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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2007-04-12 19:06:39 UTC
Update Date2021-09-14 15:40:02 UTC
HMDB IDHMDB0005972
Secondary Accession Numbers
  • HMDB05972
Metabolite Identification
Common NameTetrahydrodeoxycortisol
DescriptionTetrahydrodeoxycortisol (THS) is a mineralocorticoid, the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approximately 5% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4%) and the T-allele of the -344 C/T polymorphism of CYP11B2 is more strongly associated with higher THS levels than the C-allele. (PMID: 16984984 , 15522937 , 15272911 ).
Structure
Data?1582752369
Synonyms
ValueSource
Tetrahydro-11-deoxycortisolKegg
11-DeoxytetrahydrocortisolHMDB
3alpha,17alpha,21-Trihydroxy-5beta-pregnan-20-oneHMDB
5beta-Pregnane-3alpha,17alpha,21-triol-20-oneHMDB
tetrahydro-SHMDB
TetrahydrocortexoloneHMDB
5 beta-Pregnane-3alpha,17alpha,21-triol-20-oneMeSH, HMDB
tetrahydro Compound SMeSH, HMDB
3 alpha, 17,21-Trihydroxy-5 beta-pregnan-20-oneMeSH, HMDB
tetrahydro-Reichstein's substance SMeSH, HMDB
TrihydroxypregnanoneMeSH, HMDB
3alpha,5beta-THSMeSH, HMDB
Chemical FormulaC21H34O4
Average Molecular Weight350.4923
Monoisotopic Molecular Weight350.245709576
IUPAC Name1-[(1S,2S,5R,7R,10R,11S,14R,15S)-5,14-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-2-hydroxyethan-1-one
Traditional Nametetrahydro-s
CAS Registry Number68-60-0
SMILES
[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C
InChI Identifier
InChI=1S/C21H34O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h13-17,22-23,25H,3-12H2,1-2H3/t13-,14-,15-,16+,17+,19+,20+,21+/m1/s1
InChI KeyUPTAPIKFKZGAGM-FAIYVORSSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • Progestogin-skeleton
  • 21-hydroxysteroid
  • 20-oxosteroid
  • Pregnane-skeleton
  • 3-hydroxysteroid
  • Oxosteroid
  • 3-alpha-hydroxysteroid
  • 17-hydroxysteroid
  • Cyclic alcohol
  • Tertiary alcohol
  • Alpha-hydroxy ketone
  • Ketone
  • Secondary alcohol
  • Primary alcohol
  • Alcohol
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organic oxide
  • Organic oxygen compound
  • Carbonyl group
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Ontology
Physiological effect

Adverse health effect

Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Spectral PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.044 g/LALOGPS
logP10(2.49) g/LALOGPS
logP10(2.42) g/LChemAxon
logS10(-3.9) g/LALOGPS
pKa (Strongest Acidic)12.59ChemAxon
pKa (Strongest Basic)-1.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area77.76 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity96.01 m³·mol⁻¹ChemAxon
Polarizability40.06 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Spectral Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+183.19731661259
DarkChem[M-H]-179.19831661259

Predicted Kovats Retention Indices

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Tetrahydrodeoxycortisol,1TMS,#1C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O[Si](C)(C)C)C(=O)CO3121.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,1TMS,#2C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO[Si](C)(C)C3069.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,1TMS,#3C[C@]12CC[C@@H](O[Si](C)(C)C)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO3087.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,1TMS,#4C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O)C(=CO)O[Si](C)(C)C2993.6Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TMS,#1C[C@]12CC[C@@H](O[Si](C)(C)C)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O[Si](C)(C)C)C(=O)CO3123.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TMS,#2C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O[Si](C)(C)C)C(=O)CO[Si](C)(C)C3155.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TMS,#3C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O[Si](C)(C)C)C(=CO)O[Si](C)(C)C3066.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TMS,#4C[C@]12CC[C@@H](O[Si](C)(C)C)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO[Si](C)(C)C3100.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TMS,#5C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O)C(=CO[Si](C)(C)C)O[Si](C)(C)C3032.8Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TMS,#6C[C@]12CC[C@@H](O[Si](C)(C)C)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O)C(=CO)O[Si](C)(C)C3000.6Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,3TMS,#1C[C@]12CC[C@@H](O[Si](C)(C)C)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O[Si](C)(C)C)C(=O)CO[Si](C)(C)C3157.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,3TMS,#2C[C@]12CC[C@@H](O[Si](C)(C)C)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O[Si](C)(C)C)C(=CO)O[Si](C)(C)C3068.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,3TMS,#3C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O[Si](C)(C)C)C(=CO[Si](C)(C)C)O[Si](C)(C)C3137.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,3TMS,#4C[C@]12CC[C@@H](O[Si](C)(C)C)C[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(O)C(=CO[Si](C)(C)C)O[Si](C)(C)C3051.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,1TBDMS,#1CC(C)(C)[Si](C)(C)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3383.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,1TBDMS,#2CC(C)(C)[Si](C)(C)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3369.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,1TBDMS,#3CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@]4(O)C(=O)CO)[C@@H]3CC[C@@H]2C13353.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,1TBDMS,#4CC(C)(C)[Si](C)(C)OC(=CO)[C@@]1(O)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3270.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TBDMS,#1CC(C)(C)[Si](C)(C)OCC(=O)[C@@]1(O[Si](C)(C)C(C)(C)C)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3697.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TBDMS,#2CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@]4(O[Si](C)(C)C(C)(C)C)C(=O)CO)[C@@H]3CC[C@@H]2C13626.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TBDMS,#3CC(C)(C)[Si](C)(C)OC(=CO)[C@@]1(O[Si](C)(C)C(C)(C)C)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3582.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TBDMS,#4CC(C)(C)[Si](C)(C)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3629.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TBDMS,#5CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@@]1(O)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3538.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,2TBDMS,#6CC(C)(C)[Si](C)(C)OC(=CO)[C@@]1(O)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3503.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,3TBDMS,#1CC(C)(C)[Si](C)(C)OCC(=O)[C@@]1(O[Si](C)(C)C(C)(C)C)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3919.1Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,3TBDMS,#2CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@@]1(O[Si](C)(C)C(C)(C)C)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C3899.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,3TBDMS,#3CC(C)(C)[Si](C)(C)OC(=CO)[C@@]1(O[Si](C)(C)C(C)(C)C)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3806.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
Tetrahydrodeoxycortisol,3TBDMS,#4CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@@]1(O)CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C3780.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Tetrahydrodeoxycortisol EI-B (Non-derivatized)splash10-00vi-1691000000-505dadab0d513b5e6ab32017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Tetrahydrodeoxycortisol EI-B (Non-derivatized)splash10-00vi-1691000000-505dadab0d513b5e6ab32018-05-18HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Tetrahydrodeoxycortisol GC-MS (Non-derivatized) - 70eV, Positivesplash10-05v3-4398000000-6a2c90339fca7bd2d7f42017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Tetrahydrodeoxycortisol GC-MS (3 TMS) - 70eV, Positivesplash10-0udi-1014290000-45f9340b322c9f38f64a2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Tetrahydrodeoxycortisol GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 10V, Positive-QTOFsplash10-0f89-0029000000-2dafef0c1c57c19d16172016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 20V, Positive-QTOFsplash10-00lu-0098000000-04fb94b06295b11c2c4b2016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 40V, Positive-QTOFsplash10-00fs-0491000000-808f4214bb9c8457d0ca2016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 10V, Negative-QTOFsplash10-0002-0019000000-f2cfd2cd5c4f89708bc92016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 20V, Negative-QTOFsplash10-05v4-3089000000-b615dbc2d0bb4012fa7a2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 40V, Negative-QTOFsplash10-0a4i-6093000000-32c633b5606b6e86a5662016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 10V, Negative-QTOFsplash10-00kb-0009000000-38d3f733587d36806d7a2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 20V, Negative-QTOFsplash10-0ldi-3029000000-63d6bbd371d07c340a6c2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 40V, Negative-QTOFsplash10-007c-0091000000-66ecef0bf396b725ea442021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 10V, Positive-QTOFsplash10-0ue9-0009000000-de8ae4e2139ee50b1b492021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 20V, Positive-QTOFsplash10-0002-0902000000-f8e993eaaffa04db04192021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Tetrahydrodeoxycortisol 40V, Positive-QTOFsplash10-0002-2920000000-a342bcadbf94f1bae4022021-09-22Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot Available
Normal
      Not Available
details
UrineDetected and Quantified<0.0333 umol/mmol creatinineNot SpecifiedBothNormal details
UrineDetected and Quantified0.092 +/- 0.055 umol/mmol creatinineAdult (>18 years old)FemaleNormal details
UrineDetected and Quantified0.000031 +/- 0.000093 umol/mmol creatinineAdult (>18 years old)FemaleNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected and Quantified0.011 +/- 0.0092 umol/mmol creatinineAdult (>18 years old)FemalePregnant with an anencephalic foetus details
UrineDetected and Quantified0.036 +/- 0.024 umol/mmol creatinineAdult (>18 years old)BothPregnant with a normal foetus details
UrineDetected and Quantified0.713-1.580 umol/mmol creatinineNewborn (0-30 days old)Female11-beta-hydroxylase deficiency details
UrineDetected and Quantified0.360-0.960 umol/mmol creatinineChildren (1-13 years old)Both11-beta-hydroxylase deficiency details
UrineDetected and Quantified0.022 +/- 0.014 umol/mmol creatinineAdult (>18 years old)FemaleThyroid cancer details
UrineDetected and Quantified0.000072 +/- 0.0001 umol/mmol creatinineAdult (>18 years old)FemaleStress urinary incontinence details
Associated Disorders and Diseases
Disease References
Thyroid cancer
  1. Kim KM, Jung BH, Lho DS, Chung WY, Paeng KJ, Chung BC: Alteration of urinary profiles of endogenous steroids and polyunsaturated fatty acids in thyroid cancer. Cancer Lett. 2003 Dec 30;202(2):173-9. [PubMed:14643447 ]
11-beta-Hydroxylase deficiency
  1. Burren CP, Montalto J, Yong AB, Batch JA: CYP11 beta 1 (11-beta-hydroxylase) deficiency in congenital adrenal hyperplasia. J Paediatr Child Health. 1996 Oct;32(5):433-8. [PubMed:8933406 ]
Associated OMIM IDs
  • 202010 (11-beta-Hydroxylase deficiency)
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023794
KNApSAcK IDNot Available
Chemspider ID58998
KEGG Compound IDC14594
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound65555
PDB IDNot Available
ChEBI ID34352
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDMDB00000477
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Keavney B, Mayosi B, Gaukrodger N, Imrie H, Baker M, Fraser R, Ingram M, Watkins H, Farrall M, Davies E, Connell J: Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. J Clin Endocrinol Metab. 2005 Feb;90(2):1072-7. Epub 2004 Nov 2. [PubMed:15522937 ]
  2. Imrie H, Freel M, Mayosi BM, Davies E, Fraser R, Ingram M, Cordell HJ, Farrall M, Avery PJ, Watkins H, Keavney B, Connell JM: Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene. J Clin Endocrinol Metab. 2006 Dec;91(12):5051-6. Epub 2006 Sep 19. [PubMed:16984984 ]
  3. Kennon B, Ingram MC, Friel EC, Anderson NH, MacKenzie SM, Davies E, Shakerdi L, Wallace AM, Fraser R, Connell JM: Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects. Clin Endocrinol (Oxf). 2004 Aug;61(2):174-81. [PubMed:15272911 ]