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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2021-09-14 15:20:33 UTC
HMDB IDHMDB0014903
Secondary Accession Numbers
  • HMDB14903
Metabolite Identification
Common NameMetyrosine
DescriptionMetyrosine is only found in individuals that have used or taken this drug. It is an inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed)Metyrosine inhibits tyrosine hydroxylase, which catalyzes the first transformation in catecholamine biosynthesis, i.e., the conversion of tyrosine to dihydroxyphenylalanine (DOPA). Because the first step is also the rate-limiting step, blockade of tyrosine hydroxylase activity results in decreased endogenous levels of catecholamines and their synthesis. This consequently, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body,usually measured as decreased urinary excretion of catecholamines and their metabolites. One main end result of the catecholamine depletion is a decrease in blood presure.
Structure
Data?1582753233
Synonyms
ValueSource
(-)-alpha-Methyl-L-tyrosineChEBI
(S)-alpha-MethyltyrosineChEBI
alpha-Methyl-L-p-tyrosineChEBI
alpha-Methyl-p-tyrosineChEBI
alpha-Methyl-para-tyrosineChEBI
alpha-MethyltyrosineChEBI
L-alpha-MethyltyrosineChEBI
MethyltyrosineChEBI
MetirosinaChEBI
MetirosineChEBI
MetirosinumChEBI
DemserKegg
(-)-a-Methyl-L-tyrosineGenerator
(-)-Α-methyl-L-tyrosineGenerator
(S)-a-MethyltyrosineGenerator
(S)-Α-methyltyrosineGenerator
a-Methyl-L-p-tyrosineGenerator
Α-methyl-L-p-tyrosineGenerator
a-Methyl-p-tyrosineGenerator
Α-methyl-p-tyrosineGenerator
a-Methyl-para-tyrosineGenerator
Α-methyl-para-tyrosineGenerator
a-MethyltyrosineGenerator
Α-methyltyrosineGenerator
L-a-MethyltyrosineGenerator
L-Α-methyltyrosineGenerator
alpha Methyltyrosine hydrochlorideHMDB
alpha-Methyltyrosine, (+,-)-isomerHMDB
alpha MPTHMDB
alpha Methyl para tyrosineHMDB
alpha-MPTHMDB
alpha-Methyltyrosine, (D,L)-isomerHMDB
alpha-Methyltyrosine, (L)-isomerHMDB
Hydrochloride, alpha-methyltyrosineHMDB
Metyrosine merck brandHMDB
RacemetirosineHMDB
alpha Methyl p tyrosineHMDB
Merck brand OF metyrosineHMDB
Merck sharp and dohme brand OF metyrosineHMDB
alpha MethyltyrosineHMDB
alpha-Methyltyrosine hydrochlorideHMDB
alpha-Methyl- DL-tyrosineHMDB
a-Methyl-L-tyrosineHMDB
Α-methyl-L-tyrosineHMDB
MetyrosineChEBI
Chemical FormulaC10H13NO3
Average Molecular Weight195.2151
Monoisotopic Molecular Weight195.089543287
IUPAC Name(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
Traditional Namemetyrosine
CAS Registry Number672-87-7
SMILES
C[C@](N)(CC1=CC=C(O)C=C1)C(O)=O
InChI Identifier
InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
InChI KeyNHTGHBARYWONDQ-JTQLQIEISA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phenylpropanoic acids. Phenylpropanoic acids are compounds with a structure containing a benzene ring conjugated to a propanoic acid.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassPhenylpropanoic acids
Sub ClassNot Available
Direct ParentPhenylpropanoic acids
Alternative Parents
Substituents
  • 3-phenylpropanoic-acid
  • Alpha-amino acid
  • Alpha-amino acid or derivatives
  • Amphetamine or derivatives
  • D-alpha-amino acid
  • Phenylpropane
  • 1-hydroxy-2-unsubstituted benzenoid
  • Aralkylamine
  • Phenol
  • Monocyclic benzene moiety
  • Benzenoid
  • Amino acid or derivatives
  • Amino acid
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic nitrogen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Organooxygen compound
  • Primary amine
  • Carbonyl group
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Amine
  • Organic oxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point312.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility2.48 g/LNot Available
LogP-1.7Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility2.48 g/LALOGPS
logP10(-1.9) g/LALOGPS
logP10(-1.1) g/LChemAxon
logS10(-1.9) g/LALOGPS
pKa (Strongest Acidic)2.06ChemAxon
pKa (Strongest Basic)9.93ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area83.55 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity51.81 m³·mol⁻¹ChemAxon
Polarizability19.9 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+145.43331661259
DarkChem[M-H]-145.73331661259
DeepCCS[M+H]+140.56230932474
DeepCCS[M-H]-138.1730932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
MetyrosineC[C@](N)(CC1=CC=C(O)C=C1)C(O)=O3174.7Standard polar33892256
MetyrosineC[C@](N)(CC1=CC=C(O)C=C1)C(O)=O1820.9Standard non polar33892256
MetyrosineC[C@](N)(CC1=CC=C(O)C=C1)C(O)=O2023.2Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Metyrosine,1TMS,isomer #1C[C@](N)(CC1=CC=C(O[Si](C)(C)C)C=C1)C(=O)O1911.2Semi standard non polar33892256
Metyrosine,1TMS,isomer #2C[C@](N)(CC1=CC=C(O)C=C1)C(=O)O[Si](C)(C)C1942.8Semi standard non polar33892256
Metyrosine,1TMS,isomer #3C[C@@](CC1=CC=C(O)C=C1)(N[Si](C)(C)C)C(=O)O2019.3Semi standard non polar33892256
Metyrosine,2TMS,isomer #1C[C@](N)(CC1=CC=C(O[Si](C)(C)C)C=C1)C(=O)O[Si](C)(C)C1892.9Semi standard non polar33892256
Metyrosine,2TMS,isomer #2C[C@@](CC1=CC=C(O[Si](C)(C)C)C=C1)(N[Si](C)(C)C)C(=O)O1972.4Semi standard non polar33892256
Metyrosine,2TMS,isomer #3C[C@@](CC1=CC=C(O)C=C1)(N[Si](C)(C)C)C(=O)O[Si](C)(C)C2003.8Semi standard non polar33892256
Metyrosine,2TMS,isomer #4C[C@](CC1=CC=C(O)C=C1)(C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2163.8Semi standard non polar33892256
Metyrosine,3TMS,isomer #1C[C@@](CC1=CC=C(O[Si](C)(C)C)C=C1)(N[Si](C)(C)C)C(=O)O[Si](C)(C)C1959.0Semi standard non polar33892256
Metyrosine,3TMS,isomer #1C[C@@](CC1=CC=C(O[Si](C)(C)C)C=C1)(N[Si](C)(C)C)C(=O)O[Si](C)(C)C1943.7Standard non polar33892256
Metyrosine,3TMS,isomer #1C[C@@](CC1=CC=C(O[Si](C)(C)C)C=C1)(N[Si](C)(C)C)C(=O)O[Si](C)(C)C2054.2Standard polar33892256
Metyrosine,3TMS,isomer #2C[C@](CC1=CC=C(O[Si](C)(C)C)C=C1)(C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2149.5Semi standard non polar33892256
Metyrosine,3TMS,isomer #2C[C@](CC1=CC=C(O[Si](C)(C)C)C=C1)(C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2020.3Standard non polar33892256
Metyrosine,3TMS,isomer #2C[C@](CC1=CC=C(O[Si](C)(C)C)C=C1)(C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2276.4Standard polar33892256
Metyrosine,3TMS,isomer #3C[C@](CC1=CC=C(O)C=C1)(C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2137.3Semi standard non polar33892256
Metyrosine,3TMS,isomer #3C[C@](CC1=CC=C(O)C=C1)(C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2101.7Standard non polar33892256
Metyrosine,3TMS,isomer #3C[C@](CC1=CC=C(O)C=C1)(C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2227.9Standard polar33892256
Metyrosine,4TMS,isomer #1C[C@](CC1=CC=C(O[Si](C)(C)C)C=C1)(C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2169.9Semi standard non polar33892256
Metyrosine,4TMS,isomer #1C[C@](CC1=CC=C(O[Si](C)(C)C)C=C1)(C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2076.7Standard non polar33892256
Metyrosine,4TMS,isomer #1C[C@](CC1=CC=C(O[Si](C)(C)C)C=C1)(C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2048.3Standard polar33892256
Metyrosine,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC=C(C[C@](C)(N)C(=O)O)C=C12167.2Semi standard non polar33892256
Metyrosine,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@@](C)(N)CC1=CC=C(O)C=C12193.3Semi standard non polar33892256
Metyrosine,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)N[C@@](C)(CC1=CC=C(O)C=C1)C(=O)O2248.4Semi standard non polar33892256
Metyrosine,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@](C)(N)CC1=CC=C(O[Si](C)(C)C(C)(C)C)C=C12440.0Semi standard non polar33892256
Metyrosine,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N[C@@](C)(CC1=CC=C(O[Si](C)(C)C(C)(C)C)C=C1)C(=O)O2509.5Semi standard non polar33892256
Metyrosine,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)N[C@@](C)(CC1=CC=C(O)C=C1)C(=O)O[Si](C)(C)C(C)(C)C2496.4Semi standard non polar33892256
Metyrosine,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)N([C@@](C)(CC1=CC=C(O)C=C1)C(=O)O)[Si](C)(C)C(C)(C)C2608.4Semi standard non polar33892256
Metyrosine,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N[C@@](C)(CC1=CC=C(O[Si](C)(C)C(C)(C)C)C=C1)C(=O)O[Si](C)(C)C(C)(C)C2687.2Semi standard non polar33892256
Metyrosine,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N[C@@](C)(CC1=CC=C(O[Si](C)(C)C(C)(C)C)C=C1)C(=O)O[Si](C)(C)C(C)(C)C2546.0Standard non polar33892256
Metyrosine,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N[C@@](C)(CC1=CC=C(O[Si](C)(C)C(C)(C)C)C=C1)C(=O)O[Si](C)(C)C(C)(C)C2418.9Standard polar33892256
Metyrosine,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=CC=C(C[C@@](C)(C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C12884.6Semi standard non polar33892256
Metyrosine,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=CC=C(C[C@@](C)(C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C12622.0Standard non polar33892256
Metyrosine,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=CC=C(C[C@@](C)(C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C12543.8Standard polar33892256
Metyrosine,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@](C)(CC1=CC=C(O)C=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2813.5Semi standard non polar33892256
Metyrosine,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@](C)(CC1=CC=C(O)C=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2688.1Standard non polar33892256
Metyrosine,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@](C)(CC1=CC=C(O)C=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2489.9Standard polar33892256
Metyrosine,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@](C)(CC1=CC=C(O[Si](C)(C)C(C)(C)C)C=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3081.2Semi standard non polar33892256
Metyrosine,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@](C)(CC1=CC=C(O[Si](C)(C)C(C)(C)C)C=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2813.8Standard non polar33892256
Metyrosine,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@](C)(CC1=CC=C(O[Si](C)(C)C(C)(C)C)C=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2458.5Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Metyrosine GC-MS (Non-derivatized) - 70eV, Positivesplash10-052f-4900000000-946ec0a9cb27d9dde8742017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Metyrosine GC-MS (2 TMS) - 70eV, Positivesplash10-00fu-9651000000-11b1bed7129ec3e5c27a2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Metyrosine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 10V, Positive-QTOFsplash10-0udi-0900000000-7b2e7907b466193628f32016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 20V, Positive-QTOFsplash10-0udi-0900000000-8ee69272ff1683e7b6792016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 40V, Positive-QTOFsplash10-0a6r-3900000000-95f4506f225bff0a13e32016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 10V, Negative-QTOFsplash10-0006-3900000000-9aec0e31d6c52c6d42182016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 20V, Negative-QTOFsplash10-000i-9500000000-ea5a5dcd5c96018a361e2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 40V, Negative-QTOFsplash10-0kac-7900000000-25650809bb77fee5eb832016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 10V, Positive-QTOFsplash10-0ug1-0900000000-01322d7fad379ffae3362021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 20V, Positive-QTOFsplash10-053r-0900000000-0f9c6bd0ffbe22e32c942021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 40V, Positive-QTOFsplash10-004i-9200000000-30cb5b9f46a6576862672021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 10V, Negative-QTOFsplash10-0f6x-1900000000-3caf5c634bee6695a4622021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 20V, Negative-QTOFsplash10-001i-3900000000-a9dda666c5606b5014802021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metyrosine 40V, Negative-QTOFsplash10-0536-7900000000-2d7f96942196ae0b76e02021-10-11Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00765 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00765 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00765
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID390103
KEGG Compound IDC07921
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkMetirosine
METLIN IDNot Available
PubChem Compound441350
PDB IDNot Available
ChEBI ID6912
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Plays an important role in the physiology of adrenergic neurons.
Gene Name:
TH
Uniprot ID:
P07101
Molecular weight:
55611.26
References
  1. Nasrallah HA, Donnelly EF, Bigelow LB, Rivera-Calimlim L, Rogol A, Potkin S, Rauscher FP, Wyatt RJ: Inhibition of dopamine synthesis in chronic schizophrenia. Clinical ineffectiveness of metyrosine. Arch Gen Psychiatry. 1977 Jun;34(6):649-55. [PubMed:17374 ]
  2. Yoshimoto Y, Nakaso K, Nakashima K: L-dopa and dopamine enhance the formation of aggregates under proteasome inhibition in PC12 cells. FEBS Lett. 2005 Feb 14;579(5):1197-202. Epub 2005 Jan 21. [PubMed:15710413 ]
  3. Shore PA, Dorris RL: On a prime role for newly synthesized dopamine in striatal function. Eur J Pharmacol. 1975 Feb;30(2):315-8. [PubMed:1168577 ]
  4. Moore KE, Demarest KT, Johnston CA: Influence of prolactin on dopaminergic neuronal systems in the hypothalamus. Fed Proc. 1980 Sep;39(11):2912-6. [PubMed:7409209 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]