Record Information |
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Version | 5.0 |
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Status | Detected but not Quantified |
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Creation Date | 2012-09-11 17:43:57 UTC |
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Update Date | 2022-03-07 02:53:01 UTC |
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HMDB ID | HMDB0031542 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Methylcyclopentane |
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Description | Methylcyclopentane, also known as methylpentamethylene, belongs to the class of organic compounds known as cycloalkanes. These are saturated monocyclic hydrocarbons (with or without side chains). Methylcyclopentane has been detected, but not quantified, in celeriacs and celery stalks. This could make methylcyclopentane a potential biomarker for the consumption of these foods. At high amounts methylcyclopentane is a potentially toxic compound and central nervous system depression may occur, with symptoms such as weakness, dizziness, slow and shallow respiration, unconsciousness, and convulsions. Methylcyclopentane is a volatile component of petroleum distillates. Petroleum distillates are aspiration hazards and may cause pulmonary damage, central nervous system depression, and cardiac effects such as cardiac arrhythmias. They may also affect the blood, immune system, liver, and kidney. Volatile hydrocarbons are absorbed mainly through the lungs, and may also enter the body after ingestion via aspiration. Treatment is mainly symptomatic and supportive. Petroleum distillates are also irritating to the skin. Petroleum distillate poisoning may cause nausea, vomiting, cough, pulmonary irritation progressing to pulmonary edema, bloody sputum, and bronchial pneumonia. Gastric lavage, emesis, and the administration of activated charcoal should be avoided, as vomiting increases the risk of aspiration. |
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Structure | InChI=1S/C6H12/c1-6-4-2-3-5-6/h6H,2-5H2,1H3 |
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Synonyms | Value | Source |
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Methyl cyclopentane | ChEBI | Methyl-cyclopentane | ChEBI | Methylpentamethylene | ChEBI |
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Chemical Formula | C6H12 |
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Average Molecular Weight | 84.1595 |
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Monoisotopic Molecular Weight | 84.093900384 |
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IUPAC Name | methylcyclopentane |
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Traditional Name | methylcyclopentane |
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CAS Registry Number | 96-37-7 |
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SMILES | CC1CCCC1 |
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InChI Identifier | InChI=1S/C6H12/c1-6-4-2-3-5-6/h6H,2-5H2,1H3 |
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InChI Key | GDOPTJXRTPNYNR-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as cycloalkanes. These are saturated monocyclic hydrocarbons (with or without side chains). |
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Kingdom | Organic compounds |
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Super Class | Hydrocarbons |
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Class | Saturated hydrocarbons |
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Sub Class | Cycloalkanes |
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Direct Parent | Cycloalkanes |
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Alternative Parents | Not Available |
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Substituents | - Cycloalkane
- Aliphatic homomonocyclic compound
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Molecular Framework | Aliphatic homomonocyclic compounds |
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External Descriptors | Not Available |
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Ontology |
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Physiological effect | |
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Disposition | |
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Process | Not Available |
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Role | Not Available |
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Physical Properties |
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State | Liquid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | -139.8 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | 3.37 | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatized |
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Spectra |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental GC-MS | GC-MS Spectrum - Methylcyclopentane EI-B (Non-derivatized) | splash10-0a4l-9000000000-f36947d92a09565016ad | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Methylcyclopentane CI-B (Non-derivatized) | splash10-001i-9000000000-89652fbd27509594b619 | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Methylcyclopentane EI-B (Non-derivatized) | splash10-0a4l-9000000000-f36947d92a09565016ad | 2018-05-18 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Methylcyclopentane CI-B (Non-derivatized) | splash10-001i-9000000000-89652fbd27509594b619 | 2018-05-18 | HMDB team, MONA, MassBank | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Methylcyclopentane GC-MS (Non-derivatized) - 70eV, Positive | splash10-069u-9000000000-f20228dae0dda76bc567 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Methylcyclopentane GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | MS | Mass Spectrum (Electron Ionization) | splash10-0a4l-9000000000-e94ad8098b4b70c9d748 | 2014-09-20 | Not Available | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 10V, Positive-QTOF | splash10-000i-9000000000-32d4c2667ea3fb16d0df | 2015-04-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 20V, Positive-QTOF | splash10-000i-9000000000-d818a8aa9bf254dadac5 | 2015-04-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 40V, Positive-QTOF | splash10-0a4l-9000000000-df6a147e653036178f26 | 2015-04-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 10V, Negative-QTOF | splash10-001i-9000000000-6d1754df5318b34cabe2 | 2015-04-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 20V, Negative-QTOF | splash10-001i-9000000000-6d1754df5318b34cabe2 | 2015-04-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 40V, Negative-QTOF | splash10-00lr-9000000000-f8ed5bb4f934bc89073f | 2015-04-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 10V, Positive-QTOF | splash10-0a4r-9000000000-79a23acab097b8c24d75 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 20V, Positive-QTOF | splash10-0a4l-9000000000-deb6f40b714e47a3d132 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 40V, Positive-QTOF | splash10-0006-9000000000-87fe95b8405e28cf90fc | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 10V, Negative-QTOF | splash10-001i-9000000000-1fe2685b7f3004ca04a3 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 20V, Negative-QTOF | splash10-001i-9000000000-386a19febdb8857d4e22 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Methylcyclopentane 40V, Negative-QTOF | splash10-001i-9000000000-bea98e26b5e568f76238 | 2021-09-22 | Wishart Lab | View Spectrum |
NMR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Biological Properties |
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Cellular Locations | |
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Biospecimen Locations | |
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Tissue Locations | Not Available |
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Pathways | |
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Normal Concentrations |
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Saliva | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Not Specified | Normal | | details |
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Abnormal Concentrations |
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| Not Available |
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Associated Disorders and Diseases |
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Disease References | None |
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Associated OMIM IDs | None |
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External Links |
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DrugBank ID | Not Available |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | FDB008152 |
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KNApSAcK ID | Not Available |
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Chemspider ID | 7024 |
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KEGG Compound ID | Not Available |
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BioCyc ID | Not Available |
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BiGG ID | Not Available |
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Wikipedia Link | Methylcyclopentane |
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METLIN ID | Not Available |
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PubChem Compound | 7296 |
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PDB ID | Not Available |
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ChEBI ID | 88429 |
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Food Biomarker Ontology | Not Available |
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VMH ID | Not Available |
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MarkerDB ID | Not Available |
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Good Scents ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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Material Safety Data Sheet (MSDS) | Not Available |
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General References | - Sprengnether MM, Demerjian KL, Dransfield TJ, Clarke JS, Anderson JG, Donahue NM: Rate constants of nine C6-C9 alkanes with OH from 230 to 379 K: chemical tracers for [OH]. J Phys Chem A. 2009 Apr 30;113(17):5030-8. doi: 10.1021/jp810412m. [PubMed:19334733 ]
- Anderson RS, Huang L, Iannone R, Rudolph J: Measurements of the 12C/13C kinetic isotope effects in the gas-phase reactions of light alkanes with chlorine atoms. J Phys Chem A. 2007 Jan 25;111(3):495-504. [PubMed:17228898 ]
- de Blas M, Navazo M, Alonso L, Durana N, Gomez MC, Iza J: Simultaneous indoor and outdoor on-line hourly monitoring of atmospheric volatile organic compounds in an urban building. The role of inside and outside sources. Sci Total Environ. 2012 Jun 1;426:327-35. doi: 10.1016/j.scitotenv.2012.04.003. Epub 2012 Apr 26. [PubMed:22542255 ]
- Fischader G, Roder-Stolinski C, Wichmann G, Nieber K, Lehmann I: Release of MCP-1 and IL-8 from lung epithelial cells exposed to volatile organic compounds. Toxicol In Vitro. 2008 Mar;22(2):359-66. Epub 2007 Oct 5. [PubMed:17993253 ]
- Wu Z, Lifka J, Ondruschka B: Aquasonolysis of selected cyclic C(6)H(x) hydrocarbons. Ultrason Sonochem. 2004 May;11(3-4):187-90. [PubMed:15081979 ]
- Davis AC, Tangprasertchai N, Francisco JS: Hydrogen migrations in alkylcycloalkyl radicals: implications for chain-branching reactions in fuels. Chemistry. 2012 Sep 3;18(36):11296-305. doi: 10.1002/chem.201103517. Epub 2012 Jul 24. [PubMed:22829453 ]
- Overett MJ, Blann K, Bollmann A, Dixon JT, Haasbroek D, Killian E, Maumela H, McGuinness DS, Morgan DH: Mechanistic investigations of the ethylene tetramerisation reaction. J Am Chem Soc. 2005 Aug 3;127(30):10723-30. [PubMed:16045361 ]
- Yoshida T: Approach to estimation of absorption of aliphatic hydrocarbons diffusing from interior materials in an automobile cabin by inhalation toxicokinetic analysis in rats. J Appl Toxicol. 2010 Jan;30(1):42-52. doi: 10.1002/jat.1470. [PubMed:19743389 ]
- Wu Z, Lifka J, Ondruschka B: Benzene formation during aquasonolysis of selected cyclic C6Hx hydrocarbons. Ultrason Sonochem. 2005 Jan;12(1-2):133-6. [PubMed:15474966 ]
- Zhang L, Feng L, Jia Q, Xu J, Wang R, Wang Z, Wu Y, Li Y: Effects of beta-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorg Med Chem. 2011 Aug 15;19(16):4882-6. doi: 10.1016/j.bmc.2011.06.069. Epub 2011 Jun 29. [PubMed:21775152 ]
- Zimniak A: Electron ionization-induced fragmentation of R2N2Fe2(CO)6 complexes with distinct geometries of the tetrahedral core: investigation of mu-1,2-(1,2-diaza-3-methylcyclopentane)diylbis(tricarbonyliron) and bis(mu2-acetophenoniminato)bis(tricarbonyliron). J Mass Spectrom. 2002 Nov;37(11):1145-51. [PubMed:12447891 ]
- Lee JW, Lu H, Moudrakovski IL, Ratcliffe CI, Ohmura R, Alavi S, Ripmeester JA: 13C NMR studies of hydrocarbon guests in synthetic structure H gas hydrates: experiment and computation. J Phys Chem A. 2011 Mar 10;115(9):1650-7. doi: 10.1021/jp1118184. Epub 2011 Feb 17. [PubMed:21329330 ]
- Sari O, Roy V, Balzarini J, Snoeck R, Andrei G, Agrofoglio LA: Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2'-deoxyuridines. Eur J Med Chem. 2012 Jul;53:220-8. doi: 10.1016/j.ejmech.2012.04.001. Epub 2012 Apr 21. [PubMed:22578783 ]
- Moustafa NE: Gas chromatographic analysis of petroleum associated condensate oil with simultaneous determination of some characteristic physical parameters. J Chromatogr Sci. 2008 May-Jun;46(5):388-91. [PubMed:18492346 ]
- Iwahashi M, Kasahara Y: Effects of molecular size and structure on self-diffusion coefficient and viscosity for saturated hydrocarbons having six carbon atoms. J Oleo Sci. 2007;56(8):443-8. [PubMed:17898511 ]
- Tripp JC, Schiesser CH, Curran DP: Stereochemistry of hexenyl radical cyclizations with tert-butyl and related large groups: substituent and temperature effects. J Am Chem Soc. 2005 Apr 20;127(15):5518-27. [PubMed:15826190 ]
- Chakrapani H, Liu C, Widenhoefer RA: Enantioselective cyclization/hydrosilylation of 1,6-enynes catalyzed by a cationic rhodium bis(phosphine) complex. Org Lett. 2003 Jan 23;5(2):157-9. [PubMed:12529129 ]
- (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .
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