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Record Information

Version

5.0

Status

Expected but not Quantified

Creation Date

2007-04-12 15:40:01 UTC

Update Date

2022-03-07 02:49:29 UTC

HMDB ID

HMDB0005844

Secondary Accession Numbers

HMDB05844

Metabolite Identification

Common Name

8-isoprostaglandin E2

Description

8-isoprostaglandin E2 is an isoprostane generated from the endoperoxide intermediate 8-iso-PGH2. Isoprostanes (IsoPs) are formed in vivo from the free radical-catalyzed peroxidation of arachidonate independent of cyclooxygenase (COX). Although the structures of these compounds are very similar to COX-derived prostaglandins (PGs), an important distinction between IsoPs and PGs is that IsoP bicycloendoperoxide intermediates contain side chains that are predominantly (>90%) oriented cis in relation to the prostane ring because the generation of these intermediates is favored kinetically. In contrast to other types of prostanoids, E2/D2-IsoPs are beta-hydroxyketone-containing compounds that can undergo reversible keto-enol tautomerization under both acidic and basic conditions, allowing rearrangement of the side chains that are initially cis to the more stable trans-configuration (PMID: 12746435 ). Dinoprostone is a naturally occurring prostaglandin E2 (PGE2) and the most common and most biologically active of the mammalian prostaglandins. It has important effects in labour and also stimulates osteoblasts to release factors which stimulate bone resorption by osteoclasts (a type of bone cell that removes bone tissue by removing the bone's mineralized matrix). PGE2 has been shown to increase vasodilation and cAMP production, to enhance the effects of bradykinin and histamine, to induce uterine contractions and to activate platelet aggregation. PGE2 is also responsible for maintaining the open passageway of the fetal ductus arteriosus; decreasing T-cell proliferation and lymphocyte migration and activating the secretion of IL-1alpha and IL-2. PGE2 exhibits both pro- and anti-inflammatory effects, particularly on dendritic cells (DC). Depending on the nature of maturation signals, PGE2 has different and sometimes opposite effects on DC biology. PGE2 exerts an inhibitory action, reducing the maturation of DC and their ability to present antigen. PGE2 has also been shown to stimulate DC and promote IL-12 production when given in combination with TNF-alpha. PGE2 is an environmentally bioactive substance. Its action is prolonged and sustained by other factors especially IL-10. It modulates the activities of professional DC by acting on their differentiation, maturation and their ability to secrete cytokines. PGE2 is a potent inducer of IL-10 in bone marrow-derived DC (BM-DC), and PGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype. (PMID: 16978535 )Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0005844
     RDKit          3D
8-isoprostaglandin E2
 57 57  0  0  0  0  0  0  0  0999 V2000
    6.7985    1.2862    0.0436 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3131    1.4274   -0.0945 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5816    0.1042    0.0273 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0117   -0.8749   -1.0273 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3193   -2.1787   -0.9198 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8477   -2.1998   -1.0535 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4029   -1.7119   -2.2884 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0848   -1.6096    0.0761 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9683   -0.9487   -0.0961 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2241   -0.3659    1.0626 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.1525   -0.8947    1.1813 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.7486   -1.2379   -0.2060 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0998   -1.7281    0.0676 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1701   -1.1708   -0.4345 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1038   -0.0150   -1.3120 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8417    1.2126   -0.7510 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3217    0.8816   -0.5413 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0186    2.0751   -0.0118 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2715    3.0259   -0.8007 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4099    2.2021    1.3133 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9590    0.1939    1.7381 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0962    0.0737    2.1585 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1539    1.4354    1.6947 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0946    1.1143    0.9498 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2064    1.7371    1.5664 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1789    0.6858   -0.8097 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1029    0.7941    0.9920 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.2184    2.3277   -0.0138 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9547    2.0332    0.7893 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875    1.9573   -1.0250 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4974    0.3668   -0.1031 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7333   -0.3029    1.0323 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1076   -1.0738   -0.8439 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9896   -0.4316   -2.0461 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7215   -2.8962   -1.6970 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6477   -2.6593    0.0474 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5388   -3.2902   -1.0606 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1089   -2.4230   -2.9035 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4719   -1.7367    1.0734 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5970   -0.8333   -1.1076 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7529   -0.5771    2.0232 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2096   -1.8257    1.8113 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6320   -0.3310   -0.7774 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1046   -2.0807   -0.5862 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1851   -2.6156    0.7361 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1738   -1.5614   -0.2106 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1616    0.2533   -1.7659 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7640   -0.2888   -2.2134 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4539    1.4997    0.2443 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7990    2.0458   -1.4706 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7924    0.5573   -1.5032 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4555    0.0267    0.1506 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8905    3.0233    1.6519 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7226    2.2858    1.2688 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8500    1.7373    2.7356 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1055    1.4672   -0.1018 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8743    2.0329    0.9000 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 11 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 24 25  1  0
 24 10  1  0
  1 26  1  0
  1 27  1  0
  1 28  1  0
  2 29  1  0
  2 30  1  0
  3 31  1  0
  3 32  1  0
  4 33  1  0
  4 34  1  0
  5 35  1  0
  5 36  1  0
  6 37  1  6
  7 38  1  0
  8 39  1  0
  9 40  1  0
 10 41  1  1
 11 42  1  1
 12 43  1  0
 12 44  1  0
 13 45  1  0
 14 46  1  0
 15 47  1  0
 15 48  1  0
 16 49  1  0
 16 50  1  0
 17 51  1  0
 17 52  1  0
 20 53  1  0
 23 54  1  0
 23 55  1  0
 24 56  1  6
 25 57  1  0
M  END

  Mrv0541 02231220312D          

 25 25  0  0  1  0            999 V2000
   20.0583   -8.5564    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.7088  -10.2634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.6062   -5.8514    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.6726   -5.9228    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.2310   -7.2817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.6062   -8.3264    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   17.9388   -8.8114    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   19.2736   -8.8114    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   19.0187   -9.5960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.1937   -9.5960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1541   -8.5564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.6062   -7.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.3207   -7.0889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.5411   -9.1085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.3207   -6.2639    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   20.0351   -5.8514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0351   -5.0264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7564   -8.8535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7497   -4.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5849   -8.0465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7497   -3.7890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8003   -7.7917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6287   -6.9847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4641   -3.3765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8441   -6.7297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  8  1  1  6  0  0  0
  2 10  2  0  0  0  0
 15  3  1  1  0  0  0
  4 25  1  0  0  0  0
  5 25  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6 12  1  1  0  0  0
  7 10  1  0  0  0  0
  7 11  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  2  0  0  0  0
 13 15  1  0  0  0  0
 14 18  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0005844

> <DATABASE_NAME>
hmdb

> <SMILES>
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17+,19+/m0/s1

> <INCHI_KEY>
XEYBRNLFEZDVAW-CLQOMRTCSA-N

> <FORMULA>
C20H32O5

> <MOLECULAR_WEIGHT>
352.4651

> <EXACT_MASS>
352.224974134

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_AVERAGE_POLARIZABILITY>
41.05519908887001

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(5Z)-7-[(1S,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid

> <ALOGPS_LOGP>
3.31

> <JCHEM_LOGP>
3.2252701369999994

> <ALOGPS_LOGS>
-3.90

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
14.678908140463108

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.303359525644919

> <JCHEM_PKA_STRONGEST_BASIC>
-1.6263175986188916

> <JCHEM_POLAR_SURFACE_AREA>
94.83000000000001

> <JCHEM_REFRACTIVITY>
99.43509999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
12

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
4.40e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
8-Iso-PGE2

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0005844
     RDKit          3D
8-isoprostaglandin E2
 57 57  0  0  0  0  0  0  0  0999 V2000
    6.7985    1.2862    0.0436 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3131    1.4274   -0.0945 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5816    0.1042    0.0273 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0117   -0.8749   -1.0273 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3193   -2.1787   -0.9198 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8477   -2.1998   -1.0535 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4029   -1.7119   -2.2884 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0848   -1.6096    0.0761 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9683   -0.9487   -0.0961 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2241   -0.3659    1.0626 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.1525   -0.8947    1.1813 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.7486   -1.2379   -0.2060 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0998   -1.7281    0.0676 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1701   -1.1708   -0.4345 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1038   -0.0150   -1.3120 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8417    1.2126   -0.7510 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3217    0.8816   -0.5413 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0186    2.0751   -0.0118 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2715    3.0259   -0.8007 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4099    2.2021    1.3133 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9590    0.1939    1.7381 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0962    0.0737    2.1585 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1539    1.4354    1.6947 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0946    1.1143    0.9498 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2064    1.7371    1.5664 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1789    0.6858   -0.8097 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1029    0.7941    0.9920 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.2184    2.3277   -0.0138 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9547    2.0332    0.7893 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875    1.9573   -1.0250 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4974    0.3668   -0.1031 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7333   -0.3029    1.0323 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1076   -1.0738   -0.8439 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9896   -0.4316   -2.0461 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7215   -2.8962   -1.6970 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6477   -2.6593    0.0474 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5388   -3.2902   -1.0606 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1089   -2.4230   -2.9035 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4719   -1.7367    1.0734 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5970   -0.8333   -1.1076 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7529   -0.5771    2.0232 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2096   -1.8257    1.8113 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6320   -0.3310   -0.7774 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1046   -2.0807   -0.5862 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1851   -2.6156    0.7361 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1738   -1.5614   -0.2106 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1616    0.2533   -1.7659 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7640   -0.2888   -2.2134 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4539    1.4997    0.2443 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7990    2.0458   -1.4706 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7924    0.5573   -1.5032 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4555    0.0267    0.1506 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8905    3.0233    1.6519 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7226    2.2858    1.2688 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8500    1.7373    2.7356 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1055    1.4672   -0.1018 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8743    2.0329    0.9000 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 11 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 24 25  1  0
 24 10  1  0
  1 26  1  0
  1 27  1  0
  1 28  1  0
  2 29  1  0
  2 30  1  0
  3 31  1  0
  3 32  1  0
  4 33  1  0
  4 34  1  0
  5 35  1  0
  5 36  1  0
  6 37  1  6
  7 38  1  0
  8 39  1  0
  9 40  1  0
 10 41  1  1
 11 42  1  1
 12 43  1  0
 12 44  1  0
 13 45  1  0
 14 46  1  0
 15 47  1  0
 15 48  1  0
 16 49  1  0
 16 50  1  0
 17 51  1  0
 17 52  1  0
 20 53  1  0
 23 54  1  0
 23 55  1  0
 24 56  1  6
 25 57  1  0
M  END

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  O   UNK     0      37.442 -15.972   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      33.056 -19.158   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      34.732 -10.923   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      25.522 -11.056   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      24.698 -13.593   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0      34.732 -15.543   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      33.486 -16.448   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      35.977 -16.448   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      35.502 -17.913   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      33.962 -17.913   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      32.021 -15.972   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      34.732 -14.003   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      36.065 -13.233   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      30.877 -17.003   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      36.065 -11.693   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      37.399 -10.923   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      37.399  -9.383   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      29.412 -16.527   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      38.733  -8.613   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      29.092 -15.020   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      38.733  -7.073   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      27.627 -14.545   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      27.307 -13.038   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      40.066  -6.303   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      25.842 -12.562   0.000  0.00  0.00           C+0
CONECT    1    8                                                            
CONECT    2   10                                                            
CONECT    3   15                                                            
CONECT    4   25                                                            
CONECT    5   25                                                            
CONECT    6    7    8   12                                                  
CONECT    7    6   10   11                                                  
CONECT    8    1    6    9                                                  
CONECT    9    8   10                                                       
CONECT   10    2    7    9                                                  
CONECT   11    7   14                                                       
CONECT   12    6   13                                                       
CONECT   13   12   15                                                       
CONECT   14   11   18                                                       
CONECT   15    3   13   16                                                  
CONECT   16   15   17                                                       
CONECT   17   16   19                                                       
CONECT   18   14   20                                                       
CONECT   19   17   21                                                       
CONECT   20   18   22                                                       
CONECT   21   19   24                                                       
CONECT   22   20   23                                                       
CONECT   23   22   25                                                       
CONECT   24   21                                                            
CONECT   25    4    5   23                                                  
MASTER        0    0    0    0    0    0    0    0   25    0   50    0
END

COMPND    HMDB0005844
HETATM    1  C1  UNL     1       6.799   1.286   0.044  1.00  0.00           C  
HETATM    2  C2  UNL     1       5.313   1.427  -0.094  1.00  0.00           C  
HETATM    3  C3  UNL     1       4.582   0.104   0.027  1.00  0.00           C  
HETATM    4  C4  UNL     1       5.012  -0.875  -1.027  1.00  0.00           C  
HETATM    5  C5  UNL     1       4.319  -2.179  -0.920  1.00  0.00           C  
HETATM    6  C6  UNL     1       2.848  -2.200  -1.054  1.00  0.00           C  
HETATM    7  O1  UNL     1       2.403  -1.712  -2.288  1.00  0.00           O  
HETATM    8  C7  UNL     1       2.085  -1.610   0.076  1.00  0.00           C  
HETATM    9  C8  UNL     1       0.968  -0.949  -0.096  1.00  0.00           C  
HETATM   10  C9  UNL     1       0.224  -0.366   1.063  1.00  0.00           C  
HETATM   11  C10 UNL     1      -1.152  -0.895   1.181  1.00  0.00           C  
HETATM   12  C11 UNL     1      -1.749  -1.238  -0.206  1.00  0.00           C  
HETATM   13  C12 UNL     1      -3.100  -1.728   0.068  1.00  0.00           C  
HETATM   14  C13 UNL     1      -4.170  -1.171  -0.435  1.00  0.00           C  
HETATM   15  C14 UNL     1      -4.104  -0.015  -1.312  1.00  0.00           C  
HETATM   16  C15 UNL     1      -4.842   1.213  -0.751  1.00  0.00           C  
HETATM   17  C16 UNL     1      -6.322   0.882  -0.541  1.00  0.00           C  
HETATM   18  C17 UNL     1      -7.019   2.075  -0.012  1.00  0.00           C  
HETATM   19  O2  UNL     1      -7.272   3.026  -0.801  1.00  0.00           O  
HETATM   20  O3  UNL     1      -7.410   2.202   1.313  1.00  0.00           O  
HETATM   21  C18 UNL     1      -1.959   0.194   1.738  1.00  0.00           C  
HETATM   22  O4  UNL     1      -3.096   0.074   2.158  1.00  0.00           O  
HETATM   23  C19 UNL     1      -1.154   1.435   1.695  1.00  0.00           C  
HETATM   24  C20 UNL     1       0.095   1.114   0.950  1.00  0.00           C  
HETATM   25  O5  UNL     1       1.206   1.737   1.566  1.00  0.00           O  
HETATM   26  H1  UNL     1       7.179   0.686  -0.810  1.00  0.00           H  
HETATM   27  H2  UNL     1       7.103   0.794   0.992  1.00  0.00           H  
HETATM   28  H3  UNL     1       7.218   2.328  -0.014  1.00  0.00           H  
HETATM   29  H4  UNL     1       4.955   2.033   0.789  1.00  0.00           H  
HETATM   30  H5  UNL     1       5.088   1.957  -1.025  1.00  0.00           H  
HETATM   31  H6  UNL     1       3.497   0.367  -0.103  1.00  0.00           H  
HETATM   32  H7  UNL     1       4.733  -0.303   1.032  1.00  0.00           H  
HETATM   33  H8  UNL     1       6.108  -1.074  -0.844  1.00  0.00           H  
HETATM   34  H9  UNL     1       4.990  -0.432  -2.046  1.00  0.00           H  
HETATM   35  H10 UNL     1       4.722  -2.896  -1.697  1.00  0.00           H  
HETATM   36  H11 UNL     1       4.648  -2.659   0.047  1.00  0.00           H  
HETATM   37  H12 UNL     1       2.539  -3.290  -1.061  1.00  0.00           H  
HETATM   38  H13 UNL     1       2.109  -2.423  -2.904  1.00  0.00           H  
HETATM   39  H14 UNL     1       2.472  -1.737   1.073  1.00  0.00           H  
HETATM   40  H15 UNL     1       0.597  -0.833  -1.108  1.00  0.00           H  
HETATM   41  H16 UNL     1       0.753  -0.577   2.023  1.00  0.00           H  
HETATM   42  H17 UNL     1      -1.210  -1.826   1.811  1.00  0.00           H  
HETATM   43  H18 UNL     1      -1.632  -0.331  -0.777  1.00  0.00           H  
HETATM   44  H19 UNL     1      -1.105  -2.081  -0.586  1.00  0.00           H  
HETATM   45  H20 UNL     1      -3.185  -2.616   0.736  1.00  0.00           H  
HETATM   46  H21 UNL     1      -5.174  -1.561  -0.211  1.00  0.00           H  
HETATM   47  H22 UNL     1      -3.162   0.253  -1.766  1.00  0.00           H  
HETATM   48  H23 UNL     1      -4.764  -0.289  -2.213  1.00  0.00           H  
HETATM   49  H24 UNL     1      -4.454   1.500   0.244  1.00  0.00           H  
HETATM   50  H25 UNL     1      -4.799   2.046  -1.471  1.00  0.00           H  
HETATM   51  H26 UNL     1      -6.792   0.557  -1.503  1.00  0.00           H  
HETATM   52  H27 UNL     1      -6.456   0.027   0.151  1.00  0.00           H  
HETATM   53  H28 UNL     1      -7.891   3.023   1.652  1.00  0.00           H  
HETATM   54  H29 UNL     1      -1.723   2.286   1.269  1.00  0.00           H  
HETATM   55  H30 UNL     1      -0.850   1.737   2.736  1.00  0.00           H  
HETATM   56  H31 UNL     1       0.106   1.467  -0.102  1.00  0.00           H  
HETATM   57  H32 UNL     1       1.874   2.033   0.900  1.00  0.00           H  
CONECT    1    2   26   27   28
CONECT    2    3   29   30
CONECT    3    4   31   32
CONECT    4    5   33   34
CONECT    5    6   35   36
CONECT    6    7    8   37
CONECT    7   38
CONECT    8    9    9   39
CONECT    9   10   40
CONECT   10   11   24   41
CONECT   11   12   21   42
CONECT   12   13   43   44
CONECT   13   14   14   45
CONECT   14   15   46
CONECT   15   16   47   48
CONECT   16   17   49   50
CONECT   17   18   51   52
CONECT   18   19   19   20
CONECT   20   53
CONECT   21   22   22   23
CONECT   23   24   54   55
CONECT   24   25   56
CONECT   25   57
END

HMDB0005844
     RDKit          3D
8-isoprostaglandin E2
 57 57  0  0  0  0  0  0  0  0999 V2000
    6.7985    1.2862    0.0436 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3131    1.4274   -0.0945 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5816    0.1042    0.0273 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0117   -0.8749   -1.0273 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3193   -2.1787   -0.9198 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8477   -2.1998   -1.0535 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4029   -1.7119   -2.2884 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0848   -1.6096    0.0761 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9683   -0.9487   -0.0961 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2241   -0.3659    1.0626 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.1525   -0.8947    1.1813 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.7486   -1.2379   -0.2060 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0998   -1.7281    0.0676 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1701   -1.1708   -0.4345 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1038   -0.0150   -1.3120 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8417    1.2126   -0.7510 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3217    0.8816   -0.5413 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0186    2.0751   -0.0118 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2715    3.0259   -0.8007 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4099    2.2021    1.3133 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9590    0.1939    1.7381 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0962    0.0737    2.1585 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1539    1.4354    1.6947 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0946    1.1143    0.9498 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2064    1.7371    1.5664 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1789    0.6858   -0.8097 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1029    0.7941    0.9920 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.2184    2.3277   -0.0138 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9547    2.0332    0.7893 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875    1.9573   -1.0250 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4974    0.3668   -0.1031 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7333   -0.3029    1.0323 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1076   -1.0738   -0.8439 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9896   -0.4316   -2.0461 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7215   -2.8962   -1.6970 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6477   -2.6593    0.0474 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5388   -3.2902   -1.0606 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1089   -2.4230   -2.9035 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4719   -1.7367    1.0734 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5970   -0.8333   -1.1076 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7529   -0.5771    2.0232 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2096   -1.8257    1.8113 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6320   -0.3310   -0.7774 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1046   -2.0807   -0.5862 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1851   -2.6156    0.7361 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1738   -1.5614   -0.2106 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1616    0.2533   -1.7659 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7640   -0.2888   -2.2134 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4539    1.4997    0.2443 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7990    2.0458   -1.4706 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7924    0.5573   -1.5032 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4555    0.0267    0.1506 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8905    3.0233    1.6519 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7226    2.2858    1.2688 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8500    1.7373    2.7356 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1055    1.4672   -0.1018 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8743    2.0329    0.9000 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 11 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 24 25  1  0
 24 10  1  0
  1 26  1  0
  1 27  1  0
  1 28  1  0
  2 29  1  0
  2 30  1  0
  3 31  1  0
  3 32  1  0
  4 33  1  0
  4 34  1  0
  5 35  1  0
  5 36  1  0
  6 37  1  6
  7 38  1  0
  8 39  1  0
  9 40  1  0
 10 41  1  1
 11 42  1  1
 12 43  1  0
 12 44  1  0
 13 45  1  0
 14 46  1  0
 15 47  1  0
 15 48  1  0
 16 49  1  0
 16 50  1  0
 17 51  1  0
 17 52  1  0
 20 53  1  0
 23 54  1  0
 23 55  1  0
 24 56  1  6
 25 57  1  0
M  END

View in JSmol View Stereo Labels

Synonyms

Value	Source
7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid	ChEBI
8-Epi-pge2	ChEBI
8-Iso-pge2	ChEBI
7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoate	Generator
(5Z,8b,11a,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-Oate	HMDB
(5Z,8b,11a,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-Oic acid	HMDB
8-Isoprostaglandin e2	ChEBI

Chemical Formula

C₂₀H₃₂O₅

Average Molecular Weight

352.4651

Monoisotopic Molecular Weight

352.224974134

IUPAC Name

(5Z)-7-[(1S,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid

Traditional Name

8-Iso-PGE2

CAS Registry Number

27415-25-4

SMILES

CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O

InChI Identifier

InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17+,19+/m0/s1

InChI Key

XEYBRNLFEZDVAW-CLQOMRTCSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Eicosanoids

Direct Parent

Prostaglandins and related compounds

Alternative Parents

Substituents

Prostaglandin skeleton
Long-chain fatty acid
Hydroxy fatty acid
Cyclopentanol
Fatty acid
Unsaturated fatty acid
Cyclic alcohol
Ketone
Cyclic ketone
Secondary alcohol
Carboxylic acid
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Alcohol
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Organooxygen compound
Carbonyl group
Aliphatic homomonocyclic compound

Molecular Framework

Aliphatic homomonocyclic compounds

External Descriptors

Isoprostanes (LMFA03110003 )

Ontology

Physiological effect

Not Available

Disposition

Biological location

Cellular substructure

Extracellular (HMDB: HMDB0005844)
Membrane (HMDB: HMDB0005844)

Source

Exogenous

Exogenous (HMDB: HMDB0005844)

Food

Animal origin

Poultry

Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Equine

Horse (FooDB: FOOD00378)

Endogenous

Endogenous (HMDB: HMDB0005844)

Process

Not Available

Role

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
Water Solubility	0.044 g/L	ALOGPS
logP	3.31	ALOGPS
logP	3.23	ChemAxon
logS	-3.9	ALOGPS
pKa (Strongest Acidic)	4.3	ChemAxon
pKa (Strongest Basic)	-1.6	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	94.83 Å²	ChemAxon
Rotatable Bond Count	12	ChemAxon
Refractivity	99.44 m³·mol⁻¹	ChemAxon
Polarizability	41.06 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	186.816	31661259
DarkChem	[M-H]-	190.144	31661259
DeepCCS	[M+H]+	197.265	30932474
DeepCCS	[M-H]-	194.884	30932474
DeepCCS	[M-2H]-	228.922	30932474
DeepCCS	[M+Na]+	204.011	30932474
AllCCS	[M+H]+	192.6	32859911
AllCCS	[M+H-H2O]+	189.9	32859911
AllCCS	[M+NH4]+	195.1	32859911
AllCCS	[M+Na]+	195.8	32859911
AllCCS	[M-H]-	191.2	32859911
AllCCS	[M+Na-2H]-	192.5	32859911
AllCCS	[M+HCOO]-	194.2	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
8-isoprostaglandin E2	CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O	4382.1	Standard polar	33892256
8-isoprostaglandin E2	CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O	2671.1	Standard non polar	33892256
8-isoprostaglandin E2	CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O	2857.4	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
8-isoprostaglandin E2,1TMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O)C(=O)C[C@H]1O)O[Si](C)(C)C	2825.3	Semi standard non polar	33892256
8-isoprostaglandin E2,1TMS,isomer #2	CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O)C(=O)C[C@H]1O[Si](C)(C)C	2760.1	Semi standard non polar	33892256
8-isoprostaglandin E2,1TMS,isomer #3	CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O[Si](C)(C)C)C(=O)C[C@H]1O	2777.3	Semi standard non polar	33892256
8-isoprostaglandin E2,1TMS,isomer #4	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O	2792.8	Semi standard non polar	33892256
8-isoprostaglandin E2,1TMS,isomer #5	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O	2715.1	Semi standard non polar	33892256
8-isoprostaglandin E2,2TMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O[Si](C)(C)C)C(=O)C[C@H]1O)O[Si](C)(C)C	2783.0	Semi standard non polar	33892256
8-isoprostaglandin E2,2TMS,isomer #2	CCCCC[C@@H](/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O)C(=O)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	2722.0	Semi standard non polar	33892256
8-isoprostaglandin E2,2TMS,isomer #3	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O)O[Si](C)(C)C	2827.1	Semi standard non polar	33892256
8-isoprostaglandin E2,2TMS,isomer #4	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	2726.3	Semi standard non polar	33892256
8-isoprostaglandin E2,2TMS,isomer #5	CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O[Si](C)(C)C)C(=O)C[C@H]1O[Si](C)(C)C	2721.7	Semi standard non polar	33892256
8-isoprostaglandin E2,2TMS,isomer #6	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C	2793.1	Semi standard non polar	33892256
8-isoprostaglandin E2,2TMS,isomer #7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O	2747.3	Semi standard non polar	33892256
8-isoprostaglandin E2,2TMS,isomer #8	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O	2787.4	Semi standard non polar	33892256
8-isoprostaglandin E2,2TMS,isomer #9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	2724.3	Semi standard non polar	33892256
8-isoprostaglandin E2,3TMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O[Si](C)(C)C)C(=O)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	2711.5	Semi standard non polar	33892256
8-isoprostaglandin E2,3TMS,isomer #2	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O)O[Si](C)(C)C	2800.8	Semi standard non polar	33892256
8-isoprostaglandin E2,3TMS,isomer #3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	2734.4	Semi standard non polar	33892256
8-isoprostaglandin E2,3TMS,isomer #4	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	2781.6	Semi standard non polar	33892256
8-isoprostaglandin E2,3TMS,isomer #5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	2743.2	Semi standard non polar	33892256
8-isoprostaglandin E2,3TMS,isomer #6	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C	2774.0	Semi standard non polar	33892256
8-isoprostaglandin E2,3TMS,isomer #7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	2733.4	Semi standard non polar	33892256
8-isoprostaglandin E2,4TMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	2794.8	Semi standard non polar	33892256
8-isoprostaglandin E2,4TMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	2871.7	Standard non polar	33892256
8-isoprostaglandin E2,4TMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	2843.1	Standard polar	33892256
8-isoprostaglandin E2,4TMS,isomer #2	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	2769.5	Semi standard non polar	33892256
8-isoprostaglandin E2,4TMS,isomer #2	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	2714.3	Standard non polar	33892256
8-isoprostaglandin E2,4TMS,isomer #2	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	2917.3	Standard polar	33892256
8-isoprostaglandin E2,1TBDMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O)C(=O)C[C@H]1O)O[Si](C)(C)C(C)(C)C	3071.9	Semi standard non polar	33892256
8-isoprostaglandin E2,1TBDMS,isomer #2	CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O)C(=O)C[C@H]1O[Si](C)(C)C(C)(C)C	2962.4	Semi standard non polar	33892256
8-isoprostaglandin E2,1TBDMS,isomer #3	CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)C(=O)C[C@H]1O	3031.5	Semi standard non polar	33892256
8-isoprostaglandin E2,1TBDMS,isomer #4	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O	3056.6	Semi standard non polar	33892256
8-isoprostaglandin E2,1TBDMS,isomer #5	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O	2956.7	Semi standard non polar	33892256
8-isoprostaglandin E2,2TBDMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)C(=O)C[C@H]1O)O[Si](C)(C)C(C)(C)C	3289.1	Semi standard non polar	33892256
8-isoprostaglandin E2,2TBDMS,isomer #2	CCCCC[C@@H](/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O)C(=O)C[C@H]1O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3207.8	Semi standard non polar	33892256
8-isoprostaglandin E2,2TBDMS,isomer #3	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O)O[Si](C)(C)C(C)(C)C	3290.5	Semi standard non polar	33892256
8-isoprostaglandin E2,2TBDMS,isomer #4	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C	3207.1	Semi standard non polar	33892256
8-isoprostaglandin E2,2TBDMS,isomer #5	CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)C(=O)C[C@H]1O[Si](C)(C)C(C)(C)C	3197.1	Semi standard non polar	33892256
8-isoprostaglandin E2,2TBDMS,isomer #6	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O[Si](C)(C)C(C)(C)C	3236.4	Semi standard non polar	33892256
8-isoprostaglandin E2,2TBDMS,isomer #7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O	3198.7	Semi standard non polar	33892256
8-isoprostaglandin E2,2TBDMS,isomer #8	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O	3275.5	Semi standard non polar	33892256
8-isoprostaglandin E2,2TBDMS,isomer #9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C	3205.0	Semi standard non polar	33892256
8-isoprostaglandin E2,3TBDMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)C(=O)C[C@H]1O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3438.1	Semi standard non polar	33892256
8-isoprostaglandin E2,3TBDMS,isomer #2	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O)O[Si](C)(C)C(C)(C)C	3520.4	Semi standard non polar	33892256
8-isoprostaglandin E2,3TBDMS,isomer #3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3460.0	Semi standard non polar	33892256
8-isoprostaglandin E2,3TBDMS,isomer #4	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3460.1	Semi standard non polar	33892256
8-isoprostaglandin E2,3TBDMS,isomer #5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C	3450.1	Semi standard non polar	33892256
8-isoprostaglandin E2,3TBDMS,isomer #6	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O[Si](C)(C)C(C)(C)C	3464.0	Semi standard non polar	33892256
8-isoprostaglandin E2,3TBDMS,isomer #7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C	3450.9	Semi standard non polar	33892256
8-isoprostaglandin E2,4TBDMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3648.3	Semi standard non polar	33892256
8-isoprostaglandin E2,4TBDMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3490.1	Standard non polar	33892256
8-isoprostaglandin E2,4TBDMS,isomer #1	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)=C(O[Si](C)(C)C(C)(C)C)C[C@H]1O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3150.4	Standard polar	33892256
8-isoprostaglandin E2,4TBDMS,isomer #2	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3645.5	Semi standard non polar	33892256
8-isoprostaglandin E2,4TBDMS,isomer #2	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3215.8	Standard non polar	33892256
8-isoprostaglandin E2,4TBDMS,isomer #2	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C=C(O[Si](C)(C)C(C)(C)C)[C@H]1C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	3179.9	Standard polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - 8-isoprostaglandin E2 GC-MS (Non-derivatized) - 70eV, Positive	splash10-0a73-5395000000-02aad995307bb6a67f94	2017-09-01	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - 8-isoprostaglandin E2 GC-MS (3 TMS) - 70eV, Positive	splash10-0ufu-9302550000-70dfa502c5c46d488f7a	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - 8-isoprostaglandin E2 GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 10V, Positive-QTOF	splash10-00kr-0019000000-f68c6b496bc66132ac05	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 20V, Positive-QTOF	splash10-00kr-3197000000-5c1986771d855fb6ed90	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 40V, Positive-QTOF	splash10-000i-9210000000-12fff721757996d80d14	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 10V, Negative-QTOF	splash10-0ue9-0009000000-8f0c944be1857e336476	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 20V, Negative-QTOF	splash10-0f89-2059000000-3515e7355791e5a9219f	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 40V, Negative-QTOF	splash10-0a4i-9430000000-8cbabd2bf835ca82e917	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 10V, Negative-QTOF	splash10-00lr-0049000000-1d1e45c7e0b65ddd683e	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 20V, Negative-QTOF	splash10-001i-0097000000-dcf0f9c6213818037863	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 40V, Negative-QTOF	splash10-001i-8590000000-6ae1006cdd7f50388698	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 10V, Positive-QTOF	splash10-014i-0009000000-3d13808f266c10b60336	2021-09-24	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 20V, Positive-QTOF	splash10-014i-4289000000-1d06c57536d9cf1761f9	2021-09-24	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 8-isoprostaglandin E2 40V, Positive-QTOF	splash10-014u-9800000000-a2144167462af022d6f9	2021-09-24	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Membrane

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Not Available

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB023780

KNApSAcK ID

Not Available

Chemspider ID

4446334

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5283213

PDB ID

Not Available

ChEBI ID

131888

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Harizi H, Gualde N: Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derived inflammatory mediators. Cell Mol Immunol. 2006 Aug;3(4):271-7. [PubMed:16978535 ]
Gao L, Zackert WE, Hasford JJ, Danekis ME, Milne GL, Remmert C, Reese J, Yin H, Tai HH, Dey SK, Porter NA, Morrow JD: Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. J Biol Chem. 2003 Aug 1;278(31):28479-89. Epub 2003 May 13. [PubMed:12746435 ]

Showing metabocard for 8-isoprostaglandin E2 (HMDB0005844)

MOL for HMDB0005844 (8-isoprostaglandin E2)

3D MOL for HMDB0005844 (8-isoprostaglandin E2)

3D SDF for HMDB0005844 (8-isoprostaglandin E2)

3D-SDF for HMDB0005844 (8-isoprostaglandin E2)

PDB for HMDB0005844 (8-isoprostaglandin E2)

3D PDB for HMDB0005844 (8-isoprostaglandin E2)

SMILES for HMDB0005844 (8-isoprostaglandin E2)

INCHI for HMDB0005844 (8-isoprostaglandin E2)

Structure for HMDB0005844 (8-isoprostaglandin E2)

3D Structure for HMDB0005844 (8-isoprostaglandin E2)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra