Hmdb loader
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2007-05-22 18:32:06 UTC
Update Date2022-03-07 02:49:30 UTC
HMDB IDHMDB0006228
Secondary Accession Numbers
  • HMDB06228
Metabolite Identification
Common Name24-Hydroxycalcitriol
Description24-Hydroxycalcitriol stimulates intestinal calcium transport but not bone calcium mobilization or phosphate transport reactions. (PMID: 163578 ). Vitamin D-24-hydroxylase (24-OHase) is a cytochrome P-450 enzyme that catalyzes the conversion of 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] to 24-Hydroxycalcitriol (1,24,25-trihydroxyvitamin D3). (PMID: 9165006 ). The administration of 24-Hydroxycalcitriol at doses of 0.2 and 0.3 microg/kg/day produced strong anabolic effects, especially on vertebral cancellous bone that can prevent estrogen depletion-induced bone loss in ovariectomized (OVX) rats. (PMID: 9115161 ).
Structure
Data?1582752376
Synonyms
ValueSource
1alpha,24R,25(OH)3D3ChEBI
1alpha,24R,25-TrihydroxycholecalciferolChEBI
1alpha,24R,25-Trihydroxyvitamin D3ChEBI
1a,24R,25(OH)3D3Generator
1Α,24R,25(OH)3D3Generator
1a,24R,25-TrihydroxycholecalciferolGenerator
1Α,24R,25-trihydroxycholecalciferolGenerator
1a,24R,25-Trihydroxyvitamin D3Generator
1Α,24R,25-trihydroxyvitamin D3Generator
(1-alpha,3-beta,5Z,7E,24R)-10-Secocholesta-5,7,10(19)-triene-1,3,24,25-tetrolHMDB
(1-alpha,3-beta,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24,25-tetrolHMDB
(24R)-24-HydroxycalcitriolHMDB
1-alpha,24(R),25-Trihydroxyvitamin D3HMDB
1-alpha,24R,25-Trihydroxyvitamin D3HMDB
CalcitetrolHMDB
ro 21-7729HMDB
Chemical FormulaC27H44O4
Average Molecular Weight432.6359
Monoisotopic Molecular Weight432.323959896
IUPAC Name(1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
Traditional Namecalcitetrol
CAS Registry Number56142-94-0
SMILES
C[C@H](CC[C@@H](O)C(O)(C)C)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
InChI Identifier
InChI=1S/C27H44O4/c1-17(8-13-25(30)26(3,4)31)22-11-12-23-19(7-6-14-27(22,23)5)9-10-20-15-21(28)16-24(29)18(20)2/h9-10,17,21-25,28-31H,2,6-8,11-16H2,1,3-5H3/b19-9+,20-10-/t17-,21-,22-,23+,24+,25-,27-/m1/s1
InChI KeyWFZKUWGUJVKMHC-UKBUZQLGSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as vitamin d and derivatives. Vitamin D and derivatives are compounds containing a secosteroid backbone, usually secoergostane or secocholestane.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassVitamin D and derivatives
Direct ParentVitamin D and derivatives
Alternative Parents
Substituents
  • Triterpenoid
  • Tertiary alcohol
  • Cyclic alcohol
  • Secondary alcohol
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.02 g/LALOGPS
logP4.39ALOGPS
logP3.28ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)13.74ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area80.92 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity127.89 m³·mol⁻¹ChemAxon
Polarizability52.13 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+203.86131661259
DarkChem[M-H]-198.77631661259
DeepCCS[M-2H]-245.01230932474
DeepCCS[M+Na]+219.19130932474
AllCCS[M+H]+211.232859911
AllCCS[M+H-H2O]+209.232859911
AllCCS[M+NH4]+213.132859911
AllCCS[M+Na]+213.732859911
AllCCS[M-H]-208.932859911
AllCCS[M+Na-2H]-211.132859911
AllCCS[M+HCOO]-213.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
24-HydroxycalcitriolC[C@H](CC[C@@H](O)C(O)(C)C)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C4091.5Standard polar33892256
24-HydroxycalcitriolC[C@H](CC[C@@H](O)C(O)(C)C)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C3502.1Standard non polar33892256
24-HydroxycalcitriolC[C@H](CC[C@@H](O)C(O)(C)C)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C3700.2Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
24-Hydroxycalcitriol,1TMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C)C(C)(C)O)C[C@@H](O)C[C@@H]1O3630.7Semi standard non polar33892256
24-Hydroxycalcitriol,1TMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O[Si](C)(C)C)C[C@@H](O)C[C@@H]1O3667.5Semi standard non polar33892256
24-Hydroxycalcitriol,1TMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O)C[C@@H](O[Si](C)(C)C)C[C@@H]1O3552.8Semi standard non polar33892256
24-Hydroxycalcitriol,1TMS,isomer #4C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O)C[C@@H](O)C[C@@H]1O[Si](C)(C)C3558.3Semi standard non polar33892256
24-Hydroxycalcitriol,2TMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C)C(C)(C)O[Si](C)(C)C)C[C@@H](O)C[C@@H]1O3684.6Semi standard non polar33892256
24-Hydroxycalcitriol,2TMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C)C(C)(C)O)C[C@@H](O[Si](C)(C)C)C[C@@H]1O3544.5Semi standard non polar33892256
24-Hydroxycalcitriol,2TMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C)C(C)(C)O)C[C@@H](O)C[C@@H]1O[Si](C)(C)C3538.8Semi standard non polar33892256
24-Hydroxycalcitriol,2TMS,isomer #4C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O[Si](C)(C)C)C[C@@H](O[Si](C)(C)C)C[C@@H]1O3600.9Semi standard non polar33892256
24-Hydroxycalcitriol,2TMS,isomer #5C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O[Si](C)(C)C)C[C@@H](O)C[C@@H]1O[Si](C)(C)C3593.3Semi standard non polar33892256
24-Hydroxycalcitriol,2TMS,isomer #6C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O)C[C@@H](O[Si](C)(C)C)C[C@@H]1O[Si](C)(C)C3448.6Semi standard non polar33892256
24-Hydroxycalcitriol,3TMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C)C(C)(C)O[Si](C)(C)C)C[C@@H](O[Si](C)(C)C)C[C@@H]1O3594.3Semi standard non polar33892256
24-Hydroxycalcitriol,3TMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C)C(C)(C)O[Si](C)(C)C)C[C@@H](O)C[C@@H]1O[Si](C)(C)C3582.5Semi standard non polar33892256
24-Hydroxycalcitriol,3TMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C)C(C)(C)O)C[C@@H](O[Si](C)(C)C)C[C@@H]1O[Si](C)(C)C3476.6Semi standard non polar33892256
24-Hydroxycalcitriol,3TMS,isomer #4C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O[Si](C)(C)C)C[C@@H](O[Si](C)(C)C)C[C@@H]1O[Si](C)(C)C3521.6Semi standard non polar33892256
24-Hydroxycalcitriol,4TMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C)C(C)(C)O[Si](C)(C)C)C[C@@H](O[Si](C)(C)C)C[C@@H]1O[Si](C)(C)C3537.3Semi standard non polar33892256
24-Hydroxycalcitriol,1TBDMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C(C)(C)C)C(C)(C)O)C[C@@H](O)C[C@@H]1O3851.5Semi standard non polar33892256
24-Hydroxycalcitriol,1TBDMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O)C[C@@H]1O3890.1Semi standard non polar33892256
24-Hydroxycalcitriol,1TBDMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O3749.1Semi standard non polar33892256
24-Hydroxycalcitriol,1TBDMS,isomer #4C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O)C[C@@H](O)C[C@@H]1O[Si](C)(C)C(C)(C)C3737.2Semi standard non polar33892256
24-Hydroxycalcitriol,2TBDMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C(C)(C)C)C(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O)C[C@@H]1O4135.4Semi standard non polar33892256
24-Hydroxycalcitriol,2TBDMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C(C)(C)C)C(C)(C)O)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O3983.6Semi standard non polar33892256
24-Hydroxycalcitriol,2TBDMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C(C)(C)C)C(C)(C)O)C[C@@H](O)C[C@@H]1O[Si](C)(C)C(C)(C)C3954.7Semi standard non polar33892256
24-Hydroxycalcitriol,2TBDMS,isomer #4C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O4034.9Semi standard non polar33892256
24-Hydroxycalcitriol,2TBDMS,isomer #5C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O)C[C@@H]1O[Si](C)(C)C(C)(C)C4001.4Semi standard non polar33892256
24-Hydroxycalcitriol,2TBDMS,isomer #6C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O[Si](C)(C)C(C)(C)C3834.1Semi standard non polar33892256
24-Hydroxycalcitriol,3TBDMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C(C)(C)C)C(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O4272.9Semi standard non polar33892256
24-Hydroxycalcitriol,3TBDMS,isomer #2C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C(C)(C)C)C(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O)C[C@@H]1O[Si](C)(C)C(C)(C)C4235.3Semi standard non polar33892256
24-Hydroxycalcitriol,3TBDMS,isomer #3C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C(C)(C)C)C(C)(C)O)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O[Si](C)(C)C(C)(C)C4071.5Semi standard non polar33892256
24-Hydroxycalcitriol,3TBDMS,isomer #4C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O[Si](C)(C)C(C)(C)C4136.2Semi standard non polar33892256
24-Hydroxycalcitriol,4TBDMS,isomer #1C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O[Si](C)(C)C(C)(C)C)C(C)(C)O[Si](C)(C)C(C)(C)C)C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O[Si](C)(C)C(C)(C)C4361.5Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 24-Hydroxycalcitriol GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a4i-8019800000-bd957cd71fdc43e3cf942017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 24-Hydroxycalcitriol GC-MS (3 TMS) - 70eV, Positivesplash10-001i-2212039000-ff7c0fc06a74f042ea4e2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 24-Hydroxycalcitriol GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 10V, Positive-QTOFsplash10-014j-0119800000-971c62e3a9b4450853742017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 20V, Positive-QTOFsplash10-002b-0329200000-87fe5af08f7d613843ad2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 40V, Positive-QTOFsplash10-01ta-1249100000-e02dd2ffb8dcfe6ac44d2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 10V, Negative-QTOFsplash10-001i-0001900000-1a4a0abd4a0f9c808d152017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 20V, Negative-QTOFsplash10-03e9-0006900000-f4091fa625ee0575ca962017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 40V, Negative-QTOFsplash10-00y0-9005200000-f5bbc4087082427238c72017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 10V, Negative-QTOFsplash10-001i-0001900000-e16e6b947da6d8aa4af12021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 20V, Negative-QTOFsplash10-01x0-4404900000-13694b4cd0190a34af952021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 40V, Negative-QTOFsplash10-056s-3409500000-aa6bf641780066a0b0e32021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 10V, Positive-QTOFsplash10-0002-0229500000-9dce7354a42f6ad2e96c2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 20V, Positive-QTOFsplash10-05mt-2269100000-aa636e01f91f796635dc2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 24-Hydroxycalcitriol 40V, Positive-QTOFsplash10-00dr-2950000000-8a96dbb2c0ff0897a2bd2021-09-23Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
  • Mitochondria
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023848
KNApSAcK IDNot Available
Chemspider ID4949843
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG ID2290333
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound6446280
PDB IDNot Available
ChEBI ID47799
Food Biomarker OntologyNot Available
VMH ID1A2425THVITD3
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. DeLuca HF: The kidney as an endocrine organ involved in the function of vitamin D. Am J Med. 1975 Jan;58(1):39-47. [PubMed:163578 ]
  2. Akeno N, Saikatsu S, Kawane T, Horiuchi N: Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3. Endocrinology. 1997 Jun;138(6):2233-40. [PubMed:9165006 ]
  3. Erben RG, Bante U, Birner H, Stangassinger M: Prophylactic effects of 1,24,25-trihydroxyvitamin D3 on ovariectomy-induced cancellous bone loss in the rat. Calcif Tissue Int. 1997 May;60(5):434-40. [PubMed:9115161 ]

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
Gene Name:
CYP24A1
Uniprot ID:
Q07973
Molecular weight:
58874.695
Reactions
Calcitriol + NADPH + Oxygen → 24-Hydroxycalcitriol + NADP + Waterdetails
Calcitriol + NADPH + Hydrogen Ion + Oxygen → 24-Hydroxycalcitriol + NADP + Waterdetails