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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-08-14 00:24:46 UTC
Update Date2021-09-14 15:47:03 UTC
HMDB IDHMDB0004684
Secondary Accession Numbers
  • HMDB04684
Metabolite Identification
Common Name11,12,15-THETA
Description11,12,15-trihydroxyeicosatrienoic acid (11,12,15-THETA) is a metabolite of the 15-lipoxygenase (15-LO) pathway of arachidonic acid (AA). 11,12,15-THETA is an endothelium-derived relaxing factor. Acetylcholine stimulates AA release from membrane phospholipids of vascular endothelial cells (ECs). AA is released from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by phospholipase A2 (PLA2), or from phosphatidylinositol (PI) by phospholipase C (PLC) pathway. The diacylglycerol (DAG) lipase can convert DAG into 2-arachidonoylglycerol from which free AA can be released by monoacylglycerol (MAG) lipase or fatty acid amidohydrolase (FAAH). 11,12,15-THETA mediates the acetylcholine-induced vaso-relaxation, via activation of the K+ channels to hyperpolarize the smooth muscle membrane and induce relaxation. (PMID: 12907422 , 16024567 , 15388505 , 14622984 ).
Structure
Data?1582752311
Synonyms
ValueSource
11,12,15-Trihydroxyicosatrienoic acidKegg
(5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acidKegg
(5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acidKegg
11,12,15-TrihydroxyicosatrienoateGenerator
(5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoateGenerator
(5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoateGenerator
11,12,15-TriHETREHMDB
11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoateHMDB
11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acidHMDB
Chemical FormulaC20H34O5
Average Molecular Weight354.481
Monoisotopic Molecular Weight354.240624198
IUPAC Name(5Z,8Z,13E,15S)-11,12,15-trihydroxyicosa-5,8,13-trienoic acid
Traditional Name(5Z,8Z,13E,15S)-11,12,15-trihydroxyicosa-5,8,13-trienoic acid
CAS Registry NumberNot Available
SMILES
CCCCC[C@H](O)\C=C\C(O)C(O)C\C=C/C\C=C/CCCC(O)=O
InChI Identifier
InChI=1S/C20H34O5/c1-2-3-9-12-17(21)15-16-19(23)18(22)13-10-7-5-4-6-8-11-14-20(24)25/h4,6-7,10,15-19,21-23H,2-3,5,8-9,11-14H2,1H3,(H,24,25)/b6-4-,10-7-,16-15+/t17-,18?,19?/m0/s1
InChI KeyPRMWQIVYOYCJQC-YZSNCDGGSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hydroxyeicosatrienoic acids. These are eicosanoic acids with an attached hydroxyl group and three CC double bonds.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassEicosanoids
Direct ParentHydroxyeicosatrienoic acids
Alternative Parents
Substituents
  • Hydroxyeicosatrienoic acid
  • Long-chain fatty acid
  • Hydroxy fatty acid
  • Fatty acid
  • Unsaturated fatty acid
  • Secondary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Polyol
  • Organic oxide
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Carbonyl group
  • Organooxygen compound
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Process

Naturally occurring process

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.052 g/LALOGPS
logP10(4.46) g/LALOGPS
logP10(3.41) g/LChemAxon
logS10(-3.8) g/LALOGPS
pKa (Strongest Acidic)4.82ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area97.99 ŲChemAxon
Rotatable Bond Count15ChemAxon
Refractivity103.23 m³·mol⁻¹ChemAxon
Polarizability40.45 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+193.5731661259
DarkChem[M-H]-190.13831661259
DeepCCS[M+H]+195.23330932474
DeepCCS[M-H]-192.87430932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
11,12,15-THETACCCCC[C@H](O)\C=C\C(O)C(O)C\C=C/C\C=C/CCCC(O)=O4573.5Standard polar33892256
11,12,15-THETACCCCC[C@H](O)\C=C\C(O)C(O)C\C=C/C\C=C/CCCC(O)=O2583.1Standard non polar33892256
11,12,15-THETACCCCC[C@H](O)\C=C\C(O)C(O)C\C=C/C\C=C/CCCC(O)=O2796.8Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
11,12,15-THETA,1TMS,isomer #1CCCCC[C@@H](/C=C/C(O)C(O)C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C3020.5Semi standard non polar33892256
11,12,15-THETA,1TMS,isomer #2CCCCC[C@H](O)/C=C/C(O[Si](C)(C)C)C(O)C/C=C\C/C=C\CCCC(=O)O2989.6Semi standard non polar33892256
11,12,15-THETA,1TMS,isomer #3CCCCC[C@H](O)/C=C/C(O)C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C2987.2Semi standard non polar33892256
11,12,15-THETA,1TMS,isomer #4CCCCC[C@H](O)/C=C/C(O)C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C2914.6Semi standard non polar33892256
11,12,15-THETA,2TMS,isomer #1CCCCC[C@@H](/C=C/C(O[Si](C)(C)C)C(O)C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C2982.4Semi standard non polar33892256
11,12,15-THETA,2TMS,isomer #2CCCCC[C@@H](/C=C/C(O)C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C2994.7Semi standard non polar33892256
11,12,15-THETA,2TMS,isomer #3CCCCC[C@@H](/C=C/C(O)C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2928.0Semi standard non polar33892256
11,12,15-THETA,2TMS,isomer #4CCCCC[C@H](O)/C=C/C(O[Si](C)(C)C)C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C2986.9Semi standard non polar33892256
11,12,15-THETA,2TMS,isomer #5CCCCC[C@H](O)/C=C/C(O[Si](C)(C)C)C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C2916.7Semi standard non polar33892256
11,12,15-THETA,2TMS,isomer #6CCCCC[C@H](O)/C=C/C(O)C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2914.4Semi standard non polar33892256
11,12,15-THETA,3TMS,isomer #1CCCCC[C@@H](/C=C/C(O[Si](C)(C)C)C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C2939.5Semi standard non polar33892256
11,12,15-THETA,3TMS,isomer #2CCCCC[C@@H](/C=C/C(O[Si](C)(C)C)C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2876.3Semi standard non polar33892256
11,12,15-THETA,3TMS,isomer #3CCCCC[C@@H](/C=C/C(O)C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C2886.0Semi standard non polar33892256
11,12,15-THETA,3TMS,isomer #4CCCCC[C@H](O)/C=C/C(O[Si](C)(C)C)C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2895.1Semi standard non polar33892256
11,12,15-THETA,4TMS,isomer #1CCCCC[C@@H](/C=C/C(O[Si](C)(C)C)C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C2852.6Semi standard non polar33892256
11,12,15-THETA,1TBDMS,isomer #1CCCCC[C@@H](/C=C/C(O)C(O)C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3252.5Semi standard non polar33892256
11,12,15-THETA,1TBDMS,isomer #2CCCCC[C@H](O)/C=C/C(O[Si](C)(C)C(C)(C)C)C(O)C/C=C\C/C=C\CCCC(=O)O3241.9Semi standard non polar33892256
11,12,15-THETA,1TBDMS,isomer #3CCCCC[C@H](O)/C=C/C(O)C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3235.6Semi standard non polar33892256
11,12,15-THETA,1TBDMS,isomer #4CCCCC[C@H](O)/C=C/C(O)C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C3171.6Semi standard non polar33892256
11,12,15-THETA,2TBDMS,isomer #1CCCCC[C@@H](/C=C/C(O[Si](C)(C)C(C)(C)C)C(O)C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3437.8Semi standard non polar33892256
11,12,15-THETA,2TBDMS,isomer #2CCCCC[C@@H](/C=C/C(O)C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3444.3Semi standard non polar33892256
11,12,15-THETA,2TBDMS,isomer #3CCCCC[C@@H](/C=C/C(O)C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3416.6Semi standard non polar33892256
11,12,15-THETA,2TBDMS,isomer #4CCCCC[C@H](O)/C=C/C(O[Si](C)(C)C(C)(C)C)C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C3432.1Semi standard non polar33892256
11,12,15-THETA,2TBDMS,isomer #5CCCCC[C@H](O)/C=C/C(O[Si](C)(C)C(C)(C)C)C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C3399.6Semi standard non polar33892256
11,12,15-THETA,2TBDMS,isomer #6CCCCC[C@H](O)/C=C/C(O)C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3389.1Semi standard non polar33892256
11,12,15-THETA,3TBDMS,isomer #1CCCCC[C@@H](/C=C/C(O[Si](C)(C)C(C)(C)C)C(C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3619.0Semi standard non polar33892256
11,12,15-THETA,3TBDMS,isomer #2CCCCC[C@@H](/C=C/C(O[Si](C)(C)C(C)(C)C)C(O)C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3609.9Semi standard non polar33892256
11,12,15-THETA,3TBDMS,isomer #3CCCCC[C@@H](/C=C/C(O)C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3627.6Semi standard non polar33892256
11,12,15-THETA,3TBDMS,isomer #4CCCCC[C@H](O)/C=C/C(O[Si](C)(C)C(C)(C)C)C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3580.8Semi standard non polar33892256
11,12,15-THETA,4TBDMS,isomer #1CCCCC[C@@H](/C=C/C(O[Si](C)(C)C(C)(C)C)C(C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3768.2Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 11,12,15-THETA GC-MS (Non-derivatized) - 70eV, Positivesplash10-000j-6923000000-729d8425f6b7961f12d62017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 11,12,15-THETA GC-MS (4 TMS) - 70eV, Positivesplash10-004i-9114245000-a9570b215fa6eaa9ff8c2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 11,12,15-THETA GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 10V, Positive-QTOFsplash10-00kr-0109000000-ab120d0eda68ea7185662017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 20V, Positive-QTOFsplash10-066r-2914000000-0b5d4d8637219b27e3892017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 40V, Positive-QTOFsplash10-0abc-9720000000-6f9ba40124a0e432ec2a2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 10V, Negative-QTOFsplash10-0udi-0009000000-2fe2fc467f93d0346dcd2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 20V, Negative-QTOFsplash10-0k9i-1926000000-cebc50fd199b4b5d0e572017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 40V, Negative-QTOFsplash10-0a4i-8910000000-87e98db32bedae5d986e2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 10V, Positive-QTOFsplash10-00kr-0029000000-ebef111dafd7c78d37ac2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 20V, Positive-QTOFsplash10-014i-4569000000-4dc08f53204dfc55a3442021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 40V, Positive-QTOFsplash10-0apl-9510000000-2862ca5a79b8eded3e162021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 10V, Negative-QTOFsplash10-0udi-0009000000-cbb73f896579bb3935fd2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 20V, Negative-QTOFsplash10-0f79-1649000000-07299e0617da708c9b9a2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11,12,15-THETA 40V, Negative-QTOFsplash10-052b-9651000000-4bdcfd2275713a32e9062021-09-24Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified<0.0001 uMAdult (>18 years old)Both
Normal
details
BloodDetected and Quantified<0.0001 uMAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023403
KNApSAcK IDNot Available
Chemspider ID10128338
KEGG Compound IDC14782
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound11954043
PDB IDNot Available
ChEBI ID34128
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Campbell WB, Spitzbarth N, Gauthier KM, Pfister SL: 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2648-56. Epub 2003 Aug 7. [PubMed:12907422 ]
  2. Tang X, Edwards EM, Holmes BB, Falck JR, Campbell WB: Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H37-45. Epub 2005 Jul 15. [PubMed:16024567 ]
  3. Zhang DX, Gauthier KM, Chawengsub Y, Holmes BB, Campbell WB: Cyclooxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries. Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H302-9. Epub 2004 Sep 23. [PubMed:15388505 ]
  4. Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB: Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450. Arch Biochem Biophys. 2003 Dec 1;420(1):142-52. [PubMed:14622984 ]

Only showing the first 10 proteins. There are 24 proteins in total.

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
General function:
Involved in monooxygenase activity
Specific function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular weight:
56848.42
General function:
Involved in monooxygenase activity
Specific function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular weight:
57756.285
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.
Gene Name:
CYP1B1
Uniprot ID:
Q16678
Molecular weight:
60845.33
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular weight:
55710.075
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.
Gene Name:
CYP2F1
Uniprot ID:
P24903
Molecular weight:
55500.64
General function:
Involved in monooxygenase activity
Specific function:
Not Available
Gene Name:
CYP4X1
Uniprot ID:
Q8N118
Molecular weight:
58874.62
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.81

Only showing the first 10 proteins. There are 24 proteins in total.