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Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2006-08-14 01:03:56 UTC

Update Date

2022-09-22 17:43:53 UTC

HMDB ID

HMDB0004701

Secondary Accession Numbers

HMDB04701

Metabolite Identification

Common Name

9,10-Epoxyoctadecenoic acid

Description

9,10-Epoxyoctadecenoic acid (9,10-EOA) is a peroxidation product of linoleic acid (LA). 9,10-EOA is a naturally occurring component of oxidized low density lipoprotein (LDL), the level of which increases with aging, atherosclerosis, and rheumatoid arthritis, perhaps due to an increase in 15-lipoxygenase and free oxygen radicals. 9,10-EOA is a proliferator-activated receptors (PPAR) gamma2 ligand, that is antiosteogenic without stimulating adipocyte differentiation. Studies in dogs suggest that 9,10-EOA has toxic cardiovascular effects. (PMID: 12665667 , 12021203 , 10667371 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0004701
     RDKit          3D
9,10-Epoxyoctadecenoic acid
 53 53  0  0  0  0  0  0  0  0999 V2000
   -7.1223    1.0316    0.7276 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3261   -0.0746   -0.2684 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0790   -0.9221   -0.3762 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8898   -0.0688   -0.8325 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6683   -0.9969   -0.9172 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4911   -0.2436   -1.3494 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4055   -0.1205   -0.6435 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1846   -0.6991    0.6685 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9102    0.3724    1.6685 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6425   -0.0720    2.9854 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4134    0.6417    2.2589 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6397   -0.1459    2.0463 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1913   -0.2103    0.6724 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5543    1.1547    0.1190 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0998    1.0263   -1.2579 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3386    0.1963   -1.3954 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4375    0.7818   -0.5744 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7370    0.0635   -0.6211 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7078   -1.3263   -0.1621 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6504   -1.8701    0.2498 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8362   -2.1469   -0.1454 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1873    0.8292    1.2891 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9370    1.0486    1.4621 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0576    1.9961    0.1630 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1355   -0.7376    0.1015 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6436    0.3324   -1.2434 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8263   -1.2972    0.6366 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2137   -1.7486   -1.0831 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0734    0.4213   -1.7957 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6474    0.7098   -0.0888 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5874   -1.6518   -0.0696 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9244   -1.6867   -1.7915 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5489    0.2504   -2.3554 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5950    0.4688   -1.0793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3523   -1.4216    0.6626 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0718   -1.3055    1.0329 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6313    1.2238    1.6958 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5356    1.6436    2.8052 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4590   -1.2089    2.4105 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369    0.2279    2.7467 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1861   -0.7654    0.7094 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5980   -0.7329   -0.0608 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1970    1.6855    0.8258 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6041    1.7237    0.0516 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2540    2.0001   -1.7537 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3056    0.5114   -1.8759 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1295   -0.8599   -1.1937 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6572    0.3033   -2.4755 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1401    0.9662    0.4874 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6258    1.8184   -0.9842 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4758    0.6058    0.0158 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1937    0.0948   -1.6527 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7479   -1.8440   -0.4455 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 11  9  1  0
  1 22  1  0
  1 23  1  0
  1 24  1  0
  2 25  1  0
  2 26  1  0
  3 27  1  0
  3 28  1  0
  4 29  1  0
  4 30  1  0
  5 31  1  0
  5 32  1  0
  6 33  1  0
  7 34  1  0
  8 35  1  0
  8 36  1  0
  9 37  1  0
 11 38  1  0
 12 39  1  0
 12 40  1  0
 13 41  1  0
 13 42  1  0
 14 43  1  0
 14 44  1  0
 15 45  1  0
 15 46  1  0
 16 47  1  0
 16 48  1  0
 17 49  1  0
 17 50  1  0
 18 51  1  0
 18 52  1  0
 21 53  1  0
M  END

  Mrv1652304202019532D          

 21 21  0  0  0  0            999 V2000
   22.4291  -18.9189    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   29.2720  -20.0458    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   28.5575  -18.8083    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   22.8416  -19.6333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.0165  -19.6333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.5561  -20.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.3021  -20.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.2706  -19.6333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.9850  -20.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   25.6995  -19.6333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.5876  -19.6333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   26.4141  -20.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.8732  -20.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   27.1285  -19.6333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.8732  -20.8708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.1586  -21.2834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   27.8430  -20.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.1586  -22.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.4441  -22.5209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.5575  -19.6333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.4441  -23.3459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  2 20  1  0  0  0  0
  3 20  2  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7 11  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 16 18  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0004701

> <DATABASE_NAME>
hmdb

> <SMILES>
CCCCC\C=C/CC1OC1CCCCCCCC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C18H32O3/c1-2-3-4-5-7-10-13-16-17(21-16)14-11-8-6-9-12-15-18(19)20/h7,10,16-17H,2-6,8-9,11-15H2,1H3,(H,19,20)/b10-7-

> <INCHI_KEY>
FBUKMFOXMZRGRB-YFHOEESVSA-N

> <FORMULA>
C18H32O3

> <MOLECULAR_WEIGHT>
296.4449

> <EXACT_MASS>
296.23514489

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
53

> <JCHEM_AVERAGE_POLARIZABILITY>
37.219920234338566

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
8-{3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl}octanoic acid

> <ALOGPS_LOGP>
6.35

> <JCHEM_LOGP>
5.483879889333333

> <ALOGPS_LOGS>
-5.77

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.615325352098631

> <JCHEM_PKA_STRONGEST_BASIC>
-4.204825765954202

> <JCHEM_POLAR_SURFACE_AREA>
49.83

> <JCHEM_REFRACTIVITY>
86.92309999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
14

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
5.02e-04 g/l

> <JCHEM_TRADITIONAL_IUPAC>
9,10-epoxyoctadecenoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0004701
     RDKit          3D
9,10-Epoxyoctadecenoic acid
 53 53  0  0  0  0  0  0  0  0999 V2000
   -7.1223    1.0316    0.7276 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3261   -0.0746   -0.2684 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0790   -0.9221   -0.3762 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8898   -0.0688   -0.8325 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6683   -0.9969   -0.9172 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4911   -0.2436   -1.3494 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4055   -0.1205   -0.6435 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1846   -0.6991    0.6685 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9102    0.3724    1.6685 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6425   -0.0720    2.9854 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4134    0.6417    2.2589 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6397   -0.1459    2.0463 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1913   -0.2103    0.6724 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5543    1.1547    0.1190 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0998    1.0263   -1.2579 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3386    0.1963   -1.3954 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4375    0.7818   -0.5744 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7370    0.0635   -0.6211 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7078   -1.3263   -0.1621 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6504   -1.8701    0.2498 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8362   -2.1469   -0.1454 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1873    0.8292    1.2891 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9370    1.0486    1.4621 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0576    1.9961    0.1630 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1355   -0.7376    0.1015 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6436    0.3324   -1.2434 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8263   -1.2972    0.6366 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2137   -1.7486   -1.0831 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0734    0.4213   -1.7957 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6474    0.7098   -0.0888 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5874   -1.6518   -0.0696 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9244   -1.6867   -1.7915 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5489    0.2504   -2.3554 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5950    0.4688   -1.0793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3523   -1.4216    0.6626 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0718   -1.3055    1.0329 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6313    1.2238    1.6958 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5356    1.6436    2.8052 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4590   -1.2089    2.4105 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369    0.2279    2.7467 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1861   -0.7654    0.7094 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5980   -0.7329   -0.0608 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1970    1.6855    0.8258 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6041    1.7237    0.0516 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2540    2.0001   -1.7537 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3056    0.5114   -1.8759 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1295   -0.8599   -1.1937 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6572    0.3033   -2.4755 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1401    0.9662    0.4874 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6258    1.8184   -0.9842 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4758    0.6058    0.0158 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1937    0.0948   -1.6527 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7479   -1.8440   -0.4455 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 11  9  1  0
  1 22  1  0
  1 23  1  0
  1 24  1  0
  2 25  1  0
  2 26  1  0
  3 27  1  0
  3 28  1  0
  4 29  1  0
  4 30  1  0
  5 31  1  0
  5 32  1  0
  6 33  1  0
  7 34  1  0
  8 35  1  0
  8 36  1  0
  9 37  1  0
 11 38  1  0
 12 39  1  0
 12 40  1  0
 13 41  1  0
 13 42  1  0
 14 43  1  0
 14 44  1  0
 15 45  1  0
 15 46  1  0
 16 47  1  0
 16 48  1  0
 17 49  1  0
 17 50  1  0
 18 51  1  0
 18 52  1  0
 21 53  1  0
M  END

HEADER    PROTEIN                                 20-APR-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   20-APR-20         0                                  
HETATM    1  O   UNK     0      41.868 -35.315   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      54.641 -37.419   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      53.307 -35.109   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0      42.638 -36.649   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      41.097 -36.649   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      43.971 -37.419   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      39.764 -37.419   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      45.305 -36.649   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      46.639 -37.419   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      47.972 -36.649   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      38.430 -36.649   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      49.306 -37.419   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      37.097 -37.419   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      50.640 -36.649   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      37.097 -38.959   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      35.763 -39.729   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      51.974 -37.419   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      35.763 -41.269   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      34.429 -42.039   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      53.307 -36.649   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      34.429 -43.579   0.000  0.00  0.00           C+0
CONECT    1    4    5                                                       
CONECT    2   20                                                            
CONECT    3   20                                                            
CONECT    4    1    5    6                                                  
CONECT    5    1    4    7                                                  
CONECT    6    4    8                                                       
CONECT    7    5   11                                                       
CONECT    8    6    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   12                                                       
CONECT   11    7   13                                                       
CONECT   12   10   14                                                       
CONECT   13   11   15                                                       
CONECT   14   12   17                                                       
CONECT   15   13   16                                                       
CONECT   16   15   18                                                       
CONECT   17   14   20                                                       
CONECT   18   16   19                                                       
CONECT   19   18   21                                                       
CONECT   20    2    3   17                                                  
CONECT   21   19                                                            
MASTER        0    0    0    0    0    0    0    0   21    0   42    0
END

COMPND    HMDB0004701
HETATM    1  C1  UNL     1      -7.122   1.032   0.728  1.00  0.00           C  
HETATM    2  C2  UNL     1      -7.326  -0.075  -0.268  1.00  0.00           C  
HETATM    3  C3  UNL     1      -6.079  -0.922  -0.376  1.00  0.00           C  
HETATM    4  C4  UNL     1      -4.890  -0.069  -0.832  1.00  0.00           C  
HETATM    5  C5  UNL     1      -3.668  -0.997  -0.917  1.00  0.00           C  
HETATM    6  C6  UNL     1      -2.491  -0.244  -1.349  1.00  0.00           C  
HETATM    7  C7  UNL     1      -1.405  -0.121  -0.643  1.00  0.00           C  
HETATM    8  C8  UNL     1      -1.185  -0.699   0.668  1.00  0.00           C  
HETATM    9  C9  UNL     1      -0.910   0.372   1.669  1.00  0.00           C  
HETATM   10  O1  UNL     1      -0.642  -0.072   2.985  1.00  0.00           O  
HETATM   11  C10 UNL     1       0.413   0.642   2.259  1.00  0.00           C  
HETATM   12  C11 UNL     1       1.640  -0.146   2.046  1.00  0.00           C  
HETATM   13  C12 UNL     1       2.191  -0.210   0.672  1.00  0.00           C  
HETATM   14  C13 UNL     1       2.554   1.155   0.119  1.00  0.00           C  
HETATM   15  C14 UNL     1       3.100   1.026  -1.258  1.00  0.00           C  
HETATM   16  C15 UNL     1       4.339   0.196  -1.395  1.00  0.00           C  
HETATM   17  C16 UNL     1       5.438   0.782  -0.574  1.00  0.00           C  
HETATM   18  C17 UNL     1       6.737   0.063  -0.621  1.00  0.00           C  
HETATM   19  C18 UNL     1       6.708  -1.326  -0.162  1.00  0.00           C  
HETATM   20  O2  UNL     1       5.650  -1.870   0.250  1.00  0.00           O  
HETATM   21  O3  UNL     1       7.836  -2.147  -0.145  1.00  0.00           O  
HETATM   22  H1  UNL     1      -6.187   0.829   1.289  1.00  0.00           H  
HETATM   23  H2  UNL     1      -7.937   1.049   1.462  1.00  0.00           H  
HETATM   24  H3  UNL     1      -7.058   1.996   0.163  1.00  0.00           H  
HETATM   25  H4  UNL     1      -8.135  -0.738   0.102  1.00  0.00           H  
HETATM   26  H5  UNL     1      -7.644   0.332  -1.243  1.00  0.00           H  
HETATM   27  H6  UNL     1      -5.826  -1.297   0.637  1.00  0.00           H  
HETATM   28  H7  UNL     1      -6.214  -1.749  -1.083  1.00  0.00           H  
HETATM   29  H8  UNL     1      -5.073   0.421  -1.796  1.00  0.00           H  
HETATM   30  H9  UNL     1      -4.647   0.710  -0.089  1.00  0.00           H  
HETATM   31  H10 UNL     1      -3.587  -1.652  -0.070  1.00  0.00           H  
HETATM   32  H11 UNL     1      -3.924  -1.687  -1.792  1.00  0.00           H  
HETATM   33  H12 UNL     1      -2.549   0.250  -2.355  1.00  0.00           H  
HETATM   34  H13 UNL     1      -0.595   0.469  -1.079  1.00  0.00           H  
HETATM   35  H14 UNL     1      -0.352  -1.422   0.663  1.00  0.00           H  
HETATM   36  H15 UNL     1      -2.072  -1.306   1.033  1.00  0.00           H  
HETATM   37  H16 UNL     1      -1.631   1.224   1.696  1.00  0.00           H  
HETATM   38  H17 UNL     1       0.536   1.644   2.805  1.00  0.00           H  
HETATM   39  H18 UNL     1       1.459  -1.209   2.410  1.00  0.00           H  
HETATM   40  H19 UNL     1       2.437   0.228   2.747  1.00  0.00           H  
HETATM   41  H20 UNL     1       3.186  -0.765   0.709  1.00  0.00           H  
HETATM   42  H21 UNL     1       1.598  -0.733  -0.061  1.00  0.00           H  
HETATM   43  H22 UNL     1       3.197   1.685   0.826  1.00  0.00           H  
HETATM   44  H23 UNL     1       1.604   1.724   0.052  1.00  0.00           H  
HETATM   45  H24 UNL     1       3.254   2.000  -1.754  1.00  0.00           H  
HETATM   46  H25 UNL     1       2.306   0.511  -1.876  1.00  0.00           H  
HETATM   47  H26 UNL     1       4.130  -0.860  -1.194  1.00  0.00           H  
HETATM   48  H27 UNL     1       4.657   0.303  -2.476  1.00  0.00           H  
HETATM   49  H28 UNL     1       5.140   0.966   0.487  1.00  0.00           H  
HETATM   50  H29 UNL     1       5.626   1.818  -0.984  1.00  0.00           H  
HETATM   51  H30 UNL     1       7.476   0.606   0.016  1.00  0.00           H  
HETATM   52  H31 UNL     1       7.194   0.095  -1.653  1.00  0.00           H  
HETATM   53  H32 UNL     1       8.748  -1.844  -0.445  1.00  0.00           H  
CONECT    1    2   22   23   24
CONECT    2    3   25   26
CONECT    3    4   27   28
CONECT    4    5   29   30
CONECT    5    6   31   32
CONECT    6    7    7   33
CONECT    7    8   34
CONECT    8    9   35   36
CONECT    9   10   11   37
CONECT   10   11
CONECT   11   12   38
CONECT   12   13   39   40
CONECT   13   14   41   42
CONECT   14   15   43   44
CONECT   15   16   45   46
CONECT   16   17   47   48
CONECT   17   18   49   50
CONECT   18   19   51   52
CONECT   19   20   20   21
CONECT   21   53
END

HMDB0004701
     RDKit          3D
9,10-Epoxyoctadecenoic acid
 53 53  0  0  0  0  0  0  0  0999 V2000
   -7.1223    1.0316    0.7276 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3261   -0.0746   -0.2684 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0790   -0.9221   -0.3762 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8898   -0.0688   -0.8325 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6683   -0.9969   -0.9172 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4911   -0.2436   -1.3494 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4055   -0.1205   -0.6435 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1846   -0.6991    0.6685 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9102    0.3724    1.6685 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6425   -0.0720    2.9854 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4134    0.6417    2.2589 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6397   -0.1459    2.0463 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1913   -0.2103    0.6724 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5543    1.1547    0.1190 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0998    1.0263   -1.2579 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3386    0.1963   -1.3954 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4375    0.7818   -0.5744 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7370    0.0635   -0.6211 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7078   -1.3263   -0.1621 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6504   -1.8701    0.2498 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8362   -2.1469   -0.1454 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1873    0.8292    1.2891 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9370    1.0486    1.4621 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0576    1.9961    0.1630 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1355   -0.7376    0.1015 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6436    0.3324   -1.2434 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8263   -1.2972    0.6366 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2137   -1.7486   -1.0831 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0734    0.4213   -1.7957 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6474    0.7098   -0.0888 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5874   -1.6518   -0.0696 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9244   -1.6867   -1.7915 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5489    0.2504   -2.3554 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5950    0.4688   -1.0793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3523   -1.4216    0.6626 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0718   -1.3055    1.0329 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6313    1.2238    1.6958 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5356    1.6436    2.8052 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4590   -1.2089    2.4105 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369    0.2279    2.7467 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1861   -0.7654    0.7094 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5980   -0.7329   -0.0608 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1970    1.6855    0.8258 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6041    1.7237    0.0516 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2540    2.0001   -1.7537 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3056    0.5114   -1.8759 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1295   -0.8599   -1.1937 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6572    0.3033   -2.4755 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1401    0.9662    0.4874 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6258    1.8184   -0.9842 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4758    0.6058    0.0158 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1937    0.0948   -1.6527 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7479   -1.8440   -0.4455 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 11  9  1  0
  1 22  1  0
  1 23  1  0
  1 24  1  0
  2 25  1  0
  2 26  1  0
  3 27  1  0
  3 28  1  0
  4 29  1  0
  4 30  1  0
  5 31  1  0
  5 32  1  0
  6 33  1  0
  7 34  1  0
  8 35  1  0
  8 36  1  0
  9 37  1  0
 11 38  1  0
 12 39  1  0
 12 40  1  0
 13 41  1  0
 13 42  1  0
 14 43  1  0
 14 44  1  0
 15 45  1  0
 15 46  1  0
 16 47  1  0
 16 48  1  0
 17 49  1  0
 17 50  1  0
 18 51  1  0
 18 52  1  0
 21 53  1  0
M  END

View in JSmol View Stereo Labels

Synonyms

Value	Source
9(10)-Epoxyoctadec-12Z-enoic acid	ChEBI
9,10-EOA	ChEBI
9,10-Epoxy-12Z-octadecenoic acid	ChEBI
9,10-Epoxyoctadec-12(Z)-enoic acid	ChEBI
Coronaric acid	ChEBI
9(10)-Epoxyoctadec-12Z-enoate	Generator
9,10-Epoxy-12Z-octadecenoate	Generator
9,10-Epoxyoctadec-12(Z)-enoate	Generator
Coronarate	Generator
9,10-Epoxyoctadecenoate	Generator
(+/-)-9(10)-epoxy-12Z-octadecenoate	HMDB
(+/-)-9(10)-epoxy-12Z-octadecenoic acid	HMDB
9(10)-EpOME	HMDB
9,10-Epoxyoctadecenoic acid	ChEBI

Chemical Formula

C₁₈H₃₂O₃

Average Molecular Weight

296.4449

Monoisotopic Molecular Weight

296.23514489

IUPAC Name

8-{3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl}octanoic acid

Traditional Name

9,10-epoxyoctadecenoic acid

CAS Registry Number

Not Available

SMILES

CCCCC\C=C/CC1OC1CCCCCCCC(O)=O

InChI Identifier

InChI=1S/C18H32O3/c1-2-3-4-5-7-10-13-16-17(21-16)14-11-8-6-9-12-15-18(19)20/h7,10,16-17H,2-6,8-9,11-15H2,1H3,(H,19,20)/b10-7-

InChI Key

FBUKMFOXMZRGRB-YFHOEESVSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as medium-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty acids and conjugates

Direct Parent

Medium-chain fatty acids

Alternative Parents

Substituents

Medium-chain fatty acid
Epoxy fatty acid
Heterocyclic fatty acid
Carboxylic acid derivative
Carboxylic acid
Dialkyl ether
Oxirane
Ether
Monocarboxylic acid or derivatives
Oxacycle
Organoheterocyclic compound
Organic oxide
Carbonyl group
Organooxygen compound
Hydrocarbon derivative
Organic oxygen compound
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

epoxyoctadecenoic acid (CHEBI:34494 )
Other Octadecanoids (LMFA02000037 )

Ontology

Physiological effect

Not Available

Disposition

Biological location

Non-excretory biofluid

Biofluid or Excreta

Blood (PMID: 18953024)
Cerebrospinal Fluid (CSF) (HMDB: HMDB0004701)

Cellular substructure

Extracellular (HMDB: HMDB0004701)
Membrane (HMDB: HMDB0004701)

Source

Exogenous

Exogenous (HMDB: HMDB0004701)

Food

Animal origin

Poultry

Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Equine

Horse (FooDB: FOOD00378)

Endogenous

Endogenous (HMDB: HMDB0004701)

Process

Not Available

Role

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
Water Solubility	0.0005 g/L	ALOGPS
logP	6.35	ALOGPS
logP	5.48	ChemAxon
logS	-5.8	ALOGPS
pKa (Strongest Acidic)	4.62	ChemAxon
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	49.83 Å²	ChemAxon
Rotatable Bond Count	14	ChemAxon
Refractivity	86.92 m³·mol⁻¹	ChemAxon
Polarizability	37.22 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	177.254	31661259
DarkChem	[M-H]-	174.319	31661259
DeepCCS	[M+H]+	177.723	30932474
DeepCCS	[M-H]-	174.027	30932474
DeepCCS	[M-2H]-	210.248	30932474
DeepCCS	[M+Na]+	186.538	30932474
AllCCS	[M+H]+	182.5	32859911
AllCCS	[M+H-H2O]+	179.6	32859911
AllCCS	[M+NH4]+	185.3	32859911
AllCCS	[M+Na]+	186.1	32859911
AllCCS	[M-H]-	182.3	32859911
AllCCS	[M+Na-2H]-	183.6	32859911
AllCCS	[M+HCOO]-	185.2	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
9,10-Epoxyoctadecenoic acid	CCCCC\C=C/CC1OC1CCCCCCCC(O)=O	3394.5	Standard polar	33892256
9,10-Epoxyoctadecenoic acid	CCCCC\C=C/CC1OC1CCCCCCCC(O)=O	2129.9	Standard non polar	33892256
9,10-Epoxyoctadecenoic acid	CCCCC\C=C/CC1OC1CCCCCCCC(O)=O	2298.1	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
9,10-Epoxyoctadecenoic acid,1TMS,isomer #1	CCCCC/C=C\CC1OC1CCCCCCCC(=O)O[Si](C)(C)C	2301.1	Semi standard non polar	33892256
9,10-Epoxyoctadecenoic acid,1TBDMS,isomer #1	CCCCC/C=C\CC1OC1CCCCCCCC(=O)O[Si](C)(C)C(C)(C)C	2549.1	Semi standard non polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - 9,10-Epoxyoctadecenoic acid GC-MS (Non-derivatized) - 70eV, Positive	splash10-0596-7950000000-a7d6f240b5040a8c27a7	2017-09-01	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - 9,10-Epoxyoctadecenoic acid GC-MS (1 TMS) - 70eV, Positive	splash10-0h99-9752000000-4d63c881504328381437	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - 9,10-Epoxyoctadecenoic acid GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 10V, Positive-QTOF	splash10-004i-0190000000-8fcb6e52fa137a01bdb5	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 20V, Positive-QTOF	splash10-020r-6940000000-aed267f1e6e4cb3f5209	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 40V, Positive-QTOF	splash10-0536-9200000000-3e01c026dad4bd3c61a5	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 10V, Negative-QTOF	splash10-0002-0190000000-60908406af279bf8075c	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 20V, Negative-QTOF	splash10-0f92-1390000000-3d68f1fc729ac1835d04	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 40V, Negative-QTOF	splash10-052f-9800000000-847443fa21f1bd143f61	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 10V, Positive-QTOF	splash10-01ta-3290000000-554c7484119c1f68c4c9	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 20V, Positive-QTOF	splash10-0adm-9640000000-07c88224b92305706929	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 40V, Positive-QTOF	splash10-0aou-9200000000-d5f3572fdd2199e507de	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 10V, Negative-QTOF	splash10-0002-0090000000-ca4c92b9d45ecad2cc0f	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 20V, Negative-QTOF	splash10-0002-0290000000-136d7186b67f37f9af41	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 9,10-Epoxyoctadecenoic acid 40V, Negative-QTOF	splash10-002f-9870000000-4f02d014245eec92d3a9	2021-09-23	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Membrane

Biospecimen Locations

Blood
Cerebrospinal Fluid (CSF)
Urine

Tissue Locations

Not Available

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	0.00150 +/- 0.000974 uM	Adult (>18 years old)	Both	Normal	18953024	details
Blood	Detected and Quantified	0.00217 +/- 0.00023 uM	Adult (>18 years old)	Both	Normal	21359215	details
Blood	Detected and Quantified	0.00547 +/- 0.0074 uM	Adult (>18 years old)	Both	Normal	21359215	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.00151 +/- 0.00121 uM	Adult (>18 years old)	Both	Normal	John W. Newman, U...	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Urine	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Cancer patients undergoing total body irradiation	31424920	details

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB112216

KNApSAcK ID

Not Available

Chemspider ID

4861048

KEGG Compound ID

C14825

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

6246154

PDB ID

Not Available

ChEBI ID

34494

Food Biomarker Ontology

Not Available

VMH ID

C14825

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Mitchell LA, Grant DF, Melchert RB, Petty NM, Kennedy RH: Linoleic acid metabolites act to increase contractility in isolated rat heart. Cardiovasc Toxicol. 2002;2(3):219-30. [PubMed:12665667 ]
Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL: Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology. 2002 Jun;143(6):2376-84. [PubMed:12021203 ]
Jira W, Spiteller G: Dramatic increase of linoleic acid peroxidation products by aging, atherosclerosis, and rheumatoid arthritis. Adv Exp Med Biol. 1999;469:479-83. [PubMed:10667371 ]

Only showing the first 10 proteins. There are 24 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. Cytochrome P450 3A4

General function:: Involved in monooxygenase activity
Specific function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:: CYP3A4
Uniprot ID:: P08684
Molecular weight:: 57255.585

Enzyme Details

2. Cytochrome P450 2C9

General function:: Involved in monooxygenase activity
Specific function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:: CYP2C9
Uniprot ID:: P11712
Molecular weight:: 55627.365

Enzyme Details

3. Cytochrome P450 2C19

General function:: Involved in monooxygenase activity
Specific function:: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:: CYP2C19
Uniprot ID:: P33261
Molecular weight:: 55944.565

Enzyme Details

4. Cytochrome P450 2E1

General function:: Involved in monooxygenase activity
Specific function:: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:: CYP2E1
Uniprot ID:: P05181
Molecular weight:: 56848.42

Enzyme Details

5. Cytochrome P450 3A43

General function:: Involved in monooxygenase activity
Specific function:: Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:: CYP3A43
Uniprot ID:: Q9HB55
Molecular weight:: 57756.285

Enzyme Details

6. Cytochrome P450 1B1

General function:: Involved in monooxygenase activity
Specific function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.
Gene Name:: CYP1B1
Uniprot ID:: Q16678
Molecular weight:: 60845.33

Enzyme Details

7. Cytochrome P450 2C18

General function:: Involved in monooxygenase activity
Specific function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:: CYP2C18
Uniprot ID:: P33260
Molecular weight:: 55710.075

Enzyme Details

8. Cytochrome P450 2F1

General function:: Secondary metabolites biosynthesis, transport and catabolism
Specific function:: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.
Gene Name:: CYP2F1
Uniprot ID:: P24903
Molecular weight:: 55500.64

Enzyme Details

9. Cytochrome P450 4X1

General function:: Involved in monooxygenase activity
Specific function:: Not Available
Gene Name:: CYP4X1
Uniprot ID:: Q8N118
Molecular weight:: 58874.62

Enzyme Details

10. Cytochrome P450 2B6

General function:: Involved in monooxygenase activity
Specific function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:: CYP2B6
Uniprot ID:: P20813
Molecular weight:: 56277.81

Only showing the first 10 proteins. There are 24 proteins in total.

Show all enzymes and transporters

Showing metabocard for 9,10-Epoxyoctadecenoic acid (HMDB0004701)

MOL for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

3D MOL for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

3D SDF for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

3D-SDF for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

PDB for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

3D PDB for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

SMILES for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

INCHI for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

Structure for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

3D Structure for HMDB0004701 (9,10-Epoxyoctadecenoic acid)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

Enzymes