| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental GC-MS | GC-MS Spectrum - Indole-3-propionic acid EI-B (Non-derivatized) | splash10-001i-1900000000-7964cf38946a23d63104 | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Indole-3-propionic acid EI-B (Non-derivatized) | splash10-001i-1900000000-7964cf38946a23d63104 | 2018-05-18 | HMDB team, MONA, MassBank | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Indole-3-propionic acid GC-MS (Non-derivatized) - 70eV, Positive | splash10-002f-1900000000-79b70b4d80349fed40a2 | 2017-08-28 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Indole-3-propionic acid GC-MS (1 TMS) - 70eV, Positive | splash10-00dl-8910000000-cc3bf52f2cbb339eea4a | 2017-10-06 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Indole-3-propionic acid GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | MS | Mass Spectrum (Electron Ionization) | splash10-001i-1900000000-de72f9061ea0bb241ef7 | 2015-03-01 | Not Available | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid Quattro_QQQ 10V, Positive-QTOF (Annotated) | splash10-004i-0900000000-5bf41cc0642ca12d91dd | 2012-07-25 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid Quattro_QQQ 25V, Positive-QTOF (Annotated) | splash10-004i-0900000000-2bdd32c86cd63a03b739 | 2012-07-25 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid Quattro_QQQ 40V, Positive-QTOF (Annotated) | splash10-004i-8900000000-fa98f64c6c35db6c3425 | 2012-07-25 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid EI-B (Unknown) , Positive-QTOF | splash10-001i-1900000000-7964cf38946a23d63104 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid LC-ESI-IT , positive-QTOF | splash10-00e9-0900000000-aa04863f4b124d617168 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid , positive-QTOF | splash10-001i-1900000000-c3c14c76cdb38c3798f0 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 20V, Positive-QTOF | splash10-001i-1900000000-db653a92384089e7272c | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 35V, Positive-QTOF | splash10-001i-0900000000-2837a9689ebb97e17c89 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 40V, Negative-QTOF | splash10-03di-9400000000-20084f0045f0393dcaad | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 10V, Negative-QTOF | splash10-0a4i-9500000000-d39c747b7db2e42acefc | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 10V, Positive-QTOF | splash10-001i-0900000000-8927c2758d647a804f4a | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 20V, Negative-QTOF | splash10-0a4i-9300000000-282c233baa3c0e5bf365 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 40V, Positive-QTOF | splash10-001i-4900000000-1e1179cded69a29a5047 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 20V, Negative-QTOF | splash10-0a4i-9300000000-0aaa5de6ae1a4aafa661 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 10V, Positive-QTOF | splash10-001i-0900000000-1b79a66b12c3205108c5 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 35V, Negative-QTOF | splash10-0aor-6900000000-909aa5100e4655d54267 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 40V, Negative-QTOF | splash10-05mo-9600000000-e85aca97bdac26c3d258 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 40V, Positive-QTOF | splash10-003r-4900000000-29142c5171637b4d5e5f | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Indole-3-propionic acid 10V, Negative-QTOF | splash10-0a4i-9600000000-bc2ddd9f185d76d60d50 | 2021-09-20 | HMDB team, MONA | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Indole-3-propionic acid 10V, Positive-QTOF | splash10-006x-0900000000-4be398aaf9b927637228 | 2017-07-26 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Indole-3-propionic acid 20V, Positive-QTOF | splash10-0006-0900000000-5f65be50e34cc07d1a77 | 2017-07-26 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Indole-3-propionic acid 40V, Positive-QTOF | splash10-00lu-2900000000-747697a81c30bbf35e01 | 2017-07-26 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Indole-3-propionic acid 10V, Negative-QTOF | splash10-000i-0900000000-76970d017d781fd87474 | 2017-07-26 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Indole-3-propionic acid 20V, Negative-QTOF | splash10-000l-1900000000-35d9289d5e0f2905c29d | 2017-07-26 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Indole-3-propionic acid 40V, Negative-QTOF | splash10-052f-9700000000-8a8af8b32271e2d2eef0 | 2017-07-26 | Wishart Lab | View Spectrum |
NMR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Experimental 1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, experimental) | 2021-10-10 | Wishart Lab | View Spectrum |
IR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Predicted IR Spectrum | IR Ion Spectrum (Quadrupole Ion Trap, ESI+, Adduct: [M+Na]+) | 2022-02-11 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Quadrupole Ion Trap, ESI+, Adduct: [M+H]+) | 2022-02-11 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Quadrupole Ion Trap, ESI-, Adduct: [M-H]-) | 2022-02-11 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-) | 2023-02-03 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+) | 2023-02-03 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+) | 2023-02-03 | FELIX lab | View Spectrum |
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- Zhao ZH, Xin FZ, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu XL, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y, Fan JG: Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats. Exp Mol Med. 2019 Sep 10;51(9):1-14. doi: 10.1038/s12276-019-0304-5. [PubMed:31506421 ]
- Mimori S, Kawada K, Saito R, Takahashi M, Mizoi K, Okuma Y, Hosokawa M, Kanzaki T: Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death. Biochem Biophys Res Commun. 2019 Oct 1;517(4):623-628. doi: 10.1016/j.bbrc.2019.07.074. Epub 2019 Aug 1. [PubMed:31378367 ]
- Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA: The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation. Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E350-E361. doi: 10.1152/ajpendo.00572.2018. Epub 2019 Jun 18. [PubMed:31211619 ]
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- Konopelski P, Konop M, Gawrys-Kopczynska M, Podsadni P, Szczepanska A, Ufnal M: Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats. Nutrients. 2019 Mar 11;11(3). pii: nu11030591. doi: 10.3390/nu11030591. [PubMed:30862081 ]
- Alexeev EE, Lanis JM, Kao DJ, Campbell EL, Kelly CJ, Battista KD, Gerich ME, Jenkins BR, Walk ST, Kominsky DJ, Colgan SP: Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor. Am J Pathol. 2018 May;188(5):1183-1194. doi: 10.1016/j.ajpath.2018.01.011. Epub 2018 Feb 16. [PubMed:29454749 ]
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- Karbownik M, Stasiak M, Zasada K, Zygmunt A, Lewinski A: Comparison of potential protective effects of melatonin, indole-3-propionic acid, and propylthiouracil against lipid peroxidation caused by potassium bromate in the thyroid gland. J Cell Biochem. 2005 May 1;95(1):131-8. doi: 10.1002/jcb.20404. [PubMed:15723291 ]
- Bendheim PE, Poeggeler B, Neria E, Ziv V, Pappolla MA, Chain DG: Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct;19(1-2):213-7. doi: 10.1007/s12031-002-0036-0. [PubMed:12212784 ]
- Karbownik M, Garcia JJ, Lewinski A, Reiter RJ: Carcinogen-induced, free radical-mediated reduction in microsomal membrane fluidity: reversal by indole-3-propionic acid. J Bioenerg Biomembr. 2001 Feb;33(1):73-8. doi: 10.1023/a:1005628808688. [PubMed:11460928 ]
- Karbownik M, Reiter RJ, Garcia JJ, Cabrera J, Burkhardt S, Osuna C, Lewinski A: Indole-3-propionic acid, a melatonin-related molecule, protects hepatic microsomal membranes from iron-induced oxidative damage: relevance to cancer reduction. J Cell Biochem. 2001;81(3):507-13. [PubMed:11255233 ]
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- Hardeland R, Zsizsik BK, Poeggeler B, Fuhrberg B, Holst S, Coto-Montes A: Indole-3-pyruvic and -propionic acids, kynurenic acid, and related metabolites as luminophores and free-radical scavengers. Adv Exp Med Biol. 1999;467:389-95. doi: 10.1007/978-1-4615-4709-9_49. [PubMed:10721080 ]
- Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S: Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity. 2014 Aug 21;41(2):296-310. doi: 10.1016/j.immuni.2014.06.014. Epub 2014 Jul 24. [PubMed:25065623 ]
- Dvorak Z, Kopp F, Costello CM, Kemp JS, Li H, Vrzalova A, Stepankova M, Bartonkova I, Jiskrova E, Poulikova K, Vyhlidalova B, Nordstroem LU, Karunaratne CV, Ranhotra HS, Mun KS, Naren AP, Murray IA, Perdew GH, Brtko J, Toporova L, Schon A, Wallace BD, Walton WG, Redinbo MR, Sun K, Beck A, Kortagere S, Neary MC, Chandran A, Vishveshwara S, Cavalluzzi MM, Lentini G, Cui JY, Gu H, March JC, Chatterjee S, Matson A, Wright D, Flannigan KL, Hirota SA, Sartor RB, Mani S: Targeting the pregnane X receptor using microbial metabolite mimicry. EMBO Mol Med. 2020 Mar 10:e11621. doi: 10.15252/emmm.201911621. [PubMed:32153125 ]
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