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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2008-08-06 13:24:12 UTC
Update Date2021-09-14 15:40:01 UTC
HMDB IDHMDB0006757
Secondary Accession Numbers
  • HMDB06757
Metabolite Identification
Common Name11b,21-Dihydroxy-5b-pregnane-3,20-dione
Description11beta,21-Dihydroxy-5beta-pregnane-3,20-dione is an intermediate in C21-Steroid hormone metabolism. 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione is the 3rd to last step in the synthesis of 3alpha,20alpha,21-Trihydroxy-5beta-pregnane-11-one and is converted from Corticosterone via the enzyme 3-oxo-5beta-steroid 4-dehydrogenase (EC 1.3.99.6). It is then converted to Tetrahydrocorticosterone via the enzyme 3-alpha-hydroxysteroid dehydrogenase (EC 1.1.1.50).
Structure
Data?1582752404
Synonyms
ValueSource
11beta,21-Dihydroxy-5beta-pregnane-3,20-dioneHMDB
5beta-Pregnane-11beta,21-diol-3,20-dioneHMDB
Chemical FormulaC21H32O4
Average Molecular Weight348.4764
Monoisotopic Molecular Weight348.230059512
IUPAC Name(1S,2S,7R,10S,11S,15S,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one
Traditional Name(1S,2S,7R,10S,11S,15S,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one
CAS Registry Number566-01-8
SMILES
[H][C@@]12CCC(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CC[C@]2([H])CC(=O)CC[C@]12C
InChI Identifier
InChI=1S/C21H32O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12,14-17,19,22,24H,3-11H2,1-2H3/t12-,14+,15+,16?,17+,19-,20+,21+/m1/s1
InChI KeyCTTOFMJLOGMZRN-MGXYISIMSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • Progestogin-skeleton
  • 21-hydroxysteroid
  • 20-oxosteroid
  • Pregnane-skeleton
  • 3-oxosteroid
  • Oxosteroid
  • 11-beta-hydroxysteroid
  • 11-hydroxysteroid
  • 3-oxo-5-beta-steroid
  • Cyclic alcohol
  • Alpha-hydroxy ketone
  • Ketone
  • Secondary alcohol
  • Cyclic ketone
  • Primary alcohol
  • Alcohol
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organic oxide
  • Organic oxygen compound
  • Carbonyl group
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
  • C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives (LMST02030188 )
Ontology
Disposition

Biological location

Source

Route of exposure

Process

Naturally occurring process

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Spectral PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.073 g/LALOGPS
logP10(2.24) g/LALOGPS
logP10(2.07) g/LChemAxon
logS10(-3.7) g/LALOGPS
pKa (Strongest Acidic)13.86ChemAxon
pKa (Strongest Basic)-0.29ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area74.6 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity95.17 m³·mol⁻¹ChemAxon
Polarizability39.36 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Spectral Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+185.01631661259
DarkChem[M-H]-181.34731661259

Predicted Kovats Retention Indices

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TMS,#1C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CCC2C(=O)CO[Si](C)(C)C3165.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TMS,#2C[C@]12C[C@H](O[Si](C)(C)C)[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CCC2C(=O)CO3094.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TMS,#3C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3126.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TMS,#4C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3125.8Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TMS,#5C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4CC(O[Si](C)(C)C)=CC[C@]34C)[C@@H]1CCC2C(=O)CO3168.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TMS,#6C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4C=C(O[Si](C)(C)C)CC[C@]34C)[C@@H]1CCC2C(=O)CO3160.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#1C[C@]12C[C@H](O[Si](C)(C)C)[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CCC2C(=O)CO[Si](C)(C)C3039.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#2C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3144.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#3C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4CC(O[Si](C)(C)C)=CC[C@]34C)[C@@H]1CCC2C(=O)CO[Si](C)(C)C3131.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#4C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4C=C(O[Si](C)(C)C)CC[C@]34C)[C@@H]1CCC2C(=O)CO[Si](C)(C)C3120.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#5C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3167.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#6C[C@]12C[C@H](O[Si](C)(C)C)[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3032.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#7C[C@]12C[C@H](O[Si](C)(C)C)[C@H]3[C@@H](CC[C@@H]4CC(O[Si](C)(C)C)=CC[C@]34C)[C@@H]1CCC2C(=O)CO3031.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#8C[C@]12C[C@H](O[Si](C)(C)C)[C@H]3[C@@H](CC[C@@H]4C=C(O[Si](C)(C)C)CC[C@]34C)[C@@H]1CCC2C(=O)CO3039.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#9C[C@]12C[C@H](O[Si](C)(C)C)[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3014.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#10C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4CC(O[Si](C)(C)C)=CC[C@]34C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3126.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#11C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4C=C(O[Si](C)(C)C)CC[C@]34C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3124.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#12C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4CC(O[Si](C)(C)C)=CC[C@]34C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3083.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TMS,#13C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@@H]4C=C(O[Si](C)(C)C)CC[C@]34C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3066.6Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TBDMS,#1CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C3458.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TBDMS,#2CC(C)(C)[Si](C)(C)O[C@H]1C[C@]2(C)C(C(=O)CO)CC[C@H]2[C@@H]2CC[C@@H]3CC(=O)CC[C@]3(C)[C@@H]123349.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TBDMS,#3CC(C)(C)[Si](C)(C)OC(CO)=C1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C3415.6Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TBDMS,#4CC(C)(C)[Si](C)(C)OC(=CO)C1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C3376.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TBDMS,#5CC(C)(C)[Si](C)(C)OC1=CC[C@]2(C)[C@H]3[C@@H](O)C[C@]4(C)C(C(=O)CO)CC[C@H]4[C@@H]3CC[C@@H]2C13429.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,1TBDMS,#6CC(C)(C)[Si](C)(C)OC1=C[C@H]2CC[C@H]3[C@@H]4CCC(C(=O)CO)[C@@]4(C)C[C@H](O)[C@@H]3[C@@]2(C)CC13416.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#1CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12C3556.6Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C3666.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#3CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C3628.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#4CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CC[C@@H]4CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C3645.1Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#5CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CC[C@@H]4C=C(O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C3616.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#6CC(C)(C)[Si](C)(C)OC(CO)=C1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12C3517.8Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#7CC(C)(C)[Si](C)(C)OC(=CO)C1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12C3473.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#8CC(C)(C)[Si](C)(C)OC1=CC[C@]2(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]4(C)C(C(=O)CO)CC[C@H]4[C@@H]3CC[C@@H]2C13493.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#9CC(C)(C)[Si](C)(C)OC1=C[C@H]2CC[C@H]3[C@@H]4CCC(C(=O)CO)[C@@]4(C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]3[C@@]2(C)CC13484.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#10CC(C)(C)[Si](C)(C)OC1=CC[C@]2(C)[C@H]3[C@@H](O)C[C@]4(C)C(=C(CO)O[Si](C)(C)C(C)(C)C)CC[C@H]4[C@@H]3CC[C@@H]2C13638.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#11CC(C)(C)[Si](C)(C)OC1=C[C@H]2CC[C@H]3[C@@H]4CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]4(C)C[C@H](O)[C@@H]3[C@@]2(C)CC13630.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#12CC(C)(C)[Si](C)(C)OC1=CC[C@]2(C)[C@H]3[C@@H](O)C[C@]4(C)C(C(=CO)O[Si](C)(C)C(C)(C)C)CC[C@H]4[C@@H]3CC[C@@H]2C13550.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
11b,21-Dihydroxy-5b-pregnane-3,20-dione,2TBDMS,#13CC(C)(C)[Si](C)(C)OC1=C[C@H]2CC[C@H]3[C@@H]4CCC(C(=CO)O[Si](C)(C)C(C)(C)C)[C@@]4(C)C[C@H](O)[C@@H]3[C@@]2(C)CC13523.6Semi standard non polarhttps://arxiv.org/abs/1905.12712
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione GC-MS (Non-derivatized) - 70eV, Positivesplash10-000i-0967000000-2bd8bffaffb50939c4932017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione GC-MS (2 TMS) - 70eV, Positivesplash10-004i-1678900000-566d143945a3f4b52be32017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 10V, Positive-QTOFsplash10-001j-0019000000-0e71fe5c93e16a4cdf432017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 20V, Positive-QTOFsplash10-01qa-1239000000-f52a428e20d7dd49be682017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 40V, Positive-QTOFsplash10-01b9-3393000000-deb1166aa0a817378f802017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 10V, Negative-QTOFsplash10-0002-0009000000-4fc0c91330f741f36c932017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 20V, Negative-QTOFsplash10-00mk-1039000000-1fc49c3cd7bc3ee2d17a2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 40V, Negative-QTOFsplash10-0abi-5093000000-507f39e32c2a160043382017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 10V, Positive-QTOFsplash10-0002-0009000000-7276daecfbdb64d20c1b2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 20V, Positive-QTOFsplash10-01q9-1779000000-c2eb0110f553b40989512021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 40V, Positive-QTOFsplash10-0900-6690000000-927e37b4fc2df6d01a4d2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 10V, Negative-QTOFsplash10-0002-0009000000-a946d4450827aea0df542021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 20V, Negative-QTOFsplash10-014j-0029000000-234879f9f1780aa219db2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 11b,21-Dihydroxy-5b-pregnane-3,20-dione 40V, Negative-QTOFsplash10-00kb-1096000000-ee3717ee0bd77d2944ee2021-09-22Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB024061
KNApSAcK IDNot Available
Chemspider ID24850104
KEGG Compound IDC05475
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound44263339
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Gene Name:
AKR1C4
Uniprot ID:
P17516
Molecular weight:
37094.57
Reactions
Tetrahydrocorticosterone + NAD → 11b,21-Dihydroxy-5b-pregnane-3,20-dione + NADH + Hydrogen Iondetails
Tetrahydrocorticosterone + NADP → 11b,21-Dihydroxy-5b-pregnane-3,20-dione + NADPH + Hydrogen Iondetails
General function:
Involved in oxidoreductase activity
Specific function:
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Gene Name:
AKR1D1
Uniprot ID:
P51857
Molecular weight:
32889.38