  0999 V2000
   -0.0004    0.3717   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8185   -0.1860   -0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8188   -0.1857    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  1  3  1  0
M  END
Download

3D SDF for HMDB0002111 (Water)


  Mrv1652309042000262D          

  1  0  0  0  0  0            999 V2000
   25.6983  -15.0132    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0002111

> <DATABASE_NAME>
hmdb

> <SMILES>
O

> <INCHI_IDENTIFIER>
InChI=1S/H2O/h1H2

> <INCHI_KEY>
XLYOFNOQVPJJNP-UHFFFAOYSA-N

> <FORMULA>
H2O

> <MOLECULAR_WEIGHT>
18.0153

> <EXACT_MASS>
18.010564686

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
3

> <JCHEM_AVERAGE_POLARIZABILITY>
1.5082203897359623

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
water

> <JCHEM_LOGP>
-0.6519999999999999

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
15.7

> <JCHEM_PKA_STRONGEST_BASIC>
-1.7999999999999998

> <JCHEM_POLAR_SURFACE_AREA>
25.3

> <JCHEM_REFRACTIVITY>
3.7

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
water

> <JCHEM_VEBER_RULE>
1

$$$$
Download

3D-SDF for HMDB0002111 (Water)

HMDB0002111
     RDKit          3D
Water
  3  2  0  0  0  0  0  0  0  0999 V2000
   -0.0004    0.3717   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8185   -0.1860   -0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8188   -0.1857    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  1  3  1  0
M  END
Download

PDB for HMDB0002111 (Water)

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  O   UNK     0      47.970 -28.025   0.000  0.00  0.00           O+0
MASTER        0    0    0    0    0    0    0    0    1    0    0    0
END
Download

3D PDB for HMDB0002111 (Water)

COMPND    HMDB0002111
HETATM    1  O1  UNL     1      -0.000   0.372  -0.000  1.00  0.00           O  
HETATM    2  H1  UNL     1      -0.818  -0.186  -0.000  1.00  0.00           H  
HETATM    3  H2  UNL     1       0.819  -0.186   0.000  1.00  0.00           H  
CONECT    1    2    3
END
Download

SMILES for HMDB0002111 (Water)

O
Download

INCHI for HMDB0002111 (Water)

InChI=1S/H2O/h1H2
Download
View in JSmolView Stereo Labels
Synonyms
ValueSource
[OH2]ChEBI
AcquaChEBI
AguaChEBI
AquaChEBI
BOUND waterChEBI
DihydridooxygenChEBI
Dihydrogen oxideChEBI
eauChEBI
H2OChEBI
HOHChEBI
Hydrogen hydroxideChEBI
WasserChEBI
Purified waterKegg
Purified water in containersKegg
Water, purifiedKegg
Sterile purified water in containersKegg
Water for injectionKegg
Water for injection in containersKegg
Sterile waterKegg
SteamHMDB
Hydrogen oxideHMDB
Chemical FormulaH2O
Average Molecular Weight18.0153
Monoisotopic Molecular Weight18.010564686
IUPAC Namewater
Traditional Namewater
CAS Registry Number7732-18-5
SMILES
O
InChI Identifier
InChI=1S/H2O/h1H2
InChI KeyXLYOFNOQVPJJNP-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous other non-metal compounds
Sub ClassNot Available
Direct ParentHomogeneous other non-metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous other non metal
Molecular FrameworkNot Available
External Descriptors
Ontology
Not AvailableNot Available
Physical Properties
StateLiquid
Experimental Molecular Properties
PropertyValueReference
Melting Point0 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility55.5 mol/LNot Available
LogP-1.38HANSCH,C ET AL. (1995)
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP-0.65ChemAxon
pKa (Strongest Acidic)15.7ChemAxon
pKa (Strongest Basic)-1.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area25.3 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity3.7 m³·mol⁻¹ChemAxon
Polarizability1.51 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
WaterO728.1Standard polar33892256
WaterO246.8Standard non polar33892256
WaterO71.4Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Water GC-MS (Non-derivatized) - 70eV, Positivesplash10-014i-9000000000-940497ad1005c84fc1f12016-09-22Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Water GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-014i-9000000000-f7ee14225b4277f6218c2015-03-01Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Water Linear Ion Trap , positive-QTOFsplash10-0006-0940000000-08a1813d85727d668cf42017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Water Linear Ion Trap , positive-QTOFsplash10-0a4l-0980000000-5b109ff45e0e5e5051ae2017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 10V, Positive-QTOFsplash10-014i-9000000000-1a741e1ffb75284635fc2015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 20V, Positive-QTOFsplash10-014i-9000000000-1a741e1ffb75284635fc2015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 40V, Positive-QTOFsplash10-014i-9000000000-1a741e1ffb75284635fc2015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 10V, Negative-QTOFsplash10-014i-9000000000-a2a06393708ba68baab02015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 20V, Negative-QTOFsplash10-014i-9000000000-a2a06393708ba68baab02015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 40V, Negative-QTOFsplash10-014i-9000000000-a2a06393708ba68baab02015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 10V, Negative-QTOFsplash10-014i-9000000000-f607d1cf161edb4c90532021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 20V, Negative-QTOFsplash10-014i-9000000000-f607d1cf161edb4c90532021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 40V, Negative-QTOFsplash10-014i-9000000000-f607d1cf161edb4c90532021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 10V, Positive-QTOFsplash10-014i-9000000000-3c10d712de0a101f8fef2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 20V, Positive-QTOFsplash10-014i-9000000000-3c10d712de0a101f8fef2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Water 40V, Positive-QTOFsplash10-014i-9000000000-3c10d712de0a101f8fef2021-09-22Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Lysosome
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Biospecimen Locations
  • Amniotic Fluid
  • Aqueous Humour
  • Ascites Fluid
  • Blood
  • Breast Milk
  • Cerebrospinal Fluid (CSF)
  • Lymph
  • Saliva
  • Sweat
  • Tears
Tissue Locations
  • All Tissues
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
Amniotic FluidDetected and Quantified55000000 uMAdult (>18 years old)BothNormal details
Aqueous HumourDetected and Quantified55000000 uMAdult (>18 years old)BothNormal details
Ascites FluidDetected and Quantified55000000 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified55000000 uMAdult (>18 years old)BothNormal details
Breast MilkDetected and Quantified55000000 uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified55000000 uMAdult (>18 years old)BothNormal details
LymphDetected and Quantified55000000 uMAdult (>18 years old)BothNormal details
SalivaDetected and Quantified55000000 uMAdult (>18 years old)BothNormal details
SweatDetected and Quantified55000000 uMAdult (>18 years old)BothNormal details
TearsDetected and Quantified55000000 uMAdult (>18 years old)BothNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB09145
Phenol Explorer Compound IDNot Available
FooDB IDFDB030900
KNApSAcK IDNot Available
Chemspider ID937
KEGG Compound IDC00001
BioCyc IDWATER
BiGG ID33474
Wikipedia LinkWater
METLIN ID3194
PubChem Compound962
PDB IDNot Available
ChEBI ID15377
Food Biomarker OntologyNot Available
VMH IDH2O
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General ReferencesNot Available

Only showing the first 10 proteins. There are 1159 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. 5'-nucleotidase
General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Gene Name:
NT5E
Uniprot ID:
P21589
Molecular weight:
57948.125
Reactions
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphatedetails
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
Enzyme Details
2. Deoxycytidylate deaminase
General function:
Involved in zinc ion binding
Specific function:
Supplies the nucleotide substrate for thymidylate synthetase.
Gene Name:
DCTD
Uniprot ID:
P32321
Molecular weight:
21013.96
Reactions
dCMP + Water → dUMP + Ammoniadetails
Enzyme Details
3. Cytosolic 5'-nucleotidase 1B
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:
NT5C1B
Uniprot ID:
Q96P26
Molecular weight:
68803.055
Reactions
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphatedetails
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
Enzyme Details
4. Cytosolic 5'-nucleotidase 1A
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:
NT5C1A
Uniprot ID:
Q9BXI3
Molecular weight:
41020.145
Reactions
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphatedetails
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
Enzyme Details
5. 5'(3')-deoxyribonucleotidase, cytosolic type
General function:
Involved in metal ion binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:
NT5C
Uniprot ID:
Q8TCD5
Molecular weight:
Not Available
Reactions
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
Enzyme Details
6. 5'(3')-deoxyribonucleotidase, mitochondrial
General function:
Involved in phosphatase activity
Specific function:
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:
NT5M
Uniprot ID:
Q9NPB1
Molecular weight:
Not Available
Reactions
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
Enzyme Details
7. Acyl-coenzyme A thioesterase 12
General function:
Lipid transport and metabolism
Specific function:
Hydrolyzes acetyl-CoA to acetate and CoA.
Gene Name:
ACOT12
Uniprot ID:
Q8WYK0
Molecular weight:
62033.46
Reactions
Acetyl-CoA + Water → Coenzyme A + Acetic aciddetails
Enzyme Details
8. Fatty acid synthase
General function:
Involved in transferase activity
Specific function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Gene Name:
FASN
Uniprot ID:
P49327
Molecular weight:
273424.06
Reactions
A (3R)-3-hydroxyacyl-[acyl-carrier protein] → a trans-2-enoyl-[acyl-carrier protein] + Waterdetails
Oleoyl-[acyl-carrier-protein] + Water → [acyl-carrier-protein] + Oleic aciddetails
Hexadecanoyl-[acp] + Water → Acyl-carrier protein + Palmitic aciddetails
(3R)-3-Hydroxybutanoyl-[acyl-carrier protein] → But-2-enoyl-[acyl-carrier protein] + Waterdetails
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein] → trans-Dec-2-enoyl-[acp] + Waterdetails
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] → trans-Oct-2-enoyl-[acp] + Waterdetails
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] → trans-Hexadec-2-enoyl-[acp] + Waterdetails
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] → trans-Tetradec-2-enoyl-[acp] + Waterdetails
(R)-3-Hydroxyhexanoyl-[acp] → trans-Hex-2-enoyl-[acp] + Waterdetails
(R)-3-Hydroxydodecanoyl-[acp] → trans-Dodec-2-enoyl-[acp] + Waterdetails
Tetradecanoyl-[acp] + Water → Acyl-carrier protein + Myristic aciddetails
Enzyme Details
9. Hydroxymethylglutaryl-CoA synthase, mitochondrial
General function:
Involved in hydroxymethylglutaryl-CoA synthase activity
Specific function:
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Gene Name:
HMGCS2
Uniprot ID:
P54868
Molecular weight:
52481.065
Reactions
Acetyl-CoA + Water + Acetoacetyl-CoA → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme Adetails
3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A → Acetyl-CoA + Water + Acetoacetyl-CoAdetails
Enzyme Details
10. Citrate synthase, mitochondrial
General function:
Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
Specific function:
Not Available
Gene Name:
CS
Uniprot ID:
O75390
Molecular weight:
51712.025
Reactions
Acetyl-CoA + Water + Oxalacetic acid → Citric acid + Coenzyme Adetails
Citric acid + Coenzyme A → Acetyl-CoA + Water + Oxalacetic aciddetails

Transporters

Enzyme Details
1. Copper-transporting ATPase 2
General function:
Involved in ATP binding
Specific function:
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Gene Name:
ATP7B
Uniprot ID:
P35670
Molecular weight:
157261.34
Enzyme Details
2. Copper-transporting ATPase 1
General function:
Involved in ATP binding
Specific function:
May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Gene Name:
ATP7A
Uniprot ID:
Q04656
Molecular weight:
163372.275

Only showing the first 10 proteins. There are 1159 proteins in total.

Show all enzymes and transporters