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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-08-13 15:01:23 UTC
Update Date2022-03-07 02:49:20 UTC
HMDB IDHMDB0004240
Secondary Accession Numbers
  • HMDB04240
Metabolite Identification
Common Name15-Keto-prostaglandin F2a
Description15-Keto-prostaglandin F2a is the oxidized product of prostaglandin F2a by 15-hydroxyprostaglandin dehydrogenase, which is present in lung, kidney, placenta and other tissues and catalyzes the NAD- or NADP-dependent dehydrogenation of 15-dydroxyl group. 15-Keto-prostaglandin F2a is further metabolized by its delta13-reduction, beta-oxidation and omega oxidation. The ultimate metabolite is 5a,7a-dihydroxy-11-keto-tetranorprosta-1,16-dioic acid, and excreted in urine. Prostaglandin F2a (PGF2) is one of the earliest discovered and most common prostaglandins is actively biosynthesized in various organs of mammals and exhibits a variety of biological activities, including contraction of pulmonary arteries. PGF2 is mainly synthesized directly from PGH2 by PGH2 9,11-endoperoxide reductase. A small amount of PGF2 is also produced from PGE2 by PGE2 9-ketoreductase. A PGF2 epimer has been reported to exhibit various biological activities, and its levels are increased in bronchoalveolar lavage fluid, plasma, and urine in patients with mastocytosis and bronchial asthma. PGF2 is synthesized from PGD2 by PGD2 11-ketoreductase. (PMID: 16475787 , 184496 , 5951401 , 12432938 )Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.
Structure
Data?1582752303
Synonyms
ValueSource
15-Keto-PGF2aChEBI
15-Keto-PGF2alphaChEBI
15-Keto-prostaglandin F2alphaChEBI
15-Ketoprostaglandin F2alphaChEBI
15-Keto-PGF2αGenerator
15-Keto-prostaglandin F2αGenerator
15-Ketoprostaglandin F2aGenerator
15-Ketoprostaglandin F2αGenerator
15-Keto-prostaglandin F2 alphaHMDB
15-oxo PGF-2alphaHMDB
15-oxo-Prostaglandin F2alphaHMDB
9S,11R-Dihydroxy-15-oxo-5Z,13E-prostadienoateHMDB
9S,11R-Dihydroxy-15-oxo-5Z,13E-prostadienoic acidHMDB
15-Oxoprostaglandin F2aHMDB
15-Oxoprostaglandin F2αHMDB
15-Keto-prostaglandin F2aChEBI
Chemical FormulaC20H32O5
Average Molecular Weight352.4651
Monoisotopic Molecular Weight352.224974134
IUPAC Name(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E)-3-oxooct-1-en-1-yl]cyclopentyl]hept-5-enoic acid
Traditional Name15-keto-prostaglandin F2 α
CAS Registry Number35850-13-6
SMILES
CCCCCC(=O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
InChI Identifier
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-19,22-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17-,18+,19-/m1/s1
InChI KeyLOLJEILMPWPILA-AMFHKTBMSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassEicosanoids
Direct ParentProstaglandins and related compounds
Alternative Parents
Substituents
  • Prostaglandin skeleton
  • Long-chain fatty acid
  • Hydroxy fatty acid
  • Cyclopentanol
  • Unsaturated fatty acid
  • Fatty acid
  • Enone
  • Acryloyl-group
  • Cyclic alcohol
  • Alpha,beta-unsaturated ketone
  • Secondary alcohol
  • Ketone
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organic oxide
  • Organic oxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic homomonocyclic compound
Molecular FrameworkAliphatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.093 g/LALOGPS
logP3.03ALOGPS
logP3.02ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)4.36ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area94.83 ŲChemAxon
Rotatable Bond Count12ChemAxon
Refractivity99.57 m³·mol⁻¹ChemAxon
Polarizability40.62 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+199.91930932474
DeepCCS[M-H]-197.52430932474
DeepCCS[M-2H]-231.29130932474
DeepCCS[M+Na]+206.13130932474
AllCCS[M+H]+192.632859911
AllCCS[M+H-H2O]+189.932859911
AllCCS[M+NH4]+195.032859911
AllCCS[M+Na]+195.732859911
AllCCS[M-H]-191.132859911
AllCCS[M+Na-2H]-192.532859911
AllCCS[M+HCOO]-194.132859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
15-Keto-prostaglandin F2aCCCCCC(=O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O4596.6Standard polar33892256
15-Keto-prostaglandin F2aCCCCCC(=O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O2639.5Standard non polar33892256
15-Keto-prostaglandin F2aCCCCCC(=O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O2948.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
15-Keto-prostaglandin F2a,1TMS,isomer #1CCCCCC(=O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O2758.3Semi standard non polar33892256
15-Keto-prostaglandin F2a,1TMS,isomer #2CCCCCC(=O)/C=C/[C@H]1[C@H](O)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O2753.6Semi standard non polar33892256
15-Keto-prostaglandin F2a,1TMS,isomer #3CCCCCC(=O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C2839.3Semi standard non polar33892256
15-Keto-prostaglandin F2a,1TMS,isomer #4CCCCC=C(/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C3159.9Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TMS,isomer #1CCCCCC(=O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O2700.5Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TMS,isomer #2CCCCCC(=O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C2724.7Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TMS,isomer #3CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C3046.3Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TMS,isomer #4CCCCCC(=O)/C=C/[C@H]1[C@H](O)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C2726.2Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TMS,isomer #5CCCCC=C(/C=C/[C@H]1[C@H](O)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C3034.3Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TMS,isomer #6CCCCC=C(/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C3078.6Semi standard non polar33892256
15-Keto-prostaglandin F2a,3TMS,isomer #1CCCCCC(=O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C2696.6Semi standard non polar33892256
15-Keto-prostaglandin F2a,3TMS,isomer #2CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C3006.4Semi standard non polar33892256
15-Keto-prostaglandin F2a,3TMS,isomer #3CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2998.7Semi standard non polar33892256
15-Keto-prostaglandin F2a,3TMS,isomer #4CCCCC=C(/C=C/[C@H]1[C@H](O)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2984.9Semi standard non polar33892256
15-Keto-prostaglandin F2a,4TMS,isomer #1CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2964.5Semi standard non polar33892256
15-Keto-prostaglandin F2a,4TMS,isomer #1CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2751.3Standard non polar33892256
15-Keto-prostaglandin F2a,4TMS,isomer #1CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C)C[C@H](O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2956.4Standard polar33892256
15-Keto-prostaglandin F2a,1TBDMS,isomer #1CCCCCC(=O)/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O2984.7Semi standard non polar33892256
15-Keto-prostaglandin F2a,1TBDMS,isomer #2CCCCCC(=O)/C=C/[C@H]1[C@H](O)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O2985.2Semi standard non polar33892256
15-Keto-prostaglandin F2a,1TBDMS,isomer #3CCCCCC(=O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C3113.6Semi standard non polar33892256
15-Keto-prostaglandin F2a,1TBDMS,isomer #4CCCCC=C(/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3400.4Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TBDMS,isomer #1CCCCCC(=O)/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O3185.1Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TBDMS,isomer #2CCCCCC(=O)/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C3225.6Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TBDMS,isomer #3CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3480.8Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TBDMS,isomer #4CCCCCC(=O)/C=C/[C@H]1[C@H](O)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C3225.2Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TBDMS,isomer #5CCCCC=C(/C=C/[C@H]1[C@H](O)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3478.3Semi standard non polar33892256
15-Keto-prostaglandin F2a,2TBDMS,isomer #6CCCCC=C(/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3568.2Semi standard non polar33892256
15-Keto-prostaglandin F2a,3TBDMS,isomer #1CCCCCC(=O)/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C3401.9Semi standard non polar33892256
15-Keto-prostaglandin F2a,3TBDMS,isomer #2CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3647.7Semi standard non polar33892256
15-Keto-prostaglandin F2a,3TBDMS,isomer #3CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3701.3Semi standard non polar33892256
15-Keto-prostaglandin F2a,3TBDMS,isomer #4CCCCC=C(/C=C/[C@H]1[C@H](O)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3690.8Semi standard non polar33892256
15-Keto-prostaglandin F2a,4TBDMS,isomer #1CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3844.9Semi standard non polar33892256
15-Keto-prostaglandin F2a,4TBDMS,isomer #1CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3447.5Standard non polar33892256
15-Keto-prostaglandin F2a,4TBDMS,isomer #1CCCCC=C(/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3218.3Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - 15-Keto-prostaglandin F2a GC-EI-TOF (Non-derivatized)splash10-001r-2920000000-a626ce383bf6aa5f26152017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 15-Keto-prostaglandin F2a GC-EI-TOF (Non-derivatized)splash10-001r-2920000000-a626ce383bf6aa5f26152018-05-18HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 15-Keto-prostaglandin F2a GC-MS (Non-derivatized) - 70eV, Positivesplash10-0570-4498000000-cc0a6152c4c014df4b6f2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 15-Keto-prostaglandin F2a GC-MS (3 TMS) - 70eV, Positivesplash10-0udi-6300890000-f0f8f41dcfc9d8dec0cd2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 15-Keto-prostaglandin F2a GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 10V, Positive-QTOFsplash10-00kr-0019000000-910369cab5e253b484e62017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 20V, Positive-QTOFsplash10-00kr-2295000000-e2c04166a9405e56f2fc2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 40V, Positive-QTOFsplash10-00dr-9160000000-23fb78d0cc03202e32122017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 10V, Negative-QTOFsplash10-0ue9-0009000000-e05daa9da0040142e39c2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 20V, Negative-QTOFsplash10-0f8i-2069000000-8c098522c3791b504d192017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 40V, Negative-QTOFsplash10-0a4i-9441000000-d1759dfb65fcc9f9b4702017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 10V, Negative-QTOFsplash10-0udi-0039000000-db45ea43b0b32962d5432021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 20V, Negative-QTOFsplash10-0fri-0094000000-e560b2602cb2e45b3c662021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 40V, Negative-QTOFsplash10-052p-9151000000-c46a461dbc0a557352d52021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 10V, Positive-QTOFsplash10-014r-0019000000-e81e2e2f5abdc4bb9c392021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 20V, Positive-QTOFsplash10-014r-9356000000-a519ec47287e412b92ed2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 15-Keto-prostaglandin F2a 40V, Positive-QTOFsplash10-00kf-9100000000-fb5ea9c2e3392b9c60142021-09-24Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane (predicted from logP)
Biospecimen Locations
  • Blood
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.000209 +/- 0.000006 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.000188 +/- 0.000111 uMAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023345
KNApSAcK IDNot Available
Chemspider ID4444410
KEGG Compound IDC05960
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID7035
PubChem Compound5280887
PDB IDNot Available
ChEBI ID28442
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Cornette JC, Kirton KT, Schneider WP, Sun FF, Johnson RA, Nidy EG: Preparation and quantitation of urinary metabolites of prostaglandin F2alpha by radioimmunoassay. Prostaglandins. 1975 Feb;9(2):323-38. [PubMed:1135444 ]
  2. Satoh K, Yasumizu T, Fukuoka H, Kinoshita K, Kaneko Y, Tsuchiya M, Sakamoto S: Prostaglandin F2 alpha metabolite levels in plasma, amniotic fluid, and urine during pregnancy and labor. Am J Obstet Gynecol. 1979 Apr 15;133(8):886-90. [PubMed:434032 ]
  3. Komoto J, Yamada T, Watanabe K, Woodward DF, Takusagawa F: Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost. Biochemistry. 2006 Feb 21;45(7):1987-96. [PubMed:16475787 ]
  4. Tai HH, Ensor CM, Tong M, Zhou H, Yan F: Prostaglandin catabolizing enzymes. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:483-93. [PubMed:12432938 ]
  5. Hansen HS: 15-hydroxyprostaglandin dehydrogenase. A review. Prostaglandins. 1976 Oct;12(4):647-79. [PubMed:184496 ]
  6. Anggard E: The biological activities of three metabolites of prostaglandin E 1. Acta Physiol Scand. 1966 Apr;66(4):509-10. [PubMed:5951401 ]

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
Gene Name:
HPGD
Uniprot ID:
P15428
Molecular weight:
28977.105