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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:51 UTC
Update Date2021-09-14 14:59:42 UTC
HMDB IDHMDB0015252
Secondary Accession Numbers
  • HMDB15252
Metabolite Identification
Common NameGliclazide
DescriptionGliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Gliclazide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%).
Structure
Data?1582753275
Synonyms
ValueSource
1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)ureaChEBI
1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)ureaChEBI
GlimicronChEBI
1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulphonyl)ureaGenerator
1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulphonyl)ureaGenerator
N-(4-Methylbenzenesulfonyl)-n'-(3-azabicyclo(3.3.0)oct-3-yl)ureaHMDB
Generics brand OF gliclazideMeSH, HMDB
novo GliclazideMeSH, HMDB
novo-GliclazideMeSH, HMDB
Novopharm brand OF gliclazideMeSH, HMDB
DiabrezideMeSH, HMDB
Gen gliclazideMeSH, HMDB
Servier brand OF gliclazideMeSH, HMDB
Alphapharm brand OF gliclazideMeSH, HMDB
DiaglykMeSH, HMDB
DiaikronMeSH, HMDB
DiamicronMeSH, HMDB
Gen-gliclazideMeSH, HMDB
Gliclazide servier brandMeSH, HMDB
GlyadeMeSH, HMDB
GlyclazideMeSH, HMDB
Genpharm brand OF gliclazideMeSH, HMDB
GliklazidMeSH, HMDB
Helsinn brand OF gliclazideMeSH, HMDB
Chemical FormulaC15H21N3O3S
Average Molecular Weight323.411
Monoisotopic Molecular Weight323.130362243
IUPAC Name1-(4-methylbenzenesulfonyl)-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea
Traditional Namegliclazide
CAS Registry Number21187-98-4
SMILES
CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN1CC2CCCC2C1
InChI Identifier
InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)
InChI KeyBOVGTQGAOIONJV-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentBenzenesulfonamides
Alternative Parents
Substituents
  • Benzenesulfonamide
  • Tosyl compound
  • Benzenesulfonyl group
  • Toluene
  • Sulfonylurea
  • Pyrrolidine
  • Semicarbazide
  • Organic sulfonic acid or derivatives
  • Aminosulfonyl compound
  • Sulfonyl
  • Organosulfonic acid or derivatives
  • Carbonic acid derivative
  • Azacycle
  • Organoheterocyclic compound
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxygen compound
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point181 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.19 g/LNot Available
LogP2.6Not Available
Experimental Spectral Properties

Experimental Collision Cross Sections

PredictorAdduct TypeData SourceCCS Value (Å2)Reference
AllCCS[M+H]+Not Available177.975http://allccs.zhulab.cn/database/detail?ID=AllCCS00000911
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.19 g/LALOGPS
logP10(1.52) g/LALOGPS
logP10(1.73) g/LChemAxon
logS10(-3.2) g/LALOGPS
pKa (Strongest Acidic)4.07ChemAxon
pKa (Strongest Basic)1.38ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area78.51 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity83.88 m³·mol⁻¹ChemAxon
Polarizability34.22 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Spectral Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+176.69231661259
DarkChem[M-H]-171.70231661259

Predicted Kovats Retention Indices

Not Available
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Gliclazide GC-MS (Non-derivatized) - 70eV, Positivesplash10-090u-9710000000-41d9060ced438af45b282017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Gliclazide GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Gliclazide GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Gliclazide GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 10V, Positive-QTOFsplash10-00di-0906000000-61b1e48114f8b1718b8c2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 20V, Positive-QTOFsplash10-004i-1900000000-72eec1bad0600cc005562016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 40V, Positive-QTOFsplash10-017i-9200000000-13a3993b0b1cc083ea4d2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 10V, Negative-QTOFsplash10-00di-0918000000-260aeeb89b9404c56f7c2016-08-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 20V, Negative-QTOFsplash10-00di-1900000000-203f48d342734f8e7b9b2016-08-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 40V, Negative-QTOFsplash10-05di-8900000000-db98ef26f5be17980cda2016-08-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 10V, Positive-QTOFsplash10-00di-0509000000-7b4a79b4b48ae80c7b432021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 20V, Positive-QTOFsplash10-03kc-4902000000-cd8eecee62c14a855d432021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 40V, Positive-QTOFsplash10-0006-9200000000-5d783afa0afef9e90b802021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 10V, Negative-QTOFsplash10-00di-0109000000-073e1f26bf7df99de6582021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 20V, Negative-QTOFsplash10-00di-0900000000-6c0a8c8143980bba70952021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gliclazide 40V, Negative-QTOFsplash10-00di-6910000000-e3926c03e36a20a9165b2021-10-11Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01120 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01120 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB01120
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3356
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkGliclazide
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI ID31654
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available