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Record Information
StatusExpected but not Quantified
Creation Date2012-09-11 17:42:09 UTC
Update Date2019-07-23 06:08:26 UTC
Secondary Accession Numbers
  • HMDB31292
Metabolite Identification
Common NameOctafluorocyclobutane
DescriptionPropellant and aerating agent in foamed or sprayed food products Octafluorocyclobutane is a dimer of tetrafluoroethylene. Its critical point is at 115.3 °C and 2.79 MPa. Octafluorocyclobutane, or perfluorocyclobutane, C4F8, is a compound of carbon and fluorine used in the production and processing of semiconductor materials and devices, for example as a deposition gas and etchant. It has also been investigated as a refrigerant in specialised applications, as a replacement for Ozone depleting chlorofluorocarbon refrigerants
e 946ChEBI
Freon 318ChEBI
Freon C 318ChEBI
Freon C-318ChEBI
Fluorocarbon C-318HMDB
Freon C318HMDB
Halocarbon C-138HMDB
Propellant C318HMDB
Chemical FormulaC4F8
Average Molecular Weight200.03
Monoisotopic Molecular Weight199.98722564
IUPAC Nameoctafluorocyclobutane
Traditional Nameoctafluorocyclobutane
CAS Registry Number115-25-3
InChI Identifier
Chemical Taxonomy
Description belongs to the class of organic compounds known as organofluorides. Organofluorides are compounds containing a chemical bond between a carbon atom and a fluorine atom.
KingdomOrganic compounds
Super ClassOrganohalogen compounds
Sub ClassNot Available
Direct ParentOrganofluorides
Alternative Parents
  • Hydrocarbon derivative
  • Organofluoride
  • Alkyl halide
  • Alkyl fluoride
  • Aliphatic homomonocyclic compound
Molecular FrameworkAliphatic homomonocyclic compounds
External Descriptors

Biological location:


Physical Properties
Experimental Properties
Melting Point-41.4 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.024 mg/mL at 25 °CNot Available
LogPNot AvailableNot Available
Predicted Properties
Water Solubility0.13 g/LALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity18.67 m³·mol⁻¹ChemAxon
Polarizability8.36 ųChemAxon
Number of Rings1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0002-9500000000-5faf4443ecf16cfe4ee7Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0090000000-602dc2e702cca36e6220Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udi-0190000000-ed06d55114c63af22b08Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0udi-0590000000-24d087ab9ec873afea7fSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0002-0900000000-d8510ea56ce7a6e6d831Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0002-0900000000-d8510ea56ce7a6e6d831Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0002-0900000000-d8510ea56ce7a6e6d831Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB003338
KNApSAcK IDNot Available
Chemspider ID13846040
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkOctafluorocyclobutane
METLIN IDNot Available
PubChem Compound8263
PDB IDNot Available
ChEBI ID31007
Food Biomarker OntologyNot Available
VMH IDNot Available
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
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  2. Simaan JA, Aviado DM: Hemodynamic effects of aerosol propellants. I. Cardiac depression in the dog. Toxicology. 1975 Nov;5(2):127-38. [PubMed:1209645 ]
  3. Zadoo S, Thompson JE: Rayleigh scattering measurements of several fluorocarbon gases. J Environ Monit. 2011 Nov;13(11):3294-7. doi: 10.1039/c1em10667h. Epub 2011 Oct 25. [PubMed:22027960 ]
  4. Andersson H, van der Wijngaart W, Stemme G: Micromachined filter-chamber array with passive valves for biochemical assays on beads. Electrophoresis. 2001 Jan;22(2):249-57. [PubMed:11288892 ]
  5. Peri SR, Akgun B, Satija SK, Jiang H, Enlow J, Bunning TJ, Foster MD: Control of interface nanoscale structure created by plasma-enhanced chemical vapor deposition. ACS Appl Mater Interfaces. 2011 Sep;3(9):3375-83. doi: 10.1021/am200543x. Epub 2011 Aug 29. [PubMed:21875044 ]
  6. Peyman GA, Namperumalsamy P, Vygantas C: Clinical trail of intravitreal C F in retinal detachment surgery. Can J Ophthalmol. 1975 Apr;10(2):218-21. [PubMed:1125848 ]
  7. Yeo LP, Yan YH, Lam YC, Chan-Park MB: Design of experiment for optimization of plasma-polymerized octafluorocyclobutane coating on very high aspect ratio silicon molds. Langmuir. 2006 Nov 21;22(24):10196-203. [PubMed:17107021 ]
  8. Bhandari D, Kravchenko II, Lavrik NV, Sepaniak MJ: Nanotransfer printing using plasma etched silicon stamps and mediated by in situ deposited fluoropolymer. J Am Chem Soc. 2011 May 25;133(20):7722-4. doi: 10.1021/ja201497a. Epub 2011 Apr 28. [PubMed:21526774 ]
  9. Wolf U, Scholz A, Terekhov M, Koebrich R, David M, Schreiber LM: Visualization of inert gas wash-out during high-frequency oscillatory ventilation using fluorine-19 MRI. Magn Reson Med. 2010 Nov;64(5):1478-83. doi: 10.1002/mrm.22528. [PubMed:20593369 ]
  10. van der Kooij AM, Luijendijk SC: Longitudinal dispersion of gases measured in a model of the bronchial airways. J Appl Physiol (1985). 1985 Nov;59(5):1343-9. [PubMed:4066563 ]
  11. Constable IJ, Swann DA: Vitreous substitution with gases. Arch Ophthalmol. 1975 Jun;93(6):416-9. [PubMed:805581 ]
  12. Spohr R, Sharma G, Forsberg P, Karlsson M, Hallen A, Westerberg L: Stroke asymmetry of tilted superhydrophobic ion track textures. Langmuir. 2010 May 4;26(9):6790-6. doi: 10.1021/la904137t. [PubMed:20085343 ]
  13. Peyman GA, Vygantas CM, Bennett TO, Vygantas AM, Brubaker S: Octafluorocyclobutane in vitreous and aqueous humor replacement. Arch Ophthalmol. 1975 Jul;93(7):514-7. [PubMed:806278 ]
  14. Vygantas CM, Peyman GA, Daily MJ, Ericson ES: Octafluorocyclobutane and other gases for vitreous replacement. Arch Ophthalmol. 1973 Sep;90(3):235-6. [PubMed:4729778 ]
  15. Urrets-Zavalia A, Maldonado A: The insufflation of freon in vitreoretinal surgery. Mod Probl Ophthalmol. 1977;18:253-8. [PubMed:876060 ]
  16. Shiotani M, Lund A, Lunell S, Williams F: Structures of the hexafluorocyclopropane, octafluorocyclobutane, and decafluorocyclopentane radical anions probed by experimental and computational studies of anisotropic electron spin resonance (ESR) spectra. J Phys Chem A. 2007 Jan 18;111(2):321-38. [PubMed:17214470 ]
  17. Miller TM, Friedman JF, Viggiano AA: Electron attachment and detachment and the electron affinity of cyclo-C4F8. J Chem Phys. 2004 Apr 15;120(15):7024-8. [PubMed:15267603 ]
  18. Brubaker S, Peyman GA, Vygantas C: Toxicity of octafluorocyclobutane after intracameral injection. Arch Ophthalmol. 1974 Oct;92(4):324-8. [PubMed:4416676 ]
  19. (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .