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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2008-09-16 13:20:24 UTC
Update Date2021-09-14 15:43:42 UTC
HMDB IDHMDB0010410
Secondary Accession Numbers
  • HMDB10410
Metabolite Identification
Common NameResolvin E1
DescriptionResolvin E1 is a resolvin, a bioactive oxygenated product of EPA (eicosapentaenoic acid). It is a inflammation-resolving lipid mediator. RvE1 reduces neutrophil hyper-function, it also prevents the initiation and progression of tissue destruction (PMID: 16373400 ). RvE1, can also act as a host response modulator in the control of the inflammatory diseases that also involve bone loss such as periodontitis and arthritis. RvE1 has been shown to display specific binding sites on human neutrophils with an apparent Kd of 47 nM (PMID: 15753205 ; 16373400 ). RvE1 is a potent modulator of leukocytes as well as selective platelet responses in blood and platelet-rich plasma (PMID: 18480426 ).
Structure
Data?1582752824
Synonyms
ValueSource
5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-epaHMDB
ResolvinE1HMDB
RvE1HMDB
5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acidHMDB
(6Z,8E,10E,14Z,16E)-5,12,18-Trihydroxyicosa-6,8,10,14,16-pentaenoateHMDB
Resolvin e1MeSH
Chemical FormulaC20H30O5
Average Molecular Weight350.4492
Monoisotopic Molecular Weight350.20932407
IUPAC Name(6Z,8E,10E,14Z,16E)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid
Traditional NameRvE1
CAS Registry NumberNot Available
SMILES
CCC(O)\C=C\C=C/CC(O)\C=C\C=C\C=C/C(O)CCCC(O)=O
InChI Identifier
InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)/b4-3+,9-5-,11-8+,12-6+,13-7-
InChI KeyAOPOCGPBAIARAV-WEKRNNBPSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hydroxyeicosapentaenoic acids. These are eicosanoic acids with an attached hydroxyl group and five CC double bonds.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassEicosanoids
Direct ParentHydroxyeicosapentaenoic acids
Alternative Parents
Substituents
  • Hydroxyeicosapentaenoic acid
  • Long-chain fatty acid
  • Hydroxy fatty acid
  • Fatty acid
  • Unsaturated fatty acid
  • Secondary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Polyol
  • Organic oxide
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Carbonyl group
  • Organooxygen compound
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Spectral PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.045 g/LALOGPS
logP10(4.24) g/LALOGPS
logP10(2.53) g/LChemAxon
logS10(-3.9) g/LALOGPS
pKa (Strongest Acidic)4.65ChemAxon
pKa (Strongest Basic)-1.1ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area97.99 ŲChemAxon
Rotatable Bond Count13ChemAxon
Refractivity105.62 m³·mol⁻¹ChemAxon
Polarizability39.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Spectral Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+192.65531661259
DarkChem[M-H]-190.81231661259

Predicted Kovats Retention Indices

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Resolvin E1,1TMS,#1CCC(/C=C/C=C\CC(O)/C=C/C=C/C=C\C(O)CCCC(=O)O)O[Si](C)(C)C3197.1Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,1TMS,#2CCC(O)/C=C/C=C\CC(/C=C/C=C/C=C\C(O)CCCC(=O)O)O[Si](C)(C)C3208.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,1TMS,#3CCC(O)/C=C/C=C\CC(O)/C=C/C=C/C=C\C(CCCC(=O)O)O[Si](C)(C)C3213.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,1TMS,#4CCC(O)/C=C/C=C\CC(O)/C=C/C=C/C=C\C(O)CCCC(=O)O[Si](C)(C)C3108.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TMS,#1CCC(/C=C/C=C\CC(/C=C/C=C/C=C\C(O)CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C3234.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TMS,#2CCC(/C=C/C=C\CC(O)/C=C/C=C/C=C\C(CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C3228.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TMS,#3CCC(/C=C/C=C\CC(O)/C=C/C=C/C=C\C(O)CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C3129.1Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TMS,#4CCC(O)/C=C/C=C\CC(/C=C/C=C/C=C\C(CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C3241.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TMS,#5CCC(O)/C=C/C=C\CC(/C=C/C=C/C=C\C(O)CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C3137.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TMS,#6CCC(O)/C=C/C=C\CC(O)/C=C/C=C/C=C\C(CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C3140.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,3TMS,#1CCC(/C=C/C=C\CC(/C=C/C=C/C=C\C(CCCC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3193.6Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,3TMS,#2CCC(/C=C/C=C\CC(/C=C/C=C/C=C\C(O)CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3123.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,3TMS,#3CCC(/C=C/C=C\CC(O)/C=C/C=C/C=C\C(CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3117.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,3TMS,#4CCC(O)/C=C/C=C\CC(/C=C/C=C/C=C\C(CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3114.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,4TMS,#1CCC(/C=C/C=C\CC(/C=C/C=C/C=C\C(CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3104.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,1TBDMS,#1CCC(/C=C/C=C\CC(O)/C=C/C=C/C=C\C(O)CCCC(=O)O)O[Si](C)(C)C(C)(C)C3442.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,1TBDMS,#2CCC(O)/C=C/C=C\CC(/C=C/C=C/C=C\C(O)CCCC(=O)O)O[Si](C)(C)C(C)(C)C3446.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,1TBDMS,#3CCC(O)/C=C/C=C\CC(O)/C=C/C=C/C=C\C(CCCC(=O)O)O[Si](C)(C)C(C)(C)C3448.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,1TBDMS,#4CCC(O)/C=C/C=C\CC(O)/C=C/C=C/C=C\C(O)CCCC(=O)O[Si](C)(C)C(C)(C)C3353.6Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TBDMS,#1CCC(/C=C/C=C\CC(/C=C/C=C/C=C\C(O)CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3696.1Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TBDMS,#2CCC(/C=C/C=C\CC(O)/C=C/C=C/C=C\C(CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3696.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TBDMS,#3CCC(/C=C/C=C\CC(O)/C=C/C=C/C=C\C(O)CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3615.1Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TBDMS,#4CCC(O)/C=C/C=C\CC(/C=C/C=C/C=C\C(CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3698.1Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TBDMS,#5CCC(O)/C=C/C=C\CC(/C=C/C=C/C=C\C(O)CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3614.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,2TBDMS,#6CCC(O)/C=C/C=C\CC(O)/C=C/C=C/C=C\C(CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3627.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,3TBDMS,#1CCC(/C=C/C=C\CC(/C=C/C=C/C=C\C(CCCC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3936.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,3TBDMS,#2CCC(/C=C/C=C\CC(/C=C/C=C/C=C\C(O)CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3879.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,3TBDMS,#3CCC(/C=C/C=C\CC(O)/C=C/C=C/C=C\C(CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3884.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,3TBDMS,#4CCC(O)/C=C/C=C\CC(/C=C/C=C/C=C\C(CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3878.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
Resolvin E1,4TBDMS,#1CCC(/C=C/C=C\CC(/C=C/C=C/C=C\C(CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4083.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Resolvin E1 GC-MS (Non-derivatized) - 70eV, Positivesplash10-001i-5379000000-0d3673588a0031b08acc2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Resolvin E1 GC-MS (4 TMS) - 70eV, Positivesplash10-00bc-8210967000-0976f920f1060120fe1a2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Resolvin E1 GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.001 +/- 0.000234 uMAdult (>18 years old)Not SpecifiedNormal details
BloodDetected and Quantified0.001 +/- 0.00023 uMAdult (>18 years old)Both
Normal
details
BloodDetected and Quantified0.000521 +/- 0.00098 uMAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB027561
KNApSAcK IDNot Available
Chemspider ID35032053
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound25063347
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE: RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. FASEB J. 2006 Feb;20(2):401-3. Epub 2005 Dec 22. [PubMed:16373400 ]
  2. Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN: Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med. 2005 Mar 7;201(5):713-22. [PubMed:15753205 ]
  3. Dona M, Fredman G, Schwab JM, Chiang N, Arita M, Goodarzi A, Cheng G, von Andrian UH, Serhan CN: Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood. 2008 Aug 1;112(3):848-55. doi: 10.1182/blood-2007-11-122598. Epub 2008 May 14. [PubMed:18480426 ]