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Record Information
Version4.0
StatusDetected and Quantified
Creation Date2006-05-22 14:17:55 UTC
Update Date2020-02-26 21:24:11 UTC
HMDB IDHMDB0002501
Secondary Accession Numbers
  • HMDB02501
Metabolite Identification
Common NameGermanium
DescriptionGermanium is not an essential element. Physiologically, it exists as an ion in the body. Its acute toxicity is low. Germanium-containing dietary supplements became popular in the 1970s in Japan and later in other countries, as elixirs for certain diseases (e.g., cancer and AIDS). However, at least 31 reported human cases linked prolonged intake of germanium products with renal failure and even death.
Structure
Data?1582752251
Synonyms
ValueSource
Ge(4+)ChEBI
GeHMDB
GermideHMDB
SerocionHMDB
Chemical FormulaGe
Average Molecular Weight72.64
Monoisotopic Molecular Weight73.921178213
IUPAC Namegermanium(4+) ion
Traditional Namegermanium(4+) ion
CAS Registry Number7440-56-4
SMILES
[Ge+4]
InChI Identifier
InChI=1S/Ge/q+4
InChI KeyCULSIAXQVSZNSV-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as homogeneous metalloid compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a metalloid atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous metalloid compounds
Sub ClassNot Available
Direct ParentHomogeneous metalloid compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous metalloid
Molecular FrameworkNot Available
External Descriptors
Ontology
Disposition

Route of exposure:

Biological location:

Source:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point938.3 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge4ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-9000000000-d30e86fb68c056ba94faSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-9000000000-d30e86fb68c056ba94faSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-9000000000-d30e86fb68c056ba94faSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-9000000000-0aec2ac48ffee5c3828aSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-9000000000-0aec2ac48ffee5c3828aSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-9000000000-0aec2ac48ffee5c3828aSpectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Saliva
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot Available
Normal
      Not Available
details
SalivaDetected and Quantified0.006 +/- 0.003 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
UrineDetected and Quantified1.58 (0.49-2.6) umol/mmol creatinineAdult (>18 years old)BothNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB003630
KNApSAcK IDNot Available
Chemspider ID10605699
KEGG Compound IDC15472
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkGermanium
METLIN IDNot Available
PubChem Compound73608878
PDB IDNot Available
ChEBI ID30550
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB ID
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Nielsen FH: How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? J Nutr. 1996 Sep;126(9 Suppl):2377S-2385S. [PubMed:8811801 ]
  2. Tao SH, Bolger PM: Hazard assessment of germanium supplements. Regul Toxicol Pharmacol. 1997 Jun;25(3):211-9. [PubMed:9237323 ]