Record Information |
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Version | 5.0 |
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Status | Expected but not Quantified |
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Creation Date | 2012-09-11 18:36:59 UTC |
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Update Date | 2023-02-21 17:23:41 UTC |
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HMDB ID | HMDB0033843 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Polyvidone |
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Description | Polyvidone is used as a diluent in colour additive mixtures for marking food; in coatings on fresh citrus fruits; as a clarifying agent for beer, wine and vinegar; as a tableting adjuvant. A cross-linked form of PVP is also used as a disintegrant (see also excipients) in pharmaceutical tablets. It is also known as cross-linked polyvinyl pyrrolidone, Polyvinyl Polypyrrolidone (PVPP), crospovidone, crospolividone. Basically, PVPP is a highly cross-linked version of PVP, which makes it insoluble in water but it still absorbs water and swells very rapidly and generate a swelling force. That is why it can be used a disintegrant in tablets. It is also used to bind impurities to remove them from solutions.It is also used as a fining to extract impurities (via agglomeration followed by filtration). Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced. PVPP can be used as well as a drug taken as a tablet or suspension and it absorbs compounds (so called Endotoxins) causing diarrhoea. (Cf. bone char, charcoal.); As a food additive, PVP is a stabilizer and has E number E1201. PVPP is E1202. It is also used in the wine industry as a fining agent for white wine. Other references state that as polyvinyl pyrrolidone and its derivatives are fully from mineral synthetic origin. Therefore, its use in the production should not be a problem for vegans. PVP is soluble in water and other polar solvents. In water it has the useful property of Newtonian viscosity. When dry it is a light flaky powder, which readily absorbs up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings. PVP was first synthesized by Prof. Walter Reppe and a patent was filed in 1939 for one of the most interesting derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production. Polyvinylpolypyrrolidone (PVPP, crospovidone) is a highly cross-linked modification of PVP. Polyvinylpyrrolidone (PVP) is a water-soluble polymer made from the monomer N-vinylpyrrolidone:. |
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Structure | InChI=1S/C6H13NOP2/c8-5-2-1-3-7(5)6(10)4-9/h6H,1-4,9-10H2 |
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Synonyms | Value | Source |
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Alphadine | MeSH | Alphadines | MeSH | Enterode | MeSH | Lacophtal | MeSH | Liquifilm lagrimas | MeSH | Nutrivisc | MeSH | PVP 40 | MeSH | PVP Iodine | MeSH | PVP-Iodine | MeSH | PVP-Iodines | MeSH | Pharmadine | MeSH | Pharmadines | MeSH | Polyvinylpyrrolidone | MeSH | Povidone-iodine | MeSH | Povidone-iodines | MeSH | Protagens | MeSH | Unspecified povidone | MeSH | Wet-comod | MeSH | Disadine | MeSH | Duratears free | MeSH | Hypotear | MeSH | Isodine | MeSH | Lagrifilm | MeSH | PVP-I | MeSH | Periston | MeSH | Polyvidon | MeSH | Povidone iodine | MeSH | Povidone, unspecified | MeSH | Protagen | MeSH | Protagent | MeSH | Providines | MeSH | Betaisodona | MeSH | Disadines | MeSH | Dulcilarme | MeSH | Enterodez | MeSH | Hypotears | MeSH | Isodines | MeSH | Lacri-stulln | MeSH | Polvidone | MeSH | Povidone | MeSH | Providine | MeSH | Vidisic PVP ophtiole | MeSH | Arufil | MeSH | Betadine | MeSH | Betadines | MeSH | Bolinan | MeSH | Bolinan 40 | MeSH | Crospovidone | MeSH | Dulcilarmes | MeSH | Enterodes | MeSH | Kollidon | MeSH | Oculotect | MeSH | Plasdone | MeSH | Polyplasdone XL | MeSH | Polyvidons | MeSH | Polyvinylpyrrolidone iodine | MeSH | Polyvinylpyrrolidone iodines | MeSH | Unifluid | MeSH | Vidirakt S mit PVP | MeSH | 'Kollidon 25' | HMDB | 'plasdone' | HMDB | 1-Ethenyl-2-pyrrolidinone | HMDB | 1-Ethenyl-2-pyrrolidinone (9ci) | HMDB | 1-Ethenyl-2-pyrrolidinone homopolymer | HMDB | 1-Ethenyl-2-pyrrolidinone homopolymer, 9ci | HMDB | 1-Ethenyl-2-pyrrolidinone polymers | HMDB | 1-Ethenyl-2-pyrrolidinone, homopolymer | HMDB | 1-Vinyl-2-pyrrolidinone | HMDB | 1-Vinyl-2-pyrrolidinone cross-linked insoluble polymer | HMDB | 1-Vinyl-2-pyrrolidinone homopolymer | HMDB | 1-Vinyl-2-pyrrolidinone polymer | HMDB | 1-Vinyl-2-pyrrolidinone, monomer | HMDB | 1-Vinyl-2-pyrrolidinone, polymer | HMDB | 1-Vinyl-2-pyrrolidone | HMDB | 1-Vinyl-2-pyrrolidone polymer | HMDB | 1-Vinylpyrrolidin-2-one | HMDB | 1-Vinylpyrrolidinone | HMDB | 1-Vinylpyrrolidone | HMDB | 2-Pyrrolidinone, 1-ethenyl, homopolymer | HMDB | 2-Pyrrolidinone, 1-ethenyl-, homopolymer | HMDB | 2-Pyrrolidinone, 1-vinyl-, polymers | HMDB | Agent at 717 | HMDB | Agent at-717 | HMDB | Agrimer | HMDB | Albigen a | HMDB | Aldacol Q | HMDB | Antaron P 804 | HMDB | Ganex P 804 | HMDB | Ganex P-804 | HMDB | Hemodesis | HMDB | Hemodez | HMDB | K 115 (Polyamide) | HMDB | K 25 (Polymer) | HMDB | K 25 | HMDB | K 30 (Polymer) | HMDB | K 30 | HMDB | K 60 (Polymer) | HMDB | K 60 | HMDB | K115 (Polyamide) | HMDB | K25 (Polymer) | HMDB | K30 (Polymer) | HMDB | K60 (Polymer) | HMDB | Kollidin CLM | HMDB | Kollidon 17 | HMDB | Kollidon 25 | HMDB | Kollidon 30 | HMDB | Kollidon CL | HMDB | Luviskol | HMDB | Luviskol K 30 | HMDB | Luviskol K 90 | HMDB | Luviskol K-30 | HMDB | Luviskol K30 | HMDB | Luviskol K90 | HMDB | N-Vinyl pyrrolidone | HMDB | N-Vinyl-2-pyrrolidinone | HMDB | N-Vinyl-2-pyrrolidone | HMDB | N-Vinyl-2-pyrrolidone polymer | HMDB | N-Vinylbutyrolactam polymer | HMDB | N-Vinylpyrrolidinone | HMDB | N-Vinylpyrrolidinone polymer | HMDB | N-Vinylpyrrolidone | HMDB | N-Vinylpyrrolidone polymer | HMDB | N-Vinylpyrrolidone-2 | HMDB | Neocompensan | HMDB | Peragal ST | HMDB | Peregal ST | HMDB | Periston-N | HMDB | Peviston | HMDB | Plasdone 4 | HMDB | Plasdone K 29-32 | HMDB | Plasdone K-26/28 | HMDB | Plasdone no. 4 | HMDB | Plasdone XL | HMDB | Plasmosan | HMDB | Polividone | HMDB | Poly(1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl) | HMDB | Poly(1-(2-oxo-1-pyrrolidinyl)ethylene) | HMDB | Poly(1-ethenyl-2-pyrrolidinone) | HMDB | Poly(1-vinyl-2-pyrrolidinone) | HMDB | Poly(1-vinyl-2-pyrrolidinone) homopolymer | HMDB | Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.1 | HMDB | Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.2 | HMDB | Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.3 | HMDB | Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.4 | HMDB | Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.5 | HMDB | Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.6 | HMDB | Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.7 | HMDB | Poly(1-vinyl-2-pyrrolidone) | HMDB | Poly(1-vinylpyrrolidinone) | HMDB | Poly(N-vinyl-2-pyrrolidinone) | HMDB | Poly(N-vinyl-2-pyrrolidone) | HMDB | Poly(N-vinylbutyrolactam) | HMDB | Poly(N-vinylpyrrolidinone) | HMDB | Poly(N-vinylpyrrolidone) | HMDB | Poly(vinylpolypyrrolidone) | HMDB | Poly(vinylpyrrolidinone) | HMDB | Poly(vinylpyrrolidone) | HMDB | Poly-N-vinyl pyrrolidone | HMDB | Poly-N-vinylpyrrolidone | HMDB | Polyclar a. t | HMDB | Polyclar a. t. | HMDB | Polyclar at | HMDB | Polyclar H | HMDB | Polyclar L | HMDB | Polyclar-at | HMDB | Polygyl | HMDB | Polyplasdone | HMDB | Polyvidonum | HMDB | Polyvinyl pyrrolidone | HMDB | Polyvinylpolypyrrolidone | HMDB | Polyvinylpyrrolidone polymers | HMDB | Polyvinylpyrrolidone, cross-linked | HMDB | Povidone(usan) | HMDB | Povidone, ban, usan | HMDB | PVP 1 | HMDB | PVP 2 | HMDB | PVP 3 | HMDB | PVP 4 | HMDB | PVP 5 | HMDB | PVP 6 | HMDB | PVP 7 | HMDB | PVP K 3 | HMDB | PVP-K 15 | HMDB | PVP-K 3 | HMDB | PVP-K 30 | HMDB | PVP-K 60 | HMDB | PVP-K 90 | HMDB | PVP10_SIAL | HMDB | PVP40_SIAL | HMDB | PVPP | HMDB | Refresh | HMDB | Sauflon | HMDB | Soothe | HMDB | Subtosan | HMDB | Tears plus | HMDB | Tolpovidone I 131 | HMDB | Tolpovidone I-131 | HMDB | Toxobin | HMDB | V-Pyrol | HMDB | Vinisil | HMDB | Vinyl-2-pyrrolidone | HMDB | Vinylbutyrolactam | HMDB | Vinylpyrrolidinone | HMDB | Vinylpyrrolidinone polymer | HMDB | Vinylpyrrolidone | HMDB | Vinylpyrrolidone polymer | HMDB | Betaisodonas | MeSH | Huntington laboratories brand OF povidone iodine | MeSH | Huntington laboratories brand OF povidone-iodine | MeSH |
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Chemical Formula | C6H13NOP2 |
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Average Molecular Weight | 177.121 |
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Monoisotopic Molecular Weight | 177.047237067 |
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IUPAC Name | 1-(1,2-diphosphanylethyl)pyrrolidin-2-one |
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Traditional Name | 1-(1,2-diphosphanylethyl)pyrrolidin-2-one |
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CAS Registry Number | 9003-39-8 |
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SMILES | PCC(P)N1CCCC1=O |
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InChI Identifier | InChI=1S/C6H13NOP2/c8-5-2-1-3-7(5)6(10)4-9/h6H,1-4,9-10H2 |
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InChI Key | LQIAZOCLNBBZQK-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as n-alkylpyrrolidines. N-alkylpyrrolidines are compounds containing a pyrrolidine moiety that is substituted at the N1-position with an alkyl group. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Pyrrolidines |
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Sub Class | N-alkylpyrrolidines |
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Direct Parent | N-alkylpyrrolidines |
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Alternative Parents | |
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Substituents | - Pyrrolidone
- 2-pyrrolidone
- N-alkylpyrrolidine
- Tertiary carboxylic acid amide
- Carboxamide group
- Lactam
- Carboxylic acid derivative
- Azacycle
- Organic oxide
- Organopnictogen compound
- Organic oxygen compound
- Organic nitrogen compound
- Organophosphorus compound
- Organooxygen compound
- Organonitrogen compound
- Carbonyl group
- Hydrocarbon derivative
- Aliphatic heteromonocyclic compound
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Molecular Framework | Aliphatic heteromonocyclic compounds |
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External Descriptors | Not Available |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | Not Available |
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Role | |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | 110 - 180 °C (glass temperature) | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | 42.97 mg/L @ 25 °C (est) | The Good Scents Company Information System | LogP | Not Available | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatized |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - Polyvidone GC-MS (Non-derivatized) - 70eV, Positive | splash10-0006-9500000000-a03b576f5815192ee7e5 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Polyvidone GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Polyvidone GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 10V, Positive-QTOF | splash10-004i-0900000000-012deab505c817500d72 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 20V, Positive-QTOF | splash10-000x-4900000000-27d3c90c48287687f736 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 40V, Positive-QTOF | splash10-0a4l-9200000000-4e005207ebec5aa70058 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 10V, Negative-QTOF | splash10-004i-0900000000-20451f4214337e090de5 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 20V, Negative-QTOF | splash10-004l-1900000000-23e2829b8da7d7deee29 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 40V, Negative-QTOF | splash10-053u-9000000000-6511800c7b4ed3f9571e | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 10V, Positive-QTOF | splash10-004i-0900000000-72ba633ad32f83af5c06 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 20V, Positive-QTOF | splash10-003r-0900000000-f07e0d7bb3148b067224 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 40V, Positive-QTOF | splash10-014i-5900000000-1f33078800397ac60ac1 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 10V, Negative-QTOF | splash10-004i-0900000000-ffea4601a1662a935d43 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 20V, Negative-QTOF | splash10-004i-1900000000-5b780139fd398f54ac36 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Polyvidone 40V, Negative-QTOF | splash10-05nb-0900000000-9bba71bba8f6e3fafbcc | 2021-09-22 | Wishart Lab | View Spectrum |
NMR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Predicted 1D NMR | 13C NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-25 | Wishart Lab | View Spectrum |
IR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+) | 2023-02-04 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+) | 2023-02-04 | FELIX lab | View Spectrum |
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General References | - Du B, Shen G, Wang D, Pang L, Chen Z, Liu Z: Development and characterization of glimepiride nanocrystal formulation and evaluation of its pharmacokinetic in rats. Drug Deliv. 2013;20(1):25-33. doi: 10.3109/10717544.2012.742939. [PubMed:23311650 ]
- Pandit V, Pai RS, Devi K, Suresh S: In vitro-in vivo evaluation of fast-dissolving tablets containing solid dispersion of pioglitazone hydrochloride. J Adv Pharm Technol Res. 2012 Jul;3(3):160-70. doi: 10.4103/2231-4040.101008. [PubMed:23057002 ]
- (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .
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