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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2007-01-22 12:36:42 UTC
Update Date2022-03-07 02:49:28 UTC
HMDB IDHMDB0005784
Secondary Accession Numbers
  • HMDB05784
Metabolite Identification
Common NameHydroxytyrosol
DescriptionHydroxytyrosol, also known as dopet, belongs to the class of organic compounds known as tyrosols. These are organic aromatic compounds containing a phenethyl alcohol moiety that carries a hydroxyl group at the 4-position of the benzene group. Hydroxytyrosol is found, on average, in the highest concentration within olives (Olea europaea) and grape wine. Hydroxytyrosol has also been detected, but not quantified in, several different foods, such as cloves (Syzygium aromaticum), fruits, olive oil, and rapes (Brassica napus var. napus). This could make hydroxytyrosol a potential biomarker for the consumption of these foods. Hydroxytyrosol is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. Based on a literature review a significant number of articles have been published on Hydroxytyrosol.
Structure
Data?1582752364
Synonyms
ValueSource
3,4-DihydroxyphenylethanolChEBI
DopetChEBI
2-(3,4-Dihydroxyphenyl)ethanolMeSH
beta-3,4-Dihydroxyphenylethyl alcoholMeSH
3-HydroxytyrosolHMDB
4-(2-Hydroxyethyl)-1,2-benzenediolHMDB
2-(3'-hydroxyphenyl)ethanolHMDB
2-(3-hydroxyphenyl)ethanolHMDB
2-(3',4'-Dihydroxyphenyl)ethanolHMDB
2-(3,4-Hydroxyphenyl)ethanolHMDB
3'-HydroxytyrosolHMDB
3,4-Dihydroxyphenethyl alcoholHMDB
Homoprotocatechuyl alcoholHMDB
Chemical FormulaC8H10O3
Average Molecular Weight154.1632
Monoisotopic Molecular Weight154.062994186
IUPAC Name4-(2-hydroxyethyl)benzene-1,2-diol
Traditional Namehydroxytyrosol
CAS Registry Number10597-60-1
SMILES
OCCC1=CC=C(O)C(O)=C1
InChI Identifier
InChI=1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2
InChI KeyJUUBCHWRXWPFFH-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as tyrosols. These are organic aromatic compounds containing a phenethyl alcohol moiety that carries a hydroxyl group at the 4-position of the benzene group.
KingdomOrganic compounds
Super ClassBenzenoids
ClassPhenols
Sub ClassTyrosols and derivatives
Direct ParentTyrosols
Alternative Parents
Substituents
  • Tyrosol
  • Catechol
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Monocyclic benzene moiety
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling Point355.40 °C. @ 760.00 mm Hg (est)The Good Scents Company Information System
Water Solubility271600 mg/L @ 25 °C (est)The Good Scents Company Information System
LogP0.020 (est)The Good Scents Company Information System
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility17.4 g/LALOGPS
logP0.13ALOGPS
logP0.89ChemAxon
logS-0.95ALOGPS
pKa (Strongest Acidic)9.45ChemAxon
pKa (Strongest Basic)-2.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area60.69 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity41.59 m³·mol⁻¹ChemAxon
Polarizability15.74 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+131.78731661259
DarkChem[M-H]-129.90531661259
DeepCCS[M+H]+132.29630932474
DeepCCS[M-H]-128.46630932474
DeepCCS[M-2H]-166.11930932474
DeepCCS[M+Na]+141.65930932474
AllCCS[M+H]+133.432859911
AllCCS[M+H-H2O]+128.932859911
AllCCS[M+NH4]+137.632859911
AllCCS[M+Na]+138.832859911
AllCCS[M-H]-131.432859911
AllCCS[M+Na-2H]-132.732859911
AllCCS[M+HCOO]-134.332859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
HydroxytyrosolOCCC1=CC=C(O)C(O)=C13036.3Standard polar33892256
HydroxytyrosolOCCC1=CC=C(O)C(O)=C11701.8Standard non polar33892256
HydroxytyrosolOCCC1=CC=C(O)C(O)=C11693.5Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Hydroxytyrosol,1TMS,isomer #1C[Si](C)(C)OCCC1=CC=C(O)C(O)=C11768.8Semi standard non polar33892256
Hydroxytyrosol,1TMS,isomer #2C[Si](C)(C)OC1=CC=C(CCO)C=C1O1655.7Semi standard non polar33892256
Hydroxytyrosol,1TMS,isomer #3C[Si](C)(C)OC1=CC(CCO)=CC=C1O1660.2Semi standard non polar33892256
Hydroxytyrosol,2TMS,isomer #1C[Si](C)(C)OCCC1=CC=C(O[Si](C)(C)C)C(O)=C11703.1Semi standard non polar33892256
Hydroxytyrosol,2TMS,isomer #2C[Si](C)(C)OCCC1=CC=C(O)C(O[Si](C)(C)C)=C11696.3Semi standard non polar33892256
Hydroxytyrosol,2TMS,isomer #3C[Si](C)(C)OC1=CC=C(CCO)C=C1O[Si](C)(C)C1693.8Semi standard non polar33892256
Hydroxytyrosol,3TMS,isomer #1C[Si](C)(C)OCCC1=CC=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C11741.4Semi standard non polar33892256
Hydroxytyrosol,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCCC1=CC=C(O)C(O)=C11973.5Semi standard non polar33892256
Hydroxytyrosol,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=CC=C(CCO)C=C1O1904.5Semi standard non polar33892256
Hydroxytyrosol,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC1=CC(CCO)=CC=C1O1899.9Semi standard non polar33892256
Hydroxytyrosol,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCCC1=CC=C(O[Si](C)(C)C(C)(C)C)C(O)=C12176.8Semi standard non polar33892256
Hydroxytyrosol,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCCC1=CC=C(O)C(O[Si](C)(C)C(C)(C)C)=C12165.2Semi standard non polar33892256
Hydroxytyrosol,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC1=CC=C(CCO)C=C1O[Si](C)(C)C(C)(C)C2176.6Semi standard non polar33892256
Hydroxytyrosol,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCCC1=CC=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C12419.2Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Hydroxytyrosol GC-MS (Non-derivatized) - 70eV, Positivesplash10-00di-2900000000-8d596359f3e8b95f4fa72017-07-27Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hydroxytyrosol GC-MS (3 TMS) - 70eV, Positivesplash10-0avi-8194000000-1246fe8fdd02629c75a62017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hydroxytyrosol GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hydroxytyrosol GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 10V, Positive-QTOFsplash10-052r-0900000000-a1441b9d84728fafbb092016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 20V, Positive-QTOFsplash10-052r-1900000000-fb3b6c0cad97ea8833c92016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 40V, Positive-QTOFsplash10-102i-9500000000-6b10b75df8f0b9e05c362016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 10V, Negative-QTOFsplash10-0udi-0900000000-eedf780d36ff3efc3d4a2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 20V, Negative-QTOFsplash10-0fk9-1900000000-0a567eded9b9beab7d872016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 40V, Negative-QTOFsplash10-0596-7900000000-7f6f49833d505eb07a7f2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 10V, Negative-QTOFsplash10-00di-0900000000-ee9e9b8403f62cfc7fdf2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 20V, Negative-QTOFsplash10-00di-0900000000-37557f00ee289c910aae2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 40V, Negative-QTOFsplash10-00di-4900000000-4f2e2d4e2b43d505841d2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 10V, Positive-QTOFsplash10-000i-0900000000-49cbe0a256086ac73ab62021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 20V, Positive-QTOFsplash10-0670-1900000000-89117076f87a6733280c2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hydroxytyrosol 40V, Positive-QTOFsplash10-0gb9-9100000000-300510e1926eff1f33362021-09-23Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Feces
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.16 +/- 0.084 uMAdult (>18 years old)BothNormal details
FecesDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableConsuming polyphenols described by Phenol-Explorer entry 674 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableConsuming polyphenols described by Phenol-Explorer entry 674 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableConsuming polyphenols described by Phenol-Explorer entry 674 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableConsuming polyphenols described by Phenol-Explorer entry 674 details
UrineDetected and Quantified0.163 umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified0.0230-5.850 umol/mmol creatinineAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected and Quantified0.0543 umol/mmol creatinineAdult (>18 years old)Female
High risk of coronary artery disease
details
UrineDetected and Quantified0.0924 umol/mmol creatinineAdult (>18 years old)Male
High risk of coronary artery disease
details
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB12771
Phenol Explorer Compound ID1051
FooDB IDFDB008754
KNApSAcK IDC00032635
Chemspider ID74680
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkHydroxytyrosol
METLIN IDNot Available
PubChem Compound82755
PDB IDNot Available
ChEBI ID68889
Food Biomarker OntologyNot Available
VMH ID34DHPE
MarkerDB IDNot Available
Good Scents IDrw1700131
References
Synthesis ReferenceVoswinckel, Hugo. Derivatives of Pyrocatechol. Berichte der Deutschen Chemischen Gesellschaft (1910), 42 4651-4.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. O'Dowd Y, Driss F, Dang PM, Elbim C, Gougerot-Pocidalo MA, Pasquier C, El-Benna J: Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils. Biochem Pharmacol. 2004 Nov 15;68(10):2003-8. [PubMed:15476671 ]
  2. D'Angelo S, Ingrosso D, Migliardi V, Sorrentino A, Donnarumma G, Baroni A, Masella L, Tufano MA, Zappia M, Galletti P: Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radic Biol Med. 2005 Apr 1;38(7):908-19. [PubMed:15749387 ]
  3. Satoh Y, Tajima K, Munekata M, Keasling JD, Lee TS: Engineering of L-tyrosine oxidation in Escherichia coli and microbial production of hydroxytyrosol. Metab Eng. 2012 Nov;14(6):603-10. doi: 10.1016/j.ymben.2012.08.002. Epub 2012 Aug 29. [PubMed:22948011 ]