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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2022-03-07 02:51:42 UTC
HMDB IDHMDB0014690
Secondary Accession Numbers
  • HMDB14690
Metabolite Identification
Common NamePropylthiouracil
DescriptionPropylthiouracil is only found in individuals that have used or taken this drug. It is a thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones.
Structure
Data?1582753209
Synonyms
ValueSource
2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinoneChEBI
2-Mercapto-6-propyl-4-pyrimidoneChEBI
2-Mercapto-6-propylpyrimid-4-oneChEBI
2-Thio-4-oxo-6-propyl-1,3-pyrimidineChEBI
2-Thio-6-propyl-1,3-pyrimidin-4-oneChEBI
4-Propyl-2-thiouracilChEBI
6-Propyl-2-thio-2,4(1H,3H)pyrimidinedioneChEBI
6-Propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-oneChEBI
6-PropylthiouracilChEBI
6-Thio-4-propyluracilChEBI
PropiltiouraciloChEBI
PropylthiouracileChEBI
PropylthiouracilumChEBI
ProcasilHMDB
PropacilHMDB
PropilthiouracilHMDB
PropycilHMDB
Propyl-thioristHMDB
Propyl-thioritHMDB
Propyl-thyracilHMDB
PropylthioritHMDB
PropythiouracilHMDB
ProthiucilHMDB
ProthiuroneHMDB
ProthycilHMDB
ProthyranHMDB
ProtiuralHMDB
ThiuragylHMDB
6-Propyl-2-thiouracilHMDB
6 Propyl 2 thiouracilHMDB
PropylthiouracilChEBI
Chemical FormulaC7H10N2OS
Average Molecular Weight170.232
Monoisotopic Molecular Weight170.051383642
IUPAC Name6-propyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one
Traditional Namepropylthiouracil
CAS Registry Number51-52-5
SMILES
CCCC1=CC(=O)NC(=S)N1
InChI Identifier
InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
InChI KeyKNAHARQHSZJURB-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as pyrimidones. Pyrimidones are compounds that contain a pyrimidine ring, which bears a ketone. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazines
Sub ClassPyrimidines and pyrimidine derivatives
Direct ParentPyrimidones
Alternative Parents
Substituents
  • 2-thiopyrimidine
  • Pyrimidinethione
  • Thiopyrimidine
  • Pyrimidone
  • Hydropyrimidine
  • Heteroaromatic compound
  • Vinylogous amide
  • Lactam
  • Thiourea
  • Azacycle
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxygen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point219 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.47 g/LNot Available
LogP0.4Not Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+Not Available134.652http://allccs.zhulab.cn/database/detail?ID=AllCCS00000986
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.47 g/LALOGPS
logP1.53ALOGPS
logP1.2ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)8.09ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area41.13 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity48.9 m³·mol⁻¹ChemAxon
Polarizability17.79 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+135.34731661259
DarkChem[M-H]-134.21431661259
DeepCCS[M+H]+138.13230932474
DeepCCS[M-H]-134.90530932474
DeepCCS[M-2H]-172.15330932474
DeepCCS[M+Na]+147.27430932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
PropylthiouracilCCCC1=CC(=O)NC(=S)N12582.0Standard polar33892256
PropylthiouracilCCCC1=CC(=O)NC(=S)N11629.8Standard non polar33892256
PropylthiouracilCCCC1=CC(=O)NC(=S)N12005.2Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Propylthiouracil,1TMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C)C(=S)[NH]11724.6Semi standard non polar33892256
Propylthiouracil,1TMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C)C(=S)[NH]11702.6Standard non polar33892256
Propylthiouracil,1TMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C)C(=S)[NH]12184.8Standard polar33892256
Propylthiouracil,1TMS,isomer #2CCCC1=CC(=O)[NH]C(=S)N1[Si](C)(C)C1747.9Semi standard non polar33892256
Propylthiouracil,1TMS,isomer #2CCCC1=CC(=O)[NH]C(=S)N1[Si](C)(C)C1762.6Standard non polar33892256
Propylthiouracil,1TMS,isomer #2CCCC1=CC(=O)[NH]C(=S)N1[Si](C)(C)C2186.4Standard polar33892256
Propylthiouracil,2TMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C)C(=S)N1[Si](C)(C)C1931.0Semi standard non polar33892256
Propylthiouracil,2TMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C)C(=S)N1[Si](C)(C)C1837.7Standard non polar33892256
Propylthiouracil,2TMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C)C(=S)N1[Si](C)(C)C1994.4Standard polar33892256
Propylthiouracil,1TBDMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C(C)(C)C)C(=S)[NH]11887.0Semi standard non polar33892256
Propylthiouracil,1TBDMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C(C)(C)C)C(=S)[NH]11938.3Standard non polar33892256
Propylthiouracil,1TBDMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C(C)(C)C)C(=S)[NH]12285.7Standard polar33892256
Propylthiouracil,1TBDMS,isomer #2CCCC1=CC(=O)[NH]C(=S)N1[Si](C)(C)C(C)(C)C1917.7Semi standard non polar33892256
Propylthiouracil,1TBDMS,isomer #2CCCC1=CC(=O)[NH]C(=S)N1[Si](C)(C)C(C)(C)C2006.7Standard non polar33892256
Propylthiouracil,1TBDMS,isomer #2CCCC1=CC(=O)[NH]C(=S)N1[Si](C)(C)C(C)(C)C2281.4Standard polar33892256
Propylthiouracil,2TBDMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C(C)(C)C)C(=S)N1[Si](C)(C)C(C)(C)C2228.1Semi standard non polar33892256
Propylthiouracil,2TBDMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C(C)(C)C)C(=S)N1[Si](C)(C)C(C)(C)C2271.6Standard non polar33892256
Propylthiouracil,2TBDMS,isomer #1CCCC1=CC(=O)N([Si](C)(C)C(C)(C)C)C(=S)N1[Si](C)(C)C(C)(C)C2185.9Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Propylthiouracil GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-3900000000-31cf32b92bb0613f38642017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Propylthiouracil GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-00dl-9800000000-dd34c50b7aa55979d5f22014-09-20Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-qTof , Positive-QTOFsplash10-00di-0900000000-6549521c2c4645bc95422017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , negative-QTOFsplash10-014i-0900000000-f857bb6ee86a6e7b0ab32017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , negative-QTOFsplash10-066r-7900000000-e5e5c265147935fdd8d22017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , negative-QTOFsplash10-0a4i-9000000000-927304e1ff32407a8d182017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , negative-QTOFsplash10-0a4i-9000000000-343c26fd83ebb89d346d2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , negative-QTOFsplash10-0a4i-9000000000-0d1467a930d2ddf9349b2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QTOF , positive-QTOFsplash10-00di-0900000000-0b376a1be2d2d48ad8752017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QTOF , positive-QTOFsplash10-0fk9-0900000000-f095bd0fa6c365161ec92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QTOF , positive-QTOFsplash10-0udi-0900000000-2ce23fa0cb6ec6129e292017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , positive-QTOFsplash10-00di-0900000000-9ee3b1971c716e9a4dc12017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , positive-QTOFsplash10-00di-0900000000-7d9cf3791e4e7800916d2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , positive-QTOFsplash10-0ik9-5900000000-41be31a4c739b4ea29a42017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , positive-QTOFsplash10-03xr-9200000000-8eb9b68ae97914399fc02017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil LC-ESI-QQ , positive-QTOFsplash10-00di-1900000000-b867c06c7c74b627274c2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil , positive-QTOFsplash10-00di-0900000000-6549521c2c4645bc95422017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil 30V, Negative-QTOFsplash10-0a4i-9300000000-1c45f7c8a1ed2bb4ff1a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil 45V, Negative-QTOFsplash10-0a4i-9000000000-316f99d9fa451f830ecc2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil 15V, Negative-QTOFsplash10-0a4i-9300000000-6e8260b8f96483c7a7252021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Propylthiouracil 60V, Negative-QTOFsplash10-0a4i-9000000000-acdbd4788bf0a434a52c2021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Propylthiouracil 10V, Positive-QTOFsplash10-00di-1900000000-c92d3e54c5a5d44238b62016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Propylthiouracil 20V, Positive-QTOFsplash10-0fk9-2900000000-02a40d3cf3fcf71171432016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Propylthiouracil 40V, Positive-QTOFsplash10-0pbc-9100000000-d83421a35456bb2cd5162016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Propylthiouracil 10V, Negative-QTOFsplash10-014i-2900000000-0171c0c7c9c5fd9b0d232016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Propylthiouracil 20V, Negative-QTOFsplash10-066u-9700000000-e296fd0e7563b2f97dd72016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Propylthiouracil 40V, Negative-QTOFsplash10-0a4i-9100000000-74e2c284c39ca64e90d42016-08-03Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00550 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00550 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00550
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID571424
KEGG Compound IDC07569
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkPropylthiouracil
METLIN IDNot Available
PubChem Compound657298
PDB IDNot Available
ChEBI ID8502
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Conversion of dopamine to noradrenaline.
Gene Name:
DBH
Uniprot ID:
P09172
Molecular weight:
69064.45
References
  1. Hidaka H, Nagasaka A: Inhibition of dopamine beta-hydroxylase by anti-thyroid agents, methimazole and propylthiouracil. Biochem Pharmacol. 1977 Jun 1;26(11):1092-3. [PubMed:880264 ]
General function:
Involved in calcium ion binding
Specific function:
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Gene Name:
TPO
Uniprot ID:
P07202
Molecular weight:
102961.63
References
  1. Sugawara M, Sugawara Y, Wen K: Methimazole and propylthiouracil increase cellular thyroid peroxidase activity and thyroid peroxidase mRNA in cultured porcine thyroid follicles. Thyroid. 1999 May;9(5):513-8. [PubMed:10365684 ]
  2. Manzon RG, Holmes JA, Youson JH: Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus). J Exp Zool. 2001 Apr 15;289(5):290-303. [PubMed:11241400 ]
  3. Ferreira AC, de Carvalho Cardoso L, Rosenthal D, de Carvalho DP: Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole. Eur J Biochem. 2003 Jun;270(11):2363-8. [PubMed:12755690 ]
  4. Schmutzler C, Bacinski A, Gotthardt I, Huhne K, Ambrugger P, Klammer H, Schlecht C, Hoang-Vu C, Gruters A, Wuttke W, Jarry H, Kohrle J: The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase. Endocrinology. 2007 Jun;148(6):2835-44. Epub 2007 Mar 22. [PubMed:17379648 ]
  5. Taurog A, Dorris ML: A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil. Endocrinology. 1989 Jun;124(6):3038-42. [PubMed:2656250 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
General function:
Involved in peroxidase activity
Specific function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Gene Name:
MPO
Uniprot ID:
P05164
Molecular weight:
83867.71
References
  1. Lee E, Miki Y, Katsura H, Kariya K: Mechanism of inactivation of myeloperoxidase by propylthiouracil. Biochem Pharmacol. 1990 May 1;39(9):1467-71. [PubMed:2159305 ]
  2. Kariya K, Lee E, Hirouchi M: Relationship between leukopenia and bone marrow myeloperoxidase in the rat treated with propylthiouracil. Jpn J Pharmacol. 1984 Oct;36(2):217-22. [PubMed:6096612 ]
  3. Zhang AH, Chen M, Gao Y, Zhao MH, Wang HY: Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis. Clin Immunol. 2007 Feb;122(2):187-93. Epub 2006 Oct 27. [PubMed:17070108 ]
  4. Lee E, Hirouchi M, Hosokawa M, Sayo H, Kohno M, Kariya K: Inactivation of peroxidases of rat bone marrow by repeated administration of propylthiouracil is accompanied by a change in the heme structure. Biochem Pharmacol. 1988 Jun 1;37(11):2151-3. [PubMed:2837228 ]