Record Information |
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Version | 5.0 |
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Status | Detected and Quantified |
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Creation Date | 2006-08-13 04:25:20 UTC |
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Update Date | 2022-03-07 02:49:19 UTC |
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HMDB ID | HMDB0003759 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | 5a-Pregnane-3,20-dione |
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Description | 5a-Pregnane-3,20-dione, also known as 5alpha-dihydroprogesterone or 3,20-allopregnanedione, belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety. Thus, 5a-pregnane-3,20-dione is considered to be a steroid. Based on a literature review a significant number of articles have been published on 5a-Pregnane-3,20-dione. |
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Structure | [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14-,16-,17+,18-,19-,20-,21+/m0/s1 |
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Synonyms | Value | Source |
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3,20-Allopregnanedione | ChEBI | 3,20-Dioxo-5alpha-pregnane | ChEBI | 5-alpha-Dihydroprogesterone | ChEBI | 5alpha-Dihydroprogesterone | ChEBI | 3,20-Dioxo-5a-pregnane | Generator | 3,20-Dioxo-5α-pregnane | Generator | 5-a-Dihydroprogesterone | Generator | 5-Α-dihydroprogesterone | Generator | 5a-Dihydroprogesterone | Generator | 5Α-dihydroprogesterone | Generator | 5-alpha-Pregnane-3,20-dione | HMDB, MeSH | 5a-Pregnan-3,20-dione | HMDB | 5alpha-Pregnan-3,20-dione | HMDB | 5alpha-Pregnane-3,20-dione | HMDB, MeSH | 5b-Pregnane-3,20-dione | HMDB | 5beta-Pregnane-3,20-dione | HMDB | Allopregnan-3,20-dione | HMDB | Pregnane-3,20-dione | HMDB | 5 alpha Dihydroprogesterone | MeSH, HMDB | 5 beta Pregnane 3,20 dione | MeSH, HMDB | 5 beta-Pregnane-3,20-dione | MeSH, HMDB | 5-beta-Dihydroprogesterone | MeSH, HMDB | 5alpha-DHP | MeSH, HMDB | 3,20-Allopregnanedione, (5beta,13alpha,17alpha)-isomer | MeSH, HMDB | 5 alpha Pregnanedione | MeSH, HMDB | 5alpha DHP | MeSH, HMDB | 5alpha Pregnane 3,20 dione | MeSH, HMDB | 5beta DHP | MeSH, HMDB | 5beta-DHP | MeSH, HMDB | 3,20 Allopregnanedione | MeSH, HMDB | 3,20-Allopregnanedione, (5alpha)-isomer | MeSH, HMDB | 5 alpha Pregnane 3,20 dione | MeSH, HMDB | 5 alpha-Dihydroprogesterone | MeSH, HMDB | 5 alpha-Pregnane-3,20-dione | MeSH, HMDB | 5 beta Dihydroprogesterone | MeSH, HMDB | 5-alpha-Pregnanedione | MeSH, HMDB |
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Chemical Formula | C21H32O2 |
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Average Molecular Weight | 316.4776 |
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Monoisotopic Molecular Weight | 316.240230268 |
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IUPAC Name | (1S,2S,7S,10R,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one |
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Traditional Name | 5a-pregnane-3,20-dione |
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CAS Registry Number | 566-65-4 |
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SMILES | [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C |
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InChI Identifier | InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14-,16-,17+,18-,19-,20-,21+/m0/s1 |
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InChI Key | XMRPGKVKISIQBV-BJMCWZGWSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Steroids and steroid derivatives |
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Sub Class | Pregnane steroids |
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Direct Parent | Gluco/mineralocorticoids, progestogins and derivatives |
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Alternative Parents | |
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Substituents | - Progestogin-skeleton
- 20-oxosteroid
- 3-oxo-5-alpha-steroid
- Oxosteroid
- 3-oxosteroid
- Cyclic ketone
- Ketone
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Aliphatic homopolycyclic compound
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Molecular Framework | Aliphatic homopolycyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | |
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Disposition | |
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Process | |
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Role | |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | 200 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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5a-Pregnane-3,20-dione,1TMS,isomer #1 | CC(O[Si](C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 2796.2 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #1 | CC(O[Si](C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 2729.1 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #1 | CC(O[Si](C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 3108.6 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #2 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 2781.6 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #2 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 2657.1 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #2 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3124.2 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #3 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 2764.7 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #3 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 2674.8 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #3 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3122.0 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #4 | C=C(O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 2782.9 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #4 | C=C(O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 2733.5 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TMS,isomer #4 | C=C(O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 3215.6 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #1 | CC(O[Si](C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 2823.8 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #1 | CC(O[Si](C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 2766.4 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #1 | CC(O[Si](C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3149.9 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #2 | CC(O[Si](C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 2831.2 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #2 | CC(O[Si](C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 2790.0 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #2 | CC(O[Si](C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3148.7 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #3 | C=C(O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 2794.2 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #3 | C=C(O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 2757.4 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #3 | C=C(O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3243.6 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #4 | C=C(O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 2776.7 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #4 | C=C(O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 2781.7 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TMS,isomer #4 | C=C(O[Si](C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3241.1 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #1 | CC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 3039.3 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #1 | CC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 2980.0 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #1 | CC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 3265.1 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #2 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3020.9 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #2 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 2854.7 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #2 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3268.1 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #3 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 2994.9 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #3 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 2886.4 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #3 | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3267.2 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #4 | C=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 3040.0 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #4 | C=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 2996.7 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,1TBDMS,isomer #4 | C=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | 3354.2 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #1 | CC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3305.5 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #1 | CC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3131.9 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #1 | CC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3382.1 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #2 | CC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3306.9 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #2 | CC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3197.3 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #2 | CC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3384.6 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #3 | C=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3301.1 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #3 | C=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3123.7 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #3 | C=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3CC[C@]12C | 3448.0 | Standard polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #4 | C=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3265.9 | Semi standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #4 | C=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3187.1 | Standard non polar | 33892256 | 5a-Pregnane-3,20-dione,2TBDMS,isomer #4 | C=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3449.6 | Standard polar | 33892256 |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental GC-MS | GC-MS Spectrum - 5a-Pregnane-3,20-dione GC-MS (Non-derivatized) | splash10-0umu-9810000000-76ef4cf96a30792f4d73 | 2014-06-16 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - 5a-Pregnane-3,20-dione GC-MS (Non-derivatized) | splash10-0umu-9810000000-7151501afadd028a99ec | 2014-06-16 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - 5a-Pregnane-3,20-dione GC-MS (Non-derivatized) | splash10-0umu-9810000000-76ef4cf96a30792f4d73 | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - 5a-Pregnane-3,20-dione GC-MS (Non-derivatized) | splash10-0umu-9810000000-7151501afadd028a99ec | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - 5a-Pregnane-3,20-dione GC-EI-TOF (Non-derivatized) | splash10-0f76-4910000000-81546b52d59f9518cb0c | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - 5a-Pregnane-3,20-dione GC-EI-TOF (Non-derivatized) | splash10-0f76-4910000000-dbf8c4ca357b5f19f54d | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 5a-Pregnane-3,20-dione GC-MS (Non-derivatized) - 70eV, Positive | splash10-0fkj-0391000000-1964b2faffc1ae5ab9b4 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 5a-Pregnane-3,20-dione GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 10V, Positive-QTOF | splash10-014i-0159000000-fdffc096796499edd3d4 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 20V, Positive-QTOF | splash10-05p2-0492000000-3f8a5badfddf1ced4edf | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 40V, Positive-QTOF | splash10-052f-2590000000-932901e825351ef60bc4 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 10V, Negative-QTOF | splash10-014i-0019000000-8848319d0e10bc22bc8c | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 20V, Negative-QTOF | splash10-014i-0039000000-04efc7afcedbf957d0ee | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 40V, Negative-QTOF | splash10-006t-1090000000-259e4f493b06ea76a0d6 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 10V, Positive-QTOF | splash10-014j-0069000000-c9fab448f80ee78066da | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 20V, Positive-QTOF | splash10-0002-0491000000-c1e83a8609698882ba42 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 40V, Positive-QTOF | splash10-0f6x-3920000000-1083c653754015836eb2 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 10V, Negative-QTOF | splash10-014i-0009000000-be6e06313d0abca8e664 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 20V, Negative-QTOF | splash10-014i-0049000000-e44dad0db5aa758e4dd5 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 5a-Pregnane-3,20-dione 40V, Negative-QTOF | splash10-00ls-0091000000-f15b1c3e520b40f7172b | 2021-09-22 | Wishart Lab | View Spectrum |
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General References | - Pearson Murphy BE, Steinberg SI, Hu FY, Allison CM: Neuroactive ring A-reduced metabolites of progesterone in human plasma during pregnancy: elevated levels of 5 alpha-dihydroprogesterone in depressed patients during the latter half of pregnancy. J Clin Endocrinol Metab. 2001 Dec;86(12):5981-7. [PubMed:11739473 ]
- Kwan TK, Kraevskaya MA, Makin HL, Trafford DJ, Gower DB: Use of gas chromatographic-mass spectrometric techniques in studies of androst-16-ene and androgen biosynthesis in human testis; cytosolic specific binding of 5alpha-androst-16-en-3-one. J Steroid Biochem Mol Biol. 1997 Jan;60(1-2):137-46. [PubMed:9182868 ]
- Zhang J, Ming LJ, Sjovall J, Cook HW, Ridgway ND, Byers DM: Progesterone metabolism in human fibroblasts is independent of P-glycoprotein levels and Niemann-Pick type C disease. J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):123-31. [PubMed:10622400 ]
- Sandow J, Engelbart K, von Rechenberg W: The different mechanisms for suppression of pituitary and testicular function. Med Biol. 1986;63(5-6):192-200. [PubMed:3010006 ]
- Jarczok T, Zwirner M, Schindler AE: Progesterone and 5 alpha-pregnane-3,20-dione in human amniotic fluid. Exp Clin Endocrinol. 1987 Mar;89(1):39-47. [PubMed:3595731 ]
- Gomez-Sanchez EP, Cox D, Foecking M, Ganjam V, Gomez-Sanchez CE: 11 beta-hydroxysteroid dehydrogenases of the choriocarcinoma cell line JEG-3 and their inhibition by glycyrrhetinic acid and other natural substances. Steroids. 1996 Mar;61(3):110-5. [PubMed:8852827 ]
- Chantilis S, Dombroski R, Shackleton CH, Casey ML, MacDonald PC: Metabolism of 5 alpha-dihydroprogesterone in women and men: 3 beta- and 3 alpha-,6 alpha-dihydroxy-5 alpha-pregnan-20-ones are major urinary metabolites. J Clin Endocrinol Metab. 1996 Oct;81(10):3644-9. [PubMed:8855816 ]
- Zwirner M, Fawzy MM, Bopp FC, Klemm-Wolfgram E, Handschuh D, Voelter W, Schindler AE: Radioimmunoassay of 5 alpha-pregnane-3,20-dione. A metabolite of placental progesterone. Arch Gynecol. 1983;233(4):229-40. [PubMed:6660916 ]
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