Record Information |
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Version | 5.0 |
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Status | Expected but not Quantified |
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Creation Date | 2012-09-06 15:16:49 UTC |
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Update Date | 2022-03-07 02:51:35 UTC |
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HMDB ID | HMDB0014359 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Torasemide |
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Description | Torasemide, also known as demadex or luprac, belongs to the class of organic compounds known as pyridinesulfonamides. These are heterocyclic compounds containing a pyridine ring substituted by one or more sulfonamide groups. Torasemide is a strong basic compound (based on its pKa). torasemide can be converted into torasemide through the action of the enzyme solute carrier family 22 member 6. In humans, torasemide is involved in torsemide action pathway. An N-sulfonylurea obtained by formal condensation of pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. |
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Structure | CC(C)NC(=O)NS(=O)(=O)C1=C(NC2=CC=CC(C)=C2)C=CN=C1 InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) |
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Synonyms | Value | Source |
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1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea | ChEBI | Demadex | ChEBI | Luprac | ChEBI | N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide | ChEBI | Torasemida | ChEBI | Torasemidum | ChEBI | Torsemide | ChEBI | 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulphonyl)urea | Generator | N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulphonamide | Generator | 1-Isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea | HMDB |
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Chemical Formula | C16H20N4O3S |
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Average Molecular Weight | 348.42 |
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Monoisotopic Molecular Weight | 348.125611216 |
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IUPAC Name | 1-({4-[(3-methylphenyl)amino]pyridin-3-yl}sulfonyl)-3-(propan-2-yl)urea |
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Traditional Name | torsemide |
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CAS Registry Number | 56211-40-6 |
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SMILES | CC(C)NC(=O)NS(=O)(=O)C1=C(NC2=CC=CC(C)=C2)C=CN=C1 |
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InChI Identifier | InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) |
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InChI Key | NGBFQHCMQULJNZ-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as pyridinesulfonamides. These are heterocyclic compounds containing a pyridine ring substituted by one or more sulfonamide groups. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Pyridines and derivatives |
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Sub Class | Pyridinesulfonamides |
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Direct Parent | Pyridinesulfonamides |
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Alternative Parents | |
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Substituents | - Pyridine-3-sulfonamide
- Dihydropyridine
- Toluene
- Sulfonylurea
- Monocyclic benzene moiety
- Hydropyridine
- Benzenoid
- Secondary ketimine
- Heteroaromatic compound
- Organic sulfonic acid or derivatives
- Organosulfonic acid or derivatives
- Sulfonyl
- Aminosulfonyl compound
- Carboximidic acid derivative
- Azacycle
- Organic 1,3-dipolar compound
- Propargyl-type 1,3-dipolar organic compound
- Organic oxide
- Organosulfur compound
- Organooxygen compound
- Organonitrogen compound
- Organopnictogen compound
- Hydrocarbon derivative
- Organic nitrogen compound
- Organic oxygen compound
- Aromatic heteromonocyclic compound
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Molecular Framework | Aromatic heteromonocyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | |
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Role | Not Available |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | 164 - 164 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | 0.06 g/L | Not Available | LogP | 2.3 | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | | Show more...
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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Torasemide,1TMS,isomer #1 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C)=C1 | 2953.6 | Semi standard non polar | 33892256 | Torasemide,1TMS,isomer #1 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C)=C1 | 2892.4 | Standard non polar | 33892256 | Torasemide,1TMS,isomer #1 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C)=C1 | 4339.3 | Standard polar | 33892256 | Torasemide,1TMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C)=C1 | 2932.3 | Semi standard non polar | 33892256 | Torasemide,1TMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C)=C1 | 2812.9 | Standard non polar | 33892256 | Torasemide,1TMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C)=C1 | 4353.9 | Standard polar | 33892256 | Torasemide,1TMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)NC(C)C)[Si](C)(C)C)=C1 | 2847.2 | Semi standard non polar | 33892256 | Torasemide,1TMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)NC(C)C)[Si](C)(C)C)=C1 | 2817.8 | Standard non polar | 33892256 | Torasemide,1TMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)NC(C)C)[Si](C)(C)C)=C1 | 4066.5 | Standard polar | 33892256 | Torasemide,2TMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 2776.7 | Semi standard non polar | 33892256 | Torasemide,2TMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 3001.4 | Standard non polar | 33892256 | Torasemide,2TMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 3774.2 | Standard polar | 33892256 | Torasemide,2TMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 2899.1 | Semi standard non polar | 33892256 | Torasemide,2TMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 3071.2 | Standard non polar | 33892256 | Torasemide,2TMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 3993.8 | Standard polar | 33892256 | Torasemide,2TMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 2746.3 | Semi standard non polar | 33892256 | Torasemide,2TMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 2965.8 | Standard non polar | 33892256 | Torasemide,2TMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 3912.5 | Standard polar | 33892256 | Torasemide,3TMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 2774.6 | Semi standard non polar | 33892256 | Torasemide,3TMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 3236.3 | Standard non polar | 33892256 | Torasemide,3TMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C)=C1 | 3580.2 | Standard polar | 33892256 | Torasemide,1TBDMS,isomer #1 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3204.2 | Semi standard non polar | 33892256 | Torasemide,1TBDMS,isomer #1 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3129.3 | Standard non polar | 33892256 | Torasemide,1TBDMS,isomer #1 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)=C1 | 4308.6 | Standard polar | 33892256 | Torasemide,1TBDMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3196.8 | Semi standard non polar | 33892256 | Torasemide,1TBDMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3030.3 | Standard non polar | 33892256 | Torasemide,1TBDMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C(C)(C)C)=C1 | 4325.1 | Standard polar | 33892256 | Torasemide,1TBDMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)NC(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3060.1 | Semi standard non polar | 33892256 | Torasemide,1TBDMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)NC(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3030.9 | Standard non polar | 33892256 | Torasemide,1TBDMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)NC(C)C)[Si](C)(C)C(C)(C)C)=C1 | 4102.5 | Standard polar | 33892256 | Torasemide,2TBDMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3219.4 | Semi standard non polar | 33892256 | Torasemide,2TBDMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3450.4 | Standard non polar | 33892256 | Torasemide,2TBDMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)NC(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3834.2 | Standard polar | 33892256 | Torasemide,2TBDMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3396.3 | Semi standard non polar | 33892256 | Torasemide,2TBDMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3520.9 | Standard non polar | 33892256 | Torasemide,2TBDMS,isomer #2 | CC1=CC=CC(NC2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 4032.1 | Standard polar | 33892256 | Torasemide,2TBDMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3208.5 | Semi standard non polar | 33892256 | Torasemide,2TBDMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3389.6 | Standard non polar | 33892256 | Torasemide,2TBDMS,isomer #3 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)NC(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3955.5 | Standard polar | 33892256 | Torasemide,3TBDMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3434.8 | Semi standard non polar | 33892256 | Torasemide,3TBDMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3916.0 | Standard non polar | 33892256 | Torasemide,3TBDMS,isomer #1 | CC1=CC=CC(N(C2=CC=NC=C2S(=O)(=O)N(C(=O)N(C(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1 | 3729.6 | Standard polar | 33892256 |
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Spectra |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - Torasemide GC-MS (Non-derivatized) - 70eV, Positive | splash10-001i-7922000000-38709aad9fb92fea20e1 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Torasemide GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Torasemide GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , negative-QTOF | splash10-03di-0090000000-bcaf4981571fb662df86 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , negative-QTOF | splash10-03di-0090000000-00cc7369c05298ea1c97 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , negative-QTOF | splash10-03di-0490000000-60171fe07a2f255596e3 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , negative-QTOF | splash10-01ot-2950000000-359d6835f9bf703a0701 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , negative-QTOF | splash10-000t-3910000000-a5ec65a6dbedfe7a30d3 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , negative-QTOF | splash10-0564-6900000000-051171526b146f5d076c | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , negative-QTOF | splash10-03di-0190000000-1b2efe76058c7bf06b4a | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , positive-QTOF | splash10-03di-0091000000-548edfa45514c501788d | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , positive-QTOF | splash10-03di-0090000000-d7326b2b38380cd06e26 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , positive-QTOF | splash10-03di-0490000000-b9f43c4768937947d77f | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , positive-QTOF | splash10-001i-0940000000-7b7084526f7c13bf6443 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , positive-QTOF | splash10-00lr-0910000000-81aa8c9ff5d9a3cd3c10 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , positive-QTOF | splash10-0159-0900000000-87860a9931a8414432cf | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide , positive-QTOF | splash10-03di-1590000000-1b7d966c20cec1451f6c | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide , positive-QTOF | splash10-03di-0490000000-bd8b6af3fe8d0f10e117 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide , positive-QTOF | splash10-02ai-2940000000-5beb0e7e25d393903803 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide LC-ESI-QFT , positive-QTOF | splash10-03di-0390000000-314819093d7d5a1f48f4 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide 30V, Negative-QTOF | splash10-03di-0090000000-6b7078f4aeb0a9155866 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Torasemide 15V, Negative-QTOF | splash10-03di-0090000000-11bcaf88b642f06fcc7e | 2021-09-20 | HMDB team, MONA | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Torasemide 10V, Positive-QTOF | splash10-01ot-2069000000-943a38503d89c086bae7 | 2016-08-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Torasemide 20V, Positive-QTOF | splash10-0bt9-8191000000-b93ec223bde95bf1c738 | 2016-08-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Torasemide 40V, Positive-QTOF | splash10-0a4l-9210000000-19f11559fea4b58be1cf | 2016-08-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Torasemide 10V, Negative-QTOF | splash10-0002-3269000000-93ec6053a659f34ee77f | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Torasemide 20V, Negative-QTOF | splash10-06si-1490000000-5dfeefbdd22794dac739 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Torasemide 40V, Negative-QTOF | splash10-0a4l-9430000000-1d7767a4763c0a30541a | 2016-08-03 | Wishart Lab | View Spectrum |
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Biological Properties |
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Cellular Locations | |
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Biospecimen Locations | |
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Tissue Locations | Not Available |
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Pathways | |
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Normal Concentrations |
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Blood | Expected but not Quantified | Not Quantified | Not Available | Not Available | Taking drug identified by DrugBank entry DB00214 | | details | Urine | Expected but not Quantified | Not Quantified | Not Available | Not Available | Taking drug identified by DrugBank entry DB00214 | | details |
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Abnormal Concentrations |
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| Not Available |
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Associated Disorders and Diseases |
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Disease References | None |
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Associated OMIM IDs | None |
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External Links |
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DrugBank ID | DB00214 |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | Not Available |
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KNApSAcK ID | Not Available |
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Chemspider ID | 38123 |
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KEGG Compound ID | Not Available |
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BioCyc ID | Not Available |
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BiGG ID | Not Available |
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Wikipedia Link | Torasemide |
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METLIN ID | Not Available |
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PubChem Compound | 41781 |
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PDB ID | Not Available |
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ChEBI ID | 9637 |
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Food Biomarker Ontology | Not Available |
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VMH ID | TMD |
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MarkerDB ID | Not Available |
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Good Scents ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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Material Safety Data Sheet (MSDS) | Not Available |
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General References | - Dunn CJ, Fitton A, Brogden RN: Torasemide. An update of its pharmacological properties and therapeutic efficacy. Drugs. 1995 Jan;49(1):121-42. [PubMed:7705212 ]
- Authors unspecified: FDA approved new drug bulletin: torsemide (Demadex), trimetrexate glucuronate (neuTrexin). RN. 1994 May;57(5):53-6. [PubMed:8197389 ]
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