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Record Information
StatusExpected but not Quantified
Creation Date2007-05-22 21:03:43 UTC
Update Date2020-02-26 21:26:18 UTC
Secondary Accession Numbers
  • HMDB06278
Metabolite Identification
Common Name5a-Dihydrotestosterone sulfate
Description5a-Dihydrotestosterone sulfate is a sulfate derivative of 5a-Dihydrotestosterone produced through phase II metabolism. 5a-dihydrotestosterone (DHT) is a steroid similar to testosterone and androstenedione, that belongs to a class called androgens. DHT is a C19 steroid and possesses androgenic activity. Androgen production takes place mainly in the Leydig cells of the testes. Androgens circulate in the blood bound to proteins, especially sex hormone binding globulin (SHBG) and albumin. A trace amount of these steroids circulate in the unbound form in the blood and are referred to as the free fractions. DHT has at least three times the binding affinity for SHBG than testosterone. About 70% of DHT is derived from peripheral conversion of testosterone in males, while most of the DHT is derived from androstenedione in females.
(5alpha,17beta)-3-Oxoandrostan-17-yl hydrogen sulfateChEBI
5alpha-Dihydrotestosterone 17-sulfateChEBI
Dihydrotestosterone sulfateChEBI
Dihydrotestosterone sulphateChEBI
(5a,17b)-3-Oxoandrostan-17-yl hydrogen sulfateGenerator
(5a,17b)-3-Oxoandrostan-17-yl hydrogen sulfuric acidGenerator
(5a,17b)-3-Oxoandrostan-17-yl hydrogen sulphateGenerator
(5a,17b)-3-Oxoandrostan-17-yl hydrogen sulphuric acidGenerator
(5alpha,17beta)-3-Oxoandrostan-17-yl hydrogen sulfuric acidGenerator
(5alpha,17beta)-3-Oxoandrostan-17-yl hydrogen sulphateGenerator
(5alpha,17beta)-3-Oxoandrostan-17-yl hydrogen sulphuric acidGenerator
(5Α,17β)-3-oxoandrostan-17-yl hydrogen sulfateGenerator
(5Α,17β)-3-oxoandrostan-17-yl hydrogen sulfuric acidGenerator
(5Α,17β)-3-oxoandrostan-17-yl hydrogen sulphateGenerator
(5Α,17β)-3-oxoandrostan-17-yl hydrogen sulphuric acidGenerator
5a-Dihydrotestosterone 17-sulfateGenerator
5a-Dihydrotestosterone 17-sulfuric acidGenerator
5a-Dihydrotestosterone 17-sulphateGenerator
5a-Dihydrotestosterone 17-sulphuric acidGenerator
5alpha-Dihydrotestosterone 17-sulfuric acidGenerator
5alpha-Dihydrotestosterone 17-sulphateGenerator
5alpha-Dihydrotestosterone 17-sulphuric acidGenerator
5Α-dihydrotestosterone 17-sulfateGenerator
5Α-dihydrotestosterone 17-sulfuric acidGenerator
5Α-dihydrotestosterone 17-sulphateGenerator
5Α-dihydrotestosterone 17-sulphuric acidGenerator
DHT-Sulfuric acidGenerator
DHT-Sulphuric acidGenerator
Dihydrotestosterone sulfuric acidGenerator
Dihydrotestosterone sulphuric acidGenerator
5a-Dihydrotestosterone sulfuric acidGenerator
5a-Dihydrotestosterone sulphateGenerator
5a-Dihydrotestosterone sulphuric acidGenerator
5alpha-Dihydrotestosterone sulfateHMDB
5alpha-Dihydrotestosterone sulphateHMDB
Chemical FormulaC19H30O5S
Average Molecular Weight370.504
Monoisotopic Molecular Weight370.18139476
IUPAC Name[(1S,2S,7S,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[²,⁷.0¹¹,¹⁵]heptadecan-14-yl]oxidanesulfonic acid
Traditional Name5α-dihydrotestosterone sulfate
CAS Registry NumberNot Available
InChI Identifier
Chemical Taxonomy
Description belongs to the class of organic compounds known as sulfated steroids. These are sterol lipids containing a sulfate group attached to the steroid skeleton.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassSulfated steroids
Direct ParentSulfated steroids
Alternative Parents
  • Sulfated steroid skeleton
  • Androgen-skeleton
  • Androstane-skeleton
  • 3-oxosteroid
  • Oxosteroid
  • 3-oxo-5-alpha-steroid
  • Sulfuric acid ester
  • Sulfuric acid monoester
  • Sulfate-ester
  • Alkyl sulfate
  • Organic sulfuric acid or derivatives
  • Cyclic ketone
  • Ketone
  • Organooxygen compound
  • Carbonyl group
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External DescriptorsNot Available

Route of exposure:


Biological location:


Naturally occurring process:


Biological role:

Industrial application:

Physical Properties
Experimental Properties
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
Water Solubility0.0053 g/LALOGPS
pKa (Strongest Acidic)-1.3ChemAxon
pKa (Strongest Basic)-7.4ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area80.67 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity93.59 m³·mol⁻¹ChemAxon
Polarizability40.41 ųChemAxon
Number of Rings4ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-054o-0359000000-149485897a60b61396e3Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00di-0039000000-dbc19fa747f37f721203Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00di-0191000000-bb7a78b507be8c3547bcSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-002f-3595000000-0842465a9970bd04f71bSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-0029000000-b2c6c394ba2ce2ee8c15Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-000i-1092000000-887ce248e8af99737137Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-00ei-6090000000-c03f985254acf33f9b4fSpectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue Locations
  • Kidney
  • Liver
Normal Concentrations
BloodExpected but not Quantified Not AvailableNot AvailableNormal
    UrineExpected but not Quantified Not AvailableNot AvailableNormal
      Abnormal Concentrations
      Not Available
      Associated Disorders and Diseases
      Disease ReferencesNone
      Associated OMIM IDsNone
      DrugBank IDNot Available
      Phenol Explorer Compound IDNot Available
      FooDB IDFDB023873
      KNApSAcK IDNot Available
      Chemspider ID18915389
      KEGG Compound IDNot Available
      BioCyc IDNot Available
      BiGG ID2794980
      Wikipedia LinkNot Available
      METLIN IDNot Available
      PubChem Compound18665256
      PDB IDNot Available
      ChEBI ID138026
      Food Biomarker OntologyNot Available
      VMH IDNot Available
      Synthesis ReferenceNot Available
      Material Safety Data Sheet (MSDS)Not Available
      General References
      1. Purvis K, Saksena SK, Landgren BM, Cekan Z, Diczfalusy E: Steroid conjugates in human seminal plasma. Clin Endocrinol (Oxf). 1976 May;5(3):253-61. [PubMed:133773 ]
      2. Purvis K, Saksena SK, Cekan Z, Diczfalusy E, Giner J: Endocrine effects of vasectomy. Clin Endocrinol (Oxf). 1976 May;5(3):263-72. [PubMed:133774 ]
      3. Zhao X, Xu F, Qi B, Hao S, Li Y, Li Y, Zou L, Lu C, Xu G, Hou L: Serum metabolomics study of polycystic ovary syndrome based on liquid chromatography-mass spectrometry. J Proteome Res. 2014 Feb 7;13(2):1101-11. doi: 10.1021/pr401130w. Epub 2014 Jan 24. [PubMed:24428203 ]
      4. Sanchez-Guijo A, Oji V, Hartmann MF, Traupe H, Wudy SA: Simultaneous quantification of cholesterol sulfate, androgen sulfates, and progestagen sulfates in human serum by LC-MS/MS. J Lipid Res. 2015 Sep;56(9):1843-51. doi: 10.1194/jlr.D061499. Epub 2015 Aug 2. [PubMed:26239050 ]
      5. Xu H, Zheng X, Qian Y, Guan J, Yi H, Zou J, Wang Y, Meng L, Zhao A, Yin S, Jia W: Metabolomics Profiling for Obstructive Sleep Apnea and Simple Snorers. Sci Rep. 2016 Aug 2;6:30958. doi: 10.1038/srep30958. [PubMed:27480913 ]
      6. Dehennin L, Jondet M, Scholler R: Androgen and 19-norsteroid profiles in human preovulatory follicles from stimulated cycles: an isotope dilution-mass spectrometric study. J Steroid Biochem. 1987 Mar;26(3):399-405. [PubMed:3586654 ]
      7. Gibb W, Jeffery J: 5 -dihydrotestosterone sulphate and cortisone reductase. Biochim Biophys Acta. 1972 Dec 8;280(4):646-51. [PubMed:4648789 ]