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Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2012-05-18 14:35:50 UTC
Update Date2020-02-26 21:39:05 UTC
HMDB IDHMDB0013751
Secondary Accession Numbers
  • HMDB13751
Metabolite Identification
Common Name2-Hydroxypyridine
DescriptionThis colourless crystalline solid is used in peptide synthesis. It is well known to form hydrogen bonded structures somewhat related to the base-pairing mechanism found in RNA and DNA. It is also a classic case of a molecule that exists as tautomers. Some publications only focus one of the two possible patterns, and neglect the influence of the other. For example, to calculation of the energy difference of the two tautomers in a non-polar solution will lead to a wrong result if a large quantity of the substance is on the side of the dimer in an equilibrium. The direct tautomerisation is not energetically favoured, but a dimerisation followed by a double proton transfer and dissociation of the dimer is a self catalytic path from one tautomer to the other. Protic solvents also mediate the proton transfer during the tautomerisation.
Structure
Data?1582753145
Synonyms
ValueSource
2-PyridinolChEBI
2-PyridoneChEBI
1-Hydroxy-2-pyridineHMDB
1H-Pyridin-2-oneHMDB
2(1H)-PyridinoneHMDB
2(1H)-PyridoneHMDB
2-OxopyridineHMDB
2-Pyridinol (acd/name 4.0)HMDB
2-PyridinoneHMDB
2-PyridolHMDB
alpha -PyridoneHMDB
alpha-PyridoneHMDB
Pyridin-2-olHMDB
Pyridone-2HMDB
2-Hydroxypyridine sodium saltHMDB
2-HydroxypyridineChEBI
Chemical FormulaC5H5NO
Average Molecular Weight95.0993
Monoisotopic Molecular Weight95.037113787
IUPAC Namepyridin-2-ol
Traditional Name2-pyridone
CAS Registry Number142-08-5
SMILES
OC1=CC=CC=N1
InChI Identifier
InChI=1S/C5H5NO/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7)
InChI KeyUBQKCCHYAOITMY-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as pyridinones. Pyridinones are compounds containing a pyridine ring, which bears a ketone.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassHydropyridines
Direct ParentPyridinones
Alternative Parents
Substituents
  • Pyridinone
  • Dihydropyridine
  • Heteroaromatic compound
  • Lactam
  • Azacycle
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effect

Adverse health effect

Disposition

Biological location

Source

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point107.8 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility1000 mg/mL at 20 °CNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+Not Available115.8http://allccs.zhulab.cn/database/detail?ID=AllCCS00002167
Predicted Molecular Properties
PropertyValueSource
Water Solubility320 g/LALOGPS
logP0.64ALOGPS
logP1.05ChemAxon
logS0.53ALOGPS
pKa (Strongest Acidic)11.7ChemAxon
pKa (Strongest Basic)2.43ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area33.12 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity26.2 m³·mol⁻¹ChemAxon
Polarizability9.2 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+115.65931661259
DarkChem[M-H]-111.30831661259
DeepCCS[M+H]+120.98530932474
DeepCCS[M-H]-118.18630932474
DeepCCS[M-2H]-154.46530932474
DeepCCS[M+Na]+129.21630932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
2-HydroxypyridineOC1=CC=CC=N12206.5Standard polar33892256
2-HydroxypyridineOC1=CC=CC=N11023.5Standard non polar33892256
2-HydroxypyridineOC1=CC=CC=N11014.4Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
2-Hydroxypyridine,1TMS,isomer #1C[Si](C)(C)OC1=CC=CC=N11037.5Semi standard non polar33892256
2-Hydroxypyridine,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC=CC=N11288.6Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - 2-Hydroxypyridine GC-MS (1 TMS)splash10-0udi-3900000000-b326651e42bb0bf10eb32014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Hydroxypyridine EI-B (Non-derivatized)splash10-00kk-9000000000-7be5bb43b8d4efeef6122017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Hydroxypyridine EI-B (Non-derivatized)splash10-00kk-9000000000-4cb62ee57ab7319350932017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Hydroxypyridine EI-B (Non-derivatized)splash10-0udi-0900000000-1fea7566ea893b73b6e32017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Hydroxypyridine GC-EI-TOF (Non-derivatized)splash10-0udi-0900000000-37b117ff3df14c4ed2312017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Hydroxypyridine GC-MS (Non-derivatized)splash10-0udi-3900000000-b326651e42bb0bf10eb32017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 2-Hydroxypyridine GC-EI-TOF (Non-derivatized)splash10-0udi-1900000000-60c99c3a6b3cc2dbbd582017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxypyridine GC-MS (Non-derivatized) - 70eV, Positivesplash10-0002-9000000000-747619743b9601520a0b2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxypyridine GC-MS (1 TMS) - 70eV, Positivesplash10-0g4j-9300000000-8e2875030fc14961b6c92017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxypyridine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine LC-ESI-QQ , positive-QTOFsplash10-0002-9000000000-a20818a6a8c5a29485082017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine LC-ESI-QQ , positive-QTOFsplash10-0002-9000000000-7853818b4dc5663227162017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine LC-ESI-QQ , positive-QTOFsplash10-004i-9000000000-3317c4817eb06b84cef92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine LC-ESI-QQ , positive-QTOFsplash10-004i-9000000000-4dcaf228edc3750292732017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine LC-ESI-QQ , positive-QTOFsplash10-0ufr-9000000000-93805bd9f23cf0a64c912017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine LC-ESI-QTOF , positive-QTOFsplash10-0002-9000000000-91777761a571b56d86bf2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine , positive-QTOFsplash10-0002-9000000000-b5b4d0e3bdff2481efd22017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine 10V, Positive-QTOFsplash10-0002-9000000000-8f91f1101787270f55f42021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine 30V, Positive-QTOFsplash10-0ufr-9000000000-90711bd4fe302f6ae1692021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine 0V, Positive-QTOFsplash10-0002-9000000000-71b01ad27cb7ef8d9e9e2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine 0V, Positive-QTOFsplash10-0002-9000000000-c0e392a7ffac70c81b352021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine 10V, Positive-QTOFsplash10-0002-9000000000-de8294e223c7341658ff2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine 35V, Positive-QTOFsplash10-0002-9000000000-9fbb1245dc9d8924e7522021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine 35V, Positive-QTOFsplash10-0002-9000000000-a3227b123546b7fdb4ac2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine 30V, Positive-QTOFsplash10-0ufr-9000000000-bc4db4bbb9e44e11e0d12021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 2-Hydroxypyridine 35V, Positive-QTOFsplash10-004i-9000000000-daefc815bc84457502972021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxypyridine 10V, Positive-QTOFsplash10-0002-9000000000-4762afadc4bf6bdb3a122015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxypyridine 20V, Positive-QTOFsplash10-0002-9000000000-86eb4b2aaf718cf7c8b52015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxypyridine 40V, Positive-QTOFsplash10-0uxr-9000000000-ccdf3d44f5fd3066c5d22015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxypyridine 10V, Negative-QTOFsplash10-0006-9000000000-59655b6363844bc208122015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxypyridine 20V, Negative-QTOFsplash10-0006-9000000000-c41c99c1ebc3e63b5d082015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxypyridine 40V, Negative-QTOFsplash10-0006-9000000000-edd999653de0dddfb7d72015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxypyridine 10V, Positive-QTOFsplash10-0002-9000000000-01955f993bd7596355502021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxypyridine 20V, Positive-QTOFsplash10-0f6t-9000000000-f0c40fc1f91854c2820f2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxypyridine 40V, Positive-QTOFsplash10-0udi-9000000000-2c6103dab5a1000996882021-09-22Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothBladder cancer details
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB112195
KNApSAcK IDC00007405
Chemspider ID8537
KEGG Compound IDC02502
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia Link2-Pyridone
METLIN IDNot Available
PubChem Compound8871
PDB IDNot Available
ChEBI ID16540
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Nhan DD, Carvalho FP, Nam BQ: Fate of 14C-chlorpyrifos in the tropical estuarine environment. Environ Technol. 2002 Nov;23(11):1229-34. [PubMed:12472153 ]
  2. Menon R, Tolbert D, Cefali E: The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet. Biopharm Drug Dispos. 2007 Sep;28(6):297-306. [PubMed:17571283 ]