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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2006-10-16 10:59:41 UTC
Update Date2021-10-13 04:45:30 UTC
HMDB IDHMDB0004992
Secondary Accession Numbers
  • HMDB04992
Metabolite Identification
Common NameBenzocaine
DescriptionBenzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. Benzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. Benzocaine is an ester, a compound made from the organic acid PABA (para-aminobenzoic acid) and ethanol. The process in which this ester is created is known as Fischer esterification.
Structure
Data?1582752338
Synonyms
ValueSource
4-Aminobenzoic acid ethyl esterChEBI
Amben ethyl esterChEBI
BenzocainaChEBI
BenzocainumChEBI
Ethyl aminobenzoateChEBI
Ethyl p-aminobenzoateChEBI
Ethyl p-aminophenylcarboxylateChEBI
p-(Ethoxycarbonyl)anilineChEBI
p-CarbethoxyanilineChEBI
p-Ethoxycarboxylic anilineChEBI
ParathesinKegg
4-Aminobenzoate ethyl esterGenerator
Ethyl aminobenzoic acidGenerator
Ethyl p-aminobenzoic acidGenerator
Ethyl p-aminophenylcarboxylic acidGenerator
(P-(Ethoxycarbonyl)phenylamineHMDB
4-(Ethoxycarbonyl)anilineHMDB
4-(Ethoxycarbonyl)phenylamineHMDB
4-AminobenzoateHMDB
4-Aminobenzoic acidHMDB
4-CarbethoxyanilineHMDB
AethoformHMDB
AmericaineHMDB, MeSH
Anaesthan-syngalaHMDB
AnaesthesinHMDB, MeSH
AnaesthinHMDB
AnestezinHMDB
AnesthesinHMDB, MeSH
AnesthesineHMDB
AnesthoneHMDB
Baby anbesolHMDB
BenzoakHMDB
DermoplastHMDB
Diet aydsHMDB
EthoformHMDB, MeSH
Ethyl 4-aminobenzoateHMDB
Ethyl 4-aminobenzoic acidHMDB
Ethyl P-aminobenzenecarboxylateHMDB
Ethylester kyseliny P-aminobenzooveHMDB
HurricaineHMDB
IdenthesinHMDB
KeloformHMDB
NorcainHMDB
NorcaineHMDB
Ora-jelHMDB
Orabase-bHMDB
OrthesinHMDB
P-AminobenzoateHMDB
P-Aminobenzoic acidHMDB
P-Aminobenzoic acid ethyl esterHMDB
ParathesineHMDB
Slim mint gumHMDB
SolarcaineHMDB
Solu HHMDB
TopcaineHMDB
Benzocaine acetateMeSH, HMDB
Formate, benzocaineMeSH, HMDB
Acetate, benzocaineMeSH, HMDB
Benzocaine formateMeSH, HMDB
Hydrobromide, benzocaineMeSH, HMDB
Methanesulfonate, benzocaineMeSH, HMDB
BensokainMeSH, HMDB
Benzocaine hydrochlorideMeSH, HMDB
Benzocaine hydrobromideMeSH, HMDB
Benzocaine methanesulfonateMeSH, HMDB
Hydrochloride, benzocaineMeSH, HMDB
Chemical FormulaC9H11NO2
Average Molecular Weight165.1891
Monoisotopic Molecular Weight165.078978601
IUPAC Nameethyl 4-aminobenzoate
Traditional Namebenzocaine
CAS Registry Number94-09-7
SMILES
CCOC(=O)C1=CC=C(N)C=C1
InChI Identifier
InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3
InChI KeyBLFLLBZGZJTVJG-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzoic acid esters. These are ester derivatives of benzoic acid.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzoic acids and derivatives
Direct ParentBenzoic acid esters
Alternative Parents
Substituents
  • Aminobenzoic acid or derivatives
  • Benzoate ester
  • Benzoyl
  • Aniline or substituted anilines
  • Amino acid or derivatives
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Monocarboxylic acid or derivatives
  • Amine
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point92 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility23320 mg/L @ 25 °C (est)The Good Scents Company Information System
LogP1.86HANSCH,C ET AL. (1995)
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+CBM148.230932474
[M+H]+Not Available145.903http://allccs.zhulab.cn/database/detail?ID=AllCCS00000755
Predicted Molecular Properties
PropertyValueSource
Water Solubility2.85 g/LALOGPS
logP10(2.2) g/LALOGPS
logP10(1.5) g/LChemAxon
logS10(-1.8) g/LALOGPS
pKa (Strongest Basic)2.78ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area52.32 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity47.53 m³·mol⁻¹ChemAxon
Polarizability17.46 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+137.86931661259
DarkChem[M-H]-135.04531661259
DeepCCS[M+H]+139.07430932474
DeepCCS[M-H]-135.47530932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
BenzocaineCCOC(=O)C1=CC=C(N)C=C12483.7Standard polar33892256
BenzocaineCCOC(=O)C1=CC=C(N)C=C11490.8Standard non polar33892256
BenzocaineCCOC(=O)C1=CC=C(N)C=C11597.6Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Benzocaine,1TMS,isomer #1CCOC(=O)C1=CC=C(N[Si](C)(C)C)C=C11799.7Semi standard non polar33892256
Benzocaine,1TMS,isomer #1CCOC(=O)C1=CC=C(N[Si](C)(C)C)C=C11797.8Standard non polar33892256
Benzocaine,1TMS,isomer #1CCOC(=O)C1=CC=C(N[Si](C)(C)C)C=C12017.5Standard polar33892256
Benzocaine,2TMS,isomer #1CCOC(=O)C1=CC=C(N([Si](C)(C)C)[Si](C)(C)C)C=C11786.3Semi standard non polar33892256
Benzocaine,2TMS,isomer #1CCOC(=O)C1=CC=C(N([Si](C)(C)C)[Si](C)(C)C)C=C11868.0Standard non polar33892256
Benzocaine,2TMS,isomer #1CCOC(=O)C1=CC=C(N([Si](C)(C)C)[Si](C)(C)C)C=C11943.2Standard polar33892256
Benzocaine,1TBDMS,isomer #1CCOC(=O)C1=CC=C(N[Si](C)(C)C(C)(C)C)C=C12015.5Semi standard non polar33892256
Benzocaine,1TBDMS,isomer #1CCOC(=O)C1=CC=C(N[Si](C)(C)C(C)(C)C)C=C11995.9Standard non polar33892256
Benzocaine,1TBDMS,isomer #1CCOC(=O)C1=CC=C(N[Si](C)(C)C(C)(C)C)C=C12148.6Standard polar33892256
Benzocaine,2TBDMS,isomer #1CCOC(=O)C1=CC=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C12279.3Semi standard non polar33892256
Benzocaine,2TBDMS,isomer #1CCOC(=O)C1=CC=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C12248.0Standard non polar33892256
Benzocaine,2TBDMS,isomer #1CCOC(=O)C1=CC=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C12157.7Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Benzocaine GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-00dl-0980000000-9bd6d020be04ce49bd3e2014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Benzocaine EI-B (Non-derivatized)splash10-00di-4900000000-9341302295e361a20bfd2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Benzocaine EI-B (Non-derivatized)splash10-0109-9400000000-8e31c925b871e0f0299e2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Benzocaine EI-B (Non-derivatized)splash10-0109-9400000000-c755b4e5336a2867357e2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Benzocaine EI-B (Non-derivatized)splash10-01b9-1900000000-a811093acfd0672fece62017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Benzocaine CI-B (Non-derivatized)splash10-014i-0900000000-49302e8e4fd5158a36da2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Benzocaine EI-B (Non-derivatized)splash10-00di-5900000000-dcd2847110af7c87bf182017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Benzocaine GC-EI-TOF (Non-derivatized)splash10-00dl-0980000000-9bd6d020be04ce49bd3e2017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Benzocaine GC-MS (Non-derivatized) - 70eV, Positivesplash10-00di-3900000000-8d1e571ebb0276875b642017-08-28Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Benzocaine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-00xr-6900000000-0594451f3b181ab3c8832014-09-20Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-00kr-0900000000-b54aebb77e7a69ada07c2012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-014i-5900000000-ce90658bd0fc66df820d2012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-03xu-9100000000-5179b7804d2c59e71aa42012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine EI-B (HITACHI RMU-7M) , Positive-QTOFsplash10-00di-4900000000-9341302295e361a20bfd2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine EI-B (HITACHI RMU-7) , Positive-QTOFsplash10-0109-9400000000-8e31c925b871e0f0299e2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine EI-B (HITACHI RMU-6D) , Positive-QTOFsplash10-0109-9400000000-c755b4e5336a2867357e2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine EI-B (HITACHI M-60) , Positive-QTOFsplash10-01b9-1900000000-57d39b512bc5bdbb49872012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine CI-B (HITACHI M-60) , Positive-QTOFsplash10-014i-0900000000-49302e8e4fd5158a36da2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine EI-B (JEOL JMS-DX-300) , Positive-QTOFsplash10-00di-5900000000-dcd2847110af7c87bf182012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive-QTOFsplash10-014i-0900000000-a0f10abbe67842c2c9582012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive-QTOFsplash10-00du-5900000000-43a89461a4d9cc5d14092012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive-QTOFsplash10-00dl-9600000000-049e2653cbbf24aaf0102012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive-QTOFsplash10-002f-9100000000-6fbc7720b326773643af2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive-QTOFsplash10-00ou-9000000000-d7f7622c3a270c5ffcbb2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-qTof , Positive-QTOFsplash10-000i-5900100000-72ac4bcb64db0d25261e2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-QQ , positive-QTOFsplash10-014i-0900000000-e061a0f4172b47a8bd222017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-QQ , positive-QTOFsplash10-00du-5900000000-54757e57c91d3eaa19762017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-QQ , positive-QTOFsplash10-00dl-9600000000-049e2653cbbf24aaf0102017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Benzocaine LC-ESI-QQ , positive-QTOFsplash10-002f-9100000000-e16fc2db7a632fc6f4da2017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzocaine 10V, Positive-QTOFsplash10-014j-0900000000-4479c2a548f4aa1aa6972017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzocaine 20V, Positive-QTOFsplash10-00xr-0900000000-45723c7ad554a9d56bd12017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzocaine 40V, Positive-QTOFsplash10-0006-9300000000-fab7bee6cbcfbc918d9c2017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzocaine 10V, Negative-QTOFsplash10-03di-1900000000-477a27b86174851323842017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzocaine 20V, Negative-QTOFsplash10-03xr-3900000000-df3eaaf30a4e906fb0382017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Benzocaine 40V, Negative-QTOFsplash10-00kf-9400000000-e9f4c1de93ac2ce072b42017-07-26Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, CDCl3, experimental)2012-12-05Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB01086
Phenol Explorer Compound IDNot Available
FooDB IDFDB023574
KNApSAcK IDNot Available
Chemspider ID13854242
KEGG Compound IDC07527
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkBenzocaine
METLIN ID3934
PubChem Compound2337
PDB IDNot Available
ChEBI ID116735
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1836611
References
Synthesis ReferenceSalts from naphtholmonosulphonic acids and p-aminobensoic acid ethyl ether. (1904), DE 181324 19040213 CAN 1:9748 AN 1907:9748
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Bong CL, Hilliard J, Seefelder C: Severe methemoglobinemia from topical benzocaine 7.5% (baby orajel) use for teething pain in a toddler. Clin Pediatr (Phila). 2009 Mar;48(2):209-11. doi: 10.1177/0009922808324491. Epub 2008 Oct 3. [PubMed:18836057 ]
  2. FENTON PF, COWGILL GR, STONE MA, JUSTICE DH: The nutrition of the mouse. VIII. Studies on pantothenic acid, biotin, inositol and paminobenzoic acid. J Nutr. 1950 Oct;42(2):257-69. [PubMed:14795275 ]

Enzymes

General function:
Involved in ion channel activity
Specific function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms
Gene Name:
SCN10A
Uniprot ID:
Q9Y5Y9
Molecular weight:
220623.6