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Record Information
Version4.0
StatusDetected and Quantified
Creation Date2012-09-11 17:38:22 UTC
Update Date2020-11-09 23:20:03 UTC
HMDB IDHMDB0030677
Secondary Accession Numbers
  • HMDB30677
Metabolite Identification
Common Namecis-p-Coumaric acid
Descriptioncis-p-Coumaric acid, also known as cis-4-hydroxycinnamic acid, is a hydroxy derivative of cinnamic acid. Cinnamic acid and its derivatives are used as important components in flavours, perfumes, synthetic indigo, and pharmaceuticals. There are three isomers of coumaric acid: o-coumaric acid, m-coumaric acid, and p-coumaric acid. These isomers differ by the position of the hydroxy substitution. p-Coumaric acid is the most abundant isomer in nature (Wikipedia). cis-p-Coumaric acid is found in coriander.
Structure
Data?1563862021
Synonyms
ValueSource
(2Z)-3-(4-Hydroxyphenyl)acrylic acidChEBI
(Z)-3-(4-Hydroxyphenyl)-2-propenoic acidChEBI
(Z)-p-Coumaric acidChEBI
(Z)-p-Hydroxycinnamic acidChEBI
cis-4-Hydroxycinnamic acidChEBI
cis-p-CoumarateChEBI
cis-p-Coumarinic acidChEBI
cis-p-Hydroxycinnamic acidChEBI
(2Z)-3-(4-Hydroxyphenyl)acrylateGenerator
(Z)-3-(4-Hydroxyphenyl)-2-propenoateGenerator
(Z)-p-CoumarateGenerator
(Z)-p-HydroxycinnamateGenerator
cis-4-HydroxycinnamateGenerator
cis-p-CoumarinateGenerator
cis-p-HydroxycinnamateGenerator
cis-4-CoumarateHMDB
(2Z)-3-(4-Hydroxyphenyl)-2-propenoic acidHMDB
(2Z)-3-(4-Hydroxyphenyl)prop-2-enoic acidHMDB
(Z)-3-(4-Hydroxyphenyl)acrylic acidHMDB
(Z)-4-Hydroxycinnamic acidHMDB
3-(4-Hydroxyphenyl)-2-propenoic acidHMDB
3-(4-Hydroxyphenyl)acrylic acidHMDB
4-Coumaric acidHMDB
4-Hydroxycinnamic acidHMDB
beta-[4-Hydroxyphenyl]acrylic acidHMDB
cis-3-(4-Hydroxyphenyl)-2-propenoic acidHMDB
cis-4-Coumaric acidHMDB
p-Coumaric acidHMDB
p-Cumaric acidHMDB
p-Hydroxy-cis-cinnamic acidHMDB
p-Hydroxycinnamic acidHMDB
p-Hydroxyphenylacrylic acidHMDB
p-cis-Coumaric acidHMDB
Β-[4-hydroxyphenyl]acrylic acidHMDB
cis-p-Coumaric acidChEBI
Chemical FormulaC9H8O3
Average Molecular Weight164.158
Monoisotopic Molecular Weight164.047344122
IUPAC Name(2Z)-3-(4-hydroxyphenyl)prop-2-enoic acid
Traditional Namecis-p-coumaric acid
CAS Registry Number4501-31-9
SMILES
OC(=O)\C=C/C1=CC=C(O)C=C1
InChI Identifier
InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3-
InChI KeyNGSWKAQJJWESNS-UTCJRWHESA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassCinnamic acids and derivatives
Sub ClassHydroxycinnamic acids and derivatives
Direct ParentHydroxycinnamic acids
Alternative Parents
Substituents
  • Cinnamic acid
  • Coumaric acid
  • Coumaric acid or derivatives
  • Hydroxycinnamic acid
  • Styrene
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Monocyclic benzene moiety
  • Benzenoid
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic oxide
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point134 - 134.5 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP1.79Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.02 g/LALOGPS
logP1.74ALOGPS
logP1.83ChemAxon
logS-2.2ALOGPS
pKa (Strongest Acidic)3.5ChemAxon
pKa (Strongest Basic)-6ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area57.53 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity45.04 m³·mol⁻¹ChemAxon
Polarizability16.28 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectrum TypeDescriptionSplash KeyView
GC-MSGC-MS Spectrum - GC-MS (2 TMS)splash10-014m-2691000000-eaa9fb96842966079178Spectrum
GC-MSGC-MS Spectrum - GC-MS (Non-derivatized)splash10-014m-2691000000-eaa9fb96842966079178Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-014i-1900000000-06b9af47d2378036e0f4Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positivesplash10-00xu-6390000000-3110f0f6eb462a38bb64Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014j-0900000000-43c3377fad5f7488bea0Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-014j-0900000000-2264676cffcfb3110cb8Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0gdr-9600000000-9d441c7fc0720390be54Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-0900000000-2ce3562ddd5762384d09Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-03di-0900000000-f6c69044556dd2ca2134Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-014m-3900000000-f7e5cd9359ebf2ee51a6Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.142 umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified0.0160-2.940 umol/mmol creatinineAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB002592
KNApSAcK IDC00038791
Chemspider ID1266072
KEGG Compound IDC06738
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound1549106
PDB IDNot Available
ChEBI ID17450
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB ID
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .