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Record Information

Version

5.0

Status

Expected but not Quantified

Creation Date

2008-10-15 12:12:16 UTC

Update Date

2022-03-07 02:51:02 UTC

HMDB ID

HMDB0010728

Secondary Accession Numbers

HMDB10728

Metabolite Identification

Common Name

(R)-3-Hydroxydodecanoic acid

Description

(R)-3-Hydroxydodecanoic acid, also known as (3R)-3-hydroxylauric acid or (R)-beta-OH lauric acid, belongs to the class of organic compounds known as medium-chain hydroxy acids and derivatives. These are hydroxy acids with a 6 to 12 carbon atoms long side chain (R)-3-Hydroxydodecanoic acid exists in all eukaryotes, ranging from yeast to plants to humans. In humans, (R)-3-hydroxydodecanoic acid is involved in the fatty acid biosynthesis pathway (R)-3-Hydroxydodecanoic acid has been detected, but not quantified in, a few different foods, such as anatidaes (Anatidae), chickens (Gallus gallus), and domestic pigs (Sus scrofa domestica). This could make (R)-3-hydroxydodecanoic acid a potential biomarker for the consumption of these foods (R)-3-Hydroxydodecanoic acid is a primary metabolite. Primary metabolites are metabolically or physiologically essential metabolites. They are directly involved in an organism’s growth, development or reproduction. Based on a literature review a significant number of articles have been published on (R)-3-Hydroxydodecanoic acid.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0010728
     RDKit          3D
(R)-3-Hydroxydodecanoic acid
 39 38  0  0  0  0  0  0  0  0999 V2000
   -4.6157    1.5108   -0.9988 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4541    1.5645    0.4737 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7450    0.4544    1.1466 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3262    0.2012    0.8502 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0566   -0.1160   -0.5734 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5540   -0.4189   -0.8012 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0874   -1.5892    0.0046 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3727   -1.8339   -0.2880 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2287   -0.6692    0.0560 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6915   -0.8983   -0.2193 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.9236   -1.1716   -1.5732 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5499    0.2850    0.1219 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5180    0.7000    1.5270 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8606    0.1140    2.3994 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2663    1.8088    1.8918 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4912    0.5156   -1.4201 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9598    2.2586   -1.4982 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6819    1.7962   -1.2911 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9525    2.5223    0.7984 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4863    1.6712    0.9205 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3237   -0.4980    0.9433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8613    0.5673    2.2750 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6977    1.0812    1.1560 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0052   -0.6459    1.5374 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6467   -0.9374   -0.9714 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2104    0.7885   -1.2212 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0424    0.5156   -0.5094 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4572   -0.5808   -1.8915 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095   -1.4075    1.1003 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6587   -2.5057   -0.2357 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6503   -2.7710    0.2230 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4396   -2.0187   -1.3904 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0380   -0.3879    1.0991 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9335    0.1977   -0.6041 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0187   -1.7505    0.4313 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9402   -2.1463   -1.7512 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2280    1.1364   -0.5325 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5929    0.0047   -0.1760 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2710    2.6526    1.3288 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
  1 16  1  0
  1 17  1  0
  1 18  1  0
  2 19  1  0
  2 20  1  0
  3 21  1  0
  3 22  1  0
  4 23  1  0
  4 24  1  0
  5 25  1  0
  5 26  1  0
  6 27  1  0
  6 28  1  0
  7 29  1  0
  7 30  1  0
  8 31  1  0
  8 32  1  0
  9 33  1  0
  9 34  1  0
 10 35  1  1
 11 36  1  0
 12 37  1  0
 12 38  1  0
 15 39  1  0
M  END


  Mrv0541 02241201182D          

 16 15  0  0  1  0            999 V2000
    9.2913   -6.3422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0057   -6.7547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7202   -6.3422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4347   -6.7547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1491   -6.3422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8636   -6.7547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5781   -6.3422    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   14.2926   -6.7547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0071   -6.3422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7215   -6.7547    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.0071   -5.5172    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5768   -6.7547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8623   -6.3422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1478   -6.7547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9209   -5.6151    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.1649   -5.5653    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  2  1  0  0  0  0
  4  3  1  0  0  0  0
  5  4  1  0  0  0  0
  6  5  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  8  1  0  0  0  0
 10  9  2  0  0  0  0
 11  9  1  0  0  0  0
  1 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  7 15  1  1  0  0  0
  7 16  1  6  0  0  0
M  END
> <DATABASE_ID>
HMDB0010728

> <DATABASE_NAME>
hmdb

> <SMILES>
[H][C@@](O)(CCCCCCCCC)CC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C12H24O3/c1-2-3-4-5-6-7-8-9-11(13)10-12(14)15/h11,13H,2-10H2,1H3,(H,14,15)/t11-/m1/s1

> <INCHI_KEY>
MUCMKTPAZLSKTL-LLVKDONJSA-N

> <FORMULA>
C12H24O3

> <MOLECULAR_WEIGHT>
216.3172

> <EXACT_MASS>
216.172544634

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_AVERAGE_POLARIZABILITY>
26.587142030134192

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3R)-3-hydroxydodecanoic acid

> <ALOGPS_LOGP>
3.63

> <JCHEM_LOGP>
3.2474970506666665

> <ALOGPS_LOGS>
-2.80

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
15.288498288670866

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.671850167040888

> <JCHEM_PKA_STRONGEST_BASIC>
-2.798587426318786

> <JCHEM_POLAR_SURFACE_AREA>
57.53

> <JCHEM_REFRACTIVITY>
60.1951

> <JCHEM_ROTATABLE_BOND_COUNT>
10

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.45e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(R)-3-hydroxydodecanoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0010728
     RDKit          3D
(R)-3-Hydroxydodecanoic acid
 39 38  0  0  0  0  0  0  0  0999 V2000
   -4.6157    1.5108   -0.9988 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4541    1.5645    0.4737 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7450    0.4544    1.1466 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3262    0.2012    0.8502 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0566   -0.1160   -0.5734 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5540   -0.4189   -0.8012 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0874   -1.5892    0.0046 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3727   -1.8339   -0.2880 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2287   -0.6692    0.0560 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6915   -0.8983   -0.2193 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.9236   -1.1716   -1.5732 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5499    0.2850    0.1219 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5180    0.7000    1.5270 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8606    0.1140    2.3994 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2663    1.8088    1.8918 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4912    0.5156   -1.4201 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9598    2.2586   -1.4982 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6819    1.7962   -1.2911 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9525    2.5223    0.7984 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4863    1.6712    0.9205 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3237   -0.4980    0.9433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8613    0.5673    2.2750 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6977    1.0812    1.1560 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0052   -0.6459    1.5374 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6467   -0.9374   -0.9714 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2104    0.7885   -1.2212 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0424    0.5156   -0.5094 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4572   -0.5808   -1.8915 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095   -1.4075    1.1003 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6587   -2.5057   -0.2357 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6503   -2.7710    0.2230 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4396   -2.0187   -1.3904 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0380   -0.3879    1.0991 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9335    0.1977   -0.6041 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0187   -1.7505    0.4313 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9402   -2.1463   -1.7512 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2280    1.1364   -0.5325 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5929    0.0047   -0.1760 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2710    2.6526    1.3288 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
  1 16  1  0
  1 17  1  0
  1 18  1  0
  2 19  1  0
  2 20  1  0
  3 21  1  0
  3 22  1  0
  4 23  1  0
  4 24  1  0
  5 25  1  0
  5 26  1  0
  6 27  1  0
  6 28  1  0
  7 29  1  0
  7 30  1  0
  8 31  1  0
  8 32  1  0
  9 33  1  0
  9 34  1  0
 10 35  1  1
 11 36  1  0
 12 37  1  0
 12 38  1  0
 15 39  1  0
M  END

HEADER    PROTEIN                                 24-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-12         0                                  
HETATM    1  C   UNK     0      17.344 -11.839   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      18.677 -12.609   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      20.011 -11.839   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      21.345 -12.609   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      22.678 -11.839   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      24.012 -12.609   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      25.346 -11.839   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      26.680 -12.609   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      28.013 -11.839   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      29.347 -12.609   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0      28.013 -10.299   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0      16.010 -12.609   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      14.676 -11.839   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      13.343 -12.609   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0      24.119 -10.482   0.000  0.00  0.00           O+0
HETATM   16  H   UNK     0      26.441 -10.389   0.000  0.00  0.00           H+0
CONECT    1    2   12                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8   15   16                                             
CONECT    8    7    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9                                                            
CONECT   12    1   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13                                                            
CONECT   15    7                                                            
CONECT   16    7                                                            
MASTER        0    0    0    0    0    0    0    0   16    0   30    0
END

COMPND    HMDB0010728
HETATM    1  C1  UNL     1      -4.616   1.511  -0.999  1.00  0.00           C  
HETATM    2  C2  UNL     1      -4.454   1.565   0.474  1.00  0.00           C  
HETATM    3  C3  UNL     1      -3.745   0.454   1.147  1.00  0.00           C  
HETATM    4  C4  UNL     1      -2.326   0.201   0.850  1.00  0.00           C  
HETATM    5  C5  UNL     1      -2.057  -0.116  -0.573  1.00  0.00           C  
HETATM    6  C6  UNL     1      -0.554  -0.419  -0.801  1.00  0.00           C  
HETATM    7  C7  UNL     1      -0.087  -1.589   0.005  1.00  0.00           C  
HETATM    8  C8  UNL     1       1.373  -1.834  -0.288  1.00  0.00           C  
HETATM    9  C9  UNL     1       2.229  -0.669   0.056  1.00  0.00           C  
HETATM   10  C10 UNL     1       3.691  -0.898  -0.219  1.00  0.00           C  
HETATM   11  O1  UNL     1       3.924  -1.172  -1.573  1.00  0.00           O  
HETATM   12  C11 UNL     1       4.550   0.285   0.122  1.00  0.00           C  
HETATM   13  C12 UNL     1       4.518   0.700   1.527  1.00  0.00           C  
HETATM   14  O2  UNL     1       3.861   0.114   2.399  1.00  0.00           O  
HETATM   15  O3  UNL     1       5.266   1.809   1.892  1.00  0.00           O  
HETATM   16  H1  UNL     1      -4.491   0.516  -1.420  1.00  0.00           H  
HETATM   17  H2  UNL     1      -3.960   2.259  -1.498  1.00  0.00           H  
HETATM   18  H3  UNL     1      -5.682   1.796  -1.291  1.00  0.00           H  
HETATM   19  H4  UNL     1      -3.952   2.522   0.798  1.00  0.00           H  
HETATM   20  H5  UNL     1      -5.486   1.671   0.921  1.00  0.00           H  
HETATM   21  H6  UNL     1      -4.324  -0.498   0.943  1.00  0.00           H  
HETATM   22  H7  UNL     1      -3.861   0.567   2.275  1.00  0.00           H  
HETATM   23  H8  UNL     1      -1.698   1.081   1.156  1.00  0.00           H  
HETATM   24  H9  UNL     1      -2.005  -0.646   1.537  1.00  0.00           H  
HETATM   25  H10 UNL     1      -2.647  -0.937  -0.971  1.00  0.00           H  
HETATM   26  H11 UNL     1      -2.210   0.788  -1.221  1.00  0.00           H  
HETATM   27  H12 UNL     1      -0.042   0.516  -0.509  1.00  0.00           H  
HETATM   28  H13 UNL     1      -0.457  -0.581  -1.891  1.00  0.00           H  
HETATM   29  H14 UNL     1      -0.210  -1.407   1.100  1.00  0.00           H  
HETATM   30  H15 UNL     1      -0.659  -2.506  -0.236  1.00  0.00           H  
HETATM   31  H16 UNL     1       1.650  -2.771   0.223  1.00  0.00           H  
HETATM   32  H17 UNL     1       1.440  -2.019  -1.390  1.00  0.00           H  
HETATM   33  H18 UNL     1       2.038  -0.388   1.099  1.00  0.00           H  
HETATM   34  H19 UNL     1       1.934   0.198  -0.604  1.00  0.00           H  
HETATM   35  H20 UNL     1       4.019  -1.751   0.431  1.00  0.00           H  
HETATM   36  H21 UNL     1       3.940  -2.146  -1.751  1.00  0.00           H  
HETATM   37  H22 UNL     1       4.228   1.136  -0.533  1.00  0.00           H  
HETATM   38  H23 UNL     1       5.593   0.005  -0.176  1.00  0.00           H  
HETATM   39  H24 UNL     1       5.271   2.653   1.329  1.00  0.00           H  
CONECT    1    2   16   17   18
CONECT    2    3   19   20
CONECT    3    4   21   22
CONECT    4    5   23   24
CONECT    5    6   25   26
CONECT    6    7   27   28
CONECT    7    8   29   30
CONECT    8    9   31   32
CONECT    9   10   33   34
CONECT   10   11   12   35
CONECT   11   36
CONECT   12   13   37   38
CONECT   13   14   14   15
CONECT   15   39
END

HMDB0010728
     RDKit          3D
(R)-3-Hydroxydodecanoic acid
 39 38  0  0  0  0  0  0  0  0999 V2000
   -4.6157    1.5108   -0.9988 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4541    1.5645    0.4737 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7450    0.4544    1.1466 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3262    0.2012    0.8502 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0566   -0.1160   -0.5734 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5540   -0.4189   -0.8012 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0874   -1.5892    0.0046 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3727   -1.8339   -0.2880 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2287   -0.6692    0.0560 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6915   -0.8983   -0.2193 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.9236   -1.1716   -1.5732 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5499    0.2850    0.1219 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5180    0.7000    1.5270 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8606    0.1140    2.3994 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2663    1.8088    1.8918 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4912    0.5156   -1.4201 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9598    2.2586   -1.4982 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6819    1.7962   -1.2911 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9525    2.5223    0.7984 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4863    1.6712    0.9205 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3237   -0.4980    0.9433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8613    0.5673    2.2750 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6977    1.0812    1.1560 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0052   -0.6459    1.5374 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6467   -0.9374   -0.9714 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2104    0.7885   -1.2212 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0424    0.5156   -0.5094 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4572   -0.5808   -1.8915 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095   -1.4075    1.1003 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6587   -2.5057   -0.2357 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6503   -2.7710    0.2230 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4396   -2.0187   -1.3904 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0380   -0.3879    1.0991 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9335    0.1977   -0.6041 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0187   -1.7505    0.4313 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9402   -2.1463   -1.7512 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2280    1.1364   -0.5325 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5929    0.0047   -0.1760 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2710    2.6526    1.3288 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
  1 16  1  0
  1 17  1  0
  1 18  1  0
  2 19  1  0
  2 20  1  0
  3 21  1  0
  3 22  1  0
  4 23  1  0
  4 24  1  0
  5 25  1  0
  5 26  1  0
  6 27  1  0
  6 28  1  0
  7 29  1  0
  7 30  1  0
  8 31  1  0
  8 32  1  0
  9 33  1  0
  9 34  1  0
 10 35  1  1
 11 36  1  0
 12 37  1  0
 12 38  1  0
 15 39  1  0
M  END

View in JSmol View Stereo Labels

Synonyms

Value	Source
(3R)-3-Hydroxydodecanoic acid	ChEBI
(3R)-3-Hydroxylauric acid	ChEBI
(R)-3-OH Dodecanoic acid	ChEBI
(R)-3-OH Lauric acid	ChEBI
(R)-beta-Hydroxydodecanoic acid	ChEBI
(R)-beta-Hydroxylauric acid	ChEBI
(R)-beta-OH Dodecanoic acid	ChEBI
(R)-beta-OH Lauric acid	ChEBI
D-(-)-3-Hydroxydodecanoic acid	ChEBI
D-3-Hydroxydodecanoic acid	ChEBI
(3R)-3-Hydroxydodecanoate	Generator
(3R)-3-Hydroxylaate	Generator
(3R)-3-Hydroxylaic acid	Generator
(R)-3-OH Dodecanoate	Generator
(R)-3-OH Laate	Generator
(R)-3-OH Laic acid	Generator
(R)-b-Hydroxydodecanoate	Generator
(R)-b-Hydroxydodecanoic acid	Generator
(R)-beta-Hydroxydodecanoate	Generator
(R)-Β-hydroxydodecanoate	Generator
(R)-Β-hydroxydodecanoic acid	Generator
(R)-b-Hydroxylaate	Generator
(R)-b-Hydroxylaic acid	Generator
(R)-beta-Hydroxylaate	Generator
(R)-beta-Hydroxylaic acid	Generator
(R)-Β-hydroxylaate	Generator
(R)-Β-hydroxylaic acid	Generator
(R)-b-OH Dodecanoate	Generator
(R)-b-OH Dodecanoic acid	Generator
(R)-beta-OH Dodecanoate	Generator
(R)-Β-OH dodecanoate	Generator
(R)-Β-OH dodecanoic acid	Generator
(R)-b-OH Laate	Generator
(R)-b-OH Laic acid	Generator
(R)-beta-OH Laate	Generator
(R)-beta-OH Laic acid	Generator
(R)-Β-OH laate	Generator
(R)-Β-OH laic acid	Generator
D-(-)-3-Hydroxydodecanoate	Generator
D-3-Hydroxydodecanoate	Generator
(R)-3-Hydroxydodecanoate	Generator

Chemical Formula

C₁₂H₂₄O₃

Average Molecular Weight

216.3172

Monoisotopic Molecular Weight

216.172544634

IUPAC Name

(3R)-3-hydroxydodecanoic acid

Traditional Name

(R)-3-hydroxydodecanoic acid

CAS Registry Number

Not Available

SMILES

[H][C@@](O)(CCCCCCCCC)CC(O)=O

InChI Identifier

InChI=1S/C12H24O3/c1-2-3-4-5-6-7-8-9-11(13)10-12(14)15/h11,13H,2-10H2,1H3,(H,14,15)/t11-/m1/s1

InChI Key

MUCMKTPAZLSKTL-LLVKDONJSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as medium-chain hydroxy acids and derivatives. These are hydroxy acids with a 6 to 12 carbon atoms long side chain.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Hydroxy acids and derivatives

Sub Class

Medium-chain hydroxy acids and derivatives

Direct Parent

Medium-chain hydroxy acids and derivatives

Alternative Parents

Substituents

Medium-chain hydroxy acid
Medium-chain fatty acid
Beta-hydroxy acid
Hydroxy fatty acid
Fatty acyl
Fatty acid
Secondary alcohol
Carboxylic acid derivative
Carboxylic acid
Monocarboxylic acid or derivatives
Organic oxide
Alcohol
Carbonyl group
Hydrocarbon derivative
Organic oxygen compound
Organooxygen compound
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

(3R)-3-hydroxy fatty acid (CHEBI:43197 )
3-hydroxylauric acid (CHEBI:43197 )
Hydroxy fatty acids (LMFA01050251 )

Ontology

Physiological effect

Not Available

Disposition

Biological location

Cellular substructure

Source

Exogenous

Exogenous (HMDB: HMDB0010728)

Food

Food (HMDB: HMDB0010728)

Animal origin

Poultry

Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Equine

Horse (FooDB: FOOD00378)

Endogenous

Endogenous (HMDB: HMDB0010728)

Process

Naturally occurring process

Biological process

Cellular process

Cell signaling (HMDB: HMDB0010728)

Biochemical pathway

Metabolic pathway

Fatty Acid Biosynthesis (PathBank: SMP0002360)
Fatty Acid Biosynthesis (PathBank: SMP0087409)
Fatty Acid Biosynthesis (HMDB: HMDB0010728)

Role

Biological role

Energy source (HMDB: HMDB0010728)

Industrial application

Manufacturing industry

Material processing agent

Fluid processing agent

Surfactant

Surfactant (HMDB: HMDB0010728)

Pharmaceutical industry

Pharmaceutical (HMDB: HMDB0010728)

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
Water Solubility	0.34 g/L	ALOGPS
logP	3.63	ALOGPS
logP	3.25	ChemAxon
logS	-2.8	ALOGPS
pKa (Strongest Acidic)	4.67	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	57.53 Å²	ChemAxon
Rotatable Bond Count	10	ChemAxon
Refractivity	60.2 m³·mol⁻¹	ChemAxon
Polarizability	26.59 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	154.21	31661259
DarkChem	[M-H]-	151.828	31661259
DeepCCS	[M+H]+	151.108	30932474
DeepCCS	[M-H]-	148.271	30932474
DeepCCS	[M-2H]-	184.63	30932474
DeepCCS	[M+Na]+	159.459	30932474
AllCCS	[M+H]+	156.6	32859911
AllCCS	[M+H-H2O]+	153.0	32859911
AllCCS	[M+NH4]+	159.8	32859911
AllCCS	[M+Na]+	160.8	32859911
AllCCS	[M-H]-	156.0	32859911
AllCCS	[M+Na-2H]-	157.1	32859911
AllCCS	[M+HCOO]-	158.4	32859911

Predicted Retention Times

Underivatized

Chromatographic Method	Retention Time	Reference
Measured using a Waters Acquity ultraperformance liquid chromatography (UPLC) ethylene-bridged hybrid (BEH) C18 column (100 mm × 2.1 mm; 1.7 μmparticle diameter). Predicted by Afia on May 17, 2022. Predicted by Afia on May 17, 2022.	7.74 minutes	32390414
Predicted by Siyang on May 30, 2022	13.3627 minutes	33406817
Predicted by Siyang using ReTip algorithm on June 8, 2022	1.63 minutes	32390414
AjsUoB = Accucore 150 Amide HILIC with 10mM Ammonium Formate, 0.1% Formic Acid	39.4 seconds	40023050
Fem_Long = Waters ACQUITY UPLC HSS T3 C18 with Water:MeOH and 0.1% Formic Acid	2175.8 seconds	40023050
Fem_Lipids = Ascentis Express C18 with (60:40 water:ACN):(90:10 IPA:ACN) and 10mM NH4COOH + 0.1% Formic Acid	325.9 seconds	40023050
Life_Old = Waters ACQUITY UPLC BEH C18 with Water:(20:80 acetone:ACN) and 0.1% Formic Acid	159.9 seconds	40023050
Life_New = RP Waters ACQUITY UPLC HSS T3 C18 with Water:(30:70 MeOH:ACN) and 0.1% Formic Acid	185.7 seconds	40023050
RIKEN = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid	379.0 seconds	40023050
Eawag_XBridgeC18 = XBridge C18 3.5u 2.1x50 mm with Water:MeOH and 0.1% Formic Acid	591.4 seconds	40023050
BfG_NTS_RP1 =Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) with Water:ACN and 0.1% Formic Acid	568.3 seconds	40023050
HILIC_BDD_2 = Merck SeQuant ZIC-HILIC with ACN(0.1% formic acid):water(16 mM ammonium formate)	100.3 seconds	40023050
UniToyama_Atlantis = RP Waters Atlantis T3 (2.1 x 150 mm, 5 um) with ACN:Water and 0.1% Formic Acid	1186.4 seconds	40023050
BDD_C18 = Hypersil Gold 1.9µm C18 with Water:ACN and 0.1% Formic Acid	436.8 seconds	40023050
UFZ_Phenomenex = Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex with Water:MeOH and 0.1% Formic Acid	1390.7 seconds	40023050
SNU_RIKEN_POS = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid	396.1 seconds	40023050
RPMMFDA = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid	358.5 seconds	40023050
MTBLS87 = Merck SeQuant ZIC-pHILIC column with ACN:Water and :ammonium carbonate	388.7 seconds	40023050
KI_GIAR_zic_HILIC_pH2_7 = Merck SeQuant ZIC-HILIC with ACN:Water and 0.1% FA	252.2 seconds	40023050
Meister zic-pHILIC pH9.3 = Merck SeQuant ZIC-pHILIC column with ACN:Water 5mM NH4Ac pH9.3 and 5mM ammonium acetate in water	59.1 seconds	40023050

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
(R)-3-Hydroxydodecanoic acid	[H][C@@](O)(CCCCCCCCC)CC(O)=O	2843.1	Standard polar	33892256
(R)-3-Hydroxydodecanoic acid	[H][C@@](O)(CCCCCCCCC)CC(O)=O	1679.3	Standard non polar	33892256
(R)-3-Hydroxydodecanoic acid	[H][C@@](O)(CCCCCCCCC)CC(O)=O	1772.6	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
(R)-3-Hydroxydodecanoic acid,1TMS,isomer #1	CCCCCCCCC[C@H](CC(=O)O)O[Si](C)(C)C	1780.9	Semi standard non polar	33892256
(R)-3-Hydroxydodecanoic acid,1TMS,isomer #2	CCCCCCCCC[C@@H](O)CC(=O)O[Si](C)(C)C	1767.4	Semi standard non polar	33892256
(R)-3-Hydroxydodecanoic acid,2TMS,isomer #1	CCCCCCCCC[C@H](CC(=O)O[Si](C)(C)C)O[Si](C)(C)C	1855.5	Semi standard non polar	33892256
(R)-3-Hydroxydodecanoic acid,1TBDMS,isomer #1	CCCCCCCCC[C@H](CC(=O)O)O[Si](C)(C)C(C)(C)C	2007.2	Semi standard non polar	33892256
(R)-3-Hydroxydodecanoic acid,1TBDMS,isomer #2	CCCCCCCCC[C@@H](O)CC(=O)O[Si](C)(C)C(C)(C)C	2000.8	Semi standard non polar	33892256
(R)-3-Hydroxydodecanoic acid,2TBDMS,isomer #1	CCCCCCCCC[C@H](CC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C	2314.9	Semi standard non polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - (R)-3-Hydroxydodecanoic acid GC-MS (Non-derivatized) - 70eV, Positive	splash10-000f-9500000000-ce0e4abc46c623ad5053	2016-09-22	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - (R)-3-Hydroxydodecanoic acid GC-MS (2 TMS) - 70eV, Positive	splash10-00bc-9042000000-0d213d881baf293e004c	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - (R)-3-Hydroxydodecanoic acid GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - (R)-3-Hydroxydodecanoic acid GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 10V, Positive-QTOF	splash10-00kb-0930000000-57fa523571a510c84940	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 20V, Positive-QTOF	splash10-0f7k-3900000000-db0ac4f7e5c200e8ffe9	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 40V, Positive-QTOF	splash10-052f-9200000000-af4ea991e8885d84f4d2	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 10V, Negative-QTOF	splash10-014i-1790000000-438c129b69517f0cd6f1	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 20V, Negative-QTOF	splash10-0q29-3920000000-f4f68c93f91c4519ee51	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 40V, Negative-QTOF	splash10-0a4l-9600000000-05e66928d4652560bee3	2016-09-14	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 10V, Negative-QTOF	splash10-014i-1190000000-5af11549237f298c2ea2	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 20V, Negative-QTOF	splash10-0a4i-9210000000-0ad9609790293200ce6e	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 40V, Negative-QTOF	splash10-0a4l-9200000000-abdab144438d186cdcc0	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 10V, Positive-QTOF	splash10-014j-8950000000-eef6079ee3aba96447b9	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 20V, Positive-QTOF	splash10-0a4i-9200000000-2cc48879a8d7f0de8899	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - (R)-3-Hydroxydodecanoic acid 40V, Positive-QTOF	splash10-0a4l-9000000000-b899673a8a3334e8f36a	2021-09-22	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Membrane

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Pathways

Name	SMPDB/PathBank	KEGG
Fatty Acid Biosynthesis		Not Available

Normal Concentrations

Not Available

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

DB07930

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB027875

KNApSAcK ID

Not Available

Chemspider ID

4472229

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5312804

PDB ID

HXD

ChEBI ID

43197

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Not Available

Enzymes

Enzyme Details

1. Fatty acid synthase

General function:: Involved in transferase activity
Specific function:: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Gene Name:: FASN
Uniprot ID:: P49327
Molecular weight:: 273424.06

Showing metabocard for (R)-3-Hydroxydodecanoic acid (HMDB0010728)

MOL for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

3D MOL for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

3D SDF for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

3D-SDF for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

PDB for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

3D PDB for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

SMILES for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

INCHI for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

Structure for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

3D Structure for HMDB0010728 ((R)-3-Hydroxydodecanoic acid)

Predicted Collision Cross Sections

Predicted Retention Times

Underivatized

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

Enzymes