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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2006-05-22 14:17:51 UTC
Update Date2021-10-13 04:39:15 UTC
HMDB IDHMDB0002393
Secondary Accession Numbers
  • HMDB02393
Metabolite Identification
Common NameN-Methyl-D-aspartic acid
DescriptionN-Methyl-D-aspartic acid is an amino acid derivative acting as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA binds to and regulates the above receptor only, but not other glutamate receptors. NMDA is a water-soluble endogenous metabolite that plays an important role in the neuroendocrine system of species across Animalia (PMID:18096065 ). It was first synthesized in the 1960s (PMID:14056452 ). NMDA is an excitotoxin; this trait has applications in behavioural neuroscience research. The body of work utilizing this technique falls under the term "lesion studies." Researchers apply NMDA to specific regions of an (animal) subject's brain or spinal cord and subsequently test for the behaviour of interest, such as operant behaviour. If the behaviour is compromised, it suggests that the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behaviour. Examples of antagonists of the NMDA receptor are ketamine, amantadine, dextromethorphan (DXM), riluzole, and memantine. They are commonly referred to as NMDA receptor antagonists (PMID:28877137 ).
Structure
Data?1582752248
Synonyms
ValueSource
(R)-2-Methylamino-succinic acidChEBI
2-Methylamino-succinic acidChEBI
Methyl aspartic acidChEBI
N-Methyl aspartic acidChEBI
N-Methyl-D-aspartateChEBI
N-MethylaspartateChEBI
NMDAChEBI
(R)-2-Methylamino-succinateGenerator
2-Methylamino-succinateGenerator
Methyl aspartateGenerator
N-Methyl aspartateGenerator
N-Methylaspartic acidGenerator
Acid, N-methyl-D-asparticMeSH
N Methyl D aspartateMeSH
N Methyl D aspartic acidMeSH
N MethylaspartateMeSH
N-Me-D-asp-OHHMDB
N-Methyl D-aspartateHMDB
N-Methyl D-aspartic acidHMDB
Chemical FormulaC5H9NO4
Average Molecular Weight147.1293
Monoisotopic Molecular Weight147.053157781
IUPAC Name(2R)-2-(methylamino)butanedioic acid
Traditional NameN methyl D aspartate
CAS Registry Number6384-92-5
SMILES
CN[C@H](CC(O)=O)C(O)=O
InChI Identifier
InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
InChI KeyHOKKHZGPKSLGJE-GSVOUGTGSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as aspartic acid and derivatives. Aspartic acid and derivatives are compounds containing an aspartic acid or a derivative thereof resulting from reaction of aspartic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAspartic acid and derivatives
Alternative Parents
Substituents
  • Aspartic acid or derivatives
  • Alpha-amino acid
  • D-alpha-amino acid
  • Dicarboxylic acid or derivatives
  • Fatty acid
  • Amino acid
  • Carboxylic acid
  • Secondary aliphatic amine
  • Secondary amine
  • Amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Carbonyl group
  • Organopnictogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point187 - 192 °CNot Available
Boiling Point258.24 °C. @ 760.00 mm Hg (est)The Good Scents Company Information System
Water Solubility1000000 mg/L @ 25 °C (est)The Good Scents Company Information System
LogP1.390 (est)The Good Scents Company Information System
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available125.0http://allccs.zhulab.cn/database/detail?ID=AllCCS00002076
[M+H]+Not Available130.2http://allccs.zhulab.cn/database/detail?ID=AllCCS00002076
Predicted Molecular Properties
PropertyValueSource
Water Solubility40.6 g/LALOGPS
logP10(-2.6) g/LALOGPS
logP10(-3.3) g/LChemAxon
logS10(-0.56) g/LALOGPS
pKa (Strongest Acidic)1.46ChemAxon
pKa (Strongest Basic)10.34ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area86.63 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity31.31 m³·mol⁻¹ChemAxon
Polarizability13.18 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+132.25531661259
DarkChem[M-H]-128.15631661259

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
N-Methyl-D-aspartic acidCN[C@H](CC(O)=O)C(O)=O2321.2Standard polar33892256
N-Methyl-D-aspartic acidCN[C@H](CC(O)=O)C(O)=O1213.4Standard non polar33892256
N-Methyl-D-aspartic acidCN[C@H](CC(O)=O)C(O)=O1453.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
N-Methyl-D-aspartic acid,1TMS,isomer #1CN[C@H](CC(=O)O[Si](C)(C)C)C(=O)O1394.6Semi standard non polar33892256
N-Methyl-D-aspartic acid,1TMS,isomer #2CN[C@H](CC(=O)O)C(=O)O[Si](C)(C)C1361.2Semi standard non polar33892256
N-Methyl-D-aspartic acid,1TMS,isomer #3CN([C@H](CC(=O)O)C(=O)O)[Si](C)(C)C1496.2Semi standard non polar33892256
N-Methyl-D-aspartic acid,2TMS,isomer #1CN[C@H](CC(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C1433.5Semi standard non polar33892256
N-Methyl-D-aspartic acid,2TMS,isomer #2CN([C@H](CC(=O)O[Si](C)(C)C)C(=O)O)[Si](C)(C)C1522.1Semi standard non polar33892256
N-Methyl-D-aspartic acid,2TMS,isomer #3CN([C@H](CC(=O)O)C(=O)O[Si](C)(C)C)[Si](C)(C)C1524.5Semi standard non polar33892256
N-Methyl-D-aspartic acid,3TMS,isomer #1CN([C@H](CC(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C1557.7Semi standard non polar33892256
N-Methyl-D-aspartic acid,3TMS,isomer #1CN([C@H](CC(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C1556.9Standard non polar33892256
N-Methyl-D-aspartic acid,3TMS,isomer #1CN([C@H](CC(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C1666.6Standard polar33892256
N-Methyl-D-aspartic acid,1TBDMS,isomer #1CN[C@H](CC(=O)O[Si](C)(C)C(C)(C)C)C(=O)O1633.4Semi standard non polar33892256
N-Methyl-D-aspartic acid,1TBDMS,isomer #2CN[C@H](CC(=O)O)C(=O)O[Si](C)(C)C(C)(C)C1593.6Semi standard non polar33892256
N-Methyl-D-aspartic acid,1TBDMS,isomer #3CN([C@H](CC(=O)O)C(=O)O)[Si](C)(C)C(C)(C)C1743.3Semi standard non polar33892256
N-Methyl-D-aspartic acid,2TBDMS,isomer #1CN[C@H](CC(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C1865.3Semi standard non polar33892256
N-Methyl-D-aspartic acid,2TBDMS,isomer #2CN([C@H](CC(=O)O[Si](C)(C)C(C)(C)C)C(=O)O)[Si](C)(C)C(C)(C)C1995.7Semi standard non polar33892256
N-Methyl-D-aspartic acid,2TBDMS,isomer #3CN([C@H](CC(=O)O)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C1989.5Semi standard non polar33892256
N-Methyl-D-aspartic acid,3TBDMS,isomer #1CN([C@H](CC(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2217.0Semi standard non polar33892256
N-Methyl-D-aspartic acid,3TBDMS,isomer #1CN([C@H](CC(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2202.2Standard non polar33892256
N-Methyl-D-aspartic acid,3TBDMS,isomer #1CN([C@H](CC(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2093.2Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - N-Methyl-D-aspartic acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-0k96-9300000000-416b6ee56e62fb8e59612017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - N-Methyl-D-aspartic acid GC-MS (2 TMS) - 70eV, Positivesplash10-00dl-9410000000-4a49e66d4a20edeb32352017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - N-Methyl-D-aspartic acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - N-Methyl-D-aspartic acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-000i-9600000000-7a4c870f26f91384c5d02012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-000f-9000000000-5a5c118fa9bc800c8c722012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-0006-9000000000-b494ed61acdeddeb3be42012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 0V, Positive-QTOFsplash10-0002-1900000000-87587cfe05ee404f15502021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 35V, Negative-QTOFsplash10-0gba-1900000000-849defcb6a9a98faef162021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 10V, Negative-QTOFsplash10-0gba-1900000000-9f82f9c552f606136a192021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 30V, Positive-QTOFsplash10-0006-9000000000-b6e45215a0b6b9a0960f2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 0V, Positive-QTOFsplash10-0007-9500000000-060344e1da8123dc5c512021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 40V, Positive-QTOFsplash10-0006-9000000000-bbf199eb1c5bbac7de352021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 10V, Positive-QTOFsplash10-000i-9300000000-9f1996c5b204a0ee904e2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 10V, Positive-QTOFsplash10-000f-9000000000-18a491a74a3279ec33d12021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 20V, Positive-QTOFsplash10-000l-9000000000-b9b082c40ee1ed6fbb8b2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 10V, Positive-QTOFsplash10-000i-9300000000-435580f32c2f9263f08f2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 20V, Positive-QTOFsplash10-000f-9000000000-d6cd5876d7888f53004a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 10V, Positive-QTOFsplash10-000i-9400000000-6e3a2b4573d59f5f903d2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 40V, Positive-QTOFsplash10-0006-9000000000-69cb5c680dcf502b4d392021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 20V, Positive-QTOFsplash10-000l-9000000000-3b16cb5a635969b81fb42021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 40V, Positive-QTOFsplash10-0006-9000000000-6e09556b565532cc28ce2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N-Methyl-D-aspartic acid 35V, Positive-QTOFsplash10-000i-9600000000-f385ad30a0df8435d8532021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N-Methyl-D-aspartic acid 10V, Positive-QTOFsplash10-001i-0900000000-eeb3a907ee733c1543e92017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N-Methyl-D-aspartic acid 20V, Positive-QTOFsplash10-0f80-9600000000-1c3def640e73db97c7e42017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N-Methyl-D-aspartic acid 40V, Positive-QTOFsplash10-0a4i-9000000000-9f7de36da4128db64ccb2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N-Methyl-D-aspartic acid 10V, Negative-QTOFsplash10-0f6t-0900000000-6c4446f90caead6f5b512017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N-Methyl-D-aspartic acid 20V, Negative-QTOFsplash10-0ufs-3900000000-44106308c45837087fe52017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N-Methyl-D-aspartic acid 40V, Negative-QTOFsplash10-0ac3-9100000000-fe891bbc2ab7063b8bac2017-09-01Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Experimental 1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)2021-10-10Wishart LabView Spectrum
Experimental 1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)2021-10-10Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)2012-12-05Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biospecimen LocationsNot Available
Tissue Locations
  • Brain
  • Fibroblasts
  • Kidney
  • Neuron
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022992
KNApSAcK IDNot Available
Chemspider ID21436
KEGG Compound IDC12269
BioCyc IDCPD-10705
BiGG IDNot Available
Wikipedia LinkN-Methyl-D-aspartic_acid
METLIN ID6662
PubChem Compound22880
PDB IDNot Available
ChEBI ID31882
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1359131
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Baskys A, Fang L, Bayazitov I: Activation of neuroprotective pathways by metabotropic group I glutamate receptors: a potential target for drug discovery? Ann N Y Acad Sci. 2005 Aug;1053:55-73. [PubMed:16179509 ]
  2. Hitchcock IS, Skerry TM, Howard MR, Genever PG: NMDA receptor-mediated regulation of human megakaryocytopoiesis. Blood. 2003 Aug 15;102(4):1254-9. Epub 2003 Mar 20. [PubMed:12649130 ]
  3. Miller RF: D-Serine as a glial modulator of nerve cells. Glia. 2004 Aug 15;47(3):275-83. [PubMed:15252817 ]
  4. Sanelli TR, Sopper MM, Strong MJ: Sequestration of nNOS in neurofilamentous aggregate bearing neurons in vitro leads to enhanced NMDA-mediated calcium influx. Brain Res. 2004 Apr 9;1004(1-2):8-17. [PubMed:15033415 ]
  5. Weyermann J, Lochmann D, Georgens C, Zimmer A: Albumin-protamine-oligonucleotide-nanoparticles as a new antisense delivery system. Part 2: cellular uptake and effect. Eur J Pharm Biopharm. 2005 Apr;59(3):431-8. [PubMed:15760723 ]
  6. Baskys A, Blaabjerg M: Understanding regulation of nerve cell death by mGluRs as a method for development of successful neuroprotective strategies. J Neurol Sci. 2005 Mar 15;229-230:201-9. Epub 2004 Dec 15. [PubMed:15760640 ]
  7. Hardingham GE, Bading H: The Yin and Yang of NMDA receptor signalling. Trends Neurosci. 2003 Feb;26(2):81-9. [PubMed:12536131 ]
  8. Lareo LR, Corredor C: Ionotropic glutamate receptor activated by N-methyl-D-aspartate: a key molecule of conscious life. Med Hypotheses. 2004;63(2):245-9. [PubMed:15236783 ]
  9. Fonnum F, Lock EA: The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells. J Neurochem. 2004 Feb;88(3):513-31. [PubMed:14720201 ]
  10. Wang GS, Hong CJ, Yen TY, Huang HY, Ou Y, Huang TN, Jung WG, Kuo TY, Sheng M, Wang TF, Hsueh YP: Transcriptional modification by a CASK-interacting nucleosome assembly protein. Neuron. 2004 Apr 8;42(1):113-28. [PubMed:15066269 ]
  11. Liu D, Cheng T, Guo H, Fernandez JA, Griffin JH, Song X, Zlokovic BV: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2004 Dec;10(12):1379-83. Epub 2004 Oct 31. [PubMed:15516929 ]
  12. Eugenin EA, D'Aversa TG, Lopez L, Calderon TM, Berman JW: MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem. 2003 Jun;85(5):1299-311. [PubMed:12753088 ]
  13. Okuda H, Ogita K: [Protective effects of N-methyl-D-aspartate against neuronal damages]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2002 Oct;22(5):153-8. [PubMed:12451685 ]
  14. Andre VM, Flores-Hernandez J, Cepeda C, Starling AJ, Nguyen S, Lobo MK, Vinters HV, Levine MS, Mathern GW: NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. Cereb Cortex. 2004 Jun;14(6):634-46. Epub 2004 Mar 28. [PubMed:15054078 ]
  15. Reyes O, Sosa I, Kuffler DP: Neuroprotection of adult human neurons against ischemia by hypothermia and alkalinization. P R Health Sci J. 2006 Mar;25(1):43-50. [PubMed:16883678 ]
  16. Boehning D, Snyder SH: Novel neural modulators. Annu Rev Neurosci. 2003;26:105-31. [PubMed:14527267 ]
  17. Tuneva EO, Bychkova ON, Boldyrev AA: Effect of NMDA on production of reactive oxygen species by human lymphocytes. Bull Exp Biol Med. 2003 Aug;136(2):159-61. [PubMed:14631498 ]
  18. D'Aniello S, Fisher GH, Topo E, Ferrandino G, Garcia-Fernandez J, D'Aniello A: N-methyl-D-aspartic acid (NMDA) in the nervous system of the amphioxus Branchiostoma lanceolatum. BMC Neurosci. 2007 Dec 20;8:109. doi: 10.1186/1471-2202-8-109. [PubMed:18096065 ]
  19. WATKINS JC: THE SYNTHESIS OF SOME ACIDIC AMINO ACIDS POSSESSING NEUROPHARMACOLOGICAL ACTIVITY. J Med Pharm Chem. 1962 Nov;91:1187-99. doi: 10.1021/jm01241a010. [PubMed:14056452 ]
  20. Aiyer R, Mehta N, Gungor S, Gulati A: A Systematic Review of NMDA Receptor Antagonists for Treatment of Neuropathic Pain in Clinical Practice. Clin J Pain. 2018 May;34(5):450-467. doi: 10.1097/AJP.0000000000000547. [PubMed:28877137 ]

Enzymes

General function:
Cell cycle control, cell division, chromosome partitioning
Specific function:
Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations
Gene Name:
AKAP9
Uniprot ID:
Q99996
Molecular weight:
453664.2
General function:
Involved in protein binding
Specific function:
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity
Gene Name:
ARHGAP32
Uniprot ID:
A7KAX9
Molecular weight:
230527.1